• 성인간호학회지
• /
• 제28권1호
• /
• pp.61-70
• /
• 2016

Purpose: This study aimed to identify the mediating effect of the resilience on the relationship between type D personality and compliance of Coronary Artery Disease (CAD) patients. Methods: The subjects were 236 CAD patients who visited the cardiology outpatient clinics of D University Medical Center in B City in Korea. The type D personality, resilience, and compliance of subjects were measured using structured questionnaires from July to August, 2014. The mediating effect was analyzed by a multiple hierarchical regression. Results: The subjects with type D personality accounted for 30.9% of all study subjects. The resilience and compliance of type D subjects were significantly lower than those of non type D subjects. There was a significant correlation between resilience and compliance. The direct effect of type D personality on compliance was not significant (${\beta}=-.07$, p=.243), while the indirect effect of type D personality on compliance via resilience was significant (${\beta}=.23$, p<.001). Conclusion: On the basis of above results, it can be concluded that the resilience had completely mediating effect on the relation between type D personality and compliance of CAD patients. Further studies need to be done to develop the intervention enhancing resilience of CAD patients with Type D personality.

• Journal of Computing Science and Engineering
• /
• 제8권2호
• /
• pp.87-93
• /
• 2014

Coronary artery disease (CAD) is currently a prevalent disease from which many people suffer. Early detection and treatment could reduce the risk of heart attack. Currently, the golden standard for the diagnosis of CAD is angiography, which is an invasive procedure. In this article, we propose an algorithm that uses data mining techniques, a fuzzy expert system, and the imperialist competitive algorithm (ICA), to make CAD diagnosis by a non-invasive procedure. The ICA is used to adjust the fuzzy membership functions. The proposed method has been evaluated with the Cleveland and Hungarian datasets. The advantage of this method, compared with others, is the interpretability. The accuracy of the proposed method is 94.92% by 11 rules, and the average length of 4. To compare the colonial competitive algorithm with other metaheuristic algorithms, the proposed method has been implemented with the particle swarm optimization (PSO) algorithm. The results indicate that the colonial competition algorithm is more efficient than the PSO algorithm.

• 재활간호학회지
• /
• 제18권2호
• /
• pp.135-144
• /
• 2015

Purpose: This study was conducted to examine the effects of an individualized cardiac rehabilitation education program on knowledge about coronary artery disease (CAD), compliance of sick role and vascular health status in patients with percutaneous coronary intervention (PCI). Methods: Quasi-experimental design-based nonequivalent control group pretest-posttest design was employed. Using convenience sampling, data were collected from 60 patients who underwent PCI at S Hospital in S City from September 2014 to February 2015. For examining the effects of an individualized cardiac rehabilitation education program, knowledge about CAD, compliance of sick role and vascular health status were measured. Results: The experimental group showed statistically significant differences in knowledge about CAD (t=24.21, p<.001), compliance with sick role (t=20.81, p<.001) and vascular health status (t=15.07, p<.001) compared to the control group. Conclusion: The individualized cardiac rehabilitation education program is effective in improving knowledge about CAD, compliance of sick role and vascular health status in patients who underwent PCI. Based on the findings of this study, nursing intervention programs focusing on individualized approach will be useful for patients undergoing PCI.

• Korean Circulation Journal
• /
• 제53권10호
• /
• pp.655-676
• /
• 2023

Interest in sex differences in coronary artery disease (CAD) has been steadily increasing. Concurrently, most of the data on these differences have primarily been Western-oriented. The KoRean wOmen'S chest pain rEgistry (KoROSE), started in 2011, has since published numerous research findings. This review aims to summarize the reported differences between men and women in CAD, integrating data from KoROSE. Cardiovascular risk in postmenopausal women escalates dramatically due to the decrease in estrogen levels, which normally offer cardiovascular protective effects. Lower estrogen levels can lead to abdominal obesity, insulin resistance, increased blood pressure, and endothelial dysfunction in older women. Upon analyzing patients with CAD, women are typically older and exhibit more cardiovascular risk factors than men. Diagnosing CAD in women tends to be delayed due to their symptoms being more atypical than men's. While in-hospital outcome was similar between sexes, bleeding complications after percutaneous coronary intervention occur more frequently in women. The differences in long-term prognosis for CAD patients between men and women are still a subject of ongoing debate. Pregnancy and reproductive factors also play a significant role as risk factors for cardiovascular disease in women. A notable sex disparity exists, with women found to use fewer cardiovascular protective drugs and undergo fewer interventional or surgical procedures than men. Additionally, women participate less frequently than men in clinical research. Through concerted efforts to increase awareness of sex differences and mitigate sex disparity, personalized treatment can be provided. This approach can ultimately improve patient prognosis.

• 대한의생명과학회지
• /
• 제14권1호
• /
• pp.55-58
• /
• 2008

Clusterin is an 80 kDa heterodimetric glycosylated protein and it plays diverse biological roles in various tissues and organs. Clusterin is reported to be associated with the pathogenesis of coronary artery disease and atherosclerosis. Therefore, we investigated the genotype for the A/G polymorphism at the position 4,183 of clusterin gene in Koreans and compared genotype of patients with control group. 100 patients (Male 63, Female 37), who previously underwent coronary artery stent due to ischemic heart disease and 100 controls (Male 36, Female 64) participated in this study. There was a significant association between 4,183 A/G polymorphism in clusterin gene and coronary artery disease (CAD). The present study shows that clusterin gene A/G polymorphism may be associated with the pathogenesis of CAD. Further studies with larger population may be needed for the development of diagnostic methods at genetic level such as DNA chip.

• 대한간호학회지
• /
• 제54권2호
• /
• pp.162-177
• /
• 2024

Purpose: This study aimed to investigate the influence of uncertainty-related factors on the health behavior of individuals with coronary artery disease (CAD) based on Mishel's uncertainty in illness theory (UIT). Methods: We conducted a cross-sectional study and path analysis to investigate uncertainty and factors related to health behavior. The study participants were 228 CAD patients who visited the outpatient cardiology department between September 2020 and June 2021. We used SPSS 25.0 and AMOS 25.0 software to analyze the data. Results: The final model demonstrated a good fit with the data. Eleven of the twelve paths were significant. Uncertainty positively affected danger and negatively affected self-efficacy and opportunity. Danger had a positive effect on perceived risk. Opportunity positively affected social support, self-efficacy, perceived benefit and intention, whereas it negatively affected perceived risk. Social support, self-efficacy, perceived benefit and intention had a positive effect on health behavior. We found that perceived benefit and intention had the most significant direct effects, whereas self-efficacy indirectly affected the relationship between uncertainty and health behavior. Conclusion: The path model is suitable for predicting the health behavior of CAD patients who experience uncertainty. When patients experience uncertainty, interventions to increase their self-efficacy are required first. Additionally, we need to develop programs that quickly shift to appraisal uncertainty as an opportunity, increase perceived benefits of health behavior, and improve intentions.

• 공업화학
• /
• 제29권5호
• /
• pp.497-502
• /
• 2018

협심증, 심근경색과 같은 관상동맥 질환은 급속도로 증가하고 있다. 관상동맥 질환은 콜레스테롤과 칼슘과 같은 플라크들이 혈관벽에 흡착되어 발생한다. 심혈관 중재시술은 풍선 카테터와 금속스텐트를 이용하여 좁아진 관상동맥혈관을 확장시키는 비수술적 시술방법이다. 금속재질의 스텐트는 관상동맥질환에 의한 사망자를 감소시키는데 효과적이었지만 영구적으로 혈관에 금속재질 스텐트가 이식되어 있기 때문에 지속적인 염증과 후기 혈전증 등이 발생되었다. 따라서, 스텐트와 같은 영구적 보철물에 의한 합병증과 재협착 등을 해결하기 위한 생체 흡수성 혈관 지지체의 개발은 급속도로 증가되고 있다. 이 리뷰에서는 생체흡수형스텐트의 성공적인 개발을 위한 동향에 대해서 논하고자 한다.

• 대한영상의학회지
• /
• 제83권1호
• /
• pp.54-69
• /
• 2022

심장 돌연사 환자들은 종종 흉통 또는 운동성 호흡곤란 등의 전조증상이 나타나지 않기 때문에 잠재적인 무증상 관상동맥 질환을 조기에 발견하는 것이 매우 중요하다. 관상동맥 전산화단층촬영 혈관조영술은 방사선 노출로 인한 위험성 때문에 무증상 환자에서 스크리닝 검사로 정당화되지 못했었지만 최근에 전산화단층촬영 기술의 비약적인 발전으로 방사선량을 1 mSv 미만으로 최소화함으로써 무증상 환자의 관상동맥 질환 선별 검사의 유용성에 대한 많은 연구가 진행되어 왔다. 그러나, 여전히 무증상 정상인 또는 환자의 관상동맥 질환 선별 검사에 대한 관상동맥 전산화단층촬영 혈관조영술의 유용성에 대해서는 다양한 의견들이 있다. 이 종설에서는 무증상 정상인 또는 환자들에게 관상동맥 질환 선별 검사로 관상동맥 칼슘 점수와 관상동맥 전산화단층촬영 혈관조영술 유용성에 대해서 다양한 문헌고찰을 통해서 알아보았다. 관상동맥 전산화단층촬영 혈관조영술상 무증상 정상인의 2.6%에서 70% 이상의 유의한 관상동맥 협착이 발견되었고, 선별 목적의 관상동맥 전산화단층촬영 혈관조영술이 무증상 건강한 사람의 미래의 심혈관 질환 발생을 예측할 수 있다. 그러나 현재 미국국립보건원에서 진행하고 있는 SCOT-HEART 2 연구가 끝나면 관상동맥 전산화단층촬영 혈관조영술이 무증상 성인의 심혈관 예방에 선별 검사로 적절한지 결정을 내릴 수 있을 것으로 생각된다.

• 생명과학회지
• /
• 제20권4호
• /
• pp.584-588
• /
• 2010

Clusterin은 Apolipoprotein J 등으로도 불리우기도 하는데 이 유전자의 발현이 동맥경화의 진행에 영향을 미치며[4], 관상동맥질환과 같은 혈관질환에도 중요한 역할을 하는 것으로 보고되어 있다[9,10,18] 최근 연구결과에 따르면, clusterin 유전자 다형성 중 10580 C>A, 10613 A>G이 아프리카인에게서 HDL-C의 serum level에 영향을 미치며, 이들 변이가 African-American에게서 Caucasian보다는 드물게 나타나지만, Hispanic에게서는 빈번하게 일어나는 것으로 보고되어 있다[11]. 또 다른 연구에서는 11개의 유전자 다형성을 조사한 결과 -4453G >T, 4183 A>G, 5608 C>T 는 상관관계가 없는 것으로 나타났으나, 6316 delT 유전자 다형성은 상관관계가 있는 것으로 보고되었다[8]. 본 연구에서는 관상동맥질환 환자군과 대조군을 각각 100명으로 하여 한국인에서 clusterin 유전자 다형성을 조사하였고, 특히 -4453 T>G에서 유의한 차이를 보였다. 이는 이전의 연구결과[8]와는 다소 차이가 있는데, Miwa 등의 결과에 따르면 일본인에게서는 6316 delT가 4183 A>G 다형성보다 동맥경화와 상관관계가 크다고 보고되었으나, 본 연구결과를 분석해보면 5608 C>T 는 상관관계가 없었으며, -4453 T>G 다형성만 상관관계를 가지는 것으로 나타났다. 이러한 차이를 보이는 원인은 정확하게 지적할 수는 없으나, 다형성이 미치는 영향력이 서로 다른 유전적 그리고 환경적인 요인의 차이에 의해서 일어나는 것으로 추정된다. 따라서 본 연구결과의 의의를 확인하기 위하여서는 대상 환자 수와 대조군을 늘리고 clusterin 유전자의 여러 다형성에 대한 추가적인 연구를 할 필요가 있을 것으로 판단된다.

• 한국콘텐츠학회논문지
• /
• 제12권10호
• /
• pp.349-356
• /
• 2012

관상동맥 죽상경화반(atheromatous plaque)의 진단에 있어 혈관내초음파(Intravascular Ultrasound: IVUS)와 비교하여 심장전산화단층촬영(Cardiac Computed Tomographic Angiography: CCTA)의 진단 정확도를 알아보고, IVUS에서 발견된 죽상경화반의 성상을 CCTA에서 전산화단층촬영 수치(Hounsfield Unit: HU)로 구하고자 하였다. 2006년 4월부터 2008년 8월까지 관상동맥질환(Coronary Artery Disease: CAD)으로 확진 되었거나 CAD가 의심스러운 환자들 중 CCTA를 시행하여 죽상경화반을 발견하고 추후 IVUS를 시행한 200명의 환자를 대상으로 하였다. CCTA후 IVUS를 시행한 200명의 환자에서 476개의 죽상경화반이 발견되었으며, CCTA에서는 460개의 죽상경화반이 발견되었다. IVUS의 결과는 soft plaque(n; 84), fibrous plaque(n; 63), mixed plaque(n; 97), calcific plaque(n; 232)이었다. 이 결과에 따라 IVUS에서 분류된 죽상경화반의 HU는 soft plaque : $53.8{\pm}10.5$, fibrous plaque : $108.1{\pm}20.0$, mixed plaque : $371.2{\pm}113.1$, 그리고 calcific plaque : $731.0{\pm}160.4$ 이었으며, CCTA에서 민감도와 신뢰구간은 97%, 95.0-98.3이었다. CCTA를 이용한 관상동맥 죽상경화반의 진단을 위한 이번 연구에서 IVUS와 비교하여 높은 민감도와 신뢰구간을 확인할 수 있었고, IVUS 결과를 기준으로 CCTA에서 분석한 HU를 통해 죽상경화반의 성상을 구분할 수 있어 CAD 환자의 치료에 도움을 줄 수 있을 것으로 기대된다.