Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
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Association of Clusterin Polymorphisms with Coronary Heart Disease in Koreans

  • Kim, Jun-Young (Department of Biology, College of Natural Sciences, Keimyung University) ;
  • Kim, Su-Won (Medical Education Program For Human Resources, Kyungpook National University) ;
  • Lee, In-Kyu (Department of Internal Medicine, Kyungpook National University School of Medicine) ;
  • Yoo, Min (Department of Biology, College of Natural Sciences, Keimyung University)
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  • 유민 (계명대학교 자연과학대학 생물학과)
  • Published : 2008.03.31
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Abstract

Clusterin is an 80 kDa heterodimetric glycosylated protein and it plays diverse biological roles in various tissues and organs. Clusterin is reported to be associated with the pathogenesis of coronary artery disease and atherosclerosis. Therefore, we investigated the genotype for the A/G polymorphism at the position 4,183 of clusterin gene in Koreans and compared genotype of patients with control group. 100 patients (Male 63, Female 37), who previously underwent coronary artery stent due to ischemic heart disease and 100 controls (Male 36, Female 64) participated in this study. There was a significant association between 4,183 A/G polymorphism in clusterin gene and coronary artery disease (CAD). The present study shows that clusterin gene A/G polymorphism may be associated with the pathogenesis of CAD. Further studies with larger population may be needed for the development of diagnostic methods at genetic level such as DNA chip.

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