• 한국세라믹학회지
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• 제51권4호
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• pp.357-361
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• 2014

An Ni-Fe/YSZ core-shell structured anode for uniform microstructure and catalytic activity was synthesized. Flat tubular segmented-in-series solid oxide fuel cell-stacks were prepared by decalcomania method using synthesized anode powder. The Ni-Fe/YSZ core-shell anode exhibited better electrical conductivity than a commercially available Ni-YSZ cermet anode. Also power output increased by 1.3 times with a higher open circuit voltage. These results can be attributed to the uniformly distributed Ni particles in the YSZ framework. The impedance spectra of a Ni-Fe/YSZ core-shell anode showed comparable reduced ohmic resistance similar to those of the commercially available Ni-YSZ cermet anodes.

• 한국산업융합학회 논문집
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• 제20권2호
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• pp.133-140
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• 2017

This paper is a study of the central structural unit model of the sandwich core structure. The applied model is based on the honeycomb structure formed by the truss, the H-shaped honeycomb structure formed by adding the truss of H shape to the space of the center portion, and the honeycomb structure formed by the plate. Applied material property is AISI 304 stainless steel, which has cost effectiveness and easy to get near place. The truss diameter of the model is three different type: 1mm, 2mm and 3mm. ABAQUS software is obtained to do the analysis and applied test is quasi-static loading. Boundary conditions for the analysis are that vertical direction loading at top place without any rotation and bottom surface is fixed. The test results show that the H-truss model has the highest stiffness and yield strength. Therefore, it is hoped that more and more researching for the development of a unit model in sandwich core structure has been investigating and that the developed sandwich core model can be applied into various industrial fields such as mechanical or aerospace industries.

• Advances in aircraft and spacecraft science
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• 제6권2호
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• pp.169-187
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• 2019

This work presents a practical detailed finite element (FE) approach for the three-dimensional (3D) free-vibration analysis of actual aircraft and spacecraft-type lightweight and thin honeycomb sandwich panels. It consists of calling successively in $MATLAB^{(R)}$, via a developed user-friendly GUI, a detailed 3D meshing tool, a macrocommands language translator and a commercial FE solver($ABAQUS^{(R)}$ or $ANSYS^{(R)}$). In contrary to the common practice of meshing finely the faces and core cells, the proposed meshing tool represents each wall of the actual hexagonal core cells as a single two-dimensional (2D) 4 nodes quadrangularshell element or two 3 nodes triangular ones, while the faces meshes are obtained simply using the nodes at the core-faces interfaces. Moreover, as the same 2D FE interpolation type is used for meshing the core and faces, this leads to an automatic handling of their required FE compatibility relations. This proposed approach is applied to a sample made of very thin glass fiber reinforced polymer woven composite faces and a thin aluminum alloy hexagonal honeycomb core. The unknown or incomplete geometric and materials properties are first collected through direct measurements, reverse engineering techniques and experimental-FE modal analysis-based inverse identification. Then, the free-vibrations of the actual honeycomb sandwich panel are analyzed experimentally under different boundary conditions and numerically using different mesh basic cell shapes. It is found that this approach is accurate for the first few modes used for pre-design purpose.

• Archives of Pharmacal Research
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• 제25권3호
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• pp.364-369
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• 2002

Hepatitis C virus (HCV) is remarkably efficient at establishing chronic infection. One of the reasons for this appears to be the suppression of the accessory cell function of professional antigen presenting cells. In the present study, the immunosuppressive activity of HCV protein was examined on dendritic cells (DCs) generated from mouse bone marrow progenitor cells in vitro. We found that the DCs forced to express HCV protein have defective allostimulatory ability. DCs expressing HCV protein were phenotypically indistinguishable from normal DCs. However, they were unable to produce IL-12 effectively when stimulated with lipopolysaccharide. The functional domain of the HCV protein essential for immunosuppression was determined using a series of ${NH_2}-and$ C-terminal deletion mutants of HCV core protein. We found that amino acid residues residing between the 21 st and the 40th residues from the ${NH_2}-terminus$ of HCV core protein are required for immunosuppression. These findings suggest that HCV core protein suppresses the elicitation of protective Th1 responses by the inhibition of IL-12 production by DCs.

• Genomics & Informatics
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• 제8권1호
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• pp.28-33
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• 2010

Increased exposure of human to RF fields has raised concerns for its potential adverse effects on our health. To address the biological effects of RF radiation, we used genome wide gene expression as the indicator. We exposed normal WI-38 human fibroblast cells to 1763 MHz mobile phone RF radiation at a specific absorption rate (SAR) of 60 W/kg with an operating cooling system for 24 h. There were no alterations in cell numbers or morphology after RF exposure. Through microarray analysis, we identified no differentially expressed genes (DEGs) at the 0.05 significance level after controlling for multiple testing errors with the Benjaminiochberg false discovery rate (BH FDR) method. Meanwhile, 82 genes were differentially expressed between RF-exposed cells and controls when the significance level was set at 0.01 without correction for multiple comparisons. We found that 24 genes (0.08% of the total genes examined) were changed by more than 1.5-fold on RF exposure. However, significant enrichment of any gene set or pathway was not observed from the functional annotation analysis. From these results, we did not find any evidence that non-thermal RF radiation at a 60-W/kg SAR significantly affects cell proliferation or gene expression in WI-38 cells.

• 한국항공우주학회지
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• 제32권8호
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• pp.82-90
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• 2004

등방성의 2차원 단위 셀 형상을 지닌 세 종류의 심재-삼각형 심재, 육각형 심재와 starcell 심재-에 대하여 샌드위치 구조물 내에서의 응용과 관련된 기계적 특성을 연구하였다. 세 종류의 심재에 대하여 축 방향 Young 계수, 전단 계수를 계산하여 비교하고, 심재의 셀 벽을 압축 하중과 전단 하중을 받고 있는 판재로 가정하여 축 방향 압축 좌굴 강도와 전단 좌굴 강도를 산출하였다. 심재의 유연성을 나타내는 평면탄성계수를 비교하고 쌍축 굴곡 실험 (biaxial flexural test)을 실시하여 유연성을 측정하였다. 세 가지 심재 모두 축 방향으로 같은 강성을 가지고 있었으나, 삼각형 심재는 다른 두 종류의 심재에 비하여 낮은 강도를 나타내었고, starcell 심재는 다른 심재들에 비해 월등히 높은 유연성 을 나타내었다. 이러한 유연성은 starcell 심재가 곡면에 적용되는 샌드위치 구조물의 심재로서 응용될 수 있음을 보여주었다.

• Journal of Microbiology and Biotechnology
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• 제12권5호
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• pp.807-812
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• 2002

In order to analyze the cellular proteins which interact with core protein of hepatitis C virus (HCV), a yeast two-hybrid screening technique was employed. A carboxyl terminus truncated core protein, which contained amino acid residues from the 1st to 120th, was used as a bait to screen cellular proteins. The expression library prepared from HeLa cell was screened and 400 positive clones were selected. The 75 clones from the positive clones were sequenced and analyzed by undergoing the Blast search. Interestingly, 7 out of the 75 clones encoded E7 antigen of human papilloma virus (HPV). We studied in detail the Interaction between the truncated version of HCV core and E7 antigen in vitro. The core$_{120}$ protein expressed in chimeric form with G57 was able to bring down the E7 protein of HPV type 18 expressed in bacteria. It is therefore suggested that the core of HCV might affect the interaction between E7 and a normal cellular tumor suppressor, known as Rb protein.

• 생명과학회지
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• 제18권4호
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• pp.585-589
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• 2008

Actin cytoskeleton rearrangement를 조절하는 cofilin은 인산기가 제거되면서 활성화되는데 이를 담당하는 효소가 chronophin이다. 이 효소는 비타민 $B_6$의 활성형태인 pyridoxal 5'-phosphate (PLP)의 세포 내 농도를 조절하는 PLP phosphatase로도 알려져 있다. Chronophin은 cap 도메인과 core 도메인을 갖는 HAD family에 속하는 phosphatase이며 다른 HAD phosphatase와 같이 기질결합을 위해 cap 도메인과 core 도메인 사이의 활성부위가 노출되는 열린 형태로의 전환이 있을 것으로 추정되었다. 이전의 밝혀진 chronophin/PLPP의 결정구조에서는 단백질의 결정화과정이 산화된 상태에 이루어졌기에 cap 도메인의 C91과 core 도메인의 C221 사이에 disulfide bond가 있었으며 이것이 cap 도메인과 core 도메인사이의 움직임을 막고 있었다. 본 연구에서는 환원된 상태의 chronophin의 결정체를 얻어 chronophin의 구조를 규명하였다. 환원된 상태의 chronophin의 구조에는 C91과 C221간의 disulfide 결합은 없었으나 산화된 상태와 동일한 닫힌 형태이었으며 국부적인 core 도메인의 움직임이외에는 core 도메인과 cap 도메인의 구조에는 변화가 없었다. 이는 chronophin이 기질이 없는 상태에서 닫힌 형태로 유지되는 것이 disulfide bond에 의한 것이 아님을 의미하며 세포 내의 환원된 상태에서도 닫힌 구조를 유지함으로서 높은 기질 특이성을 보여줄 것임을 암시한다.

• 한국주조공학회지
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• 제27권2호
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• pp.83-87
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• 2007

Aluminum plates of the same materials as the foam were attached by the casting process inserting the foam as a core to investigate the tensile property of open cell foams. Tensile properties of the open cell 6063 aluminum alloy foam of $10{\sim}30$ PPI were measured before and after heat treatment. Densities of test specimens were between 0.14 and $0.29g/cm^3$. Tensile strength of the 6063 aluminum foam after heat treatment showed little change. C values were in the range of $0.41{\sim}0.87$ for as cast foams and $0.11{\sim}0.27$ for T6 heat treated foams in the eq. of ${\sigma}^* _{pl}/{\sigma}_{ys}=C({\rho}/{\rho}_s)^{1.5}$, and increased with increase in the cell size.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2003년도 하계종합학술대회 논문집 II
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• pp.863-866
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• 2003

Recently, there has been growing interests in the magneto-resistive random access memory (MRAM) because of its great potential as a future nonvolatile memory. In this paper, a CMOS macro-model for MRAM cell based on a twin cell structure is proposed. The READ and WRITE operations of the MTJ cell can be emulated by adopting data latch and switch blocks. The behavior of the circuit is confirmed by HSPICE simulations in a 0.35-${\mu}{\textrm}{m}$ CMOS process. We expect the macro model can be utilized to develope the core architecture and the peripheral circuitry. It can also be used for the characterization and the direction of the real MTJ cells.