• Bulletin of the Korean Chemical Society
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• 제31권11호
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• pp.3333-3340
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• 2010

A three dimensional pharmacophore model was generated for the molecules which are responsible for anti-inflammatory activities targeting Interleukin-2 inducible tyrosine kinase (Itk). 16 structurally diverse molecules were selected as training set to generate the hypotheses using Discovery Studio v2.1. The best hypothesis, Hypo1, comprises two hydrogen bond acceptor (HBA), one hydrophobic aromatic (HA), one ring aromatic (RA) and shows high cost difference (63.71), high correlation coefficient (0.97) as well as low RMS deviation (0.81). Hypo1 has been further validated toward a test set, decoy set and Fischer's randomization method. Furthermore, Hypo1 was used to screen NCI and Maybridge databases. Finally, 2 hit molecules were identified as potential leads against Itk, which may be useful for future drug development.

• 한국재료학회:학술대회논문집
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• 한국재료학회 2009년도 추계학술발표대회
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• pp.11.1-11.1
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• 2009

Ternary Al2O3.ZrO2.Y2O3 samples with a eutecticcomposition were prepared by slow cooling. The microstructural evolution wasobserved with X-ray diffraction (XRD), scanning electron microscopy (SEM). TheSEM observation of the ternary samples agreed with the XRD with a completion ofcrystallisation by slow cooling. The target materials commonly have 'cantaloupe skin' microstructures as shown inthe previous studies by Han et al. The nanocomposite may have experienceddifferent cooling rates with two different microstructures, near the surfacehaving experienced optimal conditions for the eutectic reaction during theircooling and thus formed the eutectic microstructure, near the centre havingexperienced a slower cooling rate. The crystallised eutectic ternary Al2O3.ZrO2.Y2O3 system had three different phaseswith a 3Y2O3. 5Al2O3 (yttrium.aluminiumgarnet phase), an alumina phase formed by the eutectic reaction, and a solidsolution of ZrO2 and Y2O3.

• Journal of Plant Biotechnology
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• 제35권3호
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• pp.169-176
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• 2008

SA는 천연 페놀 화합물로써 식물체가 생성하는 호르몬 중의 하나이다. SA는 특히 병저항성, 생물학적, 비생물학적 스트레스로 인해 합성이 촉진되며 식물 방어 기작을 일으킨다고 알려져 있다. 식물의 방어 기작은 바로 식물에서 얻어지는 생산량에 영향을 미치기 때문에 SA에 대한 연구가 많이 되어져 왔다. 하지만 SA를 이해하기에는 아직까지 많은 연구가 필요 되어 지고 있다. 따라서 본 연구는 애기장대에서 SA 생합성하는데 중요한 효소인 SID2가 병저항성이 강한 siz1-2 돌연변이체와 야생형에서 어떠한 조절의 차이를 보이는 지를 SID2 promoter에 의해서 조절되는 GUS와 LUC를 가진 각각의 형질전환 식물체를 통하여 관찰하였다. GUS의 발현을 GUS histochemical assay, GUS enzyme assay 그리고 LUC의 발현을 CCD 카메라를 이용한 이미지 촬영과 Luciferase enzyme assay 수행한 결과, siz1-2를 사용한 형질전환 식물체에서 야생형에 비해 발현이 높게 일어났다. 이것을 바탕으로 SA에 반응하는 유전자들의 발현이 siz1-2 돌연변이체에서는 높은 이유가 SID2의 발현이 높게 조절 받기 때문이라는 것을 SID2 promoter:GUS::LUC/siz1-2 형질전환 식물체를 통해 알 수 있었다.

• 한국결정성장학회지
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• 제25권3호
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• pp.111-115
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• 2015

$Er^{3+}$ 이온이 5, 7.3, 8, 10 at.% 치환된 $Y_3Al_5O_{12}$ 단결정을 Czochralski법으로 질소 분위기에서 성장시켰다. 1.0 mm/h의 인상속도와 10 rpm의 회전 속도로 50 mm의 결정 직경을 가진 <111> 방향의 $Er:Y_3Al_5O_{12}$ 단결정을 얻었다. 두꺼운 직경의 core 영역은 주로 결정 성장 중 직경 변화가 있는 영역에서 발생되었다. 결정 내에서 $Er^{3+}$의 농도는 융액 내의 농도와 같았다. Core 영역의 $Er^{3+}$ 농도는 core가 없는 영역보다 다소 높게 검출되었다. $Er^{3+}$ 이온의 도핑 농도가 증가함에 따라 형광 수명은 포화되었다.

• 한국재료학회지
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• 제16권8호
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• pp.524-528
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• 2006

On the synthesis of Au/$TiO_2$ core-shell structure nanoparticle, the effect of concentration of $Ti^{4+}$ and reaction temperature on the morphology and optical property of Au/$TiO_2$ core-shell nanoparticles is examined. A gold colloid was prepared by $HAuCl_4{\cdot}4H_2O\;and\;C_6H_5Na_3{\cdot}2H_2O$. Titanium stock solution was prepared by mixing solution of titanium(IV) isopropoxide (TTIP) and triethanolamine (TEOA). The concentrations of $Ti^{4+}$ stock solution were adjusted to $10.01{\sim}0.3$ mM, and then the gold colloid is added to the $Ti^{4+}$ stock solution. Au/$TiO_2$ core-shell structure nanoparticles could be prepared by the hydrolysis of the $Ti^{4+}$ stock solution at $80^{\circ}C$. The size of synthesized Au nanoparticles was 15 nm. The thickness of $TiO_2$ shell on the surface of gold particles was about 10 nm. The absorption peak of synthesized Au/$TiO_2$ core-shell nanoparticles shifted towards the red end of the spectrum by about 3 nm because of the formation of $TiO_2$ shell on the surface of gold particles. The good $TiO_2$ shell is produced when $Ti^{4+}$ concentration is varied between 0.01 and 0.05 mM, and reaction temperature is maintained at $80^{\circ}C$. The crystal structure of $TiO_2$ shell was amorphous.

• 한국운동역학회지
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• 제28권4호
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• pp.213-218
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• 2018

Objective: The purpose of this study was to examine the effect of the core muscle strength enhancement of the elderly on 8 weeks training using the core exercise equipment for the elderly on the ability to control the whole-body center of mass in posture stabilization. Method: 16 females (10 exercise group, 6 control group) participated in this study. Exercise group took part in the core strength training program for 8 weeks with total of 16 repetitions (2 repetitions per week) using a training device. External perturbation during standing as pulling force applied at the pelvic level in the anterior direction was provided to the subject. In a UCM model, the controller selects within the space of elemental variables a subspace (a manifold, UCM) corresponding to a value of a performance variable that needs to be stabilized. In the present study, we were interested in how movements of the individual segment center of mass (elemental variables) affect the whole-body center of mass (the performance variable) during balance control. Results: At the variance of task-irrelevant space, there was significant $test^*$ group interactions ($F_{1,16}=7.482$, p<.05). However, there were no significant main effect of the test ($F_{1,16}=.899$, p>.05) and group ($F_{1,16}=1.039$, p>.05). At the variance of task-relevant space, there was significant $test^*$ group interactions ($F_{1,16}=7.382$, p<.05). However, there were no significant main effect of the test ($F_{1,16}=.754$, p>.05) and group ($F_{1,16}=1.106$, p>.05). Conclusion: The results of this study showed that the 8 weeks training through the core training equipment for the elderly showed a significant decrease in the $Vcm_{TIR}$ and $Vcm_{TR}$. This result indicates that the core strength training affects the trunk stiffness control strategy to maintain balance in the standing position by minimizing total variability of individual segment CMs.

• Applied Science and Convergence Technology
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• 제26권5호
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• pp.139-142
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• 2017

In this paper, InP-based InGaAs/InAlAs quantum cascade lasers(QCLs) providing nearly zero emission wavelength mismatch between the measured emission wavelength and the designed transition wavelength of QCLs is presented. The zero emission wavelength mismatch of QCLs influenced by both the accurate compositions and thicknesses of the low-pressure metal-organic vapor-phase epitaxy(MOVPE) grown InGaAs and InAlAs layers throughout the core and the abrupt composition transitions between InGaAs and InAlAs layers. The abrupt interfaces between InGaAs and InAlAs layers have been achieved throughout the core structure by means of controlling individually purged vent/run valves of a closed coupled showerhead reactor. In addition, maintaining substrate temperature constant during InGaAs/InAlAs core growth was a partial factor of uniformity improvement of QCLs. These approaches for reducing the possible discrepancies between the designed and MOVPE grown epitaxial structures could lead to improvement of QCL performance.

• Bulletin of the Korean Chemical Society
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• 제28권2호
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• pp.200-206
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• 2007

Pharmacophore models for lymphocyte-specific protein tyrosine kinase (P56 LCK) were developed using CATALYST HypoGen with a training set comprising of 25 different P56 LCK inhibitors. The best quantitative pharmacophore hypothesis comprises of one hydrogen bond acceptor, one hydrogen bond donor, one hydrophobic aliphatic and one ring aromatic features with correlation coefficient of 0.941, root mean square deviation (RMSD) of 0.933 and cost difference (null cost-total cost) of 66.23. The pharmacophore model was validated by two methods and the validated model was further used to search databases for new compounds with good estimated LCK inhibitory activity. These compounds were evaluated for their binding properties at the active site by molecular docking studies using GOLD software. The compounds with good estimated activity and docking scores were evaluated for physiological properties based on Lipinski's rules. Finally 68 compounds satisfied all the properties required to be a successful inhibitor candidate.

• Journal of Plant Biotechnology
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• 제36권1호
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• pp.53-58
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• 2009

Calcium signals can be transduced by binding calmodulin (CaM), a $Ca^{2+}$ sensor in eukaryotes, is known to be involved in the regulation of diverse cellular functions. We isolated a CaM-binding protein 63 kD (AtCBP63) from the pathogen-treated Arabidopsis cDNA expression library. Recently, AtCBP63 was identified as a CaM bining protein. The CaM binding domain of AtCBP63 was reported to be located in its N-terminal region, In this study, however, we showed that ACaM2 could specifically bind to second CaM-binding domain (CaMBD) of AtCBP63 at the C-terminal region. The specific binding of CaM to CaM binding domain was confirmed by a gel mobility shift assay, a split ubiquitin assay, site-directed mutagenesis, and a competition assay using a $Ca^{2+}$/CaM-dependent enzyme. The gene expression of AtCBP63 was induced by pathogens and pathogens related second messengers. This result suggests that a CaM binding protein, AtCBP63, may play role in pathogen defense signaling pathway.

• 한국물환경학회지
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• 제31권3호
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• pp.304-312
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• 2015

In this study, we tried to determine the vertical variation of sediment structure and geochemical characteristics, core sediment was collected in the Nakdong River midstream on August, 2014. Core sediment mainly composed of sand (51.48%) and silt (46.21%) and coarsing upward changed from sM to mS facies. IL and TOC were decreased from lower to upper layer. C/N ratio was lower than 10 so the organic matters were originated from underwater creatures and C/S ratio was decreased from lower to upper layer. Heavy metal (Al, Fe, Zn, Cr, Pb, Ni, Cu, Cd) content were decreased from lower to upper layer and seriously polluted condition is not. These results are thought to be due to the effect of natural and anthropogenic in the fluctuation of flow.