• 정보보호학회논문지
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• 제31권3호
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• pp.387-400
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• 2021

클라우드 환경의 발전에 따른 스트리밍 플랫폼과 콘텐츠의 증가로 합법적인 콘텐츠뿐만 아니라 불법 복제된 콘텐츠 또한 빠른 속도로 증가하고 있다. 따라서 다양한 콘텐츠에 대한 저작권 침해 여부를 판별할 수 있는 기술의 개발이 요구된다. 한국저작권보호원에서는 AI를 활용한 영상 콘텐츠 실증시스템을 운영하고 있지만, 해상도 변화와 같은 왜곡에 대해 한계점을 가지고 있다. 본 논문에서는 스켈레톤 정보를 활용하여 불법 스트리밍 플랫폼에서 유통 중인 영상 콘텐츠에 대해 왜곡 저항력이 강한 저작권 침해 여부 판단 기술을 제안한다. 제안하는 기법은 빠른 연산을 위해 수집된 데이터를 이진 데이터로 변환하여 원본 영상과의 해밍거리를 계산하는 방법을 사용하였으며, 실험 결과 평균 215KB의 크기와 94.79%의 정확도로 불법 복제 영상물을 판별할 수 있음을 확인하였다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제8권2호
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• pp.462-482
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• 2014

This paper proposes a new resampling detection method for images that detects whether an image has been resampled and recovers the corresponding resampling rate. The proposed method uses a given set of zeroing masks for various resampling factors to evaluate the convolution values of the input image with the zeroing masks. Improving upon our previous work, the proposed method detects more resampling factors by checking for some periodicity with an approximate detection mechanism. The experimental results demonstrate that the proposed method is effective and efficient.

• 대한의생명과학회지
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• 제20권4호
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• pp.185-193
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• 2014

Cancers are based upon an array of orchestrated genetic changes and the identification of changes causally related to the carcinogenic process. To elucidate the mechanism of cancer carcinogenesis, it is necessary to reconstruct these molecular events at each level. Microarray technologies have been extensively used to evaluate genetic alterations associated with cancer onset and progression in clinical oncology. The clinical impact of the genomic alterations identified by microarray technologies are growing rapidly and array analysis has been evolving into a diagnostic tool to better identify high-risk patients and predict patient outcomes from their genomic profiles. Here, we discuss the state-of-the-art microarray technologies and their applications in clinical oncology, and describe the potential benefits of these analysis in the clinical implications and biological insights of cancer biology.

• Journal of Microbiology and Biotechnology
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• 제23권6호
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• pp.837-842
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• 2013

A cryptic plasmid, pMBLR00, from Leuconostoc mesenteroides subsp. mesenteroides KCTC 3733 was isolated, characterized, and used for the construction of a cloning vector to engineer Leuconostoc species. pMBLR00 is a rolling circle replication plasmid, containing 3,370 base pairs. Sequence analysis revealed that pMBLR00 has 3 open reading frames: Cop (copy number control protein), Rep (replication protein), and Mob (mobilization protein). pMBLR00 replicates by rolling circle replication, which was confirmed by the presence of a conserved double-stranded origin and single-stranded DNA intermediates. An Escherichia coli-Leuconostoc shuttle vector, pMBLR02, was constructed and was able to replicate in Leuconostoc citreum 95. pMBLR02 could be a useful genetic tool for metabolic engineering and the genetic study of Leuconostoc species.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2001년도 International Symposium on Dietary and Medicinal Antimutgens and Anticarcinogens
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• pp.190-190
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• 2001

The elucidation of the genetic changes of cholangiocarcinoma is very important for understanding the molecular mechanism of carcinogenesis and progression of cholangiocarcinoma. In order to identify the gains or losses of the copy number of DNA sequence in cholangiocarcinoma, we used comparative genomic hybridization to study 33 cases of cholangiocarcinoma. The whole DNAs from each tumor tissue were labeled with different fluorochromes and then simultaneously hybridized to normal metaphase spread chromosomes.(omitted)

• 한국시스템다이내믹스연구
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• 제1권1호
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• pp.103-131
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• 2000

If a system such as a port has a large boundary and complexity, and the system's substance is considered as a black box, forecast accuracy will be very low. Futhermore various components in a port exert significant influence on each other. To copy with these problem the form of structure models were introduced by using SD method. The Competitive Ports Model had several sub-systems consisting of each Unit Port models, and each Unit Port model was made by quantitative, qualitative factors and their feedback loops. The fact that all components of one port have influence on the components of the other ports should be taken into account to construct Competitive Port Models. However, with the current approach that is impossible, and in this paper therefore, models were simplified by HFP adapted to integrate level variables of unit port models. Although many studies on modelling of port competitive situation have been conducted, both theoretical frame and methodology are still very weak. In this study, a new algorithm called ESD(Extensional System Dynamics) for the evaluation of port competition was presented, and applied to simulate port systems in northeast asia.

• 정보과학회 논문지
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• 제44권2호
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• pp.132-138
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• 2017

본 연구에서는 뉴메모리 기반 컴퓨팅 시스템의 신뢰성을 높이기 위해 프로세스 단위로 체크포인팅하는 시스템을 설계하고 구현한다. 프로세스 체크포인팅을 위하여 일반적인 프로세스 실행에서 문맥전환이 일어나는 시점마다 결함이 발생하기 이전의 안전한 상태로 되돌아갈 수 있는 롤백 시점을 만든다. 본 연구에서는 롤백 시점의 안전한 프로세스 상태에 대한 새로운 프로세스를 만들며 이를 P-process(Persistent-process)라고 명명한다. P-process를 만드는 주기를 세밀한 간격인 문맥전환 때마다 만들기 때문에 결함이 발생하였을 때 롤백으로 인한 프로세스 실행시간 손실을 작게 만들 수 있다. P-process를 만드는 오버헤드를 줄이기 위하여 프로세스의 메모리 상태에서 변경된 부분만 저장할 수 있도록 COW(Copy-On-Write) 메커니즘을 이용하였다. 문맥전환 때마다 P-process를 생성하였을 때 PARSEC 벤치마크의 11개 워크로드 중 8개의 워크로드에서 5% 내의 실행 시간 오버헤드가 발생하였으며 오버헤드가 많이 발생한 워크로드도 P-process의 생성 주기의 조정으로 오버헤드를 감소시킬 수 있었다.

• 대한두경부종양학회지
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• 제23권1호
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• pp.21-25
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• 2007

Background：Squamous cell carcinoma(SCC)of the palatine tonsils represents approximately 15-23% of all intraoral SCC. The most frequently reported risk factors for oropharyngeal cancer are smoking and alcohol. In a recent overview of HPV and tonsillar squamous cell carcinoma(TC), 51% contained HPV DNA, and HPV-16 being the most frequent type. We aimed to clarify whether HPV directly effects on the oncogenesis and biologic behavior of TC by comparison with infection prevalence, and physical status of virus. Material and Method：We used HPV genotyping DNA chip(Biocore, Korea, Seoul) arrayed by multiple oligonucleotide probes of L1 sequence of 26 types of HPV and HPV genotypes are identified by fluorescence scanner. The copy numbers of HPV E2 and E6 open reading frames(ORF) were assessed using a TaqMan-based 5'-exonuclease quantitative real-time PCR assay. The ratio of E2 to E6 copy numbers was calculated to determine the physical status of HPV-16 viral gene. Results：We observed a significant difference in HPV prevalence between 52 TCs and 69 CFTs(73.1% vs. 11.6%), and most of the HPVs were type 16(87.2%)and non-episomal(94.1%) state. Conclusions：This study regarding HPV infection prevalence and mechanism in the largest population of palatine tonsillar squamous cell carcinoma with chronic follicular tonsillitis revealed significant difference pf HPV prevalence between TC and CFT. Most of HPV were 16 type and integrated or mixed, HPV-16 integration could be directly related to tonsillar carcinogenesis.

• 정보보호학회논문지
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• 제18권4호
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• pp.167-174
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• 2008

디지털 카메라와 캠코더의 보급이 증가함에 따라 일반 사용자들의 UCC(User Created Contents) 역시 일반화 되고 있다. 그러나 이에 따른 사생활 침해 또한 증가하고 있다. UCC는 인터넷 포탈 서비스를 통해 공유될 뿐 아니라 DVD(Digital Versatile/Video Disk)와 같은 저장매체(Recordable Media, 이하 Media)를 이용하여 보관된다. 포탈 서비스를 이용해서 콘텐츠를 게시하는 경우 포탈 시스템이 제공하는 사용자 인증 및 불법 다운로드 제어 기술을 이용하여 사생활 침해를 부분적으로 막을 수 있다. Media의 경우도 불법복제 제어기술을 채택하고 있지만, Media의 도난 또는 분실로 인한 콘텐츠 유출과 사생활 침해를 막을 수 있는 방법이 현재로서는 제공되지 않고 있다. 그러므로 Media를 이용하여 개인 콘텐츠를 관리하는 경우에도 사생활 침해를 막을 수 있는 추가적인 보안 기술의 연구가 필요하다. 본 논문에서는 Media 보안을 위해 제정된 AACS(Advanced Access Content System)의 Framework을 살펴보고 개인 콘텐츠의 접근을 제어할 수 있는 개선된 AACS 보안 Framework을 제안한다.

• Journal of Veterinary Science
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• 제24권4호
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• pp.53.1-53.12
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• 2023

Background: Mammalian orthoreovirus type 3 (MRV3), which is responsible for gastroenteritis in many mammalian species including pigs, has been isolated from piglets with severe diarrhea. However, the use of pig-derived cells as an infection model for swine-MRV3 has rarely been studied. Objectives: This study aims to establish porcine intestinal organoids (PIOs) and examine their susceptibility as an in vitro model for intestinal MRV3 infection. Methods: PIOs were isolated and established from the jejunum of a miniature pig. Established PIOs were characterized using polymerase chain reaction (PCR) and immunofluorescence assays (IFAs) to confirm the expression of small intestine-specific genes and proteins, such as Lgr5, LYZI, Mucin-2, ChgA, and Villin. The monolayered PIOs and three-dimensional (3D) PIOs, obtained through their distribution to expose the apical surface, were infected with MRV3 for 2 h, washed with Dulbecco's phosphate-buffered saline, and observed. Viral infection was confirmed using PCR and IFA. We performed quantitative real-time reverse transcription-PCR to assess changes in viral copy numbers and gene expressions linked to intestinal epithelial genes and antiviral activity. Results: The established PIOs have molecular characteristics of intestinal organoids. Infected PIOs showed delayed proliferation with disruption of structures. In addition, infection with MRV3 altered the gene expression linked to intestinal epithelial cells and antiviral activity, and these effects were observed in both 2D and 3D models. Furthermore, viral copy numbers in the supernatant of both models increased in a time-dependent manner. Conclusions: We suggest that PIOs can be an in vitro model to study the infection mechanism of MRV3 in detail, facilitating pharmaceutical development.