• IMMUNE NETWORK
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• v.2 no.1
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• pp.60-64
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• 2002

Background: Chemotherapy with 5-fluorouracil (5-FU) has been one of the mainstay in breast cancer treatment. The effects of high dose 5-FU on cell cycle regulation were studied in breast caner cells. Methods: A breast cancer cell line MCF-7 was used. Protein expressions of G1/S cyclins, $p21^{Waf1/Cip1}$, cdk2, E2F1 and retinoblastoma were tested by western blot analysis. Immunoprecipitation and immune complex kinase assay were done for the assessment of E2F1/RB interacton and the activity of cdk2 respectively. Results: $p21^{Waf1/Cip1}$ expression was barely detectable in control cells. With addition of 5-FU level of $p21^{Waf1/Cip1}$ were induced and cyclin D3 level was decreased as cell growth decreases. In accordance with increased expression of $p21^{Waf1/Cip1}$, cyclin E-associated cdk2 kinase activity was reduced. Retinoblastoma protein (RB) became dephosphorylated and E2F-1 binding activity with RB was increased. Conclusion: In this situation of high concentration of 5-FU breast cancer cells tend to be G1/S cell cycle arrested. Overexpression of $p21^{Waf1/Cip1}$ and dephosphorylation of RB may mediate the effectss of 5-FU by inhibiting E2F-1 activity, which contributes to G1/S cell cycle arrest. These results could be an indicating landmark for further study of high dose chemotherapy with 5-FU.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.41 no.2
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• pp.79-88
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• 2004

Gaze detection is to locate the position on a monitor screen where a user is looking by computer vision. Gaze detection systems have numerous fields of application. They are applicable to the man-machine interface for helping the handicapped to use computers and the view control in three dimensional simulation programs. In our work, we implement it with a computer vision system setting a IR-LED based single camera. To detect the gaze position, we locate facial features, which is effectively performed with IR-LED based camera and SVM(Support Vector Machine). When a user gazes at a position of monitor, we can compute the 3D positions of those features based on 3D rotation and translation estimation and affine transform. Finally, the gaze position by the facial movements is computed from the normal vector of the plane determined by those computed 3D positions of features. In addition, we use a trained neural network to detect the gaze position by eye's movement. As experimental results, we can obtain the facial and eye gaze position on a monitor and the gaze position accuracy between the computed positions and the real ones is about 4.8 cm of RMS error.

• Journal of Korea Water Resources Association
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• v.46 no.4
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• pp.345-359
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• 2013

In order to manage water quality efficiently and systematically through TMDL (Total Maximum Daily Load), the demand for the construction of spatial data for stream networks has increased for use with GIS-based water quality modeling, data management and spatial analysis. The objective of this study was to present an improved KRF (Korean Reach File) design as framework data for domestic stream networks to be used for various purposes in relation to the TMDL. In order to achieve this goal, the US EPA's RF (River Reach File) was initially reviewed. The improved design of the graphic and attribute data for the KRF based on the design of the EPA's RF was presented. To verify the results, the KRF was created for the Han River Basin. In total, 2,047 stream reaches were divided and the relevant nodes were generated at 2,048 points in the study area. The unique identifiers for each spatial object were input into the KRF without redundancy. This approach can serve as a means of linking the KRF with related database. Also, the enhanced topological information was included as attributes of the KRF. Therefore, the KRF can be used in conjunction with various types of network analysis. The utilization of KRF for water quality modeling, data management and spatial analysis as they pertain to the applicability of the TMDL should be conducted.

• Journal of IKEEE
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• v.5 no.1 s.8
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• pp.100-110
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• 2001

In this paper, we investigated several buffer management schemes for the design of shared-memory type ATM switches, which can enhance the utilization of switch resources and can support quality-of-service (QoS) functionalities. Our results show that dynamic threshold (DT) scheme demonstrate a moderate degree of robustness close to pushout(PO) scheme, which is known to be impractical in the perspective of hardware implementation, under various traffic conditions such as traffic loads, burstyness of incoming traffic, and load non-uniformity across output ports. Next, we considered buffer management strategies to support QoS functions, which utilize parameter values obtained via connection admission control (CAC) procedures to set tile threshold values. Through simulations, we showed that the buffer management schemes adopted behave well in the sense that they can protect regulated traffic from unregulated cell traffic in allocating buffer space. In particular, it was observed that dynamic partitioning is superior in terms of QoS support than virtual partitioning.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.36 no.10B
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• pp.1150-1158
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• 2011

More than 100 Mbps rate is needed in the UBcN for a subscriber to receive broadband traffics with multi-channel like UDTV or 3DTV. Although the optical fiber is recently deployed for the FTTH, the UTP is the most widely used medium and will be used in UBcN age. Network providers may consider the 1000BASE-T or the vectorized VDSL if they adopts the UTP in the place where does not have optical fibers. But UTP should be expanded because 1000BASE-T and vectorized UTP needs 4 and 3 pairs cable, respectively while residential region has not exceeding 2 pair UTP cable. To solve the problem, we propose a 500BASE-T technology using 2 pairs UTP in this paper. The technology introduces a rate adaptation sublayer and a SERDES sublayer above and under the PCS, respectively. The rate adaptation sublayer is compatible for the GMII. Also, if we modify the SERDES sublayer, the technology can easily obtain 250BASE-T with 2 pairs UTP. We implement such functions with FPGA and analog board and verify the function of rate adaptation and symbol vector synchronization, and effective transmission rate by experiments. In particular, we show that link efficiency is increased by enable control in the rate adaptation sublayer.

• Journal of the Korea Society for Simulation
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• v.21 no.1
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• pp.81-88
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• 2012

In the M&S filed, The Battle Lab is available for acquisition, design, development tool, validation test, and training in the weapon system of development process. Recently, the Battle Lab in the military of Korea is still in an early stage, in spite of importance of battle lab construction. In the environment of network centric warfare, a practical use of the M&S which is connecting live, virtual and constructive model can be applied to all field of System Engineering process. It is necessary thar the Battle Lab is not restricted by time and space, and is possible for the technical implementation. In this paper, to guarantee the interoperability of live and virtual simulation, virtual simulators connect live simulators by using the tactical data link. To guarantee the interoperability of virtual and constructive simulation, both virtual simulators and constructive simulators use the RTI which is the standard tool of M&S. We propose the System that constructed the Air Defence Battle Lab. In case of the approach of target tracks, The Air Defence Battle Lab is the system for the engagement based on a command of an upper system in the engagement weapon system. Constructive simulators which are target track, missile, radar, and launcher simulator connect virtual simulators which are MCRC, battalion, and fire control center simulators using the RPR-FOM 1.0 that is a kind of RTI FOM. The interoperability of virtual simulators and live simulators can be guaranteed by the connection of the tactical data links which are Link-11B and ATDL-1.

• Journal of Digital Convergence
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• v.13 no.1
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• pp.297-304
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• 2015

Recently, the demand for a PRT(Personal Rapid Transit) system based on autonomous navigation is increasing. Accordingly, the applicability investigations of the PRT system on rail tracks or roadways have been widely studied. In the case of unmanned vehicle operations without physical guideways on roadways, to monitor the position of the vehicle in real time is very important for stable, robust and reliable guidance of an autonomous vehicle. The Global Positioning System (GPS) has been commercially used for vehicle positioning. However, it cannot be applied in environments as tunnels or interiors of buildings. The PRT navigation system based on magnetic markers reference sensing that can overcome these environmental restrictions and the vehicle dynamics model for its H/W configuration are presented in this study. In addition, the design of a control S/W dedicated for unmanned operation of a PRT vehicle and its prototype implementation for experimental validation on a pilot network were successfully achieved.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.44 no.12
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• pp.34-43
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• 2007

Recently, in addition to the sharp increase of mobile nodes, various kinds of wireless technologies are available for mobile nodes. If IPv6 technology is applied to the network, multi-homing terminals which have several public IP addresses on one interface will be common. Accordingly, there are many research activities on mobility management for multi-interface, multi-homming nodes. In this paper we propose an extended fast handover mechanism for multi-interface MIPv6 environments that uses multi-interface FBU (MFBU) message instead of the existing FBU message. The MFBU message has the "tunnel destination" mobility option that points a specific tunnel destination other than NAR, and "T" flag that indicates the existence of tunnel destination option. The proposed mechanism can improve the TCP performance by mitigating packet reordering during FMIPv6 handover that can cause unnecessary congestion control due to 3 duplicate ACKs. In this paper, we implemented a multi-Interface MIPv6 simulator by extending a single-interface MIPv6 simulator in NS-2, and showed that the performance of TCP traffic is improved by using the proposed multi-interface fast MIPv6.

• Journal of the Institute of Electronics and Information Engineers
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• v.51 no.11
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• pp.205-210
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• 2014

This is concerned with the technology to display the design on Porcelain and adjust malfunction for moving effect and light intensity by curator. More precisely, the technology makes it possible that the porcelain is connected to Light module which is the device for controlling light emission and rotating rolling plate, etc that are connected to LED light module, optical fiber and controller that is for scenario from the given storytelling. In addition, with a WiFi portable device (Smart-phone, other mobile device). equipped with a scenario programs, information for operation, failure and malfunction can be obtained and analyzed in real-time, and menu color and alarm is alerted when the displaying design is in abnormal status, which makes the early reactions to the status. Furthermore, the collected data can be sent through WiFi network to the device and PC managed by the curator specialized in managing the design on the Porcelain, thus the technology could help the curator who have less knowledge about moving pattern on the Porcelain. There is always a possibility of malfunction due to various condition that are caused by wring-harness when modules are wired-connected. In this research, in order to overcome this problem, we propose a system configuration that can do monitoring and diagnosis with a device for collecting data from LED control module, Light emission sensor and a personal WiFi device. Also, we performed connection between optical Fiber and LED and interlock for the system defined by the definition for information and storytelling scenario.

• Journal of National Security and Military Science
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• s.4
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• pp.83-118
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• 2006

This study is to develop digital leadership in a field of national defense. Today, korean society is facing the crisis of national security. But national defense leadership is not show in the circumstance of national security crisis. As you know, national defense leadership is a process that make use of influence. Which means it converges people's interest and demands well and also show people the right vision of national defense and make them to comply the policy about national security. Because of the environmental change, our national defense leadership is having a new turning point. First, international order, which is under post-cold war, raises possibility of guarantee of peace and security in international society but also, cause the increase of multiple uncertainty and small size troubles in security circumstance. In addition, Korean society is rushing into democratization and localization period by success in peaceful change of political power went through about three times. The issue of political neutralization of military is stepping into settlement but still, negative inheritance of old military regime is worrying about it. In this situation, we can't expect rise in estimation about the importance of security and military's reason for being. So, military have to give their concern to not only internal maintenance of order and control and growth of soldiers but also developing external leadership to strength influence to society and military's the reason for being. So for these alternative I'm suggesting a digital leadership of national defense which fits digital era. This digital leadership is the leadership which can accept and understand digital technology and lead the digital organization. To construct digital national defense we need a practical leadership. The leadership has to be digital leadership with digital competence that can direct vision of digital national defense and carry out the policy. A leader who ha s digital leadership can lead the digital society. The ultimate key to construct digital government, digital corporate and digital citizen depends on digital leader with digital mind. To be more specific, digital leadership has network leadership, next generation leadership, knowledge driven management leadership, innovation oriented leadership. A leader with this kind of leadership is the real person with digital leadership. From now on, to rise this, we have to build up human resource development strategy and develop educational training program.