• Therapeutic Science for Rehabilitation
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• v.11 no.3
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• pp.7-22
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• 2022

Objectives : This study was a systematic review of tongue movements in stroke patients with dysphagia. This study aimed to provide a basis for verifying the effects of tongue movement and identifying the tendency of tongue movement. Methods : A systematic review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist and flow chart. PubMed, MEDLINE, CINAHL, RISS, and e-articles databases were searched. A total of six documents were investigated, and the PEDro scale was used to evaluate the quality of the papers. Results : Three intervention methods were included in the six papers analyzed. Regarding the type of tongue exercise, three TPRT (Tongue to Palate Resistance Trainings) and two TSAT (Tongue Strength and Accuracy Training) were mediated through the IOPI (Iowa Oral Performance Instrument), and only one study applied TSE (Tongue Stretching Exercise). The treatment effects for each intervention implemented in the literature were confirmed to be effective. However, generalizability of findings is difficult because of the small sample size. Further, no significant difference was found between the experimental and control groups. Conclusions : This study can help occupational therapists provide efficient swallowing rehabilitation treatment by applying tongue exercises to stroke patients with dysphagia. More research should be conducted to determine the effects of tongue exercise.

• Journal of Life Science
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• v.33 no.5
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• pp.397-405
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• 2023

Although glutathione (GSH) has been shown to play an important role in the prevention of oxidative damage as an antioxidant, studies on immune regulation by it have not been properly conducted. In this study, we investigated whether luthione^®, a reduced GSH, has an immune enhancing effect in murine macrophage RAW 264.7 cells. The results of flow cytometry and immunofluorescence experiments indicated that luthione increased phagocytic activity, a representative function of macrophages, compared to the control cells. According to the results of the cytokine array, the expression of interleukin (IL)-5, IL-1β, and IL-27 was significantly increased in the luthione-treated cells. Luthione also enhanced the production of tumor necrosis factor-α and IL-1β through increased expression of their proteins, and increased release of the immune mediators such as nitric oxide (NO) and prostaglandin E₂ was associated with increased expression of inducible NO synthase and cyclooxygenase-2. In addition, the expression of cluster of differentiation 86, an M1 macrophage marker, was dramatically enhanced in RAW 264.7 cells treated with luthione. Furthermore, as a result of heat map analysis, we found that cytokine signaling 1/3-mediated signal transducer and activator of transcription/Janus tyrosine kinase signaling pathway was involved in the immunomodulatory effect by luthione. In conclusion, our data suggested that luthione could act as a molecular regulator in M1 macrophage polarization and enhance immune capacity by promoting macrophage phagocytic function.

• Proceedings of the Korea Water Resources Association Conference
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• 2023.05a
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• pp.371-371
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• 2023

담양 및 화순 홍수조절지는 홍수 시 본류에 계획방류량만 흘러가도록 제수문을 운영하고, 계획방류량을 초과하는 홍수량은 하도 및 조절지 내에 저류하여 홍수를 지체시킨 후 저류된 홍수량은 첨두홍수가 지나간 이후 방류하는 방법으로 영산강 유역의 홍수를 방어하기 위해 '12년 건설되었다. 그러나 홍수조절지는 200년 빈도의 홍수량을 저감 시키도록 설계됨에 따라 준공 이후 10년간 '20년 8월 홍수 등 3회만 홍수방어용으로 활용되었다. 영산강은 오염부하량 대비 유출량 부족 등으로 수질관리에 취약하고 하천유지용수를 공급하는 다목적댐이 없는 등 수자원 확보가 어려우므로, 비홍수기 홍수조절지에 환경대응용수를 담수 및 방류하여 영산강의 유량확보 및 수질개선 등 활용 다변화 방안을 모색하고자 한다. 이와 관련하여 '16년 및 '19년에 시범담수를 실시하였으나, 담수 수질 관리의 어려움, 방류 전후 강우 등 제한적 여건으로 인해 하류 유량증가 및 수질 개선 효과의 확인은 어려웠으며, 제방 물비침 등을 발견하여 시설 안정성 확보가 필요한 것으로 확인되었다. '21년 안정성 확보를 위한 보강 그라우팅을 시행했으며, '19년부터 '21년 2월까지 「홍수조절지를 활용한 영산강 수질개선 방안」연구용역을 실시하여, 비홍수기 활용방안을 수립하였다. '21년 4/4분기 댐과 보 등의 연계운영협의회에 '시범담수 계획' 안건 상정 및 의결을 거쳤고, '22년 3월 25~26일까지 담양 74mm, 화순 61mm 비가 내려 담양 63만m³, 화순 151만m³를 담수하고 18~19일간 저류 후 담양은 평균 3.0m³/초로 25시간 동안, 화순은 평균 5.0m³/초로 32시간 동안 하류로 방류하였다. 방류 후 담양·화순 모두 가까운 하류 수위국 수위 상승을 확인했으며, 화순의 경우 하류 수질에 일부 영향이 있음을 확인하였다. 다만, 초기유출수 배제 등을 고려하지 않아 담수의 수질이 본류보다 좋지 않았으며, 이에 따라 수질 영향의 인과관계 확인이 어려웠다. 기존 연구용역에서 제시한 비홍수기 활용방안의 검증·보완을 위한 연구용역이 '22.5월부터 '23.12월까지 진행될 예정이며, 초기유출수 배제를 위한 조건 재수립, 수질 모니터링지점 확대 등 보완된 '시범담수 계획'을 '23.3월 댐과 보 등의 연계운영협의회에 보고하였다. 연말까지 연구용역과 연계한 시범담수·방류 시행 및 모니터링·효과분석을 통해 비홍수기 홍수조절지 최적운영방안을 마련할 계획이다.

• Journal of the Korea Society for Simulation
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• v.19 no.2
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• pp.73-80
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• 2010

A wireless sensor network which is deployed in hostile environment can be easily compromised by attackers. The selective forwarding attack can jam the packet or drop a sensitive packet such as the movement of the enemy on data flow path through the compromised node. Xiao, Yu and Gao proposed the checkpoint-based multi-hop acknowledgement scheme(CHEMAS). In CHEMAS, each path node enable to be the checkpoint node according to the pre-defined probability and then can detect the area where the selective forwarding attacks is generated through the checkpoint nodes. In this scheme, the number of hops is very important because this parameter may trade off between energy conservation and detection capacity. In this paper, we used the fuzzy rule system to determine adaptive threshold value which is the number of hops for the ACK packets. In every period, the base station determines threshold value while using fuzzy logic. The energy level, the number of compromised node, and the distance to each node from base station are used to determine threshold value in fuzzy logic.

• Journal of Korea Entertainment Industry Association
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• v.13 no.2
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• pp.253-259
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• 2019

Prostate cancer(PrCa) is a leading cause of cancer-related death in man. Medicinal plants are exploited for many drugs to treat various ailments. The drugs derived from the plants promote health, augmented the resistance of the body against disease. Pueraia lobata(wild) Ohwi(P. Lobata), kudzu, which is a twining perennial woody herb native to China, Korea, Japan, India, and the United States. Plants such as Moringa oleifera, have hypoglycemic properties and other beneficial properties. The objective of the study was to analyze the effects of kadzu and moringa, natural plant products on antioxidant activity and proliferation of the hormone-sensitive prostate cancer LNCaP cells. MTT assay, flow cytometry analysis were employed to investigate the anticancer mechanism and DPPH assay was determined to the antioxidant activity to scavenge free radicals in extract of these. All two extracts showed significantly antioxidant activity at 10 and 50mg/ml of concentration. kadzu and moringa reduced LNCaP cell viability in a dose dependent manner. Specially moringa extract was more potent cytotoxic than kadzu extract. Statistical analyses revealed kadzu and moringa exhibited significantly higher (P < 0.05) cytotoxicity and antioxidant activity in LNCaP. The finding of this study provides a scientific basis for using kadzu and moringa in future development of chemotherapeutic drugs against hormone-sensitive prostate cancer.

• Journal of Korea Water Resources Association
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• v.55 no.spc1
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• pp.1283-1293
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• 2022

The purpose of this study is to predict residual chlorine in order to maintain stable residual chlorine concentration in sedimentation basin by using artificial intelligence algorithms in water treatment process employing pre-chlorination. Available water quantity and quality data are collected and analyzed statistically to apply into mathematical multiple regression and artificial intelligence models including multi-layer perceptron neural network, random forest, long short term memory (LSTM) algorithms. Water temperature, turbidity, pH, conductivity, flow rate, alkalinity and pre-chlorination dosage data are used as the input parameters to develop prediction models. As results, it is presented that the random forest algorithm shows the most moderate prediction result among four cases, which are long short term memory, multi-layer perceptron, multiple regression including random forest. Especially, it is result that the multiple regression model can not represent the residual chlorine with the input parameters which varies independently with seasonal change, numerical scale and dimension difference between quantity and quality. For this reason, random forest model is more appropriate for predict water qualities than other algorithms, which is classified into decision tree type algorithm. Also, it is expected that real time prediction by artificial intelligence models can play role of the stable operation of residual chlorine in water treatment plant including pre-chlorination process.

• Proceedings of the Korea Water Resources Association Conference
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• 2020.06a
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• pp.261-261
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• 2020

물관리의 기본이 되는 연속적인 유량 자료 확보를 위해서는 정확도 높은 수위-유량 관계 곡선식 개발이 필수적이다. 수위-유량 관계곡선식은 모든 수문시설 설계의 기초가 되며 홍수, 가뭄 등 물재해 대응을 위해서도 중요한 의미를 가지고 있다. 그러나 일반적으로 유량 측정은 많은 비용과 시간이 들고, 식생성장, 단면변화 등의 통제특성(control)이 변함에 따라 구간분리, 기간분리와 같은 비선형적인 양상이 나타나 자료 해석에 어려움이 존재한다. 특히, 국내 하천의 경우 자연적 및 인위적인 환경 변화가 다양하여 지점 및 기간에 따라 세밀한 분석이 요구된다. 머신러닝(Machine Learning)이란 데이터를 통해 컴퓨터가 스스로 학습하여 모델을 구축하고 성능을 향상시키는 일련의 과정을 뜻한다. 기존의 수위-유량 관계곡선식은 개발자의 판단에 의해 데이터의 종류와 기간 등을 설정하여 회귀식의 파라미터를 산출한다면, 머신러닝은 유효한 전체 데이터를 이용해 스스로 학습하여 자료 간 상관성을 찾아내 모델을 구축하고 성능을 지속적으로 향상 시킬 수 있다. 머신러닝은 충분한 수문자료가 확보되었다는 전제 하에 복잡하고 가변적인 수자원 환경을 반영하여 유량 추정의 정확도를 지속적으로 향상시킬 수 있다는 이점을 가지고 있다. 본 연구는 머신러닝의 대표적인 알고리즘들을 활용하여 유량을 추정하는 모델을 구축하고 성능을 비교·분석하였다. 대상지역은 안정적인 수량을 확보하고 있는 한강수계의 거운교 지점이며, 사용자료는 2010~2018년의 시간, 수위, 유량, 수면폭 등 이다. 프로그램은 파이썬을 기반으로 한 머신러닝 라이브러리인 사이킷런(sklearn)을 사용하였고 알고리즘은 랜덤포레스트 회귀, 의사결정트리, KNN(K-Nearest Neighbor), rgboost을 적용하였다. 학습(train) 데이터는 입력자료 종류별로 조합하여 6개의 세트로 구분하여 모델을 구축하였고, 이를 적용해 검증(test) 데이터를 RMSE(Roog Mean Square Error)로 평가하였다. 그 결과 모델 및 입력 자료의 조합에 따라 3.67~171.46로 다소 넓은 범위의 값이 도출되었다. 그 중 가장 우수한 유형은 수위, 연도, 수면폭 3개의 입력자료를 조합하여 랜덤포레스트 회귀 모델에 적용한 경우이다. 비교를 위해 동일한 검증 데이터를 한국수문조사연보(2018년) 내거운교 지점의 수위별 수위-유량 곡선식을 이용해 유량을 추정한 결과 RMSE가 3.76이 산출되어, 머신러닝이 세분화된 수위-유량 곡선식과 비슷한 수준까지 성능을 내는 것으로 확인되었다. 본 연구는 양질의 유량자료 생산을 위해 기 구축된 수문자료를 기반으로 머신러닝 기법의 적용 가능성을 검토한 기초 연구로써, 국내 효율적인 수문자료 측정 및 수위-유량 곡선 산출에 도움이 될 수 있을 것으로 판단된다. 향후 수자원 환경 및 통제특성에 영향을 미치는 다양한 영향변수를 파악하기 위해 기상자료, 취수량 등의 입력 자료를 적용할 필요가 있으며, 머신러닝 내 비지도학습인 딥러닝과 같은 보다 정교한 모델에 대한 추가적인 연구도 수행되어야 할 것이다.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.2B
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• pp.225-231
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• 2006

The nonpoint source control is based on TPLMS (Total Pollution Load Management System) program. Recently, the Ministry of Environment in Korea has programed TPLMS for 4 major large rivers to improve the water quality in rivers by controling the total pollutant loadings from the watershed area. Usually the urbanization is the main pollutant sources, particularly for nonpoint pollutants, because of high imperviousness and high pollutant mass emissions. The stormwater runoff from urban areas is containing various pollutants such as sediments, metals and toxic chemicals due to human and vehicle activities. Of the various landuses, the highways are highly polluted landuses because of high pollutant accumulation rate by vehicle activities during dry periods. Therefore, this research is achieved to provide pollutant EMCs (Event Mean Concentrations) and mass loadings washed-off from highways during rainfall periods. Five monitoring locations were equipped with an automatic rainfall gage and an flow meter. The results show that the EMC ranges for 95% confidence intervals in highway land use are 45.52-125.76 mg/L for TSS, 52.04-95.48 mg/L for COD, 1.77-4.48 mg/L for TN, 0.29-0.54 mg/L for TP. The ranges of washed- off mass loading are $712.7-2,418.4mg/m^2$ for TSS and $684.1-1,779.6mg/m^2$ for COD.

• Journal of Practical Agriculture & Fisheries Research
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• v.21 no.1
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• pp.89-98
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• 2019

The aim of this study was to evaluate the change of phenolic compounds after bordeaux mixture treatment on Cheorwon onion. Onion is a perennial plant belonging to the lily family. It is native to Persia of Southwest Asia. It is cultivated much in the temperate regions of the world. Onion is a good name for the 'Okchong' to drop blood cholesterol and cardiovascular blood flow to increase the prevention of adult diseases. Cheorwon area is inland, but it has high continental climate due to its high altitude. After the treatment with bordeaux mixture, the weight, width and plant height of the onion were affected to some extent. In the phenolic compounds, caffeic acid, ferulic acid, rutin, and kaempferol except benzoic acid, p-coumaric acid and quercetin were similar to or less than the control. Therefore, it was concluded that the treatment with bordeaux mixture had some effect on onion growth and phenolic compound contents.

• Journal of Practical Agriculture & Fisheries Research
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• v.20 no.2
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• pp.105-114
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• 2018

The aim of this study was to evaluate the change of phenolic compounds after phosphite treatment on Cheorwon onion. Onion is a perennial plant belonging to the lily family. It is native to Persia of Southwest Asia. It is widely cultivated in the temperate regions of the world. Onion is a good name for the 'Okchong' to drop blood cholesterol and cardiovascular blood flow to increase the prevention of adult diseases. Cheorwon area is inland, but it has high continental climate due to its high altitude. Therefore it is said that the onion cultivated in this region has higher sugar content and higher taste than onion grown in the southern region. Phosphorus components are particularly important ingredients for promoting muscle development. However, if the phosphoric acid content of the soil part is maintained to a large extent until the harvest, the competition of the nutrients tends to cause decay of the root part. Therefore, it is important to improve the quality and shelf life of onion by inducing nutrient balance by applying foliar fertilization method on the reducing phosphorus at harvest time. In this study, acidity was controlled by diluting phosphorous acid(H₃PO₃) and potassium hydroxide(KOH), followed by leaf surface treatment with phosphite on onion. In this study, the concentration of phosphite was diluted to 500, 1,000, 1,500ppm and sprayed three times over the onion leaves in May 2018 using an atomizer and harvested at the end of June, and the phenolic compounds were analyzed by HPLC. As a result, the content of quercetin, one of the important substances in onion, was phosphite 500ppm(179.70㎍/g), 1,000(150.27), 1,500(105.95). The contents of caffeic acid, p-coumaric acid, ferulic acid, rutin, kaempferol, and sugar content were higher in the treatments than in the control. Therefore, the phosphite does not have a great influence on the growth, but it may play a role as a method of achieving balance with nitrogen in the rainy season by supplying the role of the material catalyst and the water soluble phosphoric acid and the potassium in the influence of the material change.