• Title/Summary/Keyword: Contrast agent

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Echo-PIV: in vivo Flow Measurement Technique (에코 PIV: in vivo 유동 측정기법)

  • kim Hyoung-Bum;Hertzberg Jean;Shandas Robin
    • Journal of the Korean Society of Visualization
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    • v.3 no.1
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    • pp.26-35
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    • 2005
  • The combination of ultrasound echo images with digital particle image velocimetry (DPIV) method has resulted in a two-dimensional, two-component velocity field measurement technique appropriate for opaque flow conditions including blood flow in clinical applications. Advanced PIV processing algorithms including an iterative scheme and window of offsetting were used to increase spatial resolution. The optimum concentration of the ultrasound contrast agent used for seeding was explored. Velocity validation tests in fully developed laminar pipe flow and pulsatile flow showed good agreement with both optical PIV measurements and the known analytic solution. These studies indicate that echo PIV is a promising technique for the non-invasive measurement of velocity profiles and shear stress.

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Graph Connectivity-free Consensus Algorithm for State-coupled Linear Multi-agent Systems: Adaptive Approach (적응 제어를 이용하여 그래프 연결성을 배제시킨 선형 다개체 시스템의 상태변수 일치 알고리듬)

  • Kim, Ji-Su;Kim, Hong-Keun;Shim, Hyung-Bo;Back, Ju-Hoon
    • Journal of Institute of Control, Robotics and Systems
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    • v.18 no.7
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    • pp.617-621
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    • 2012
  • This paper studies asymptotic consensus problem for linear multi-agent systems. We propose a distributed state feedback control algorithm for solving the problem under fixed and undirected network communication. In contrast with the conventional algorithms that use global information (e.g., graph connectivity), the proposed algorithm only uses local information from neighbors. The principle for achieving asymptotic consensus is that, for each agent, a distributed update law gradually increases the coupling gain of LQR-type feedback and thus, the overall stability of the multi-agent system is recovered by the gain margin of LQR.

Development of thermo-sensor used liquid crystal-polymer composite films (온도센서로서 액정잉크의 개발)

  • 남수용
    • Journal of the Korean Graphic Arts Communication Society
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    • v.16 no.1
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    • pp.25-38
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    • 1998
  • The developing agent is the materials which first acts on silver grain and make it into metallic silver by reducing reaction. There are several types in developing agent, and according to Lumiere-Andresen principle, substitution product which has amino or hydroxyl group in benzen nucleus has a developing power, but all reduing substances are not in used. In the developing effect, not only the role of developing agent but also that of assistant materials are important. But in this work, we have studied effect, change by lith developing agent which require high contrast image. We made an developing experiment after having manufactured developing solution used hydroquinone and another developing agents like chlorohydroquinone, pyrocatechol and pyrogallol as developing agent. And we added that did in addition of diethanolamine and ascorbic acid, and then we examined the possibility of use.

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Learning soccer robot using genetic programming

  • Wang, Xiaoshu;Sugisaka, Masanori
    • 제어로봇시스템학회:학술대회논문집
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    • 1999.10a
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    • pp.292-297
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    • 1999
  • Evolving in artificial agent is an extremely difficult problem, but on the other hand, a challenging task. At present the studies mainly centered on single agent learning problem. In our case, we use simulated soccer to investigate multi-agent cooperative learning. Consider the fundamental differences in learning mechanism, existing reinforcement learning algorithms can be roughly classified into two types-that based on evaluation functions and that of searching policy space directly. Genetic Programming developed from Genetic Algorithms is one of the most well known approaches belonging to the latter. In this paper, we give detailed algorithm description as well as data construction that are necessary for learning single agent strategies at first. In following step moreover, we will extend developed methods into multiple robot domains. game. We investigate and contrast two different methods-simple team learning and sub-group loaming and conclude the paper with some experimental results.

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Gadolinium Complex of 1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-1,4,7-trisacetic Acid (DO3A) Conjugate of Tranexamates: A Quest for a Liver-specific Magnetic Resonance Imaging Contrast Agent

  • Nam, Ki-Soo;Jeong, Hyun-Jeong;Kim, Hee-Kyung;Choi, Garam;Suh, Kyung-Jin;Chang, Yongmin;Kim, Tae-Jeong
    • Bulletin of the Korean Chemical Society
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    • v.35 no.1
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    • pp.87-92
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    • 2014
  • The work is directed toward the synthesis of a series of DO3A conjugates of tranexamates (1c-e) and their Gd complexes (2c-e) for use as a liver-specific MRI CA. All these complexes show thermodynamic and kinetic stabilities comparable to those of structurally related clinical agents such as Dotarem$^{(R)}$. Their $R_1$ relaxivities also compare well with those of commercial agent, ranging 3.68-4.84 $mM^{-1}s^{-1}$. In vivo MR images of mice with 2a-e reveal that only 2a exhibits liver-specificity. Although 2b and 2c show strong enhancement in liver, yet no bile-excretion is observed to be termed as a liver-specific agent. The rest behaves much like ordinary ECF CAs like Dotarem$^{(R)}$. The new series possess no toxicity to be employed in vivo.

Motility Contrast Imaging for Drug Screening Applications

  • Jeong, Kwan
    • Journal of the Optical Society of Korea
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    • v.19 no.4
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    • pp.382-389
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    • 2015
  • Motility contrast imaging is a coherence-domain imaging technique that uses cellular motility as a fully endogenous imaging contrast agent. Motility is measured inside tissue using a digital holographic coherence gate that extracts dynamic speckle from fixed depths. The dynamic speckle arises from the normal organelle motion inside cells, and from the movement of the cellular membranes driven by the cytoskeleton. It measures cellular activity and the effects of temperature and osmolarity. Motion is sensitive to cytoskeletal drugs, such as the antimitotic drugs used for cancer chemotherapy, and the effects of drug combinations also can be monitored. Motility contrast imaging is a potential tissue-based assay platform for highthroughput screening of pharmaceuticals.

Preferred Skin Color Reproduction of Digital Image by Ink-jet Printer (잉크젯 프린터에 의한 디지탈 이미지의 바람직한 피부 색재현)

  • 서봉우
    • Journal of the Korean Graphic Arts Communication Society
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    • v.14 no.2
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    • pp.37-49
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    • 1996
  • The practical lith developer is a hydroquinone solution of moderate alkalinity and low free-sulfite ion concentration with potassium bromide as the restraining agent. In the study on composition of ilth developer to promote high sensitivity, high contrast and long term preservation or use, a new composition of lith developer, namely PK lith developer, was developed and of was found that PK lith developer was superior to the lith developer which was commercially available in terms of contrast, speed and preservation. This paper also describes studies on the addition of hdydrazine to PK lith developer, which have led to further improvements in the system.

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Quantitative Analysis of Brain Metabolite Spectrum Depending on the Concentration of the Contrast Media in Phantom (팬텀 내 조영제 농도에 따른 뇌 대사물질 Spectrum의 정량분석)

  • Shin, WoonJae;Gang, EunBo;Chun, SongI
    • Journal of the Korean Society of Radiology
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    • v.9 no.1
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    • pp.47-53
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    • 2015
  • Quantitative analysis of MR spectrum depending on mole concentration of the contrast media in cereberal metabolite phantom was performed. PRESS pulse sequence was used to obtain MR spectrum at 3.0T MRI system (Archieva, Philips Healthcare, Best, Netherland), and the phantom contains brain metabolites such as N-Acetyl Asparatate (NAA), Choline (Cho), Creatine (Cr) and Lactate (Lac). In this study, optimization of MRS PRESS pulse sequency depending on the concentration of contrast media (0, 0.1 and $0.3mmol/{\ell}$) was evaluated for various repetition time(TR; 1500, 1700 and 2000 ms). In control (cotrast-media-free) group, NAA and Cho signals were the highest at TR 2000 ms than at 1700 and 1500 ms. Cr had the highest peak signal at TR 1500 ms. When concentration of contrast media was $0.1mmol/{\ell}$, the metabolites were increased NAA 73%, Cho 249%, Cr 37% at TR 1700 ms compared with other TR, and also signal increased at $0.3mmol/{\ell}$, In $0.5mmol/{\ell}$ of contrast agent, cerebral metabolite peaks reduced, especially when TR 1500 ms and 2000 ms they decreased below those of control group. The ratio of metabolite peaks such as NAA/Cr and Cho/Cr decreased as the concentration of the contrast agent increased from 0.1 to $0.5mmol/{\ell}$. Authors found that the optimization of PRESS sequence for 0.3T MRS was as follows: low density of contrast agent ($0.1mmol/{\ell}$ and $0.3mmol/{\ell}$) made the highest signal intensity, while high density of contrast agent reveals the least reduction of signal intensity at 1700 ms. In conclusion, authors believe that it is helpful to reduce TR for acquiring maximum signal intensity.

Research and Consideration of Eco-friendly Radiation Shielding using CT Contrast Agent (CT 조영제를 이용한 친환경적인 방사선 차폐에 관한 연구 및 고찰)

  • Sung-Gil Kim;Yeon-Sang Ji
    • Journal of the Korean Society of Radiology
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    • v.17 no.6
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    • pp.827-833
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    • 2023
  • CT(Computed Tomography) contrast agents are commonly used in general hospitals and university hospitals when taking radiographic examinations. The CT contrast medium contains a mixture of a substance called "Iodine", which absorbs radiation energy and makes it appear white in the CT image, further improving the image quality. In addition, the CT contrast agent, which moves like blood in the blood vessels, clearly differentiates it from muscle and water, so CT contrast agents are widely used in hospitals. These CT contrast agents absorb X-rays, but in order to absorb X-rays, they must have a high density or a high radiation absorption coefficient. Since the CT contrast agent is injected into the blood vessels, if the density is high, the blood vessels are strained and the patient is in shock. For this reason, it is necessary to match the density similar to that of water and always pay attention to side effects. In addition, the amount of CT contrast medium is adjusted according to the patient's body shape, and the remaining contrast medium is discarded. However, This study tried to find out the idea of recycling it as a radiation shielding material. Since the CT contrast medium has a high radiation absorption coefficient at a density similar to that of water, the amount to absorb radiation is adjusted, the amount of contrast medium and the amount of water are adjusted, and the amount of radiation absorbed is determined by mixing with water. In addition, a study was conducted to find out the result of the difference in radiation absorption in various ways by comparing the radiation quality coefficient and absorption coefficient with other substances or materials in an environmentally friendly method harmless to the human body by mixing CT contrast medium and water.