• Journal of Pharmaceutical Investigation
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• v.36 no.5
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• pp.339-342
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• 2006

This study was designed to prepare an animal model for partial thickness bum wound which can be employed for testing topical therapy. We first evaluated whether rabbit ear and mouse back skin wound model could differentiate the wound healing process in terms of degree of re epithelialization, required days for complete wound closure, presence of scarring. $2^{nd}$ degree wet bum were prepared on mouse back skin and rabbit ear by applying 5 mL hot water($85{\pm}0.1^{\circ}C$) for 7 see followed by 5 mL ice-cold 0.5% acrynol solution for cooling and disinfecting the inflicted area. After removing the dead epidermis layer at 24 hr, tested dressings were applied for specified time and wound progression was investigated. In mouse model, wound contraction was the primary wound closing mechanism, which is quite different from human wound healing process. In rabbit ear model, epidermal regeneration was the major wound healing process rather than wound contraction and the difference in wound healing property among tested dressings could be clearly demonstrated. A rabbit ear model could differentiate the wound progression among open, occluded and epidermal growth factor(EGF) treated wound. Four sites of circular wound(diameter: 1 cm) on the anterior part of rabbit ear could be employed for the comparative wound healing study. For obtaining reproducible bum wound, degree of bum depth and bum sites should be carefully controlled in addition, employing rabbits of same strain and weight. The result suggests that rabbit ear could be employed as a reliable and human-resembled wound model.

• Archives of Plastic Surgery
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• v.49 no.2
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• pp.258-265
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• 2022

Background Chitosan (CS) is a well-known antimicrobial dressing material. Moreover, widely used amniotic membranes contain growth factors beneficial for wound healing. Herein, we created a novel amnion-conjugated CS-alginate membrane dressing and tested its wound healing potency in a diabetic swine model. Methods The bovine amniotic powder growth factor contents were evaluated by protein assay, and the powder's wound healing effects were assessed in vitro by HaCaT cell scratch closure. In vivo, two minipigs developed streptozotocin-induced diabetes. Serial serum glucose measurements and intravenous glucose tolerance tests were performed to confirm their diabetic status. Twelve square-shaped wounds created on each pig's back were randomly divided into control (n = 4), CS (n = 4), and amnion-CS (AC; n = 4) groups and treated accordingly with different dressings. Wound healing in each group was assessed by measuring wound contraction over time, capturing wound perfusion with indocyanine green (ICG) angiography, and histologically analyzing inflammatory markers. Results Amniotic powder elution promoted HaCaT cell migration in the scratch wound model, suggesting its beneficial in vitro wound healing effects. In vivo, the CS and AC groups showed earlier wound contraction initiation and reepithelialization and earlier wound perfusion improvement by ICG angiography than the control group. Additionally, the wound size of the AC group at week 3 was significantly smaller than those in the control group. There was no significant difference in the numbers of acute and chronic inflammatory cells between the groups. Conclusion The amnion-conjugated CS-alginate membrane, as well as CS dressing alone, could be a favorable dressing option for diabetic wounds.

• Journal of the Korean Society of Food Science and Nutrition
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• v.32 no.8
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• pp.1370-1376
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• 2003

We investigated the effect of seatangle drink and seatangle extract on lipid oxidation, blood coagulation and intestinal movement in rats fed a hyperlipidemic diet. In the dietary hyperlipidemic induced group, the serum superoxide dismutase activity decreased and formation of hydroxy radical increased when compared to normal group, but these were controlled by seatangle drink treatment. The decreased of bleeding time and increased of tissue factor in the dietary hyperlipidemic rats were regulated by seatangle drink and seatangle extract, and especially the activity of tissue factor was remarkably decreased. Seatangle drink and seatangle extract were increased contraction on intestinal movement. Therefore, it can be concluded that seatangle drink or seatangle extract treatment depresses changing in absorption of gastrointestinal track in rats fed a hyperlipidemic diet.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2005.05a
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• pp.360-363
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• 2005

Biomimetic actuators composed of cellophane with an electrically conducting polyaniline(PANI) film have been fabricated and tested in air ambience conditions doped with two different counter ions such as perchlorate (${ClO_4}^-$) and tetrafluoroborate (${BF_4}^-$). Fabrication of the trilayer CP//CELLOPHANE//CP substantially enhanced the tip displacement (13.2mm) compared to the small displacement (8.3mm) of the bilaye. CP//CELLOPHANE. The ion migration among layers is the main factor behind the expansion of cellophane, while the expansion/contraction of PANI are dependent on the redox reaction of the polymer. The displacement of the composite is dominated by the humidity content. This implies that the actuation principle is possibly due to the assistance of water existing.

• Bulletin of the Society of Naval Architects of Korea
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• v.17 no.3
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• pp.5-17
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• 1980

A basic procedure to design marine propellers by a curved lifting line theory was shown. By adapting discrete singularity method, it became possible to take into account of skew, rake and the contraction of slip stream in the early stage of preliminary design procedure. It is also shown that lifting line theory based on the discrete singularity method converges to a common solution obtained by induction factor method with a relatively small number of discrete elements. Lifting the blade geometry more accurately on the basis of hydrodynamic principles. A number of numerical results from lifting line calculation are presented for the purpose of comparison with the previous method, and with these results two sample designs are carried out, which are wake-adapted optimum and wake-adapted non-optimum propellers.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.14 no.7
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• pp.578-583
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• 2001

The bushing for high voltage and large and power should endure weight of itself and force of pushing from contact with circuit breaker. Like this, epoxy mold bushing has to be strong without fault. However, the external circumstances and internal factors was caused by partial discharge, flashover and dielectric breakdown. Therefore, to remove external factor of defect and to prevent the internal cracks and cavity generated from the contraction on interface of Cu-Epoxy, we should form semi-conductive layer on Cu bar by carbon. Then, the PD properties and the insulation qualities of epoxy mold type bushing was able to improved by roles of cushions for the direction of diameter and by effects fo natural sliding like as separated from conductor for the direction of length. So, in this work, we could prove the method of semi-conductive layer in making the long conductor.

• Journal of Power System Engineering
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• v.20 no.6
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• pp.71-79
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• 2016

This paper introduces the design method of the centrifugal turbo fan and the process of developing the design program of it. The developed design program confirmed the applicability by experimental performance data. Here, we proposed new velocity coefficients and considered various losses such as impeller inlet loss, vane passage flow loss, casing pressure loss, recirculation loss power, and disk friction loss power. Especially, the inlet and outlet widths of the impeller were newly determined by reflecting the experimental results. As a result, this fan design program shows a good performance result regardless of the types of impeller and is expected to be a very useful design tool.

• Steel and Composite Structures
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• v.26 no.1
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• pp.45-53
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• 2018

Experimental investigations have revealed significant mismatches between analytical estimates and experimentally measured deflections of transmission towers. These are attributed to bolt slip and joint flexibility. This study focuses on effects of joint flexibility on tower deflections and proposes criterions for permissible deflection limits based on the stresses in joints. The objective has been framed given that guidelines are not available in the codes of practices for transmission towers with regard to the permissible limits of deflection. The analysis procedure is geometric and material nonlinear with consideration of joint flexibility in the form of extension or contraction of the cover plates. The deflections due to bolt slip are included in the study by scaling up the deflections obtained from analysis by a factor. Using the results of the analysis, deflection limits for the towers are proposed by limiting the stresses in the joints. The obtained limits are then applied to a new full scale tower to demonstrate the application of the current study.

• Journal of Biomedical Engineering Research
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• v.32 no.4
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• pp.328-335
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• 2011

For human factor engineering and wearable robot design, the quantitative assessment of physical workload is needed. Through measuring the surface EMG (sEMG) and analysis, the physical workload in overhead lifting posture is presented in quantitative manner. By normalizing sEMG activities with maximal voluntary contraction (MVC), the inter-subject variability is reduced. In all muscles, %MVC increased as the weight of lifting object increases. In anterior deltoid muscle, the %MVC was 3-4 times higher than the other muscles which imply that this muscle performs the major role in the overhead lifting posture. In fatigue analysis, %MVC and the mean frequency in muscle of anterior deltoid changed markedly when compared with other muscles. Through the suggested procedures and analysis, the physical workload for a specific posture can be represented in quantitative way but the clinical meaning for the value should be investigated further.

• Proceedings of the KSPS conference
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• 2000.07a
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• pp.117-134
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• 2000

Kim, Key-Seop(2000). English Restructuring and A Use of Music in Teaching English Pronunciation. JSEP 2000 voU This study has two-fold aims: one is to clarify the restructuring of English in utterance, and the other is to relate it to teaching English pronunciation for listening and speaking with a use of music and song by suggesting a model of 10-15 minute pronunciation class syllabus for every period in class. Generally, English utterances are restructured by stress-timed rhythm, irrespective of syntactic boundaries. So the rhythmic units are arranged in isochronous groups, of which the making is to attach clitic(s) to a host or head often leftwards and sometimes rightwards, which results in linking, contraction, reduction, sound change and rhythm adjustment in utterance, just as in music and song. With English restructuring focused on, a model of English pronunciation class syllabus is proposed to be put forward in class for every period of a lesson or unit. It tries to relate the focused factor(s) in pronunciation to the integrated, with teaching techniques and music made use of.