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http://dx.doi.org/10.3746/jkfn.2003.32.8.1370

Effect of Seatangle Oligosaccharide Drink on Oxidation of Serum Lipid and Bleeding and Plasma Clotting Time in Rats Fed a Hyperlipidemic Diet  

주동식 (동해대학교 외식산업학과)
이진경 (강릉대학교 동해안해양생물자원연구센터)
김옥선 (강릉대학교 동해안해양생물자원연구센터)
조순영 (강릉대학교 동해안해양생물자원연구센터)
이득식 (동해대학교 외식산업학과)
제외권 (동명대학 식품가공과)
최종원 (경성대학교 약학대학)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.32, no.8, 2003 , pp. 1370-1376 More about this Journal
Abstract
We investigated the effect of seatangle drink and seatangle extract on lipid oxidation, blood coagulation and intestinal movement in rats fed a hyperlipidemic diet. In the dietary hyperlipidemic induced group, the serum superoxide dismutase activity decreased and formation of hydroxy radical increased when compared to normal group, but these were controlled by seatangle drink treatment. The decreased of bleeding time and increased of tissue factor in the dietary hyperlipidemic rats were regulated by seatangle drink and seatangle extract, and especially the activity of tissue factor was remarkably decreased. Seatangle drink and seatangle extract were increased contraction on intestinal movement. Therefore, it can be concluded that seatangle drink or seatangle extract treatment depresses changing in absorption of gastrointestinal track in rats fed a hyperlipidemic diet.
Keywords
seatangle drink; seatangle extract product; hyperlipidemic diet; lipid oxidation; blood coagulation; tissue factor;
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Times Cited By KSCI : 1  (Citation Analysis)
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1 Han YN, Baik SK, Kim TH, Han BH. 1987. Antithrombotic activities of saponins from Ilex pubescens. Arch Pharm Res 10: 115-122.   과학기술학회마을   DOI
2 Anderson TJ. 1995. The effect of cholesterol-lowing and antioxidant therapy on endothelium-dependent coronary vasomotion. N Engl J Med 332: 488-494.   DOI   ScienceOn
3 Ross R, Glomset JA. 1976. The pathogenesis of atherosclerosis. N Engl J Med 295: 420-425.   DOI   ScienceOn
4 Joo DS, Kim OS, Lee JG, Choi YS, Cho SY, Je YK, Choi JW. 2003. Effect of seatangle oligosaccharide drink on serum and hepatic lipids in rats fed a hyperlipidmic diet. J Korean Soc Food Sci Nutr 32: 1364-1369.   과학기술학회마을   DOI   ScienceOn
5 Ross R. 1984. Studies of hypercholesterolemia in the nonhuman primate. I. Changes that lead to fatty streak formation. Atherosclerosis 4: 323-340.
6 Yagi K. 1987. Lipid peroxides and human diseases. Chemistry and Physics of Lipids 45: 337-342.   DOI   ScienceOn
7 Lowry OH, Rosebrough NJ, Farr AL, Rendall RJ. 1951. Protein measurement with folin phenol reagent. J Biol Chem 193: 265-272.
8 Treasure CB. 1995. Beneficial effects of cholesterol-lowing therapy on the coronary endothelium in patients with coronary artery disease. N Engl J Med 332: 481-487.   DOI   ScienceOn
9 Surprenant YM, Zuckerman SH. 1989. A novel microtiter plate assay for the quantitation of procoagulant activity on adherent monocytes, macrophages and endothelial cells. Thromb Res 53: 339-345.   DOI   ScienceOn
10 Simonm RH, Scoggin CM, Patterson D. 1981. Hydrogen peroxide causes the fetal injury to human fibroblasts exposed to oxygen radicals. J Biol Chem 266: 7181-7186.
11 Wada H, Kaneko T, Wakita Y, Minamikawa K, Nagaya S, Tamaki S, Deguchi K, Shirakawa S. 1994. Effect of lipoproteins on tissue factor activity and PAI-Ⅱ antigen in human monocytes and macrophages. Int J Cardiol 47: 521-526.
12 Oyanagui Y. 1984. Reevaluation of assay methods and establishment of kit for superoxide dismutase activity. Anal Biochem 42: 290-295.
13 Croci T, Williams GM. 1985. Activities of several phaseⅠ ane phase Ⅱ xenobiotics biotransformation enzymes in cultured hepatocytes from male and female rats. Biochem Pharmacol 34: 3029-3033.   DOI   ScienceOn
14 Halliwell B. 1978. Biochemical mechanism accounting for the toxic action of oxygen on living organisms. the key role of superoxide dismutase. Cell Biol Int Rep 2: 11-16.   DOI   ScienceOn
15 Kobatake Y, Saito M, Kuroda K, Kobayashi S, Innami S. 1987. Influence of fish consumption on serum lipid and lipid peroxide concentrations in middle aged subjects. J Japan Soc Nutr & Food Sci 40: 103-110.   DOI
16 Amlie T, Lyberg A, Kaplun JH, Prydz H. 1981. Thromboplastin activity of mouse peritoneal macrophages. Thrombosis research 24: 61-68.   DOI   ScienceOn
17 Tanaka H, Andoh K, Narahara N, Uchiyama T, Kubota T, Takada M, Kobayashi N, Maekawa T. 1986. The leukocyte membrane and its contribution to thrombosis and haemostasis with special reference to tissue factor. Acta Haematol Jpn 49: 1583-1589.
18 Freman BA, Crapo JD. 1982. Biology of disease: Free radicals and tissue injury. Lab Invest 47: 412-415.
19 Quick AJ, Stanleybrown M, Bancroft FW. 1985. A study of the coagulation defect in hemophilia and in jaundice. Am J Med Sci 190: 571-576.   DOI
20 Lee KS, Seo JS, Choi YS. 1998. Effect of sea tangle and hypoglycemic agent on lipid metabolism in diabetic rats. J Korean Soc Food Sci Nut 27: 960-967.   과학기술학회마을
21 Kim JI, Choi JH. 1992. Effect of brown algae component on obese rats induced by a high fat diet I. Body weight, feed and gross efficiences, body fat content, and obesity index. Kor J Gerontol 3: 33-38.
22 Weis HR, Pitas RE, Wilson BD, Rodgers GM. 1991. Oxidized low-density lipoprotein increases cultured human endothelial cell tissue factor activity and reduces protein C activation. The FASEB Journal 5: 2459-2465.
23 보건복지부 . 1997. 1997년도 국민 영양 조사 결과서. 문영사, 서울. p 37.