• Journal of Physiology & Pathology in Korean Medicine
• /
• v.27 no.6
• /
• pp.809-817
• /
• 2013

The aim of this study was to evaluate the mechanism of vasodilation of Lespedezea cuneata(LC) in rabbit common carotid artery and cavernosal smooth muscle. LC relaxed arterial strips precontracted with norepinephrine and cavernosal strips precontracted with phenylephrine. The arterial relaxation effects of LC was endothelium-dependent. $N{\omega}$-nitro-L-arginine(L-NNA), NOS inhibitor, methylene blue(MB), cGMP inhibitor, indomethacin(IM), cyclo-oxygenase inhibitor and tetraethylammonium chloride(TEA), KCa-channel blocker attenuate the relaxation responses of LC in arterial strips. In $Ca^{2+}$-free krebs-ringer solution, pretreatment of LC extract significantly reduced the contraction induced by addition $Ca^{2+}$. L-NNA reduced LC extract-induced relaxation in cavernosal strips, but IM, TEA and MB didn't affect LC extract-induced relaxation. When LC extract was applicated on human umbilical vein endothelial cell, the nitric oxide concentration was increased. We conclude that in rabbit common carotid artery, LC may suppress influx of extra-cellular $Ca^{2+}$ through the release of endothelium derived relaxing factor including nitric oxide, prostacyclin, endothelium derived hyperpolarizing factor. And LC exerts a relaxing effect on corpus cavernosum through activating the NO.

• The Journal of Internal Korean Medicine
• /
• v.16 no.1
• /
• pp.181-196
• /
• 1995

The present experiments were designed to investigate the effects of BangPoongSan on the cardiovascular system in the experimental Animals. And thus the change of blood pressure, auricular blood flow, artery contraction, death rate, platelet aggregation repression, plasma coagulation factor activity, plasma antithrombin activity, whole blood viscosity and plasma viscosity were studied. The result were summarized as the followings: 1. BangPoongSan dropped the blood pressure in the spontaneous hypertensive rat. 2. The drug increased the auricular blood flow in rabbit. 3. The drug relaxed the artery contraction by pretreated norepinephrine in white rat. 4. The drug inhibited the death rate of mouse which was led to thromboembolism by serotonin and collagen. 5. The drug inhibited the platelet aggregation in rat. 6. The drug prolonged the prothrombin time and activated partial thromboplastin time on the test of plasma coagulation factor activity in rat, but was not valuable. 7. The drug presented the antithrombin activity in rat. 8. The drug reduced the whole blood viscosity and plasma viscosity in rat, but the latter was not valuable. According to the results, Bangpoongsan increased the blood flow and dropped the blood pressure by dilatation of blood vessel smooth muscle. And the drug presented the antithrombin acivity, inhibited the platelet aggregation and reduced blood viscosity. Therefore these effects are assumed to improve the cardiovascular circulation disorder and prevent thrombosis.

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.25 no.12
• /
• pp.1844-1852
• /
• 2001

Recent developments in microfluidic devices based on microelectromechanical systems (MEMS) technique find many practical applications, which include electronic chip cooling devices, power MEMS devices, micro sensors, and bio-medical devices among others. For the design of such micro devices, flows characteristics inside a microchannel have to be clarified which exhibit somewhat different characteristics compared to conventional flows in a macrochannel. In the present study microchannels of various hydraulic diameters are fabricated on a silicon wafer to study the pressure drop characteristics. The effect of abrupt contraction and expansion is also studied. It is found from the results that the friction factor in a straight microchannel is about 15% higher than that in a conventional macrochannel, and the loss coefficients in abrupt expansion and contraction are about 10% higher than that obtained through conventional flow analysis.

• Analytical Science and Technology
• /
• v.11 no.3
• /
• pp.202-205
• /
• 1998

X-ray absorption fine structure spectroscopic studies at the Ni K-edge have been performed for the Ni-Zn alloy coating layer on steel. The Ni-Zn interatomic distances and Debye-Waller factors were determined by fitting the experimental data with the theoretical spectra in the temperature range of 80 to 300K. The average Ni-Zn interatomic distance was found to be $2.557{\AA}$ and the variation of the Ni-Zn interatomic distance with temperature in this range was insignificant. From the comparison of the Ni-Zn interatomic distance with the nearest neighbor distance of pure Zn lattice it has been suggested that there is an apparent contraction around Ni atom.

• Journal of Korean Institute of Industrial Engineers
• /
• v.29 no.2
• /
• pp.145-149
• /
• 2003

We consider the estimation of failure rate and acceleration factor under type-I censoring without using acceleration model when testing is conducted in only one highly accelerated condition. Failure times of an item are assumed to be exponentially distributed. It is also assumed that the uncertainty about the acceleration factor, the failure time contraction ratio between accelerated condition and use condition, can be modeled by the uniform or gamma prior distribution of appropriate parameters. We respectively use Bayes and maximum likelihood approaches to estimate acceleration factor and failure rate in the use condition. An example is given to show how the method can be applied.

• Magazine of the Korean Society of Agricultural Engineers
• /
• v.37 no.3_4
• /
• pp.82-89
• /
• 1995

The efforts of formulation have been reviewed and the results of existing laboratory experiments are investigated in order to describe the contracted flow which occurs at the final closure of sea dike construction. The regional characteristics of contracted flow is analyzed by checking the drawdown curve, and Chezy's mean velocity equation is employed to estimate the discharge rate at the closure. Weir-type discharge equations are reviewed, which are derived from Bernoulli equation, and the problems of the equations are discussed. Chezy's mean velocity equation is considered to be widely and generally applicable, and the empirical factor introduced in Chezy's equation is named 'form drag factor' since it is primarily dependent on the form drag caused by the contraction of discharge area. Laboratory experiments were conducted mainly in order to investigate the variation of form drag factor against various parameters, and an empirical equation is developed for the estimation of form drag factor.

• Journal of Korea Water Resources Association
• /
• v.48 no.8
• /
• pp.625-634
• /
• 2015

The diverse patterns of separation zone according to the marked bed discordance by dredging at confluence in addition to the confluence angle of tributary and discharge ratio between tributary and main channels have been analyzed by CCHE2D model simulation. The separation zone is defined by inside of zero velocity boundary at down-stream of confluence. The separation zone dose not formed at the $30^{\circ}$ of confluence angle of tributary. The size of separation zone increases as the discharge ratio and confluence angle increase in general. The separation zone decreases as the dredging depth increases which shows the relative momentum reduction compared by the flow volume increasing by dredging at confluence. The contraction factor with the variation of confluence angle and discharge ratio has been investigated and confirmed the corresponding conveyance decreasing results in backwater effect. The regression equation of shape factor with confluence angle and discharge and dredging depth ratios has been suggested.

• Restorative Dentistry and Endodontics
• /
• v.28 no.6
• /
• pp.457-466
• /
• 2003

The aim of study was to investigate the effect of flow, specimen geometry and adhesion on the measurement of linear polymerization shrinkage of light cured composite resins using linear shrinkage measuring device. Four commercially available composites - an anterior posterior hybrid composite Z100, a posterior packable composite P60 and two flowable composites, Filtek flow and Tetric flow-were studied. The linear polymerization shrinkage of composites was determined using 'bonded disc method' and 'non-bond-ed' free shrinkage method at varying C-factor in the range of 1∼8 by changing specimen geometry. These measured linear shrinkage values were compared with free volumetric shrinkage values. The viscosity and flow of composites were determined and compared by measuring the dropping speed of metal rod under constant load. In non-bonded method, the linear shrinkage approximated one third of true volumetric shrink-age by isotropic contraction. However, in bonded disc method, as the bonded surface increased the linear shrinkage increased up to volumetric shrinkage value by anisotropic contraction. The linear shrinkage value increased with increasing C-factor and approximated true volumetric shrinkage and reached plateau at about C-factor 5∼6. The more flow the composite was, reduced linear shrinkage was measured by compensation radial flow.

• Journal of the Korean Society of Propulsion Engineers
• /
• v.1 no.1
• /
• pp.55-63
• /
• 1997

The empirical factor and reaction force based on published data were involved to investigate compressible flows through sudden enlargement and sudden contraction passages. Analytical solutions of engineering interest were obtained from one-dimensional steady compressible gas dynamic equations. The effects of com- pressibility, cross-sectional area ratio, and inlet Mach number on the air flows were discussed with regards to the total pressure loss and flow choking. The present results provide available information necessary to design the compressible pipe flow systems.

• The Korean Journal of Physiology and Pharmacology
• /
• v.16 no.1
• /
• pp.59-64
• /
• 2012

Hypoxic pulmonary vasoconstriction (HPV) is physiologically important response for preventing mismatching between ventilation and perfusion in lungs. The HPV of isolated pulmonary arteries (HPV-PA) usually require a partial pretone by thromboxane agonist (U46619). Because the HPV of ventilated/perfused lungs (HPV-lung) can be triggered without pretone conditioning, we suspected that a putative tissue factor might be responsible for the pretone of HPV. Here we investigated whether HPV can be also observed in precision-cut lung slices (PCLS) from rats. The HPV in PCLS also required partial contraction by U46619. In addition, $K^+$ channel blockers (4AP and TEA) required U46619-pretone to induce significant contraction of PA in PCLS. In contrast, the airways in PCLS showed reversible contraction in response to the $K^+$ channel blockers without pretone conditioning. Also, the airways showed no hypoxic constriction but a relaxation under the partial pretone by U46619. The airways in PCLS showed reliable, concentration-dependent contraction by metacholine ($EC_{50}$, ~210 nM). In summary, the HPV in PCLS is more similar to isolated PA than V/P lungs. The metacholineinduced constriction of bronchioles suggested that the PLCS might be also useful for studying airway physiology in situ.