• Korean Management Science Review
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• v.26 no.3
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• pp.67-78
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• 2009

In this paper, I analyze the mobile broadband services market characterized by vertical and horizontal differentiation. Vertical differentiation as service quality differentiation is based on the transmission speed of mobile internet service and horizontal differentiation as spatial differentiation is based on the service coverage. Theoretical explanations for the competitive price policy have been developed in the game context of WiBro which represent the high quality within the limited service coverage and HSDPA which represent relatively low quality with nation-wide service. When the WiBro has a mobile broadband service quality advantage and the difference in quality is sufficiently low, the price of WiBro with limited service coverage is relatively lower than that of HSDPA. This occurs because the advantage of WiBro's vertical service differentiation is offset by the disadvantage of horizontal differentiation. The difference in the quality of mobile internet service, however, is not too high, the price of WiBro is relatively higher than that of HSDPA. Moreover, when the service quality of WiBro is sufficiently high, the low quality HSDPA service faces no demand.

• Journal of the Korean Society of Clothing and Textiles
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• v.42 no.6
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• pp.897-908
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• 2018

This study investigates the effect of mimicry buying on differentiation behavior in the context of fashion product consumption. Merging insights from social identity theory, optimal distinctiveness theory and previous research on narcissism, this article presents ingroup-outgroup categorization, narcissistic tendency and social status to serve as boundary conditions of this effect. Experiment 1 supports the hypothesis that more differentiation behavior against mimicry buying is reinforced when the mimicker is an in-group member compared to an out-group member. Based on this result, we conducted Experiment 2 to understand the effect of narcissistic tendency and mimicker's social status on differentiation behavior in the in-group context. The results show that the effect of narcissistic tendency on differentiation behavior is mediated by a perceived distinctiveness threat when the mimicker is an in-group member. In addition, this mediating effect is moderated by the mimicker's social status. Narcissistic tendencies have a direct negative effect on differentiation behavior when the mimicker is an in-group member with a high social status. However, high narcissistic tendency induces a more distinctiveness threat when the mimicker is an in-group member with a low social status. This then results in a greater differentiation behavior. Implications for marketers and suggestions for future research are also discussed.

• Journal of the Korean Society for Computer Game
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• v.31 no.4
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• pp.51-59
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• 2018

The purpose of this study is to analyze genre differentiation in digital games and examine the changing characteristics of core genre elements. Especially this study focuses on the aspect that how players recognize genre differentiation based on the conceptual blending theory. The evolution of the genre does not end with decline or extinction. The genre keeps being divided into sub-genres through partial use of genre elements. The differentiation of the genre results from the principle of frame confrontation or expansion with a parent genre. Rogue-like games are differentiated from Role-playing games by frame conflict, while Metroidvania games are differentiated from Platform adventure games by frame expansion. In the former case, the core genre elements are independent and easily combined with other genres. For example, the core mechanism of Rogue-like genre like 'perma-death' or 'procedural generation' has a decisive effect on the differentiation of the game experience become an independent genre element. In the latter case of Metroidvania, the core genre elements strongly reveals context dependency and are difficult to use outside the genre convention. The core mechanism of Metroidvania is 'backtracking' in the labyrinth style map, but it could be effective genre element within the specific context like side-scrolling action-platformer.

• The Journal of the Korea Contents Association
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• v.5 no.3
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• pp.159-166
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• 2005

The application that the user's contexts are continuously changed over time requires an efficient information retrieval. This paper proposes a new context-differentiated information retrieval method for an efficient ubiquitous service. This enables the rapid retrieval, because of no access to the most detail information at a time. This paper describes the retrieval method, the algorithms and the experimental results.

• BMB Reports
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• v.49 no.1
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• pp.3-10
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• 2016

microRNAs (miRNAs) are key regulators of cell state transition and retention during stem cell proliferation and differentiation by post-transcriptionally downregulating hundreds of conserved target genes via seed-pairing in their 3' untranslated region. In embryonic and adult stem cells, dozens of miRNAs that elaborately control stem cell processes by modulating the transcriptomic context therein have been identified. Some miRNAs accelerate the change of cell state into progenitor cell lineages—such as myoblast, myeloid or lymphoid progenitors, and neuro precursor stem cells—and other miRNAs decelerate the change but induce proliferative activity, resulting in cell state retention. This cell state choice can be controlled by endogenously or exogenously changing miRNA levels or by including or excluding target sites. This control of miRNA-mediated gene regulation could improve our understanding of stem cell biology and facilitate their development as therapeutic tools. [BMB Reports 2016; 49(1): 3-10]

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.9
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• pp.420-431
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• 2019

This study examined the mediating effect of parenting stress on the influence of self-differentiation of mothers in multicultural families on their learned helplessness. The study determined the correlation between the following variables: self-differentiation, learned helplessness, and the parenting stress of mothers in multicultural families. The study was conducted on mothers who are raising children in multicultural families and 193 cases of supplementary data were finally analyzed. The data derived from the survey was analyzed using the SPSS 23.0 and AMOS 23.0 programs. The results of the analysis are as follows. First, the self-differentiation of mothers in multicultural families showed a negative effect on parenting stress and the mothers' learned helplessness, while parenting stress had a positive effect on the mothers' learned helplessness. Parenting stress was found to have a mediating effect on the relationship between the self-differentiation and the learned helplessness of mothers in multicultural families. This study suggests that the mothers of multicultural families may decrease parenting stresses and learned helplessness by increasing the level of self-differentiation in the context of cultural differences and adapting to new societies.

• Tissue Engineering and Regenerative Medicine
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• v.15 no.6
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• pp.751-760
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• 2018

BACKGROUND: Bone tissue engineering based on pluripotent stem cells (PSCs) is a new approach to deal with bone defects. Protocols have been developed to generate osteoblasts from PSCs. However, the low efficiency of this process is still an important issue that needs to be resolved. Many studies have aimed to improve efficiency, but developing accurate methods to determine efficacy is also critical. Studies using pluripotency to estimate efficacy are rare. Telomerase is highly associated with pluripotency. METHODS: We have described a quantitative method to measure telomerase activity, telomeric repeat elongation assay based on quartz crystal microbalance (QCM). To investigate whether this method could be used to determine the efficiency of in vitro osteogenic differentiation based on pluripotency, we measured the pluripotency pattern of cultures through stemness gene expression, proliferation ability and telomerase activity, measured by QCM. RESULTS: We showed that the pluripotency pattern determined by QCM was similar to the patterns of proliferation ability and gene expression, which showed a slight upregulation at the late stages, within the context of the general downregulation tendency during differentiation. Additionally, a comprehensive gene expression pattern covering nearly every stage of differentiation was identified. CONCLUSION: Therefore, this assay may be powerful tools for determining the efficiency of differentiation systems based on pluripotency. In this study, we not only introduce a new method for determining efficiency based on pluripotency, but also provide more information about the characteristics of osteogenic differentiation which help facilitate future development of more efficient protocols.

• Toxicological Research
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• v.29 no.4
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• pp.221-227
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• 2013

Embryonic stem (ES) cells have potential for use in evaluation of developmental toxicity because they are generated in large numbers and differentiate into three germ layers following formation of embryoid bodies (EBs). In earlier study, embryonic stem cell test (EST) was established for assessment of the embryotoxic potential of compounds. Using EBs indicating the onset of differentiation of mouse ES cells, many toxicologists have refined the developmental toxicity of a variety of compounds. However, due to some limitation of the EST method resulting from species-specific differences between humans and mouse, it is an incomplete approach. In this regard, we examined the effects of several developmental toxic chemicals on formation of EBs using human ES cells. Although human ES cells are fastidious in culture and differentiation, we concluded that the relevancy of our experimental method is more accurate than that of EST using mouse ES cells. These types of studies could extend our understanding of how human ES cells could be used for monitoring developmental toxicity and its relevance in relation to its differentiation progress. In addition, this concept will be used as a model system for screening for developmental toxicity of various chemicals. This article might update new information about the usage of embryonic stem cells in the context of their possible ability in the toxicological fields.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.22 no.12
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• pp.2714-2726
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• 1997

In this paper, adaptive symbol changes-based medical image compression method is presented. First, the differenctial image domain is obtained using the differentiation rules or obaptive predictors applied to original mdeical image. Also, the algorithm determines the context associated with the differential image from the domain. Then prediction symbols which are thought tobe the most probable differential image values are maintained at a high value through the adaptive symbol changes procedure based on estimates of the symbols with polarity coincidence between the differential image values to be coded under to context and differential image values in the model template. At the coding step, the differential image values are encoded as "predicted" or "non-predicted" by the binary adaptive arithmetic encoder, where a binary decision tree is employed. The simlation results indicate that the prediction hit ratios of differential image values using the proposed algorithm improve the coding gain by 25% and 23% than arithmetic coder with ISO JPEG lossless predictor and arithmetic coder with differentiation rules or adaptive predictors, respectively. It can be used in compression part of medical PACS because the proposed method allows the encoder be directly applied to the full bit-planes medical image without a decomposition of the full bit-plane into a series of binary bit-planes as well as lower complexity of encoder through using an additions when sub-dividing recursively unit intervals.

• BMB Reports
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• v.47 no.3
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• pp.141-148
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• 2014

Bone is an active tissue, in which bone formation by osteoblast is followed by bone resorption by osteoclasts, in a repeating cycle. Proteomics approaches may allow the detection of changes in cell signal transduction, and the regulatory mechanism of cell differentiation. LC-MS/MS-based quantitative methods can be used with labeling strategies, such as SILAC, iTRAQ, TMT and enzymatic labeling. When used in combination with specific protein enrichment strategies, quantitative proteomics methods can identify various signaling molecules and modulators, and their interacting proteins in bone metabolism, to elucidate biological functions for the newly identified proteins in the cellular context. In this article, we will briefly review recent major advances in the application of proteomics for bone biology, especially from the aspect of cellular signaling.