• ETRI Journal
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• 제37권1호
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• pp.175-185
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• 2015

This paper presents a system-of-systems (SoS) approach to the formal modeling of a cyber-physical system (CPS) for simulation-based analysis. The approach is based on a convergence technology for modeling and simulation of a highly complex system in which SoS modeling methodology, hybrid systems modeling theory, and simulation interoperation technology are merged. The methodology maps each constituent system of a CPS to a disparate model of either continuous or discrete types. The theory employs two formalisms for modeling of the two model types with formal specification of interfaces between them. Finally, the technology adapts a simulation bus called DEVS BUS whose protocol synchronizes time and exchange messages between subsystems simulation. Benefits of the approach include reusability of simulation models and environments, and simulation-based analysis of subsystems of a CPS in an inter-relational manner.

• 한국실내디자인학회:학술대회논문집
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• 한국실내디자인학회 2004년도 춘계학술발표대회 논문집
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• pp.86-90
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• 2004

The whole image of circulation occupied with user has duplicated inter-relationship. It means many situation exist simultaneously, and the character of space factors are completed by the inter-relationship of the detailed structure. The purpose of this study is on the proper notation for circulation analysis of the sequential space structure which is constructed by the formal constituent and the change of visual circumstance influence on the action of user. This study investigate the possibility of notation by arranging the analysis method of the visual space and focusing on the research for the visual perception behaviour of user being applied various space, and the possibility of application as a method of space design.

• 한국항공운항학회지
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• 제12권2호
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• pp.17-28
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• 2004

In unmanned aerial vehicle (UAV), the high temperature results from friction with the air, combustion of fuel and combustion gas of a nozzle etc. It causes serious problems in the UAV structure. The characteristic analysis of heat resistant metal and ceramic materials and creep analysis for the functionally graded material (FGM) is presented in this paper. FGM is composed of two constituent materials that are mixed up according to the specific volume fraction distribution in order to withstand high heat condition. In addition, the creep behavior of FGM applied in duct structure of an engine is analyzed.

• Environmental Engineering Research
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• 제10권5호
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• pp.205-212
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• 2005

The study was conducted to investigate the removal of heavy metals by using Hydroxyapatite(HAp) made from waste oyster shells and wastewater with high concentration of phosphorus. The maximum calcium concentration for the production of HAp in this study was released up to 361 mg/L at pH of 3 by elution experiments. When the pH was at adjusted 6, the maximum calcium released concentration was 41 mg/L. During the elution experiment, most of the calcium was released within 60 minutes. This reaction occurred at both pH levels of 3 and 6. The result of the XRD analysis for the HAp product used in this study shows the main constituent was HAp, as well as OCP. The pH was 8.6. As the temperature increased, the main constituent did not vary, however its structure was crystallized. When the pH was maintained at 3, the removal efficiency decreased as the heavy metal concentration increased. The order of removal efficiency was as follows: $Fe^{2+}$(92%), $Pb^{2+}$(92%) > $Cu^{2+}$(20%) > $Cd^{2+}$(0%). Most of these products were dissolved and did not produce sludge in the course of heavy metals removal. As the heavy metal concentration increased at pH of 6, the removal efficiency increased. The removal efficiencies in all heavy metals were over 80%. From the analysis of the sludge after reaction with heavy metals, the HAp was detected and the OCP peak was not observed. Moreover, lead ion was observed at the peaks of lead-Apatite and lead oxidant. In the case of cadmium, copper and iron ions, hydroxide forms of each ion were also detected.

• The Korean Journal of Physiology and Pharmacology
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• 제24권4호
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• pp.363-372
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• 2020

Gardenia jasminoides (GJ) is a widely used herbal medicine with anti-inflammatory properties, but its effects on the ORAI1 channel, which is important in generating intracellular calcium signaling for T cell activation, remain unknown. In this study, we investigated whether 70% ethanolic GJ extract (GJ_EtOH) and its subsequent fractions inhibit ORAI1 and determined which constituents contributed to this effect. Whole-cell patch clamp analysis revealed that GJ_EtOH (64.7% ± 3.83% inhibition at 0.1 mg/ml) and all its fractions showed inhibitory effects on the ORAI1 channel. Among the GJ fractions, the hexane fraction (GJ_HEX, 66.8% ± 9.95% at 0.1 mg/ml) had the most potent inhibitory effects in hORAI1-hSTIM1 co-transfected HEK293T cells. Chemical constituent analysis revealed that the strong ORAI1 inhibitory effect of GJ_HEX was due to linoleic acid, and in other fractions, we found that genipin inhibited ORAI1. Genipin significantly inhibited I_ORAI1 and interleukin-2 production in CD3/CD28-stimulated Jurkat T lymphocytes by 35.9% ± 3.02% and 54.7% ± 1.32% at 30 μM, respectively. Furthermore, the same genipin concentration inhibited the proliferation of human primary CD4⁺ T lymphocytes stimulated with CD3/CD28 antibodies by 54.9% ± 8.22%, as evaluated by carboxyfluorescein succinimidyl ester assay. Our findings suggest that genipin may be one of the active components of GJ responsible for T cell suppression, which is partially mediated by activation of the ORAI1 channel. This study helps us understand the mechanisms of GJ in the treatment of inflammatory diseases.

• 한국균학회지
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• 제16권3호
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• pp.162-174
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• 1988

구름버섯 배양균사체와 야생 구름버섯 자실체로부터 얻은 protein-bound polysaccharide의 당과 단백질 함량을 비교하였을 때 배양균사체인 경우보다 야생 자실체의 경우가 당 함량이 더 높게 나타났으며 단백질 함량은 더 적게 나타났다. 구름버섯에서 부터 얻은 시료를 methanolysis시킨 후 HPLC로 분석하였을 때 배양균사체인 경우 4종류의 단당이 경출되었고 그중 mannose가 가장 함량이 많은 반면 야생 자실체인 경우 3종류의 단당이 경출되었으며 그중 glucose가 가장 많이 존재하였다. 구름버섯에서부터 얻은 시료에 lactose가 혼합되었을 경우 HPLC로 구별할 수 있었다. 구름버섯에서 얻은 시료의 구성 아미노산을 분석하였을 때 시료 모두에서동일한 17종의 아미노산이 검출되었다.

• 한국식생활문화학회지
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• 제9권2호
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• pp.131-136
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• 1994

한국산 씀바귀(Lactuca dentata Makino)의 ethylacetate 추출물에서 6 종류의 flavonoid 성분이 TLC에 의해서 검출 되었으며, 이들은 극성에 따라서 A에서 F가지 명명되었다. 그들 중 주성분으로 생각되는 물질 E를 column chromatography을 이용하여 분리정제 하였다. 물질 E의 녹는 점은 $249.5^{\circ}C-251^{\circ}C$ 로 나타났으며, 그 구조를 밝히기 위하여, 물질 E와 이를 가수분해한 genin에 대한 여러가지 shift reagent에서 UV와 IR분석을 하고 또한 물질 E와 그의 acetyl 유도체에 대한 NMR 분석을 하였으며 물질 E에 결합된 당은 TLC에 의하여 확인하였다. 이와같은 분석 결과에서 물질 E는 luteolin 모핵에 glucose가 결합된 $luteolin-7-0-{\beta}-D-glucoside$로서 확인되었다.

• 한국해안·해양공학회논문집
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• 제20권1호
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• pp.14-24
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• 2008

목포와 제주를 위시한 서남해안에서 최근 예측 고조위가 증가하는 경향을 보이고 있다. 조화분석을 통한 자료분석 결과 서남해안 전반에 걸쳐 평균해수면이 뚜렷하게 증가하는 반면 반일주조의 진폭은 감소하는 것으로 나타나고 있다. 또한 태양연주조(Sa분조)의 진폭이 증가한 것으로 나타나고 있으며 이에 따라 하절기의 고조위가 더욱 상승한 것으로 확인되었다. 21세기 들어 RUSA와 MAEMI등 대형 태풍의 발생이 잦아지고 있어 1990년대에 비해 서남해안에서의 최대해일고가 크게 증가하였다. 또한 이들은 7월${\sim}$9월에 집중되고 있어 하절기 고조위 상승과 함께 이상고조위 발생 가능성을 더욱 우려스럽게 하고 있다. 특히 목포해역은 하구언과 방조제 건설이후 이상고조 발생 가능성이 현격히 높아진 해역이므로 더욱 그러한 실정이며, 평균해수면 상승경향이 매우 뚜렷한 제주해역 역시 향후 이상고조 발생 가능성이 매우 높을 것으로 판단된다.

• 대한한방소아과학회지
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• 제35권1호
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• pp.1-17
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• 2021

Objectives We aimed to analyze traditional Chinese medicine (TCM) literatures in regards to the pattern identification and related symptoms of idiopathic short stature (ISS). Methods We searched relevant literatures published up to September 29, 2020 through three Chinese electronic databases. We performed frequency analysis of the selected studies by extracting information on pattern identification, clinical symptoms, and TCM treatments presenting pattern identification of ISS. Results Sixteen studies were included. Spleen deficiency, kidney deficiency, dual deficiency of spleen-kidney, and liver-kidney yin deficiency were frequently reported. Clinical symptoms of the spleen deficiency include sallow complexion, body constituent weakness, anorexia, lack of qi and no desire to speak, and loose stools. Herbal medicines (HMs) such as Sijunzi-tang were frequently reported. Clinical symptoms of the kidney deficiency include cold limb and fear of cold, soreness and weakness of waist and knees, and clear and long urine. HMs such as Bishendihuang-wan were frequently reported. Clinical symptoms of the dual deficiency of spleen-kidney include body constituent weakness, spirit lassitude and lack of strength, anorexia, soreness and weakness of waist and knees, and cold limb and fear of cold. HMs such as Sijunzi-tang plus Bishendihuang-wan were frequently reported. Clinical symptoms of the liver-kidney yin deficiency include tidal fever and night sweating, heat in the palms and soles, dizziness, and dry throat. HMs such as Liuweidihuang-wan were frequently reported. Conclusions This was the first study to analyze the frequency of pattern identification and related symptoms on ISS. In the future, a standardized Korean medicine pattern identification system should be established.

• 한국화재소방학회:학술대회논문집
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• 한국화재소방학회 2008년도 추계학술논문발표회 논문집
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• pp.422-427
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• 2008

The major cause of Concrete Spalling at high temperatures can be divided into the Vapor Pressure Rising, caused by the increase in free water temperature within the concrete, and Pore Pressure Rising induced by the vapor moving into dense pores within the concrete. Although the occurrence of spalling within concrete caused by these pressure increases can be assessed experimentally, a close examination into Mechanistic influence against various spalling factors shall be carried out first by using Mathematical Modeling and Theoretical Equations. The Spalling Prospect Process by theoretical mechanism is expedited in order of the following; selection of heating condition (fire strength and flame heating direction), a selection of constituent elements, an analysis of heat transmission, an analysis of moisture movement, distribution of water content, an analysis of pore/vapor pressure, and assessment of spalling occurrence.