• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• v.34 no.3
• /
• pp.250-265
• /
• 2008

Distraction osteogenesis is a well-established clinical treatment for limb length discrepancy and skeletal deformities. Appropriate mechanical tension-stress is believed not to break the callus but rather to stimulate osteogenesis. In contrast to fracture healing, the mode of bone formation in distraction osteogenesis is primarily intramembranous ossification. Although the biomechanical, histological, and ultrastructural changes associated with distraction osteogenesis have been widely described, the basic biology of the process is still not well known. Moreover, the molecular mechanisms in distraction osteogenesis remain largely unclear. Recent studies have implicated the growth factor cascade is likely to play an important role in distraction. And current reserch suggested that mechanical tension-stress modulates cell shape and phenotype, and stimulates the expression of the mRNA for bone matrix proteins. The purpose of this study is to examine the pattern of expression of growth factors($TGF-{\beta}1$, IGF-I, bFGF) and extracellular matrix proteins(osteoclacin, osteonectin) related to osteogenesis by osteodistraction of the mandible in rabbits. 24 rabbits is used for this experiment. Experimental group are gradual distraction(0.7mm, twice/day), acute distraction(1.4mm, twice/day) and control group is only osteotomized. After 5 days latency, osteotomic site is distracted for each 7 days and 3.5 days. Consolidation period is 28 days. The animal is sacrificed at the 3th, 7th, 14th, 28th. The distracted bone is examined by immunohistochemical analysis and RT-PCR analysis. The results obtained from this study were as follow : No significant difference was found on clinical examination according to distraction rate, but gradual distraction was shown to improve regenerate bone formation on radiographic and histologic examination. Growth factors and extracelluar matrix proteins expression increased in distraction group than control group. From these results, it could be stated that graudal distraction is shown to improve and accelerate bone formation and mechanical stress like distraction has considerable effects on osteogenesis related factors. And rabbit is the most appropriate animal model for further reseach on the molecular mechanisms that mediate osteodistraction. It is believed that understanding the biomolecular mechanisms that mediate distraction osteogenesis may guide the development of targeted strategies designed to improve distraction osteogenesis and accelerate bone healing.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.36 no.4
• /
• pp.705-713
• /
• 2016

For the soft ground construction, the factors not considered in the design stage occurs in the construction stage so that they cause the increase of the construction cost due to the structural stability and the design change. The subject of the study is the construction section of the industrial complex access road made in the Ochang region of Chungcheongbuk-do. The study is concerned with selecting the soft ground handling method such as the replacement method using rock debris and the surcharge reflecting the service load as the soft ground handling measure and analyzing the effect of reducing the construction cost with the stability of structures and the reduction of the construction period. The soft ground in the study section consists of sandy and cohesive soil and is 2.4m to 5.5m deep. It is distributed unevenly between the 1.5m to 5.9m stratums under the ground surface. Settlement is not serious, but the future uneven settlement and difference are expected so that the future settlement behavior is estimated by analyzing the site measurement results after the soft ground treatment. Moreover, in consideration of the regional characteristics and economic efficiency, soil with good quality is replaced with rock debris as the replacement material so that 29% of the construction cost is reduced due to the increase of stability and the reduction of duration. If the estimation of the dispersion of the pore water pressure within the dam body and the change of the underground water level and the relation of the actually measured soft ground with consolidation is studied further on the basis of the study, it is expected that the behavior of the soft ground will be correctly estimated in various site conditions.

• Maxillofacial Plastic and Reconstructive Surgery
• /
• v.30 no.5
• /
• pp.407-416
• /
• 2008

Purpose: The aim of the present study is to evaluate the effect of repetitive distraction and compression on new bone formation during distraction period. Materials and methods: Sixteen healthy rabbits, weighing about 2.5kg, were used in this experiment. A unilateral mandibular osteotomy was performed in the left mandible and the distractor(Track 1 $plus^{(R)}$, Gebruder Martin $GmbH^{(R)}$, Germany) was fixed with four screws (Cross driver screw $TI^{(R)}$, Gebruder Martin $GmbH^{(R)}$, Germany). After 4 days, the mandibles were distracted at a rate of 0.6mm/day for 10 days to obtain the amount of 6mm distraction in the control group(n=4). In the experimental group A(n=6), they were distracted at a rate of 1.2mm/day for 5 days and then compression of 0.6mm length and distraction of 0.6mm per 12 hours were carried out as counter direction for 5 days, relatively. In the experimental group B(n=6), distraction of 1.2mm length and compression of 0.6mm length per 12 hours were repeated for 10 days to obtain the amount of 6mm distraction finally. The experimental animals were sacrificed at 2 and 4 weeks after surgery and block specimens were obtained. With histologic and histomorphometric analysis, we observed the histologic changes of the cells and bone formation after H-E and Masson- Trichrome staining and then, measured Bone Deposition Rate with TOMORO $ScopeEye^{TM}$ ver. 3.5(Olympus, Japan), Results: Histologically, new bone formation was examined in all experimental groups and the control. But, the ability of bone formation of the experimental group A was somewhat better than any other groups. On the histomorphometric analysis, Bone Deposition Rate was higher in the experimental group A$(50.67{\pm}4.36%)$ than in the control group$(45.94{\pm}3.97%)$ and in the experimental group B$(42.68{\pm}5.70%)$. These data showed significant differences statistically(p<0.05). Conclusion: These results show that the distraction osteogenesis using repetitive compression and distraction force in the early consolidation period may be effective for new bone formation.

• The Journal of Korean Academic Society of Nursing Education
• /
• v.5 no.2
• /
• pp.232-249
• /
• 1999

The purpose of the study was to analyze the experiences of and the unmet needs for sex education of university students during their primary and secondary education. Development and refinement strategies of the sex education curriculum were constructed using the words of university students. The study was conducted during the second trimester of 1998 and the first trimester of 1999. and 356 male and female students were asked to submit weekly descriptive reports on the proposed issues related to sex education. The data were collected and analyzed by the researcher to present and summarize the in-depth meanings . The results were as follows: 1) The problems of the present sex education of primary and secondary education curriculum : it was revealed as too superficial and conventional: it brought about adverse effects because it was not efficient: also it was insufficient and not appropriate to the level of the students. The erroneous stereotypes of our society towards the sexuality act as barriers to effective sex education. 2) The abstract needs for sex education revealed on the analysis of adjectives used by the students were: 'honest, interesting, easy, useful, and correct' 3) The concrete needs for the sex education were: correct understanding of sexuality, establishment of the right sense of values towards sexuality, understanding of male and female sex psychology, knowledge of solutions for sexual problems 4) The developmental strategies for the sex education curriculum were structural, comprehensive, broad, and sufficient education content, concrete and honest explanations about sexuality : provision of early sex education; sex education provided by the parents ; establishment of an open environment for the sex education, graded education reflecting the developmental stages of the youngsters ; up-to-date sex education; preservation of the perspectives of the youngsters; provision of the same sex education opportunities for both girls and boys; practical use of audiovisual aides; open discussion; development of novel education methods like field trips 5) The change of knowledge, attitudes, and values towards sexuality after finishing the sex education course were: establishment of right sense of value towards sexuality ; reconfirmation of the concepts and value for life; belief of the necessity of sex education; change of attitudes towards womanhood; reinforcement of the self-conceit, consolidation of filial piety; and acquisition of the practical knowledge.

• Geotechnical Engineering
• /
• v.12 no.5
• /
• pp.79-88
• /
• 1996

In this study, prediction of soil behavior under vacuum preloading with vertical drain is explored on the basis of numerical models and toe results were compared with field measurements. Reasonable prediction of the time rate of settlements and pore pressure dissipation under vacuum preloading is the maj or concern. The conventional method for vatsuum preloading is based on modeling vacuum preloading as surcharge loading for the consolidation analysis. However, this modeling may violate the real behavior of soils under vacuum loading since the total stress in the analysis varies due to the modeled surcharge loading whereas in'.situ total stress of soils under vacuum loading is constant. In this study a new method is suggested. Instead of modeling vacuum loading as surcharge loading, negative hydraulic head is applied at the surface drain boundary to simulate the vacuum preloading. Comparisons of predictions and field measurements of soil behavior under vatsuum preloading are presented and the usefulness of the new modeling technique is demonstrated.

• Asian Pacific Journal of Cancer Prevention
• /
• v.17 no.4
• /
• pp.1999-2006
• /
• 2016

Background: Acute promyelocytic leukemia (APML) is characterized by the reciprocal translocation t(15;17) (p22;p12) resulting in the PML-$RAR{\alpha}$ fusion gene. A dual diagnostic and follow up approach was applied including cytogenetic demonstration of the t(15;17) translocation and detection dg PML-$RAR{\alpha}$ chimeric transcripts by molecular means. Purpose: Conventional cytogenetics involving bone marrow is beset with high probability of poor metaphase index and was substituted with phytohemagglutinin (PHA)-induced peripheral blood culture based cytogenetic analysis as a diagnostic & follow up modality in APML patients of Kashmir (North India). Both qualitative (RT-PCR) and quantitative (Q-PCR) tests were simultaneously carried out to authenticte the modified cytogenetics. Materials and Method: Patient samples were subjected to the said techniques to establish their baseline as well as follow-up status. Results: Initial cytogenetics revealed 30 patients (81%) Positive for t(15;17) whereas 7 (19%) had either cryptic translocation or were negative for t(15;17). Two cases had chromosome 16q deletion and no hallmark translocation t(15;17). Q-PCR status for PML-$RAR{\alpha}$ was found to be positive for all patients. All the APML patients were reassessed at the end of consolidation phase and during maintenance phase of chemotherapy where 6 patients had molecular relapse, wherein 4 also demonstrated cytogenetic relapse. Conclusions: It was found that PHA-induced peripheral blood cytogenetics along with molecular analysis could prove a reliable modality in the diagnosis and assessment of follow up response of APML patients.

• The Journal of the Korea Contents Association
• /
• v.11 no.11
• /
• pp.173-184
• /
• 2011

This study suggests the invigoration strategies of commercial and business functions for regeneration of old inner city as city center by examining Dangjin County which is a typical example of the local small-and-medium city where old inner city had declined as the city grew. I conducted a conjoint analysis in terms of important introduction functions and city regeneration directions for the invigoration. The results upon this are as follows. First, low-density of commercial and business places and the utilization of historical and cultural resources instead of the high-density mixed-use development should be considered. Second, It is important to promote regional specialized business and facilities rather than to attract new industry(high-tech industry) for activating local economy. Third, specific and practical countermeasures for resettlement of low-incomes and for maintenance of existing business zone should be established. Fourth, in terms of the maintenance and management, regulation on illegal commercial transactions, improvement of public spaces, and securement of user safety should be considered. Fifth, in terms of consolidation of functions, easier accessibility using public transportations, advertising and promotion of the city, and holding a number of events should be contemplated. Sixth, supporting for business activities and for establishing guides for design of old inner city should be needed. Seventh, public institutions should play a role as a bridge between local residences and experts for balanced regional development.

• Land and Housing Review
• /
• v.2 no.2
• /
• pp.163-170
• /
• 2011

Individual Vacuum Pressure Method (IVPM) is a soft ground improvement technique, in which a vacuum pressure can be directly applied to the vertical drain board to promote consolidation and to strengthen the soft ground. This method does not require surcharge loads, different to embankment or pre-loading method. In this study, the ground improvement efficiency of Individual Vacuum Pressure Method was estimated when suction pressure increases step by step(-20, -40, -60, -80kPa) with different periods. During Individual Vacuum Pressure Method process, surface settlement and pore pressure were monitored, and cone resistance as well as water content were also measured after the completion of Individual Vacuum Pressure Method treatment. From the results, optimum duration of each step of vacuum pressure was determined, and the settlement was calculated using FEM numerical analysis.

• The Journal of Engineering Geology
• /
• v.17 no.4
• /
• pp.601-613
• /
• 2007

It is reported that factors affecting the behavior of reinforced earth retaining walls built on soft ground are not only basic physical properties but also the increase of load by the reinforced earth retaining walls, consolidation period, pore water pressure, etc. This study analyzed the behavior of reinforced earth retaining walls and soft ground using SAGE CRISP, a ground analysis program. First, we examined the effect of the replacement method, which was to prevent the excessive displacement of reinforced earth retaining walls, in improving the behavior of the walls. Second, we compared and analyzed how the behavior of ground is affected by the vertical interval of stiffeners on the back of reinforced earth retaining walls after the application of the replacement method. Lastly, we proposed the optimal replacement width and depth in the application of the replacement method. The results of this study proved that the replacement method is considerably effective in improving the behavior of reinforced earth retaining walls. In addition, the vertical interval of stiffeners on the back of reinforced earth retaining walls appeared effective in improving the horizontal displacement of the top of retaining walls but not much effective in improving the vertical displacement of the back of retaining walls. In addition, improvement in horizontal-vertical displacement resulting from the increase in replacement width was not significant and this suggests that the increase of replacement width is not necessary. With regard to an adequate replacement depth, we proposed the ratio of replacement depth to the height of retaining walls(D/H) according to the ratio of the thickness of the soft layer to the height of retaining walls(H/T).

• Proceedings of KOSOMES biannual meeting
• /
• 2005.05a
• /
• pp.147-154
• /
• 2005

The ship plating is generally subjected to combined in-plane load and lateral pressure loads. In-plane loads include axial load and edge shear, which are mainly induced by overall hull girder bending and torsion of the vessel. Lateral pressure is due to water pressure and cargo. These load components are not always applied simultaneously, but more than one can normally exist and interact Hence, for more rational and safe design of ship structures, it is of crucial importance to better understand the interaction relationship of the buckling and ultimate strength for ship plating under combined loads. Actual ship plates are subjected to relatively small water pressure except for the impact load due to slamming and panting etc. The present paper describes an accurate and fast procedure for analyzing the elastic-plastic large deflection behavior up to the ultimate limit state of ship plates under combined loads. In this paper, the ultimate strength characteristics of plates under axial compressive loads and lateral pressure loads are investigated through ANSYS elastic-plastic large deflection finite element analysis with varying lateral pressure load level.