• Childhood Kidney Diseases
• /
• 제19권2호
• /
• pp.184-189
• /
• 2015

Poststreptococcal glomerulonephritis (PSGN) is one of the most well-known and important infectious renal diseases resulting from a prior infection with group A ${\beta}$-hemolytic streptococcus. The typical clinical characteristics of the disease reflect acute onset with gross hematuria, edema, hypertension and moderate proteinuria after the antecedent streptococcal infection. In children, usually PSGN is healed spontaneously but if it combines with fast progressing glomerulonephritis, it would be developed to chronic renal failure. Therefore, it is important to make a fast diagnosis and treatment by simple tools to predict the course and the prognosis of disease. Sonography is a simple tool for diagnosis but there is no typical renal sonographic finding in PSGN, so it is difficult to predict the course and the prognosis of disease by sonographic findings. In comparison between two cases of renal sonographic findings in PSGN, a patient who showed more increased echogenicity in more extended area of renal sonography had the severe results of renal pathology, prolonged treatment period and low serum C3 level. Here, we report the different findings of renal sonography and pathology depending on the degree of severity between two patients. Thus, it is necessary to gather more information from further studies to make a consensus about the relationship between the renal sonography and the prognosis of disease in PSGN.

• Journal of Microbiology
• /
• 제45권6호
• /
• pp.541-546
• /
• 2007

Red algae are distributed globally, and the group contains several commercially important species. Griffithsia okiensis is one of the most extensively studied red algal species. In this study, we conducted expressed sequence tag (ESTs) analysis and synonymous codon usage analysis using cultured G. okiensis samples. A total of 1,104 cDNA clones were sequenced using a cDNA library made from samples collected from Dolsan Island, on the southern coast of Korea. The clustering analysis of these sequences allowed for the identification of 1,048 unigene clusters consisting of 36 consensus and 1,012 singleton sequences. BLASTX searches generated 532 significant hits (E-value <$10^{-4}$) and via further Gene Ontology analysis, we constructed a functional classification of 434 unigenes. Our codon usage analysis showed that unigene clusters with more than three ESTs had higher GC contents (76.5%) at the third position of the codons than the singletons. Also, the majority of the optimal codons of G. okiensis and Chondrus crispus belonging to Bangiophycidae were G-ending, whereas those of Porphyra yezoensis belonging to Florideophycidae were G-ending. An orthologous gene search for the P. yezoensis EST database resulted in the identification of 39 unigenes commonly expressed in two rhodophytes, which have putative functions for structural proteins, protein degradation, signal transduction, stress response, and physiological processes. Although experiments have been conducted on a limited scale, this study provides a material basis for the development of microarrays useful for gene expression studies, as well as useful information for the comparative genomic analysis of red algae.

• 동의생리병리학회지
• /
• 제17권1호
• /
• pp.165-176
• /
• 2003

The present study was carried out to examine the effects of Kami-hwal-hyeol-tang(KHHT) on the immune responses of synoviocyte cells prepared from the rheumatoid arthritis patients, and also on the collagen-mediated arthritis in mouse model. Several experiments were performed in vitro and in vivo to analyse the immunomodulatory effects of KHHT, and the major findings are summarized below: 1. KHHT did not show the cytotoxicity against mLFCs and hFLSs. 2. KHHT inhibited gene expression of IL-1β, IL-6, TNF-α, COX-2, NOS and GM-CSF in hFLSs. Furthermore, KHHT-treated hFLSs showed reduced production of pro-inflammatory cytokines such as IL-1β and IL-6 compared to the control cells. 3. KHHT treatment of hFLSs inhibited the binding activity of NF-kB and AP-1 to their consensus DNA sequences. 4. KHHT treatment(400 ㎍/㎖) of hFLSs significantly inhibited hFLSs proliferations compared to the control cells. 5. KHHT significantly reduced the production of ROS in hFLSs compared to the control cells. The present data show that KHHT plays an important role for the regulation of AP-1 and NF-kB gene expression. Also, it was found that KHHT has anti-arthritis effect. Further studies of KHHT in relation to RA therapeutics may provide important information to develop drugs to treat this disease.

• 보건행정학회지
• /
• 제22권1호
• /
• pp.65-84
• /
• 2012

Because of the rising healthcare costs, there is a growing need for developing efficiency indicators for medical resources use and measuring efficiency of healthcare providers and healthcare systems using them. In this study, we aimed to develop efficiency indicators for medical resources use by means of Delphi technique. We systematically reviewed the existing measures of medical resource use. Thirty nine indicators were selected as a candidates across the six domains: medical personnel, medical equipment, medical facilities, ethical management, resource efficiency, and drug use. To develop efficiency indicators with professional consensus, a 2-round Delphi survey was conducted among 29 professional experts. The following indicators were selected based on the Delphi survey results: adjusted number of the patient per day and level of the nurse number medical personnel in medical personnel domain; the number of the scan a professional physician and the quality of the scan in medical equipment domain; bed utilization rate in medical facility domain; drug price reported pharmaceutical price by medical institutions, medical fee billing transparency, and medical care appropriateness in ethical management domain; costliness index in resource efficiency domain; and utilization of high cost drug and items per prescription in drug use domain. The efficiency indicators could provide valid information about efficiency of healthcare providers and healthcare systems with respect to their resources use and facilitate policies to improve their efficiency.

• 한국산업보건학회지
• /
• 제28권4호
• /
• pp.352-364
• /
• 2018

Objective: The Korean Industrial Hygiene Association(KIHA) held a forum on "Improvement of Material Safety Data Sheets (MSDS) regulations for enhancing the effectiveness and efficiency in the field" at its 2018 Winter Conference(February 2, 2018). This article summarized the major consensus opinions developed at the forum. Methods: Since the initial implementation of the MSDS system, the contents of the system have changed and related studies have been reviewed. Before the forum, online questionnaires were developed and opinions on the effectiveness of MSDS program were collected from various strata of the occupational health field. We also summarized the key opinions of companies, trade unions, experts, and government officials as discussed at the forums. Results: A total of 265 opinions were gathered through online questionnaire surveys from safety and health managers, trade unions, government officials, and health professionals. The results of online surveys and discussions showed some differences of opinion, but it was a common perception that the current MSDS system is not working effectively in the workplace. It was considered necessary to strengthen MSDS education and to make it easier for workers to understand and deliver the necessary information. In addition, it was confirmed that the supply of and education on MSDS to small- and medium-sized enterprise workers is not being well executed. In particular, MSDS training for subcontract workers should be carried out under the responsibility of the contracting employer. Conclusions: In order for the MSDS system to serve more effectively in the field in the future, it needs to be improved in terms of the effective education and training considering the type of industry and employment.

• Clinics in Shoulder and Elbow
• /
• 제25권1호
• /
• pp.49-56
• /
• 2022

Background: The treatment approach for proximal humeral fractures is determined by various factors, including patient age, sex, dominant arm, fracture pattern, presence of osteoporosis, preexisting arthritis, rotator cuff status, and medical comorbidities. However, there is a lack of consensus in the literature regarding the optimal treatment for displaced proximal humeral fractures. This study aimed to assess and quantify the decision-making process for either conservative or surgical treatment and the choice of surgical method among shoulder surgeons when treating proximal humeral fractures. Methods: Forty sets of true anteroposterior view, scapular Y projection view, and three-dimensional computed tomography of proximal humeral fractures were provided to 12 shoulder surgeons along with clinical information. Surveys regarding Neer classification, decisions between conservative and surgical treatments, and chosen methods were conducted twice with an interval of 2 months. The factors affecting the treatment plans were also assessed. Results: The inter-rater agreement was fair for Neer classification (kappa=0.395), moderate for the decision between conservative and surgical treatments (kappa=0.528), and substantial for the chosen method of surgical treatment (kappa=0.740). The percentage of agreement was 71.1% for Neer classification, 84.6% for the decision between conservative and surgical treatment, and 96.4% for the chosen method of surgical treatment. The fracture pattern was the most crucial factor in deciding between conservative and surgical treatments, followed by age and physical activity. Conclusions: The decision between conservative and surgical treatment for proximal humeral fractures showed good agreement, while the chosen method between osteosynthesis and arthroplasty showed substantial agreement among shoulder surgeons.

• 정보화정책
• /
• 제29권4호
• /
• pp.67-90
• /
• 2022

코로나-19 팬데믹 정점에서 치러진 2022년 3월 대통령선거는 확진자와 격리자가 투표권을 제대로 보장하지 못해 보통선거의 원칙이 훼손되었다는 비판을 크게 받게 되었다. 따라서 이들의 투표권을 보장하기 위해서는 현행 종이투표 투표소 투표의 시공간적 제한을 근본적으로 뛰어넘을 수 있는 전자투표에 대한 고민이 필요하다. 문제는 보통선거권 확대로 평등·직접·비밀선거의 원칙과 충돌하거나 침해할 소지가 높아지는 점을 어떻게 해결해 나가느냐는 것이다. 이에 대한 시사점을 얻기 위해 2005년 전자투표를 도입한 이래 11번의 전국 선거를 별 탈 없이 진행하고 있는 에스토니아의 사례를 살펴보았다. 에스토니아는 선거의 원칙에 대한 정치적·헌법적 합의와 함께 전자투표 운영에 대한 사회-기술적 시스템 전반에 걸친 제도화 및 일상화를 통해 시스템, 정부, 사회에 대한 신뢰를 성공적으로 구축해왔다. 이에 우리도 기술적 발전과 수준에서 전자투표의 가능성만을 따져보는 것이 아니라 규범적인 관점에서 선거의 원칙 간의 갈등을 조정해 사회적 합의를 이끌어내는 신뢰 구축을 위한 논의가 선행되어야 할 것이다.

• 한국콘텐츠학회논문지
• /
• 제16권11호
• /
• pp.358-368
• /
• 2016

김치산업은 우리나라의 문화에 대한 척도로서 국민들의 자긍심을 높여주는 산업일 뿐만 아니라 국경제발전과 국민의 삶의 질 향상에 기여하고 있어 반드시 육성해야 하는 전략산업 중의 하나이다. 그러나 김치산업의 중요성과 가치에 대한 국가적인 공감대의 형성 부족으로 큰 어려움을 겪고 있다. 따라서 본 연구의 목적은 한국은행이 2015년에 발표한 2013년 산업연관표를 이용하여 김치산업이 국민경제에 얼마만큼 기여하는지를 비교분석하는데 있다. 이를 위해 본 논문에서는 한국은행의 2013년 산업연관표흫를 활용하여 김치산업연관표 만들어 분석해야 한다. 분석결과 김치산업의 총샌산유발액은 564,254십억원, 생산유발계수는 1.8418(열), 1.1760(행), 감응도계수는 0.6136 영향력계수는 0.9611 소득유발계수 0.1876 생산세유발계수는 0.0084 그리고 노동유발계수는 0.003 등으로 나타났다.

• 농촌지도와개발
• /
• 제17권3호
• /
• pp.527-548
• /
• 2010

The objective of this study is to suggest the developmental tasks for the successful fostering the Farmer's Study Group which have been guided by the agricultural extension work since 1994 in Korea. The 3,278 farmers study groups with 148,420 memberships have been organized in field of grains, cash crop, horticulture, livestock, improving living conditions, food processing and so on. Although the number of study groups have rapidly expanded, there also are tasks to be secured for their successful development in terms of (a) desirable phase of the study groups and goals of its fostering, (b) managements / administration of them, (c) long-term tasks to be reviewed. With regard to the desirable phase of the study groups and goals of its fostering, they should secure differential mission and the way of works compare to the other farmer's groups. Also, there should be consensus on the proper number of study groups to be fostered with a agricultural technical center at local level. With regard to the managements / administration of the study groups, there should be the different support, assistance and guidance according to the developmental level of the groups. For these, there should be evaluation works on the groups, and guidance manuals for the extension workers. Also extension works should facilitate the establishment of networks among groups over the counties. Finally, to establish the nationwide association in hierarchy and to make the cooperative works with similar farmer's group, doing the value-added activities rather than mere information exchange, and the introduction of capacity building programs for the extension workers are long-term tasks needed to review for the successful fostering study groups.

• IMMUNE NETWORK
• /
• 제11권1호
• /
• pp.1-10
• /
• 2011

Interleukin-7 (IL-7) is an essential cytokine for T cells. However, IL-7 is not produced by T cells themselves such that T cells are dependent on extrinsic IL-7. In fact, in the absence of IL-7, T cell development in the thymus as well as survival of naive T cells in the periphery is severely impaired. Furthermore, modulating IL-7 availability in vivo either by genetic means or other experimental approaches determines the size, composition and function of the T cell pool. Consequently, understanding IL-7 expression is critical for understanding T cell immunity. Until most recently, however, the spatiotemporal expression of in vivo IL-7 has remained obscured. Shortage of such information was partly due to scarce expression of IL-7 itself but mainly due to the lack of adequate reagents to monitor IL-7 expression in vivo. This situation dramatically changed with a recent rush of four independent studies that describe the generation and characterization of IL-7 reporter mice, all utilizing bacterial artificial chromosome transgene technology. The emerging consensus of these studies confirmed thymic stromal cells as the major producers of IL-7 but also identified IL-7 reporter activities in various peripheral tissues including skin, intestine and lymph nodes. Strikingly, developmental and environmental cues actively modulated IL-7 reporter activities in vivo suggesting that IL-7 regulation might be a new mechanism of shaping T cell development and homeostasis. Collectively, the availability of these new tools opens up new venues to assess unanswered questions in IL-7 biology in T cells and beyond.