• Communications for Statistical Applications and Methods
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• 제29권4호
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• pp.471-486
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• 2022

Autoregressive moving average (ARMA) models involve nonlinearity in the model coefficients because of unobserved lagged errors, which complicates the likelihood function and makes the posterior density analytically intractable. In order to overcome this problem of posterior analysis, some approximation methods have been proposed in literature. In this paper we first review the main analytic approximations proposed to approximate the posterior density of ARMA models to be analytically tractable, which include Newbold, Zellner-Reynolds, and Broemeling-Shaarawy approximations. We then use the Kullback-Leibler divergence to study the relation between these three analytic approximations and to measure the distance between their derived approximate posteriors for ARMA models. In addition, we evaluate the impact of the approximate posteriors distance in Bayesian estimates of mean and precision of the model coefficients by generating a large number of Monte Carlo simulations from the approximate posteriors. Simulation study results show that the approximate posteriors of Newbold and Zellner-Reynolds are very close to each other, and their estimates have higher precision compared to those of Broemeling-Shaarawy approximation. Same results are obtained from the application to real-world time series datasets.

• Bulletin of the Korean Chemical Society
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• 제25권4호
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• pp.491-500
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• 2004

The Lewis acid-catalyzed reactions of anthrone with a variety of ethylenic substrates under various conditions have been studied. It has been observed that depending on kinds of ethylenic substrates and catalysts, products were varied. In particular, the $ZnCl_2$-catalyzed reaction of anthrone with ${\alpha},{\beta}$ -unsaturated ester gave bridged compounds 3 (Diels-Alder adduct type) and mono-Michael adduct 4 exclusively, while the base-catalyzed reaction gave 10,10-bis-Michael adduct as a major product independent of the amount of ethylenic substrate and base. Bridged compounds 3 were easily converted to the corresponding mono-Michael adduct 4 by a catalytic amount of base. Further Michael reaction of mono-Michael adducts with different ethylenic substrates in the presence of a catalytic amount of alkoxide gave unsymmetrical 10,10-bis Michael adducts in good or moderate yields.

• 한국식품영양과학회:학술대회논문집
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• 한국식품영양과학회 2004년도 Annual Meeting and International Symposium
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• pp.53-60
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• 2004

The pro-apoptotic effect of phenethyl isothiocyanate (PEITC) and the role of glutathione (GSH) in sulforaphane (SFN)-induced antioxidant response element-dependent gene expression were investigated. The caspase-3 and caspase-9 activities were stimulated by PEITC. The release of cytochrome c was time- and dose- dependent. SP600125 suppressed apoptosis induced by PEITC. Similarly, this JNK inhibitor attenuated both cytochrome c release and caspase-3 activation induced by PEITC. SFN is converted to the glutathione conjugate by glutathione S-transferases (GSTs). It was accumulated in mammalian cells by up to several hundred-fold over the extracellular concentration, by conjugation with intracellular GSH. The induction of ARE by SFN was 8.6-fold higher than by SFN-NAC. The decrease in ARE expression at higher concentrations of SFN and SFN-NAC was correlated with the accelerated apoptotic cell death, with a dose-dependent activation of caspase 3 activity by SFN. Upon addition of extracellular GSH within 6 hr of treatment with SFN, the effect on ARE expression was blocked almost completely.

• 대한기계학회논문집A
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• 제21권11호
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• pp.1844-1851
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• 1997

Displacement fields and interface stresses are obtained by modifying the potential energy functional with a penalty function which enforces the continuity of stresses at the interface of two-materials. Based on the displacement field and the interface stresses, a new methodology to generate a continuous stress field over the entire domain including the interface of the dissimilar materials has been proposed by combining the L$^{2}$ projection method of stress-smoothing and the Loubignac's iterative method of improving the displacement field. Stress analysis was carried out on two examples which are made of highly dissimilar materials. As a result of the analysis, it is found that the proposed method provides improved continuity of the stress field over the entire domain as well as predicting accurate nodal stresses at the interface. In contrast, the conventional displacement-based finite element method provides significant stress discontinuties at the interfaces. In addition, it was found that the total strain energy evaluated from the improved continuous stress field converge to the exact value as increasing the number of iterations in the proposed method.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2000년도 추계학술대회 논문집
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• pp.687-690
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• 2000

Lately, many studies have been progressed for the protection human's lives and property as holding in check accidents happened by human's carelessness or mistakes. One part of these is the development of an autonomouse vehicle. General control method of vision-based autonomous vehicle system is to determine the navigation direction by analyzing lane images from a camera, and to navigate using proper control algorithm. In this paper, characteristic points are abstracted from lane images using lane recognition algorithm with sobel operator. And then the vehicle is controlled using two proposed auto-steering algorithms. Two steering control algorithms are introduced in this paper. First method is to use the geometric relation of a camera. After transforming from an image coordinate to a vehicle coordinate, a steering angle is calculated using Ackermann angle. Second one is using a neural network algorithm. It doesn't need to use the geometric relation of a camera and is easy to apply a steering algorithm. In addition, It is a nearest algorithm for the driving style of human driver. Proposed controller is a multilayer neural network using Levenberg-Marquardt backpropagation learning algorithm which was estimated much better than other methods, i.e. Conjugate Gradient or Gradient Decent ones.

• Nuclear Engineering and Technology
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• 제52권3호
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• pp.485-498
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• 2020

A diffusion synthetic acceleration (DSA) technique for the S_N transport equation discretized with the linear discontinuous expansion method with subcell balance (LDEM-SCB) on unstructured tetrahedral meshes is presented. The LDEM-SCB scheme solves the transport equation with the discrete ordinates method by using the subcell balances and linear discontinuous expansion of the flux. Discretized DSA equations are derived by consistently discretizing the continuous diffusion equation with the LDEM-SCB method, however, the discretized diffusion equations are not fully consistent with the discretized transport equations. In addition, a fine mesh rebalance (FMR) method is devised to accelerate the discretized diffusion equation coupled with the preconditioned conjugate gradient (CG) method. The DSA method is applied to various test problems to show its effectiveness in speeding up the iterative convergence of the transport equation. The results show that the DSA method gives small spectral radii for the tetrahedral meshes having various minimum aspect ratios even in highly scattering dominant mediums for the homogeneous test problems. The numerical tests for the homogeneous and heterogeneous problems show that DSA with FMR (with preconditioned CG) gives significantly higher speedups and robustness than the one with the Gauss-Seidel-like iteration.

• Asian-Australasian Journal of Animal Sciences
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• 제6권2호
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• pp.211-218
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• 1993

The effect of active immunization against porcine somatostatin (SRIF-14) on somatostation and somatotropin secretion profile in 18 gilts was investigated. Gilts were assigned to the following treatments: control (sham injection, n = 6); bovine serum albumin (BSA) (injection of BSA with bacterial protein adjuvant, n = 6); SRIF (injection of BSA-SRIF-14 conjugate with bacterial protein adjuvant n = 6). Serum SRIF and pST were assayed from the blood samples taken on day 7 after the last immunization injection. Anti-SRIF antibody titres were assayed in weekly samples two weeks after the initial immunization to one week after the last immunization. Results revealed that the immunization protocol used in the present investigation failed to produce antibodies capable of neutralizing endogenous somatostatin. In addition, the porcine somatotropin assay revealed no significant differences in baseline pST concentration, mean peak amplitude and number of peaks during a 24 h secretory period among SRIF, BSA and control treatment. There were also no differences in SRIF baseline concentration, peak amplitude, and number of peaks during a 24 h secretory period among any of the three treatments. Circulating concentrations of pST and pSRIF were highly correlated (r = -0.09). Furthermore, anti-SRIF antibody titre was not detected in the serum of the gilts actively immunized against SRIF. These data, collectively, suggest that the protocol employed in the present investigation for active immunization against SRIF is not an effective method for changing SRIF and pST secretion profiles of the gilt and thus to enhance performance.

• 약학회지
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• 제59권4호
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• pp.170-176
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• 2015

In vaccine development, the major points may be induction of effective and increased levels of antibody production. This is especially the case when the antigenic sources are carbohydrates. For many years, thus, we have researched various types of formulations such as liposomal and conjugate vaccines. However, the fastidious formulation process and high costs are a problem. For this reason, there is currently a focus on utilizing immunoadjuvants. In this present study, we tested if platycodin D (PLD) from Platycodon Radix have immunoadjuvant activity against the cell wall of Candida albicans (CACW). The resulting data showed that in the murine model of antibody production, CACW combined with PLD [CACW/PLD/IFA] increased the production of antibodies specific to C. albicans when compared to the antibody production by [CACW/IFA]-induction, which was used as a negative control (P<0.05). In the case of [CACW/PLD/IFA], the antibody production was 1.4 times as that of the CFA. In addition, formulations containing either had a prolonged antibody inducing activity maintaining the initial titers of antibody as compared to the CFA formula. Cytokine profiling with the antisera displayed that the PLD produced both Th1 and Th2 immunoresponses, but Th1 dominant was much greater (P<0.05). Furthermore, [CACW/PLD/IFA] formula enhanced resistance of mice against disseminated candidiasis, whereas the CFA had no such effect. In conclusion, PLD has an immunologic activity, which is protective against the disease. Thus, PLD can be a goof candidate for a new immunoadjuvant in development of the fungal vaccine.

• Journal of Microbiology and Biotechnology
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• 제12권5호
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• pp.746-752
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• 2002

The purpose of the present study was to examine the antagonistic activities of Enterococcus faecalis strain PL9003 (PL9003) on Helicobacter pylori. This strain was isolated from infant feces and found to inhibit both the growth of H. pylori and its in vitro adherence to the human gastric cell line MKN-45. The binding of PL9003 to MKN-45 was observed under a light microscope after Cram staining and under a scanning electron microscope. When detected with an FITC-conjugate antibody, both viable and nonviable PL9003 were found to decrease the number of H. pylori bound to MKN-45. When detected by an enzyme-linked immunoabsorbent assay, about 70% of the H. pylori bound on MKN-45 disappeared with the four-1314 addition of viable or nonviable PL9003. The spent culture supernatant (SCS) of PL9003 also decreased the viability of H pylori even after neutralization and pepsin treatment. The above results suggest that PL9003 has a potential as a new probiotic for the stomach.

• 대한기계학회논문집B
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• 제33권1호
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• pp.17-27
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• 2009

Water jet impingement cooling is used to remove heat from high-temperature surfaces such as hot steel plates in the steel manufacturing process (thermo-mechanical cooling process; TMCP). In those processes, uniform cooling is the most critical factor to ensure high strength steel and good quality. In this study, experiments are performed to measure the heat transfer coefficient together with the inverse heat conduction problem (IHCP) analysis for a plate cooled by planar water jet. In the inverse heat transfer analysis, spatial and temporal variations of heat transfer coefficient, with no information regarding its functional form, are determined by employing the conjugate gradient method with an adjoint problem. To estimate the two dimensional distribution of heat transfer coefficient and heat flux for planar waterjet cooling, eight thermo-couple are installed inside the plate. The results show that heat transfer coefficient is approximately uniform in the span-wise direction in the early stage of cooling. In the later stage where the forced-convection effect is important, the heat transfer coefficient becomes larger in the edge region. The surface temperature vs. heat flux characteristics are also investigated for the entire boiling regimes. In addition, the heat transfer rate for the two different plate geometries are compared at the same Reynolds number.