• 폴리머
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• 제38권6호
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• pp.708-713
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• 2014

대부분의 플라스틱 제품은 사출성형을 통해 생산된다. 사출성형에서 성형수축은 피할 수 없으며 이는 제품에 휨이나 뒤틀림을 유발하여 제품의 치수정밀도를 떨어뜨리는 요인으로 작용한다. 사출성형 시 발생하는 휨이나 뒤틀림은 성형조건이나 제품의 형상에도 영향을 받지만 수지의 물성에 따라서도 다양하게 나타난다. 본 연구에서는 제품의 휨을 제어하기 위해 폴리카보네이트를 유리섬유로 보강하여 물성을 예측하였으며, 이를 이용하여 사출성형해석을 실시하였다. 사출성형해석을 통해 유리섬유로 보강된 수지에서 제품의 휨이 감소하는 것을 확인할 수 있었다. 본 연구방법의 타당성과 신뢰성을 검증하기 위하여 사출실험을 실시하여 수지의 물성에 따른 휨 값을 분석하였으며 해석과 실험에서 유사한 경향의 휨이 발생하는 것을 관찰할 수 있었다. 결론적으로 본 연구에서 수행한 바와 같이 해석 프로그램을 통해 수지의 물성을 설계하고 이를 통한 휨의 제어가 가능함을 확인할 수 있었다.

• Archives of Pharmacal Research
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• 제29권6호
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• pp.525-533
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• 2006

The aim of this study was to evaluate the bioequivalence of risperidone in healthy male subjects representing different CYP2D6 genotypes with respect to risperidone, 9-hydroxyrisperidone (9-OH-risperidone), and active moiety. A total of 506 Korean subjects were genotyped for $CYP2D6^*10$ by means of allele-specific polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Based on the genotype analysis, 24 subjects, 7 homozygous for $CYP2D6^*1$ for $^*10$, and 7 heterozygous for $^*10$, were recruited and received a single oral dose of 2 mg risperidone tablet in this study. Serum concentrations of risperidone and 9-OH-risperidone up to 48 h were simultaneously determined. There were no significant differences of the active moiety, risperidone, and 9-OH-risperidone between the two preparations in AUC_{0-{\propto}}$ and $C_{max}$. The 90% confidence intervals (Cls) for the ratio of means of the log-trans-formed AUC_{0-{\propto}}$ and $C_{max}$ for the active moiety, risperidone, and 9-OH-risperidone were all within the bioequivalence acceptance criteria of 0.80-1.25. The $CYP2D6^*10$ allele particularly was associated with higher serum concentrations of risperidone and the risperidone/9-OH-risperidone ratio compared with the $CYP2D6^*1$ allele. The results demonstrate that the two preparations of risperidone are bioequivalent and it can be assumed that they are therapeutically equivalent and exchangeable in clinical practice. Furthermore, the pharmacokinetic parameters of risperidone and the risperidone/9-OH-risperidone ratio are highly dependent on the CYP2D6 genotypes.

• 한국구조물진단유지관리공학회 논문집
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• 제15권1호
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• pp.120-128
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• 2011

변전소 구조물은 가스절연개폐기의 개폐로 유발되는 주기적인 충격하중을 받게 된다. 이러한 주기적인 충격하중은 구조물의 노후화 및 열화를 가속화하여 구조물의 일부 부재 혹은 전반적인 강성 감소를 초래할 수 있다. 본 연구에서는 이러한 주기적인 충격하중이 구조물에 미치는 영향을 정량적으로 평가하고, 손상 정도를 평가하는 방법을 선정하고자 한다. 따라서, 개략적인 손상 정도를 파악할 수 있는 효율적인 방법으로 인지되고 있는 시스템식별기법을 선정하였다. 선정된 기법에 대한 신뢰성을 검증하기 위해 3층 1경간 축소 모형을 대상으로 모의 손상실험 및 해석을 통해 모드형상 및 고유진동수를 산정하고 결과를 비교하였다.

• The Korean Journal of Pain
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• 제33권1호
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• pp.54-59
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• 2020

Background: The median nerve cross-sectional area (MNCSA) is a useful morphological parameter for the evaluation of carpal tunnel syndrome (CTS). However, there have been limited studies investigating the anatomical basis of median nerve flattening. Thus, to evaluate the connection between median nerve flattening and CTS, we carried out a measurement of the median nerve thickness (MNT). Methods: Both MNCSA and MNT measurement tools were collected from 20 patients with CTS, and from 20 control individuals who underwent carpal tunnel magnetic resonance imaging (CTMRI). We measured the MNCSA and MNT at the level of the hook of hamate on CTMRI. The MNCSA was measured on the transverse angled sections through the whole area. The MNT was measured based on the most compressed MNT. Results: The mean MNCSA was 9.01 ± 1.94 ㎟ in the control group and 6.58 ± 1.75 ㎟ in the CTS group. The mean MNT was 2.18 ± 0.39 mm in the control group and 1.43 ± 0.28 mm in the CTS group. Receiver operating characteristics curve analysis demonstrated that the optimal cut-off value for the MNCSA was 7.72 ㎟, with 75.0% sensitivity, 75.0% specificity, and an area under the curve (AUC) of 0.82 (95% confidence interval [CI], 0.69-0.95). The best cut off-threshold of the MNT was 1.76 mm, with 85% sensitivity, 85% specificity, and an AUC of 0.94 (95% CI, 0.87-1.00). Conclusions: Even though both MNCSA and MNT were significantly associated with CTS, MNT was identified as a more suitable measurement parameter.

• Journal of Pharmaceutical Investigation
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• 제34권6호
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• pp.499-504
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• 2004

Paroxetine, a potent and selective serotonine reuptake inhibitor, has been used for the treatment of depression, obsessive-compulsive disorder, panic disorder and social phobia. The bioequivalence of two paroxetine preparations was evaluated according to the guidelines of Korea Food & Drug Administration (KFDA). The test product was Samchully Paroxetine $tablet^{\circledR}$ made by Samchully Pharm. Co. and the reference product was Seroxat $tablet^{\circledR}$ made by GlaxoSmithKline. Twenty healthy male subjects, $22.4{\pm}2.6$ years old and $63.8{\pm}4.2\;kg$, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After one tablet containing 20 mg paroxetine was orally administered, blood was taken at predetermined time intervals and the concentration of paroxetine in plasma was determined using a validated HPLC method with fluorescence detector. Two pharmacokinetic parameters, $AUC_t$ and $C_{max}$, were calculated and analyzed statistically for the evaluation of bioequivalence of two products. Analysis of variance was carried out using logarithmically transformed parameter values. The 90% confidence intervals of $AUC_t$ and $C_{max}$ were log 0.84-log 1.16 and log 0.85-log 1.14, respectively. These values were within the acceptable bioequivalence intervals of log 0.8 to log 1.25. Thus, the criteria of the KFDA guidelines for the bioequivalence was satisfied, indicating that Samchully Paroxetine tablet is bioequivalent to Seroxat tablet.

• 한국산학기술학회논문지
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• 제14권1호
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• pp.247-256
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• 2013

본 논문은 방문요양서비스를 이용하고 있는 대상자 중심의 서비스 평가를 바탕으로 중요도와 성과도 분석을 통해 관리전략을 제시하였다. 연구대상은 강원도 S시에 소재한 3개소의 재가장기요양기관에서 서비스를 받고 있는 대상자로 하였으며, 자료 분석은 SPSS 12.0을 이용하여 기초통계, 신뢰도분석, 요인분석을 실시하였다. 분석결과 방문요양서비스 중요도는 총5점 만점에 4.55점으로 나타났고, 성과도는 4.26점으로 나타났다. 집중개선영역은 '신속한 서비스 제공'과 '안심하고 서비스 제공'으로 나타났고, 유형성의 4개 속성, 신뢰 확신성의 4개 속성, 대응 공감성의 1개 속성은 개선고려 영역으로 나타났으며, 신뢰 확신성의 3개 속성, 대응 공감성의 5개 속성은 강점유지영역으로 나타났다. 결론적으로 방문요양서비스 질을 높이기 위해서는 우선적으로 집중개선영역의 성과향상이 필요하며, 서비스 제공자의 지속적인 교육과 훈련을 통한 전문성의 확보와 규칙적인 대상자 중심의 서비스 평가를 통한 관리가 필요할 것으로 사료된다.

• Nuclear Engineering and Technology
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• 제50권3호
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• pp.396-410
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• 2018

To assist operators to properly assess the current situation of the plant, accurate fault diagnosis methodology should be available and used. A reliable fault diagnosis method is beneficial for the safety of nuclear power plants. The major idea proposed in this work is integrating the merits of different fault diagnosis methodologies to offset their obvious disadvantages and enhance the accuracy and credibility of on-line fault diagnosis. This methodology uses the principle component analysis-based model and multi-flow model to diagnose fault type. To ensure the accuracy of results from the multi-flow model, a mechanical simulation model is implemented to do the quantitative calculation. More significantly, mechanism simulation is implemented to provide training data with fault signatures. Furthermore, one of the distance formulas in similarity measurement-Mahalanobis distance-is applied for on-line failure degree evaluation. The performance of this methodology was evaluated by applying it to the reactor coolant system of a pressurized water reactor. The results of simulation analysis show the effectiveness and accuracy of this methodology, leading to better confidence of it being integrated as a part of the computerized operator support system to assist operators in decision-making.

• Biomolecules & Therapeutics
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• 제7권1호
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• pp.59-65
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• 1999

A bioequivalence study of the Dong Wha Cisapril tablets(Dong Wha Pharm. Ind. Co., Ltd.) to the Prepulsid tablets(Janssen Korea Ltd.), formulations of cisapride, was conducted. Twenty four healthy Korean male subjects received each formulation at the dose of 5 mg as cisapride in a 2$\times$2 crossover study. There was a 1-week washout period between the doses. Plasma concentrations of cisapride were monitored by an LC/MS method for over a period of 36 h after each administration. AUC(area under the plasma concentration- time curve from time zero to infinity) was calculated by the linear trapezoidal and extrapolation method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma drug concentration-time data. Analysis of variance (ANOVA) revealed that there are no differences in AUC, $C_{max}$ and $T_{max}$ between the formulations. The apparent differences between the formulations in these parameters were all far less than 20% (i.e., 6.8, -6.6 and 1.8% for AUC, $C_{max}$ and $T_{max}$, respectively). Minimum detectable differences(%) at $\alpha$=0.05 and 1-$\beta$=0.8 were all less than 20% in these parameters between the formulations (i.e., 16.5, 11.4 and 16.4% for AUC, $C_{max}$ and $T_{max}$, respectively). The 90% confidence intervals for these parameters were also within 20% (i.e., -2.9~ 16.4, -13.2~0.1 and -7.8~ 11.4% for AUC, $C_{max}$ and $T_{max}$, respectively). These results satisfy the bioequivalence criteria of the Korea Food and Drug Administration (KFDA) guidelines (No. 98-51). Therefore, these results indicate that the two formulations of cisapride are bioequivalent and, thus, may be prescribed interchangeably.hangeably.y.hangeably.

• Journal of Korean Neurosurgical Society
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• 제60권4호
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• pp.441-447
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• 2017

Objective : Computed tomography (CT)-based method of three dimensional (3D) analysis ($MIMICS^{(R)}$, Materialise, Leuven, Belgium) is reported as very useful software for evaluation of OPLL, but its reliability and reproducibility are obscure. This study was conducted to evaluate the accuracy of $MIMICS^{(R)}$ system, and inter- and intra-observer reliability in the measurement of OPLL. Methods : Three neurosurgeons independently analyzed the randomly selected 10 OPLL cases with medical image processing software ($MIMICS^{(R)}$) which create 3D model with Digital Imaging and Communication in Medicine (DICOM) data from CT images after brief explanation was given to examiners before the image construction steps. To assess the reliability of inter- and intra-examiner intraclass correlation coefficient (ICC), 3 examiners measured 4 parameters (volume, length, width, and length) in 10 cases 2 times with 1-week interval. Results : The inter-examiner ICCs among 3 examiners were 0.996 (95% confidence interval [CI], 0.987-0.999) for volume measurement, 0.973 (95% CI, 0.907-0.978) for thickness, 0.969 (95% CI, 0.895-0.993) for width, and 0.995 (95% CI, 0.983-0.999) for length. The intra-examiner ICCs were 0.994 (range, 0.991-0.996) for volume, 0.996 (range, 0.944-0.998) for length, 0.930 (range, 0.873-0.947) for width, and 0.987 (range, 0.985-0.995) for length. Conclusion : The medical image processing software ($MIMICS^{(R)}$) provided detailed quantification OPLL volume with minimal error of inter- and intra-observer reliability in the measurement of OPLL.

• 한국태양에너지학회 논문집
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• 제37권4호
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• pp.35-47
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• 2017

Energy efficiency solutions are being pursued as a sustainable approach to reducing energy consumption and related gas emissions across various sectors of the economy. Vacuum Insulation Panel (VIP) is an energy efficient advanced insulation system that facilitates slim but high-performance insulation, based on a porous core material evacuated and encapsulated in a barrier envelope. Although VIP has been applied in buildings for over a decade, it wasn't until recently that efforts have been initiated to propose and adopt a global standard on characterization and testing of VIP. One of the issues regarding VIP is its durability and aging due to pressure and moisture dependent increase of the initial low thermal conductivity with time; more so in building applications. In this paper, the aging of commercially available VIP was investigated experimentally; thermal conductivity was tested in accordance with ISO 8302 standard (guarded hot box method) and long-term durability was estimated based on a non-linear pressure-humidity dependent equation based on study of IEA/ECBCS Annex 39, with the aim of assessing durability of VIP for use in buildings. The center-of-panel thermal conductivity after 25 years based on initial 90% fractile with a confidence level of 90 % for the thermal conductivity (${\lambda}90/90$) ranged from 0.00726-0.00814 (W/m K) for silica core VIP. Significant differences between manufacturer-provided data and measurements of thermal conductivity and internal pressure were observed.