• Polymer(Korea)
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• v.38 no.6
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• pp.708-713
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• 2014

Most plastics products are being produced by injection molding process. However, mold shrinkage is inevitable in injection molding process and it deteriorates dimensional quality through deflections and warpages. Mold shrinkage depends upon the material property of resin as well as injection molding condition. In this study, material property of resin has been predicted for glass fiber reinforced polycarbonate to control the warpage, and computer simulation of injection molding has been performed using predicted property. It was observed that the deflection of part decreased by the glass fiber reinforced resin. In order to verify the validity of this method and confidence of results, experiments of injection molding were performed. The results of experiments and computer simulations showed good agreement in their tendency of deflections. Consequently, it was concluded that the method of designing the material property of resin conducted in this study can be utilized to control the dimensional accuracy of injection molded products.

• Archives of Pharmacal Research
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• v.29 no.6
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• pp.525-533
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• 2006

The aim of this study was to evaluate the bioequivalence of risperidone in healthy male subjects representing different CYP2D6 genotypes with respect to risperidone, 9-hydroxyrisperidone (9-OH-risperidone), and active moiety. A total of 506 Korean subjects were genotyped for $CYP2D6^*10$ by means of allele-specific polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Based on the genotype analysis, 24 subjects, 7 homozygous for $CYP2D6^*1$ for $^*10$, and 7 heterozygous for $^*10$, were recruited and received a single oral dose of 2 mg risperidone tablet in this study. Serum concentrations of risperidone and 9-OH-risperidone up to 48 h were simultaneously determined. There were no significant differences of the active moiety, risperidone, and 9-OH-risperidone between the two preparations in AUC_{0-{\propto}}$ and $C_{max}$. The 90% confidence intervals (Cls) for the ratio of means of the log-trans-formed AUC_{0-{\propto}}$ and $C_{max}$ for the active moiety, risperidone, and 9-OH-risperidone were all within the bioequivalence acceptance criteria of 0.80-1.25. The $CYP2D6^*10$ allele particularly was associated with higher serum concentrations of risperidone and the risperidone/9-OH-risperidone ratio compared with the $CYP2D6^*1$ allele. The results demonstrate that the two preparations of risperidone are bioequivalent and it can be assumed that they are therapeutically equivalent and exchangeable in clinical practice. Furthermore, the pharmacokinetic parameters of risperidone and the risperidone/9-OH-risperidone ratio are highly dependent on the CYP2D6 genotypes.

• Journal of the Korea institute for structural maintenance and inspection
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• v.15 no.1
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• pp.120-128
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• 2011

Recently, safety diagnosis of the existing structures has been emerged as important issue. In particular, systematical and precise safety diagnostics for steel structures for power substation, have been required. Steel structures for power substation are under the periodical impact loads from operations of gas insulated switchgear. These loading condition accelerates damage and aging of structure. The objective of this research is to evaluate damage of structure under periodical impact loads. To evaluate the integrity of structures as organizing mathematical models including the dynamic characteristics of structures, Frequency Domain Decomposition method was choiced and an algorism was proposed. For verifying this methods and algorism, a mathematical model is composed of the development of a variety of reverse analysis and a signal processing technology reflecting physical damage of structures. A series of analysis and test results indicatge that proposed method has a confidence for applying a filed test. Therefore, it is expected to be able to take advantage of system identification to detect damage for the maintenance and management of steel structures under periodical impact loads such as power substation.

• The Korean Journal of Pain
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• v.33 no.1
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• pp.54-59
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• 2020

Background: The median nerve cross-sectional area (MNCSA) is a useful morphological parameter for the evaluation of carpal tunnel syndrome (CTS). However, there have been limited studies investigating the anatomical basis of median nerve flattening. Thus, to evaluate the connection between median nerve flattening and CTS, we carried out a measurement of the median nerve thickness (MNT). Methods: Both MNCSA and MNT measurement tools were collected from 20 patients with CTS, and from 20 control individuals who underwent carpal tunnel magnetic resonance imaging (CTMRI). We measured the MNCSA and MNT at the level of the hook of hamate on CTMRI. The MNCSA was measured on the transverse angled sections through the whole area. The MNT was measured based on the most compressed MNT. Results: The mean MNCSA was 9.01 ± 1.94 ㎟ in the control group and 6.58 ± 1.75 ㎟ in the CTS group. The mean MNT was 2.18 ± 0.39 mm in the control group and 1.43 ± 0.28 mm in the CTS group. Receiver operating characteristics curve analysis demonstrated that the optimal cut-off value for the MNCSA was 7.72 ㎟, with 75.0% sensitivity, 75.0% specificity, and an area under the curve (AUC) of 0.82 (95% confidence interval [CI], 0.69-0.95). The best cut off-threshold of the MNT was 1.76 mm, with 85% sensitivity, 85% specificity, and an AUC of 0.94 (95% CI, 0.87-1.00). Conclusions: Even though both MNCSA and MNT were significantly associated with CTS, MNT was identified as a more suitable measurement parameter.

• Journal of Pharmaceutical Investigation
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• v.34 no.6
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• pp.499-504
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• 2004

Paroxetine, a potent and selective serotonine reuptake inhibitor, has been used for the treatment of depression, obsessive-compulsive disorder, panic disorder and social phobia. The bioequivalence of two paroxetine preparations was evaluated according to the guidelines of Korea Food & Drug Administration (KFDA). The test product was Samchully Paroxetine $tablet^{\circledR}$ made by Samchully Pharm. Co. and the reference product was Seroxat $tablet^{\circledR}$ made by GlaxoSmithKline. Twenty healthy male subjects, $22.4{\pm}2.6$ years old and $63.8{\pm}4.2\;kg$, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After one tablet containing 20 mg paroxetine was orally administered, blood was taken at predetermined time intervals and the concentration of paroxetine in plasma was determined using a validated HPLC method with fluorescence detector. Two pharmacokinetic parameters, $AUC_t$ and $C_{max}$, were calculated and analyzed statistically for the evaluation of bioequivalence of two products. Analysis of variance was carried out using logarithmically transformed parameter values. The 90% confidence intervals of $AUC_t$ and $C_{max}$ were log 0.84-log 1.16 and log 0.85-log 1.14, respectively. These values were within the acceptable bioequivalence intervals of log 0.8 to log 1.25. Thus, the criteria of the KFDA guidelines for the bioequivalence was satisfied, indicating that Samchully Paroxetine tablet is bioequivalent to Seroxat tablet.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.1
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• pp.247-256
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• 2013

This dissertation is based on the evaluation of service by the home help service users and suggested managing strategy through analyzing importance and performance. The subject is a person receiving the service from the three home long term institutions in S city, Gangwon province, and SPSS 12.0 is used to analyze data to conduct analysis of basic statistic, confidence level, and factors. The result came out that home help service's importance showed 4.55 out of 5, performance 4.26 out of 5. The most improvement needed factor was 'providing quick service' and 'offer service at ease'. Also it seemed that the four categories in tangibles and four categories in reliability and assurance, one category in responsiveness and empathy needs to be improved. The three in reliability and assurance and five properties in responsiveness and empathy need to remain its strength. In conclusion, in order to better the home help service first the progress result in focus improvement area needs to be achieved.

• Nuclear Engineering and Technology
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• v.50 no.3
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• pp.396-410
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• 2018

To assist operators to properly assess the current situation of the plant, accurate fault diagnosis methodology should be available and used. A reliable fault diagnosis method is beneficial for the safety of nuclear power plants. The major idea proposed in this work is integrating the merits of different fault diagnosis methodologies to offset their obvious disadvantages and enhance the accuracy and credibility of on-line fault diagnosis. This methodology uses the principle component analysis-based model and multi-flow model to diagnose fault type. To ensure the accuracy of results from the multi-flow model, a mechanical simulation model is implemented to do the quantitative calculation. More significantly, mechanism simulation is implemented to provide training data with fault signatures. Furthermore, one of the distance formulas in similarity measurement-Mahalanobis distance-is applied for on-line failure degree evaluation. The performance of this methodology was evaluated by applying it to the reactor coolant system of a pressurized water reactor. The results of simulation analysis show the effectiveness and accuracy of this methodology, leading to better confidence of it being integrated as a part of the computerized operator support system to assist operators in decision-making.

• Biomolecules & Therapeutics
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• v.7 no.1
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• pp.59-65
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• 1999

A bioequivalence study of the Dong Wha Cisapril tablets(Dong Wha Pharm. Ind. Co., Ltd.) to the Prepulsid tablets(Janssen Korea Ltd.), formulations of cisapride, was conducted. Twenty four healthy Korean male subjects received each formulation at the dose of 5 mg as cisapride in a 2$\times$2 crossover study. There was a 1-week washout period between the doses. Plasma concentrations of cisapride were monitored by an LC/MS method for over a period of 36 h after each administration. AUC(area under the plasma concentration- time curve from time zero to infinity) was calculated by the linear trapezoidal and extrapolation method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma drug concentration-time data. Analysis of variance (ANOVA) revealed that there are no differences in AUC, $C_{max}$ and $T_{max}$ between the formulations. The apparent differences between the formulations in these parameters were all far less than 20% (i.e., 6.8, -6.6 and 1.8% for AUC, $C_{max}$ and $T_{max}$, respectively). Minimum detectable differences(%) at $\alpha$=0.05 and 1-$\beta$=0.8 were all less than 20% in these parameters between the formulations (i.e., 16.5, 11.4 and 16.4% for AUC, $C_{max}$ and $T_{max}$, respectively). The 90% confidence intervals for these parameters were also within 20% (i.e., -2.9~ 16.4, -13.2~0.1 and -7.8~ 11.4% for AUC, $C_{max}$ and $T_{max}$, respectively). These results satisfy the bioequivalence criteria of the Korea Food and Drug Administration (KFDA) guidelines (No. 98-51). Therefore, these results indicate that the two formulations of cisapride are bioequivalent and, thus, may be prescribed interchangeably.hangeably.y.hangeably.

• Journal of Korean Neurosurgical Society
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• v.60 no.4
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• pp.441-447
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• 2017

Objective : Computed tomography (CT)-based method of three dimensional (3D) analysis ($MIMICS^{(R)}$, Materialise, Leuven, Belgium) is reported as very useful software for evaluation of OPLL, but its reliability and reproducibility are obscure. This study was conducted to evaluate the accuracy of $MIMICS^{(R)}$ system, and inter- and intra-observer reliability in the measurement of OPLL. Methods : Three neurosurgeons independently analyzed the randomly selected 10 OPLL cases with medical image processing software ($MIMICS^{(R)}$) which create 3D model with Digital Imaging and Communication in Medicine (DICOM) data from CT images after brief explanation was given to examiners before the image construction steps. To assess the reliability of inter- and intra-examiner intraclass correlation coefficient (ICC), 3 examiners measured 4 parameters (volume, length, width, and length) in 10 cases 2 times with 1-week interval. Results : The inter-examiner ICCs among 3 examiners were 0.996 (95% confidence interval [CI], 0.987-0.999) for volume measurement, 0.973 (95% CI, 0.907-0.978) for thickness, 0.969 (95% CI, 0.895-0.993) for width, and 0.995 (95% CI, 0.983-0.999) for length. The intra-examiner ICCs were 0.994 (range, 0.991-0.996) for volume, 0.996 (range, 0.944-0.998) for length, 0.930 (range, 0.873-0.947) for width, and 0.987 (range, 0.985-0.995) for length. Conclusion : The medical image processing software ($MIMICS^{(R)}$) provided detailed quantification OPLL volume with minimal error of inter- and intra-observer reliability in the measurement of OPLL.

• Journal of the Korean Solar Energy Society
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• v.37 no.4
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• pp.35-47
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• 2017

Energy efficiency solutions are being pursued as a sustainable approach to reducing energy consumption and related gas emissions across various sectors of the economy. Vacuum Insulation Panel (VIP) is an energy efficient advanced insulation system that facilitates slim but high-performance insulation, based on a porous core material evacuated and encapsulated in a barrier envelope. Although VIP has been applied in buildings for over a decade, it wasn't until recently that efforts have been initiated to propose and adopt a global standard on characterization and testing of VIP. One of the issues regarding VIP is its durability and aging due to pressure and moisture dependent increase of the initial low thermal conductivity with time; more so in building applications. In this paper, the aging of commercially available VIP was investigated experimentally; thermal conductivity was tested in accordance with ISO 8302 standard (guarded hot box method) and long-term durability was estimated based on a non-linear pressure-humidity dependent equation based on study of IEA/ECBCS Annex 39, with the aim of assessing durability of VIP for use in buildings. The center-of-panel thermal conductivity after 25 years based on initial 90% fractile with a confidence level of 90 % for the thermal conductivity (${\lambda}90/90$) ranged from 0.00726-0.00814 (W/m K) for silica core VIP. Significant differences between manufacturer-provided data and measurements of thermal conductivity and internal pressure were observed.