• Nutrition Research and Practice
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• v.15 no.1
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• pp.12-25
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• 2021

BACKGROUND/OBJECTIVES: The study was conducted to investigate the efficacy of the combination treatment of phytochemical resveratrol and the anticancer drug docetaxel (DTX) on prostate carcinoma LNCaP cells, including factors related to detailed cell death mechanisms. MATERIALS/METHODS: Using 2-dimensional monolayer and 3-dimensional spheroid culture systems, we examined the effects of resveratrol and DTX on cell viability, reactive oxygen species (ROS) levels, mitochondrial membrane potential, apoptosis, and necroptosis by MTT, flow cytometry, and Western blotting. RESULTS: At concentrations not toxic to normal human prostate epithelial cells, resveratrol effectively decreased the viability of LNCaP cells depending on concentration and time. The combination treatment of resveratrol and DTX exhibited synergistic inhibitory effects on cell growth, demonstrated by an increase in the sub-G0/G1 peak, Annexin V-phycoerythrin positive cell fraction, ROS, mitochondrial dysfunction, and DNA damage response as well as concurrent activation of apoptosis and necroptosis. Apoptosis and necroptosis were rescued by pretreatment with ROS scavenger N-acetylcysteine. CONCLUSIONS: We report resveratrol as an adjuvant drug candidate for improving the outcome of treatment in DTX therapy. Although the underlying mechanisms of necroptosis should be investigated comprehensively, targeting apoptosis and necroptosis simultaneously in the treatment of cancer can be a useful strategy for the development of promising drug candidates.

• Wind and Structures
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• v.37 no.3
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• pp.191-209
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• 2023

This work investigates the subcritical free-shear prism wake at Re=22,000 by the Koopman analysis using the Dynamic Mode Decomposition (DMD) algorithm. The Koopman model linearized nonlinearities in the stochastic, homogeneous anisotropic turbulent wake, generating temporally orthogonal eigen tuples that carry meaningful, coherent structures. Phenomenological analysis of dominant modes revealed their physical interpretations: Mode 1 renders the mean-field dynamics, Modes 2 describes the roll-up of the Strouhal vortex, Mode 3 describes the Bloor-Gerrard vortex resulting from the Kelvin-Helmholtz instability inside shear layers, its superposition onto the Strouhal vortex, and the concurrent flow entrainment, Modes 6 and 10 describe the low-frequency shedding of turbulent separation bubbles (TSBs) and turbulence production, respectively, which contribute to the beating phenomenon in the lift time history and the flapping motion of shear layers, Modes 4, 5, 7, 8, and 9 are the relatively trivial harmonic excitations. This work demonstrates the Koopman analysis' ability to provide insights into free-shear flows. Its success in subcritical turbulence also serves as an excellent reference for applications in other nonlinear, stochastic systems.

• Tuberculosis and Respiratory Diseases
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• v.51 no.3
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• pp.270-274
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• 2001

A functional upper airway obstruction due to a vocal cord dysfunction(VCD) is characterized by a paradoxical adduction of the vocal cords throughout the respiratory cycle with no obvious organic cause for the obstruction. It commonly occurs paroxysmally and imitates acute asthmatic attacks, often in patients with coexisting asthma. They present with episodes of dyspnea associated with inspiratory wheezing that persists despite conventional asthma treatment and a flattening of the inspiratory limb of the flow-volume curve ; an adduction of the vocal cord during inspiration. Failure to recognize concurrent vocal cord dysfunction and asthma has led not only to the excessive use of bronchodilators and corticosteroids, but also to intubation and tracheostomy. Here, we report a case of coexistent obstructive pulmonary disease and functional upper airway obstruction due to a vocal cord dysfunction where a bronchoscopy showed a paradoxical vocal cord motion and typical features of a variable extrathoracic obstruction and a lower airway obstruction on the Flow-volume loop during a symptomatic period.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2001.10a
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• pp.25-28
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• 2001

Today enterprises are bringing forward the strong needs for the Global Work Space that is able to realize the collaboration of the virtual enterprise in order to achieve the rapid entrance to market, the quality improvement as well as the cost reduction of their new products. Especially, they are building the efficient Product Management Infrastructure in parallel with the real-time knowledge management for the information generated in the course of a product lifecycle and the Process Innovation making the Concurrent Engineering possible. Building a system in the web environment cannot be the entire effort to realize the Global Work Space within an enterprise that is an essential factor for the reduction of a product development period which in turn contributes to Time to Market. Various work models and processes are found in enterprises and many different application programs are developed and utilized to support these. This study proposes a scheme for the optimized Collaborative Workflow System Architecture that is able to take in and apply various application programs accompanied by the product development work process. Through this, we are to examine various limits and problems existing in the real-time collaborative system between enterprises and to reform these.

• Journal of KIISE:Software and Applications
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• v.26 no.9
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• pp.1105-1113
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• 1999

객체 지향 소프트웨어의 확장과 더불어 소프트웨어의 재사용성의 중요도가 부각되면서 소프트웨어를 콤포넌트 단위로 구현하는 추세이다. 따라서 콤포넌트 기반의 소프트웨어 개발에서의 통합 테스트가 중요한 이슈로 떠오르고 있다. 그러나 콤포넌트들의 통합 테스트에 대한 연구는 미흡한 상태이다. 본 논문에서는 UML을 기반으로 체계적인 통합 테스트 모형을 제안하고. 나아가 본 논문에서는 "멀티미디어 정보처리 시스템"의 사례를 본 논문의 콤포넌트 통합 테스트 모형에 적용한 결과를 분석하여 기술한다. 콤포넌트 통합 테스트 모형은 UML(Unified Modeling Language)의 순서도(sequence diagram)와 협력도(collaboration diagram)를 이용하여 전체 시스템에서 UML의 사건흐름을 구성하는 콤포넌트들 사이의 인터페이스 영역에 존재하는 오류들을 추출한다. 그리고 UML을 기반으로 통합 테스트를 수행함으로써, 테스트 준비 작업을 줄이고, 기존의 UML 지원 도구들과 연계하여 테스트 자동화 도구의 구현을 앞당길 수 있다. 또한 시스템의 순차적 흐름 뿐 아니라, 동시에 수행되는 흐름에 대한 정보까지 모두 수용하여 테스트함으로써, 콤포넌트 기반의 분산 환경의 특성에 적합하다. Abstract As the object-oriented approach to software development becomes more mature, software development from pre-existing, independently developed components becomes an important aim of software engineering. Therefore, integration testing becomes an important aspect of component-based software development. However, there has been little work done in the area of the component-based integration testing. In this paper, we propose the "component integration test model" which is based on UML. Furthermore, we describe a case study on "Multimedia Information Processing System" conducted to analyse the result from which our model is applied. Our model extracts the faults, which exist in interfaces of components, using sequence diagram and collaboration diagram of UML(Unified Modeling Language). As our model is based on UML, the preparation effort for testing is reduced and its test-tools can be implemented more easily through linking existing UML tool. And our model accepts the information of concurrent flow represented by collaboration diagram as well as sequential flow, so it is more suitable to component-based distributed environment.based distributed environment.

• Journal of Environmental Science International
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• v.24 no.4
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• pp.371-381
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• 2015

In the mountain streams in Jeju Island, strong turbulence and roughness usually made it nearly impossible to utilize most of intrusive instrumentation for streamflow discharge measurements. Instead, a non-intrusive fixed electro-magnetic wave surface velocimetry (fixed EWSV: Kalesto) became alternatively popular in many representative streams to measure stream discharge seamlessly. Currently, Kalesto has shown noteworthy performance with little loss in flood discharge measurements and also has successfully provided discharge for every minute. However, Kalesto has been operated to regard its measured one-point velocity as the representative mean velocity for the given cross-section. Therefore, it could be highly possible to potentially encompass discharge measurements errors. In this study, we analyzed the difference between such Kalesto discharge measurements and other alternative concurrent discharge measurements such as Acoustic Doppler Current Profiler (ADCP) and mobile EWSV which were able to measure velocity in multi-points in the cross-section. Consequently, Kalesto discharge deviated from ADCP discharge in amount of 48% for relatively low flow, and more than 20% difference for high flow compared with mobile EWSV discharge measurements. These results indicated that the one-point velocity measured by Kalesto should be used as a cross-sectional mean velocity, rather it should be accounted for as an index-velocity in conjunction with directly measured cross-sectional mean velocity by using more reliable instrumentations. After inducing Kalesto Discharge Correction Coefficient (KDCC) that actually means relationship between index velocity and cross-sectional mean velocity, the corrected discharge from Kalesto was significantly improved. Therefore, we found that index velocity method should be applied to obtain better accuracy of discharge measurement in case of Kalesto operation.

• Smart Structures and Systems
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• v.30 no.1
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• pp.49-62
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• 2022

Experimental and discrete element methods were used to investigate the effects of triple joints lengths and triple joint angle on the failure behavior of rock mass under uniaxial compressive test. Concrete samples with dimension of 20 cm × 20 cm × 5 cm were prepared. Within the specimen, three imbedded joint were provided. The joint lengths were 2 cm, 4cm and 6 cm. In constant joint lengths, the angle between middle joint and other joints were 30°, 60°, 90°, 120° and 150°. Totally 15 different models were tested under compression test. The axial load rate on the model was 0.05 mm/min. Concurrent with experimental tests, the models containing triple joints, length and joint angle are similar to the experiments, were numerical by Particle flow code in two dimensions (PFC2D). Loading rate in numerical modelling was 0.05 mm/min. Tensile strength of material was 1 MPa. The results show that the failure behaviors of rock samples containing triple joints were governed by both of the angle and the length of the triple joints. The uniaxial compressive strengths (UCS) of the specimens were related to the fracture pattern and failure mechanism of the discontinuities. Furthermore, it was shown that the compressive behavior of discontinuities is related to the number of the induced tensile cracks which are increased by decreasing the joint length. Along with the damage failure of the samples, the acoustic emission (AE) activities are excited. There were only a few AE hits in the initial stage of loading, then AE hits rapidly grow before the applied stress reached its peak. In addition, every stress drop was accompanied by a large number of AE hits. Finally, the failure pattern and failure strength are similar in both methods i.e., the experimental testing and the numerical simulation methods.

• The Korean Journal of Financial Management
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• v.27 no.2
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• pp.169-204
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• 2010

This paper examines the dynamic relationship between fund flow and market risk at the aggregate level and explores whether sudden sharp changes in fund flow (fund run) can cause a systemic risk in the Korean financial markets. We use daily and weekly data and regression and VAR analysis. Main results of the paper are as follows: First, in the stock market, a concurrent and a lagged unexpected fund flows have a positive relationship with market volatility. A positive shock in fund flow predicts an increase in stock market volatility. In the bond market, an unexpected fund flow has a negative relationship with the default risk premium, but a positive relationship with the term premium. And an unexpected fund flow of the money market fund has a negative relationship with the liquidy risk, but the explanatory power is very low. Second, for examining whether changes in fund flow induce a systemic risk, we construct a spillover index based on the forecast error variance decomposition of VAR model. A spillover index represents that how much the shock in fund flow can explain the change of market risk in a market. In general, explanatory powers from spillover indexes are so fluctuant and low. In the stock market, the impact of shocks in fund flow on market risk is relatively high and persistent during the period from the end of 2007 to 2008, which is the subprime-mortgage crisis period. In bond market, since the end of 2008, the impact of shocks in fund flow spreads to default risk continually, while in the money market, such a systematic effect doesn't take place. The persistent patterns of spillover effect appearing around a certain period in the stock market and the bond market suggest that the shock to the unexpected fund flow may increase the market risk and can be a cause of systemic risk in the financial markets. However, summarizing the results of regression and VAR model analysis, and considering the very low explanatory power of spillover index analysis, we can conclude that changes in fund flow have a very limited power in explaining changes in market risk and it is not very likely to induce the systemic risk by a fund run in the Korean financial markets.

• Tuberculosis and Respiratory Diseases
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• v.75 no.1
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• pp.9-17
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• 2013

Background: In cancer cells, autophagy is generally induced as a pro-survival mechanism in response to treatment-associated genotoxic and metabolic stress. Thus, concurrent autophagy inhibition can be expected to have a synergistic effect with chemotherapy on cancer cell death. Monensin, a polyether antibiotic, is known as an autophagy inhibitor, which interferes with the fusion of autophagosome and lysosome. There have been a few reports of its effect in combination with anticancer drugs. We performed this study to investigate whether erlotinib, an epidermal growth factor receptor inhibitor, or rapamycin, an mammalian target of rapamycin (mTOR) inhibitor, is effective in combination therapy with monensin in non-small cell lung cancer cells. Methods: NCI-H1299 cells were treated with rapamycin or erlotinib, with or without monensin pretreatment, and then subjected to growth inhibition assay, apoptosis analysis by flow cytometry, and cell cycle analysis on the basis of the DNA contents histogram. Finally, a Western blot analysis was done to examine the changes of proteins related to apoptosis and cell cycle control. Results: Monensin synergistically increases growth inhibition and apoptosis induced by rapamycin or erlotinib. The number of cells in the sub-$G_1$ phase increases noticeably after the combination treatment. Increase of proapoptotic proteins, including bax, cleaved caspase 3, and cleaved poly(ADP-ribose) polymerase, and decrease of anti-apoptotic proteins, bcl-2 and bcl-xL, are augmented by the combination treatment with monensin. The promoters of cell cycle progression, notch3 and skp2, decrease and p21, a cyclin-dependent kinase inhibitor, accumulates within the cell during this process. Conclusion: Our findings suggest that concurrent autophagy inhibition could have a role in lung cancer treatment.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.30 no.7B
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• pp.489-498
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• 2005

A Denial of Sewice (DoS) attack attempts to prevent legitimate users of a sewice from being adequately served by monopolizing networks resources and, eventually, resulting in network or system congestion. This paper proposes a Minority First (MF) gateway, which is capable of guaranteeing the Quality of Service (QoS) of legitimate service traffic under DoS situations. A MF gateway can rapidly determine whether an aggregated flow is a congestion-inducer and can protect the QoS of legitimate traffic by providing high priority service to the legitimate as aggregate flows, and localize network congestion only upon attack traffic by providing low priority to aggregate flows regarded as congestion-inducer. We verify through simulation that the suggested mechanism possesses excellence in that it guarantees the QoS of legitimate traffic not only under a regular DoS occurrence, but also under a Distributed DoS (DDoS) attack which brings about multiple concurrent occurrences of network congestion.