• 한국전산유체공학회:학술대회논문집
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• 2009.04a
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• pp.1-8
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• 2009

This is a short review of how CFD contributed to hypersonic flights in the past 50 years. Two unexpected phenomena that occurred in the entry flights of the Apollo and Space Shuttle made us aware of the impact of the high temperature real-gas effects on hypersonic flights: pitching moment anomaly of up to 4 degrees, and radiation overshoot behind a shock wave. The so-called two-temperature nonequilibrium model was introduced to explain these phenomena. CFD techniques were developed to accommodate the two-temperature model. Presently, CFD can predict trim angle of attack to an accuracy of about 1 degree. A concerted effort was made to numerically reproduce the experimentally measured flow-field over a double-cone. As yet, perfect agreement between the experimental data and computation is not achieved. Scramjet technology development is disappointingly slow. The phenomenon of ablation during planetary entries is not yet predicted satisfactorily. In the future, one expects to see more research carried out on planetary entries and space tourism.

• Asian Journal of Innovation and Policy
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• v.3 no.2
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• pp.216-244
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• 2014

This paper empirically establishes the role played by the ecosystem related parameters in the emergence and growth of high technology start-up clusters in India. It is mainly based on secondary data from six major start-up hubs in India during the period 2005-2013. Our results throw up several interesting findings. First of all, we find that traditional infrastructure related factors or robust macroeconomic situation in general are not the most important drivers. What really seem to matter are the specific start-up ecosystem related factors - such as the Internet penetration, volume of deal flow, availability of VC funding and a pre-existing critical mass of relevant high technology businesses and skill-sets. Above all, our study points out that high economic growth alone will not automatically lead to spillovers in the form of a vibrant start-up ecosystem. Rather it has to be a product of conscious and concerted policy efforts at all levels that directly address the main challenges faced by the early-stage start-ups.

• Journal of Korea Society of Digital Industry and Information Management
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• v.13 no.4
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• pp.33-40
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• 2017

Internet of Vehicles (IoV) is a subset of Internet of Things (IoT) and it is an infrastructure for vehicles. Therefore, IoV consists of three main network including inter-vehicle network, intra-vehicle network, and vehicular mobile internet. IoV mainly used in urban traffic environment to provide network access for drivers, passengers and traffic management. Accordingly, many research works have focused on network technology. But, recent concerted efforts in academia and industry point to paradigm shift in IoV system. In this paper, we proposed a knowledge base for intelligence service in IoV. A detailed design and implementation of the proposed knowledged base is illustrated. We hope this work will show power of IoV as a disruptive technology.

• Journal of Microbiology and Biotechnology
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• v.19 no.9
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• pp.918-921
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• 2009

In the present study, we examined the inhibitory effects of protein tyrosine phosphatase (PTPase) inhibitors, including sodium orthovanadate (SOV), ammonium molybdate (AM), and iodoacetamide (IA), on cell growth, accumulation of astaxanthin, and PTPase activity in the photosynthetic algae Haematococcus lacustris. PTPase activity was assayed spectrophotometrically and was found to be inhibited 60% to 90% after treatment with the inhibitors. SOY markedly abolished PTPase activity, significantly activating the accumulation of astaxanthin. These data suggest that the accumulation of astaxanthin in H. lacustris results from the concerted actions of several PTPases.

• Journal of the Korea Organic Resources Recycling Association
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• v.13 no.2
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• pp.65-73
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• 2005

After the introduction of Volume-based Waste Fee System for municipal wastes, the disposal of food wastes became an issue an issue in society. Concerted efforts among government agencies have been made to manage food wastes separately from municipal wastes. For example, the Ministry of Environment, the Ministry of Agriculture and Forestry, and the Ministry of Health and Welfare established the '5-year('98-'02) Basic Plan for Recycling Food Wastes' in September 1998. Also changes in the waste disposal system has been sought, aiming at the Resource-circulating Society.

• Bulletin of the Korean Chemical Society
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• v.34 no.12
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• pp.3811-3816
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• 2013

Nucleophilic substitution reactions of ethyl methyl (2), ethyl propyl (4) and diisopropyl (7) chlorothiophosphates with substituted anilines and deuterated anilines are investigated kinetically in acetonitrile at $55.0^{\circ}C$. A concerted mechanism is proposed based on the selectivity parameters. The deuterium kinetic isotope effects (DKIEs; $k_H/k_D$) are secondary inverse ($k_H/k_D=0.66-0.99$) with 2, primary normal and secondary inverse ($k_H/k_D=0.78-1.19$) with 4, and primary normal ($k_H/k_D=1.06-1.21$) with 7. The primary normal and secondary inverse DKIEs are rationalized by frontside attack involving hydrogen bonded, four-center-type transition state, and backside attack involving in-line-type transition state, respectively. The anilinolyses of ten chlorothiophosphates are examined based on the reactivity, steric effect of the two ligands, thio effect, reaction mechanism, DKIE and activation parameter.

• Bulletin of the Korean Chemical Society
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• v.32 no.9
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• pp.3245-3250
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• 2011

The nucleophilic substitution reactions of diisopropyl chlorophosphate (3) with substituted anilines ($XC_6H_4NH_2$) and deuterated anilines ($XC_6H_4ND_2$) are investigated kinetically in acetonitrile at $55.0^{\circ}C$. The anilinolysis rate of 3 is rather slow to be rationalized by the conventional stereoelectronic effects. The obtained deuterium kinetic isotope effects (DKIEs; $k_H/k_D$) are secondary inverse ($k_H/k_D$ = 0.71-0.95) with maximum magnitude at X = H.A concerted mechanism involving predominant backside nucleophilic attack is proposed on the basis of the secondary inverse DKIEs.

• BMB Reports
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• v.35 no.1
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• pp.67-86
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• 2002

Three routes have been identified triggering neuronal death under physiological and pathological conditions. Excess activation of ionotropic glutamate receptors cause influx and accumulation of $Ca^{2+}$ and $Na^+$ that result in rapid swelling and subsequent neuronal death within a few hours. The second route is caused by oxidative stress due to accumulation of reactive oxygen and nitrogen species. Apoptosis or programmed cell death that often occurs during developmental process has been coined as additional route to pathological neuronal death in the mature nervous system. Evidence is being accumulated that excitotoxicity, oxidative stress, and apoptosis propagate through distinctive and mutually exclusive signal transduction pathway and contribute to neuronal loss following hypoxic-ischemic brain injury. Thus, the therapeutic intervention of hypoxic-ischemic neuronal injury should be aimed to prevent excitotoxicity, oxidative stress, and apoptosis in a concerted way.

• Bulletin of the Korean Chemical Society
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• v.32 no.12
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• pp.4403-4407
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• 2011

The nucleophilic substitution reactions of dipropyl chlorothiophosphate (3) with substituted anilines ($XC_6H_4NH_2$) and deuterated anilines ($XC_6H_4ND_2$) are investigated kinetically in acetonitrile at $55.0^{\circ}C$. The obtained deuterium kinetic isotope effects (DKIEs; $k_H/k_D$) are primary normal ($k_H/k_D$ = 1.11-1.35). A concerted mechanism involving predominant frontside nucleophilic attack is proposed on the basis of the primary normal DKIEs and selectivity parameters. Hydrogen bonded, four-center-type transition state is proposed. The steric effects of the two ligands on the anilinolysis rates of various substrates are discussed.

• Bulletin of the Korean Chemical Society
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• v.32 no.12
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• pp.4387-4391
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• 2011

The kinetic studies on the pyridinolysis of diisopropyl thiophosphinic chloride have been carried out in acetonitrile at $55.0^{\circ}C$. The free energy correlations for substituent X variations in the X-pyridines are biphasic concave upwards with a break point at X = 3-Ph. A concerted SN2 mechanism is proposed with a change of the attacking direction of the X-pyridine from a frontside attack for the strongly basic pyridines to a backside attack for the weakly basic pyridines. The factors to determine the rates and thio effects on the rates for the pyridinolyses of thiophophinic chloride, chlorothiophosphate, phosphinic chloride, phosphonochloridothioate, and chlorophosphate systems are briefly reviewed on the basis of the magnitude of the positive charge of the reaction center P atom and steric effects of the two ligands.