• Genomics & Informatics
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• v.20 no.1
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• pp.9.1-9.6
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• 2022

Mendelian randomization (MR) uses genetic variation as a natural experiment to investigate the causal effects of modifiable risk factors (exposures) on outcomes. Two-sample Mendelian randomization (2SMR) is widely used to measure causal effects between exposures and outcomes via genome-wide association studies. 2SMR can increase statistical power by utilizing summary statistics from large consortia such as the UK Biobank. However, the first-order term approximation of standard error is commonly used when applying 2SMR. This approximation can underestimate the variance of causal effects in MR, which can lead to an increased false-positive rate. An alternative is to use the second-order approximation of the standard error, which can considerably correct for the deviation of the first-order approximation. In this study, we simulated MR to show the degree to which the first-order approximation underestimates the variance. We show that depending on the specific situation, the first-order approximation can underestimate the variance almost by half when compared to the true variance, whereas the second-order approximation is robust and accurate.

• The Magazine of the Society of Air-Conditioning and Refrigerating Engineers of Korea
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• v.15 no.1
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• pp.87-96
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• 1986

An experiment on the devices that enchance the stratification of storage tanks in a solar heat ins system has been carried out. The benefits of thermal stratification in sensible heat storage are to increase the system performance such as the collector efficiency or the fraction of the total load supplied by solar energy. Using the diffuser and the distributor as the stratification enchancement device, the expeliments were perfomed in the different condition of diameter and material of the distributor. As a result of experiments, there exists the diameter of distributor in which the stratification is made maximum under certain design and operation condition. Also it was identified that the kind of distributor material influenced the degree of stratification. Comparing the experimental result to the computational results calculated under the same conditions, the node number N(stratification index) was determined. The results of computer simulation that was performed about the actual solar heating system in Seoul for 24 hours show the relative advantage of stratified over well-mixed storage and the significant improvements in system performance.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.24 no.5
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• pp.111-116
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• 2024

These days, the number of patients committing suicide due to depression and stress is rapidly increasing. In addition, if stress and depression persist for a long time, it can cause heart disease, brain disease, and high blood pressure. Arteriosclerosis, known as the main cause of cerebrovascular disease, is a dangerous disease in which cholesterol accumulates in blood vessels, narrowing them. However, no matter how much modern medicine has developed, stroke patients are in a very difficult situation with no special medicine or treatment. In this paper, to solve these problems, we proposed a smart electronic acupuncture device that treats patients' diseases based on electronic acupuncture. In addition, an algorithm for predicting the risk of health status of stroke patients and a posture recognition algorithm were proposed and a computer simulation experiment was performed.

• Transactions of the Korean Society of Automotive Engineers
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• v.17 no.2
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• pp.20-25
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• 2009

For many years there has been a trend to increased electrical energy consumption in cars caused by the replacement of mechanical parts by electronic or mechanical devices as well as the introduction of new electronic features. Whereas the number of electrical consumers continues to increase, the battery is still the only passive power source available. Because of this reason, needs for driving power of the engine accessories such as alternator system have increased. Usually, conventional alternator system is directly driven by the crankshaft of engine with belt. Since this increase bring about additional fuel economy. To improve this system automobile makers develops new controled alternator system. This paper focuses on fuel economy improvement according to control of alternator. In this paper, researches are performed on effect of type of Alternator system on fuel economy by experiment. And it is also calculated the effect on vehicle fuel economy using computer simulation with AVL cruise software. As a result, 0.64% of vehicle fuel economy improvement can be achieved in a vehicle with controled Alternator system compared to a vehicle with conventional Alternator system in NEDC mode.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.18 no.3
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• pp.111-117
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• 2018

Heterogeneous multi-core environment integrated with different functional cores is the powerful tool for the embedded system that became more complex and diverse. Specialized application requires one chip solution with different operating system over different cores. But this heterogeneity causes difficult configuration of the development environment, makes hard to develop and test software. We show the environment of heterogeneous multi-core processing can be mapped to symmetric multi-core environment. We construct Linux based RPMsg for the data exchange between processes similar with the heterogeneous multi-core RPMsg and experiment that the proposed environment can be used to reduce the steps of the heterogeneous multi-core application development. With this simplification, we suggest simulation method for easy development and debugging the heterogeneous multicore environment that makes complex steps to simple.

• Imaging Science in Dentistry
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• v.33 no.3
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• pp.187-193
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• 2003

Purpose: To compare the measurements of the mandible and the detectability of the mandibular canal on reformatted images using a newly developed 3-dimensional implant simulation program with traditionally used CT multiplanar reconstruction program and true measurements. Materials and Methods: Ten dry dog mandibles were used in this study. Occlusal templates for CT examination were fabricated and marked with gutta perch a at ten sites. Axial CT scans were taken and reconstructed using DentaScan (D group) and Vimplant program (V group), and each mandible was sectioned at the previously marked sites (R group). Maximum vertical height (H) and maximum width (W) of the mandible, the distances from buccal border of the mandibular canal to the most buccal aspect of the mandible (X), and the distance from the superior border of the mandibular canal to the alveolar crest (Y) were measured, and the mandibular measurements in each group were compared. Detectability of mandibular canal was evaluated using a 3-point scale in both V and D groups by three oral radiologists and compared. Results: H in the V group was slightly greater than that in the D group, and Wand X in the V group was slightly less than those in the D group. H in the V group was less than that in the R group, and Wand X in the V group was larger than those in the R group. The detectability of the mandibular canal did not show statistically significant differences between V and D groups. Conclusion: The results of the experiment show that the newly developed, inexpensive Vimplant/TM/ simulation program can be used as an alternative to the traditionally used, and more expensive CT multiplanar reconstruction program.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.15 no.3
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• pp.122-129
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• 2016

In modern industries, in whichwhere high productivity is one of the most important concerns, machine tools are facing difficulties to satisfy the high high-speed operation, while and at the same time achieve the precision machining. Generally, the vibrations of the structure increase proportionally to the square of the operating speed so that the precision machining is severely damaged with increased speed. which is a must for the high productivity. Therefore, the suppression of the structural vibrations of the machine tools is the a major concern in the machine tool industry in order to achieve the high productivity and the precision machining simultaneously. In this study, the dynamic properties of a machining center structure were analyzed through the experiment and the computer simulations, and furthermore the results from those were compared to confirm the validity of the simulation model. The design alterations were deduced from the analysis and applied to the simulation model to investigate the effects of those alterations to suppress the vibrations of the machine. The result shows that the relatively simple design alterations, without redesigning the main structure of the machine, can suppress the vibrations effectively.

• Journal of Korean Society on Water Environment
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• v.29 no.3
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• pp.383-392
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• 2013

In this research, mixing behavior of the floating pollutant such as oil spill accidents was analyzed by studying the advection-diffusion of GPS floaters at water surface. The LPT (Lagrangian Particle Tracking) model of EFDC (Environmental Fluid Dynamics Computer Code) was used to simulate the motion of the GPS floater tracer. In the field experiment, 35 GPS floaters were injected at the Samun Bridge of Nakdong River. GPS floaters traveled to downstream about 700 m for 90 minutes. The field data by the GPS floater experiments were compared with the simulation in order to calibrate the parameter of LPT model. The turbulent diffusion coefficient of LPT model was determined as $K_H/hu^*$ = 0.17 from the scatter diagram. The arrival time of peak concentration and transverse diffusion from the simulation results were similar with the experiments from the concentration curves. Numerical experiments for anticipation of damage from floating pollutant were conducted in the same reach of the Nakdong River and the results show that the pollutant cloud transported to the left bank where the Hwawon pumping station is located. For this reason, it is suggested that the proper action should be needed to maintain the safety of the water withdrawal at the Hwawon pumping station.

• Journal of Biomedical Engineering Research
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• v.30 no.5
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• pp.393-400
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• 2009

The present study developed a new technique with no physical object on the flow stream but enabling the air flow measurement and easily incorporated with the devices for cardiopulmonary resuscitation(CPR) procedure. A turbulence chamber was formed in the middle of the respiratory tube by locally enlarging the cross-sectional area where the flow related turbulence was generated inducing energy loss which was in turn converted into pressure difference. The turbulence chamber was simply an empty enlarged air space, thus no physical object existed on the flow stream, but still the flow rate could be evaluated. Computer simulation demonstrated stable turbulence formation big enough to measure. Experiment was followed on the proto-type transducer, the results of which were within ${\pm}5%$ error compared to the simulation data. Both inspiratory and expiratory flows were obtained with symmetric measurement characteristics. Quadratic curve fitting provided excellent calibration formula with a correlation coefficient>0.999(P<0.0001) and the mean relative error<1%. The present results can be usefully applied to accurately monitor the air flow rate during CPR.

• The Journal of the Korea institute of electronic communication sciences
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• v.15 no.5
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• pp.835-840
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• 2020

In this paper, we described the verification results on method by using the computer simulation and practical experiment for reduction of total radiated power (TRP) measurement time consuming tens of hours. TRP measurements are used in the 5G band in order to exactly evaluate the wireless communication equipment, but it takes a long measurement time because of dense sampling interval. Moreover, if there are various beam forming scenarios, the total measurement time increases exponentially. Therefore, the world-wide research on reduction method of the TRP measurement time is intensively on going. The verified method in this paper is to calculate the TRP through effective isotropical radiated power (EIRP). At first, the relation of TRP and EIRP was investigated, and an antenna for testing was designed and constructed. And, the amount of error was analyzed through simulation and measurement. The analysed results showed that the derived TRP through EIRP has very small error. This method could be applied for TRP measurements of 5G wireless communication equipments.