• 복식
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• 제56권3호
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• pp.42-56
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• 2006

The purpose of this study is to review the literatures and the wall paintings of the ancient tombs of Koguryo in an effort to try to understand the characteristics of the culture of dyeing in Koguryo. The research findings follow: 1. The colors that were in vogue in Koguryo are five cardinal colors (red, blue, white, black, and yellow) and compound colors, like purple and green. Those colors were used in some or all parts of the clothing and even on some parts of the body. 2. Some clothing of Koguryo as shown in the wall paintings were made with a single and solid color by dip dyeing method. But the majority of the clothing had a variety of patterns. Among the patterns, the geometrical dot pattern took the majority. 3. The dyeing techniques used in Koguryo were printing, yarn dyeing, embroidery, wax resist dyeing, drawing and painting. The development of yarn dyeing method, weaving with silk-threads dyed in various colors, enabled to produce Geum fabrics, which were used for the upper classes' clothing. 4. The esthetic features represented in the colors of Koguryo include the beauty of contrast coloring, preference for red, preference for geometrical patterns, and the harmony of yin and yang.

• 대한치과기공학회지
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• 제21권1호
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• pp.97-114
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• 1999

The first function of occlusion is mastication. Therefore the functional restoration of occlusal surface is very important. The restoration of occlusal surface is three method as wax bite technique, F.G.P. technique, cone technique. Many dental technician is using compound method. I have knew common point on each teeth during I have waxing up wax pattern. So I studied on the design waxup technique for maxillary molar occlusion. The results of the study were as follows ; 1. The dam wax up method can restore axial contour of teeth very easy and make short working time of wax pattern. 2. The height of dam must be same with cusp of adjacent teeth. 3. Automatically the contour of tooth is appeared if the contour of dam is relationship with cuspid line of adjacent teeth. 4. The height of contour of buccal, lingual surface is formed natural curve to add fluid wax by gravitation. 5. The development groove of Maxillary premolar is appeared V form. 6. The development groove of Maxillary molar is appeared W form. 7. The embrasure is formed to carve around contact point area as round convex. It affects to axial form of tooth. 8. I was knew that the lingual groove and stuart's groove of molar runs parallel with oblique ridge. 9. The buccal groove of molar is formed parallel with direction of teeth arrangement.

• Journal of Ginseng Research
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• 제43권2호
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• pp.172-178
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• 2019

Inflammation is an innate immune response that protects the body from pathogens, toxins, and other dangers and is initiated by recognizing pathogen-associated molecular patterns or danger-associated molecular patterns by pattern-recognition receptors expressing on or in immune cells. Intracellular pattern-recognition receptors, including nucleotide-binding oligomerization domain-like receptors (NLRs), absent in melanoma 2, and cysteine aspartate-specific protease (caspase)-4/5/11 recognize various pathogen-associated molecular patterns and danger-associated molecular patterns and assemble protein complexes called "inflammasomes." These complexes induce inflammatory responses by activating a downstream effector, caspase-1, leading to gasdermin D-mediated pyroptosis and the secretion of proinflammatory cytokines, such as interleukin $(IL)-1{\beta}$ and IL-18. Ginsenosides are natural steroid glycosides and triterpene saponins found exclusively in the plant genus Panax. Various ginsenosides have been identified, and their abilities to regulate inflammatory responses have been evaluated. These studies have suggested a link between ginsenosides and inflammasome activation in inflammatory responses. Some types of ginsenosides, including Rh1, Rg3, Rb1, compound K, chikusetsu saponin IVa, Rg5, and Rg1, have been clearly demonstrated to inhibit inflammatory responses by suppressing the activation of various inflammasomes, including the NLRP3, NLRP1, and absent in melanoma 2 inflammasomes. Ginsenosides have also been shown to inhibit caspase-1 and to decrease the expression of $IL-1{\beta}$ and IL-18. Given this body of evidence, the functional relationship between ginsenosides and inflammasome activation provides new insight into the understanding of the molecular mechanisms of ginsenoside-mediated antiinflammatory actions. This relationship also has applications regarding the development of antiinflammatory remedies by ginsenoside-mediated targeting of inflammasomes, which could be used to prevent and treat inflammatory diseases.

• Journal of Pharmaceutical Investigation
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• 제9권2호
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• pp.11-21
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• 1979

It has been reported from our department that a few agents, such as $K_2S_2O_5,\;NaHSO_3,$ nicotinamide have a marked stabilizing effect in vitro on metoclopramide which is relatively unstable compound. In order to study the effect of these stabilizers on the action of metoclopramide in vitro, the fate of this compound combined with $K_2S_2O_5,\;NaHSO_3$ and nicotinamide, respectively, was studied and furthermore, the change of the biological activity of metoclopramide due to these stabilizers was studied by using the isolated stomach strip of rat. The blood concentration of metoclopramide was measured by using Bakke's method at the various time after intravenous injection of the mixed metoclopramide solution with the stabilizers. In order to study the excretion of the drug, rabbits were anesthesized and catheterized into bladder for withdrawal of urine. After intravenous injection of the mixed metoclopramide solution, urine was collected for 5 hours and the conjugated forms of metoclopramide as well as the free form were determined by using Arita's method. In the biological study of the metoclopramide combined with stabilizers, the contractability of the isolated rat stomach strip was observed by using polygraph recorder. The results were following: 1. When metoclopramide was administered with nicotinamide as stabilizer, the blood concentration of the unchanged from and the rate of the clearance of this compound were very similar to that of metoclopramide alone. On the other hand, other stabilizers, $K_2S_2O_5\;and\;NaHSO_3$, brought about 40% decrease in blood concentration of the unchanged form at 15 min after intravenous injection however, the rate of clearance of metoclopramide with $K_2S_2O_5\;or\;NaHSO_3$ was very slow. 2. In the case of urinary excretion, the excretory pattern of the metabolites of metoclopramide with $NaHSO_3$ or nicotinamide was very similar to that of metoclopramide alone. But metodopramide plus $K_2S_2O_5$ group showed the maked depression of excretion for first 1 hour. 3. In composition of metabolites, when metoclopramide was administered with $K_2S_2O_5$ or $NaHSO_3$, the sulfonate conjugation was predominant. But the glucuronic acid conjugation was predominant in metoclopramide plus nicotinamide gronp. 4. In the experiments on the biological activity of the metoclopramide, this compound exhibited the marked contracting effect in isolatd rat stomach strip. Specially, the meetoclopramide combined with $K_2S_2O_5$ showed the strong contraction of the isolated strip, suggesting the potenciating effect of $K_2S_2O_5$ on the action of metoclopramide in the isolated strip.

• Bulletin of the Korean Chemical Society
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• 제35권7호
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• pp.1956-1964
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• 2014

To provide the scientific corroboration of the traditional uses of Akebia quinata (Thunb.) Decne., a detailed analytical examination of A. quinata stems was carried out using a reversed-phase high performance liquid chromatography (RP-HPLC) method coupled to photodiode array detector (PDA) for the simultaneous determination of four phenolic substances; cuneataside D (1), 2-(3,4-dihydroxyphenyl)ethyl-O-${\beta}$-D-glucopyranoside (2), 3-caffeoylquinic acid (3) and calceolarioside B (4). Particular attention was focused on the main compound, 3-caffeoylquinic acid (3), which has a range of biological functions. In addition, 2-(3,4-dihydroxyphenyl)ethyl-O-${\beta}$-D-glucopyranoside (2) was considered as a discernible marker of A. quinata from its easy confuse plants. The contents of compounds 2 and 3 ranged from 0.72 to 2.68 mg/g and from 1.66 to 5.64 mg/g, respectively. The validation data indicated that this HPLC/PDA assay was used successfully to quantify the four phenolic compounds in A. quinata from different locations using relatively simple conditions and procedures. The pattern-recognition analysis data from 53 samples classified them into two groups, allowing discrimination between A. quinata and comparable herbs. The results suggest that the established HPLC/PDA method is suitable for quantitation and pattern-recognition analyses for a quality evaluation of this medicinal herb.

• 대한토목학회논문집
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• 제29권4D호
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• pp.555-561
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• 2009

굴착된 터널 형상 재현에서 단면의 종단 데이터는 터널의 유지를 위해서는 아주 중요하다. 터널이 완성되기전에 설계된 모델을 고려한 완성된 터널의 변형이 고려되어져야 한다. 그리고 변형은 터널 단면 전체를 따라 연속적으로 나타날 수 있다. 본 연구에서는 먼저 수학적 분석으로 접근하였고, 그것을 관측된 터널단면 데이터에 실험 하였다. 그 다음 선추적 방법, 유전자 알고리즘, 패턴 추적 방법 등으로 3D 터널 형상 재현을 비교하였다. 수학적 방법론은 철도 터널과 같은 간단한 원통형은 쉽게 해결이 되었으나, 도로터널과 같은 더욱 복잡한 모델(복심 곡선형과 비원통형)은 구속된 상태하에서 소프트 컴퓨팅 툴을 가지고 해결할 수 있었다. 유전자 알고리즘과 직접탐색법은 많은 계산 시간이 걸렸으나 복잡한 상태하에서 더욱 유연함을 보였으며, 선추적 방법은 초기값들이 제한된 범위 하에서 가장 빠르게 계산되어졌다.

• 한국항해항만학회지
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• 제27권3호
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• pp.329-333
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• 2003

Study of the background and state of Osaka's waterfront space development and analysis of the functions of 22 chosen major facilities of development project reveals the following four types: amenity-oriented development, large-scale synthesis type development, renewal compound area type development, exchange communication promotion type development. Osaka bay area has served primely as the base of harbors, industry and energy, while analysis of the ongoing project has found that the city has been making a functional transition to a type of development to live up to the needs of the times, suggesting that is wise that Korea's future direction of waterfront development be oriented toward environmental-friendly development by taking advantage of low-density area's natural resources. Given the plurality and complexity of the law of coastal zone, what is needed is a legal maintenance for coastal zone's clear-cut coordinating function and for environmental-friendly development with the limitations of seaside and coastal functions in mind.

• 대한화장품학회지
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• 제15권1호
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• pp.1-36
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• 1989

The protective effects of 24 flavonoids against singlet oxygen - induced photohemolysis of rabbit erythrocytes were investigated and compared with their antioxidant activities. 1. All the flavonoid aglycons investigated besides flavone and 7,8-benzoflavone showed tad dose-dependant Protective effects. Especially galagin showed the most Pronounced effect under the experimental condition. 2. The order of the radical-scavenging activities of flavonoids was as follow (-)-EGCG > flavonols > flavonols > flavones > flavanonols. The radical-scavenging activities of flavonoid glycosides were not different from those of their aglycons. 3. When added after irradiation, flavonoids did not alter the photohemolysis pattern of control. In this study, several antioxidant were found and it was newly found that Photohemolysis experiment is a convenient, reproductive diagnostic method in the screening and researching the compound which has antioxidant activity or protective effect on cell membrane against active oxygen species.

• BMB Reports
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• 제28권4호
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• pp.290-292
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• 1995

Existence of a binding site for choline esters with an acyl chain of various sizes was examined by comparing the inhibitory potency of the respective compound. In contrast to acetylcholine, which showed a pure competitive pattern of inhibition, choline esters with an acyl chain of a long size ($C{\geq}5$) expressed a mixed type of inhibition. Binding of choline esters containing a long chain ($C_7-C_{12}$) to the hydrophobic region in the active site is deduced from a linear relationship between the $K_{iE}$ value and the size of acyl moiety, and a good hydrophobicity relationship. In addition, the non-competitive component in the inhibition of acetylcholinesterase seems to be due to the interaction of choline esters with both the hydrophobic site and the trimethylammonium-binding site in the active center of the acetylated acetylcholinesterase.

• International Journal of Industrial Entomology and Biomaterials
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• 제9권1호
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• pp.15-28
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• 2004

The supplementation of mulberry leaves, with the aim of yield, enhancement using vitamins, minerals and other compounds have generally been attended from 1990s and many researches have been conducted. More than 30 different compounds from complementary nutrients have been analyzed and in different regions where different climates various results have been achieved. This review has attempted to discuss the results of different works on enrichment of mulberry leaves with supplementary compound. Generally the most effects of these compounds are in the regions where productive parameters are low. In the areas that follow a normal pattern in economical parameters the enrichment of the leaves havent have significant economical effects.