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Semi-Quantitative Analysis for Determining the Optimal Threshold Value on CT to Measure the Solid Portion of Pulmonary Subsolid Nodules (폐의 아고형결절에서 침습적 병소를 검출하기 위한 반-정량 분석을 통한 최적의 CT 임계 값 결정)

  • Sunyong Lee;Da Hyun Lee;Jae Ho Lee;Sungsoo Lee;Kyunghwa Han;Chul Hwan Park;Tae Hoon Kim
    • Journal of the Korean Society of Radiology
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    • v.82 no.3
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    • pp.670-681
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    • 2021
  • Purpose This study aimed to investigate the optimal threshold value in Hounsfield units (HU) on CT to detect the solid components of pulmonary subsolid nodules using pathologic invasive foci as reference. Materials and Methods Thin-section non-enhanced chest CT scans of 25 patients with pathologically confirmed minimally invasive adenocarcinoma were retrospectively reviewed. On CT images, the solid portion was defined as the area with higher attenuation than various HU thresholds ranging from -600 to -100 HU in 50-HU intervals. The solid portion was measured as the largest diameter on axial images and as the maximum diameter on multiplanar reconstruction images. A linear mixed model was used to evaluate bias in each threshold by using the pathological size of invasive foci as reference. Results At a threshold of -400 HU, the biases were lowest between the largest/maximum diameter of the solid portion of subsolid nodule and the size of invasive foci of the pathological specimen, with 0.388 and -0.0176, respectively. They showed insignificant difference (p = 0.2682, p = 0.963, respectively) at a threshold of -400 HU. Conclusion For quantitative analysis, -400 HU may be the optimal threshold to define the solid portion of subsolid nodules as a surrogate marker of invasive foci.

Hydrochemistry, Isotopic Characteristics, and Formation Model Geothermal Waters in Dongrae, Busan, South Korea (부산 동래 온천수의 수리화학 및 동위원소 특성, 생성모델 연구)

  • Yujin Lee;Chanho Jeong;Yongcheon Lee
    • The Journal of Engineering Geology
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    • v.34 no.2
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    • pp.229-248
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    • 2024
  • This investigated the hydrogeochemical and isotopic characteristics of geothermal waters, groundwaters, and surface waters in Dongrae-gu, Busan, South Korea, in order to determine the origins of the salinity components in the geothermal waters, and their formation mechanisms and heat sources The geothermal waters are Na-Cl-type, distinct from surrounding groundwaters (Na-HCO3- and, Ca-HCO3- (SO4, Cl)-type) and surface waters (Ca-HCO3(SO4, Cl)-type). This indicates the geothermal waters formed at depth as compared with the groundwaters. δ18O and δD values of the geothermal waters are relatively depleted as compared with the groundwaters, due to altitude effects and deep circulation of the geothermal waters. Helium and neon isotope ratios (3 He/4He and, 4He/20Ne) of the geothermal waters plot on a single mixing line between mantle (3He = 3.76~4.01%) and crust (4He = 95.99~96.24 %), indirectly suggesting that the heat source is due to the decay of radioactive elements in rocks. The geothermal reservoir temperatures were calculated using the silica-enthalpy and Giggenbach models, yielding values of 82~130℃, and the depth of the geothermal reservoir is estimated to be 1.7~2.9 km below the surface. The correlation between Cl/Na and Cl/HCO3 for the Dongrae geothermal waters requires the input of salty water. The supply of saline composition is interpreted due to the dissolution of residual paleo-seawater.

Classification of Cultivation Region for Soybean (Glycine max [L.]) in South Korea Based on 30 Years of Weather Indices (평년기상을 활용한 우리나라의 콩 재배지역 구분)

  • Dong-Kyung Yoon;Jaesung Park;Jinhee Seo;Okjae Won;Man-Soo Choi;Hyeon Su Lee;Chaewon Lee
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.69 no.1
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    • pp.49-60
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    • 2024
  • A region can be divided into cultivation zones based on homogeneity in weather variables that have the greatest influence on crop growth and yield. This study classified the cultivation zone of soybean using weather indices as a prior study to classify the agroclimatic zone of soybean. Meteorological factors affecting soybeans were determined through correlation analysis over a 10 year period (from 2013 to 2022) using data from the Miryang and Suwon regions collected from the soybean yield trial database of the Rural Development Administration, Korea and the meteorological database of the Korea Meteorological Administration. The correlation between growth characteristics and the minimum temperature, daily temperature range, and precipitation were high during the vegetative growth stages. Moreover, the correlation between yield components and the maximum temperature, daily temperature range, and precipitation were high during the reproductive growth stages. As a result of k-means clustering, soybean cultivation zones were divided into three zones. Zone 1 was the central inland region and southern Gyeonggi-do; Zone 2 was the southern part of the west coast, the southern part of the east coast, and the South Sea; and Zone 3 included parts of eastern Gyeonggi-do, Gangwon-do, and areas with high altitudes. Zone 1, which has a wide latitude range, was further subdivided into three cultivation zones. The results of this study may provide useful information for estimating agrometeorological characteristics and predicting the success of soybean cultivation in South Korea.

Effects of Various Biodegradable Mulching Films on Growth, Yield, and Soil Environment in Soybean Cultivation (콩 재배지에서 다양한 생분해성 멀칭필름 종류별 작물 생육, 수량 및 토양환경에 미치는 영향)

  • Ye-Guon Kim;Yeon-Hu Woo;Hyun-Hwa Park;Do-Jin Lee;Yong-In Kuk
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.69 no.1
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    • pp.34-48
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    • 2024
  • The objective of this study was to evaluate the safety of biodegradable mulching films in soybean (Glycine max) cultivation by measuring their effects on crop growth and yield, film decomposition and soil chemical and physical properties. In 2022 and 2023, plant height, branch number, chlorophyll contents, yield components, and yield of soybean did not vary significantly in areas using PE films and biodegradable mulching films. The light transmission rate of the biodegradable mulching films ranged from 6.4 to 15.8% when measured 112 days after soybean transplanting, and was higher, on average, in 2023 than in 2022. In both years, degradation of the biodegradable mulching films began 20 days after soybean transplantation and increased over time. In addition, remains of biodegradable mulching films were present in fields at soybean harvest and remained until 50 days after harvest. Decomposition rates of the biodegradable mulching films at 112 days after soybean transplanting ranged from 9.8 to 26.7% in 2022 and 13 to 36% in 2023. Although soil pH and EC varied based on the year and timing of measurements, there was no significant difference between areas that used biodegradable mulching films and PE films. Soil organic matter, nitrate and exchangeable cation contents such as Ca, Mg, and K were not significantly different in areas that used both PE films and biodegradable films. However, significantly higher levels of available phosphoric acid content were measured in areas that used biodegradable mulch films E, S, and T. Regardless of which films were used, there were no significant differences in the soil's physical properties. In 2022 and 2023, there was no difference between areas that used biodegradable mulch films and PE films. However, soil temperature in mulched areas was 2℃ higher and soil moisture was 5-15% higher than in non-mulched areas. Barley growth was not affected by being planted in soil that had been used for soybean cultivation with biodegradable films. Therefore, the biodegradable mulch films used in this study can be used without negatively affecting the growth, yield, and soil environment of soybeans.

Improving the Nutritional Value of Tenebrio molitor Larvae by Feeding Them a Soymilk Residue-added Food Source (두유박 첨가 먹이원 급이에 따른 갈색거저리 유충의 영양성 증진 효과)

  • So-Yun Kim;Min Ji Park;Jeong-Hun Song;Sangmin Ji;Gyu-Dong Chang;Sun Young Kim
    • Journal of Life Science
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    • v.34 no.3
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    • pp.191-198
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    • 2024
  • To verify the nutritional value and safety of larvae fed with a soymilk residue-added food source, we compared and analyzed the nutritional components of and harmful substances in Tenebrio molitor larvae reared on wheat bran. Crude protein content based on dry weight was 1.2 times higher in the 10% soymilk residue-fed group (SR) (54.0%) than in the wheat bran-fed group (WB) (43.5%). Dietary fiber also tended to be 1.9 times more in the SR (4.9%) than the WB (2.5%). Among unsaturated fatty acids, the linoleic acid content was found to be 1.1-fold higher in the SR (32.9%) than in the WB (29.0%). Potassium, which was the most abundant among the macro minerals, was 1.1-fold more abundant in the WB (1,074.5 mg/100 g) than in the SR (1,014.0 mg/100 g). Among the micro minerals, zinc content was 1.2-fold higher in the SR (14.5 mg/100 g) than in the WB (11.9 mg/100 g). The results of the analysis of hazardous substances in the WB and SR revealed that the amount of heavy metals met the standards for heavy metals in edible insects, and food poisoning-inducing bacteria such as Escherichia coli and Salmonella spp. were not detected in all groups. These results indicate that mealworm larvae fed with 10% soymilk residue have abundant nutrients and are safe for intake. Thus, food sources with added soymilk residue has the potential to be used as feed ingredients.

Immunomodulatory Effect of Eleutherococcus Senticosus Stem Extract by Cultivars in RAW 264.7 Macrophage Cells (RAW 264.7 대식세포에서 산지별 가시오가피 줄기 추출물의 면역 증강 효과)

  • Ye-Eun Choi;Jung-Mo Yang;Chae-Won Jeong;Hee-Won Yoo;Hyun-Duck Jo;Ju-Hyun Cho
    • Journal of Food Hygiene and Safety
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    • v.39 no.1
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    • pp.44-53
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    • 2024
  • Global interest in natural functional materials to strengthen human immunity is increasing due to the increase in immune-related diseases associated with COVID-19 and the aging population. In this study, we determined the potential therapeutic effect of Eleutherococcus senticosus stems on immune enhancement according to the cultivation region. The contents of eleutheroside B and E, which are chemical components of E. senticosus stems, were analyzed. We showed that the eleutheroside B content of E. senticosus stems in different cultivation regions ranged from 2.96±0.11 to 6.24±0.05 mg/g and from 1.11±0.05 to 2.11±0.03 mg/g in 70% ethanol and hot water extracts, respectively. The eleutheroside E content ranged from 4.93±0.20 to 10.79±0.03 mg/g and 1.75±0.14 to 3.64±0.05 mg/g in 70% ethanol and hot water extracts, respectively. In addition, the immunomodulatory effect of E. senticosus stems was evaluated using RAW 264.7 macrophages. The 70% ethanol extract of E. senticosus stems showed no cytotoxicity up to 200 ㎍/mL, and the hot water extract showed no cytotoxicity up to 500 ㎍/mL. Additionally, the E. senticosus stem extract significantly increased the production of nitric oxide and cytokines (TNF-α, IL-6, and IL-1β) compared to their production in the control group. These results suggest that E. senticosus stem extracts are a potential functional food material and ingredient to enhance the immune response.

Effects of Compounds Isolated from an Ethanol Extract of the Sclerotium of Wolfiporia hoelen on Osteoblast Differentiation and Osteoclast Formation (복령 균핵의 에탄올 추출물에서 분리한 화합물의 조골세포 분화 촉진 및 파골세포 생성 억제 효과)

  • Sora Lee;Seokju Kim;Bowook Moon;Sik-Won Choi;Rhim Ryoo;Hyung Won Lee
    • Journal of Korean Society of Forest Science
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    • v.113 no.1
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    • pp.73-87
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    • 2024
  • Wolfiporia hoelen (Fr.) Y.C.Dai & V. Papp, commonly known as Poria cocos, is a significant traditional herb used for medicinal and culinary purposes Asian and European countries. Many studies have confirmed that the main components of W. hoelen have pharmacological activities and thatits extract has been shown to affect bone metabolism. This study aimed to the potential of a 50% ethanol extract of the sclerotium of W. hoelen for preventing and treating bone diseases. The ethanol extract was systematically fractionated using n-hexane, dichloromethane, and ethyl acetate. The dichloromethane fraction caused an approximately 29% increase in alkaline phosphatase (ALP) differentiation activity in C2C12 cells compared to the control. Four compounds isolated from this active dichloromethane fraction were identified through instrumental analysis and literature references as 3α-dehydrotrametenolic acid, ergosterol, pachymic acid, and dehydrotumulosic acid. All four compounds were evaluated at increasing concentrations (1, 3, 10, 30, and 100 μM) to determine their effects on ALP differentiation activity in C2C12 cells and RANKL-induced inhibition activity in bone marrow macrophages (BMMs), with a concurrent assessment of cytotoxicity at these concentrations. At a concentration of 3 μM, dehydrotumulosic acid caused a 160% increase in ALP activity, 24% higher than in the BMP-2 control. BMMs treated with dehydrotumulosic acid at concentrations between 10 and 100 μM showed a substantial 15-86% decrease in RANKL-induced inhibition activity compared to the control, with distinct patterns of RANKL inhibition and cytotoxicity observed at 10 μM. These findings suggest that the ethanol extract from the sclerotium of W. hoelen has potential to modulate bone-cell differentiation, while highlighting the possible benefits of dehydrotumulosic acid isolated from the dichloromethane fraction of W. hoelen for preventing and treating osteoporosis.

Comparison of the Nutritional and Functional Compounds in Naked Oats (Avena sativa L.) Cultivated in Different Regions (재배지역 차이에 따른 쌀귀리 영양성분 및 기능성 성분 비교)

  • Ji-Hye Song;Dea-Wook Kim;Hak-Young Oh;Jong-Tak Yun;Yong-In Kuk;Kwang-Yeol Yang
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.68 no.4
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    • pp.402-412
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    • 2023
  • To cope with climate change, we compared the quality of naked oats (Avena sativa L.) cultivated in different regions. Naked oats were collected from domestic farms in different cultivation regions grouped as G1 and G2 for 3 years (2020-2022). The appearance, quality, and nutritional and functional compounds in the samples were assessed. In terms of appearance quality, the brightness and yellowness of the samples from the G1 region were significantly lower than those of the samples from the G2 region in 2020; however, no differences were observed between cultivation regions in the other 2 years. The results of testing the vitality of naked oats seeds showed that the electrical conductivity value was significantly lower in the samples from the G1 region than in those from the G2 region only in 2022. Among the nutritional components, moisture content was higher in the G2 region than in the G1 region over all 3 years, and the crude protein content was significantly higher in the G2 region than in the G1 region over all years. Carbohydrate content was significantly higher in the G1 region than in the G2 region in all 3 years and was inversely proportional to the crude protein content. The crude fat content tended to be significantly higher in the G1 region than in the G2 region, except in 2022. The levels of beta-glucan, a functional compound rich in naked oats, ranged between 3.4% and 4.2%, and except in 2020, there was no significant difference between cultivation regions. In addition, the content of avenanthramides, representative functional compounds that exist only in oats, was assessed. Over 2 years, in 2021 and 2022, the avenanthramide content was in the range of 2.4-20.7 ㎍/g and tended to be significantly higher in the G2 region than in the G1 region in both years. According to a survey of the average and minimum temperatures during the growing season of naked oats from 2020 to 2022, the average and minimum temperatures in January in the G2 region, which is the cultivation-limit area, were similar to those in Haenam in the G1 region. In conclusion, differences in nutritional and functional compounds were observed in naked oats grown in different cultivation areas. Therefore, considering the cultivation area of naked oats is expanding because of climate change, changes in the compounds that affect quality should be investigated.

Transplanting Date and Planting Density Affect the Growth Characteristics and Seed Yield of Italian Ryegrass (이앙 시기와 재식 밀도에 따른 이탈리안 라이그라스의 생육 및 종실 수량 특성 평가)

  • Yun-Ho Lee;Jeong-Won Kim;Hyeok-Jin Bak;Hyun-Ki Kim;Hyeon-Soo Jang;Dea-Yuk Kim;Jong-Tak Yoon
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.68 no.4
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    • pp.438-444
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    • 2023
  • Italian ryegrass (Lolium multiflorum Lam.; IRG) sowing season is delayed due to the autumn rainy season. Therefore, to address this problem, transplanting date and plant density were investigated. Transplant times investigated were October 20th, October 30th, and November 10th and planting densities were 50, 70, and 80 hills per 3.3 m2. The plant height, leaf area index, and plant coverage rate were high in the following order: October 20th, October 30th, and November 10th. There was no significant difference among planting densities. In addition, the number of tillers and dry weight before and after wintering were high on October 20th. In terms of yield components, the number of tillers, dry weight, and seed yield per unit area were higher with the transplanting date of October 20th than with transplanting on November 10th. There was no difference in seed yield between the planting densities of 80 and 70 hills per 3.3 m2. However, seed yield was low at 50 hills per 3.3 m2. In conclusion, the transplanting time for stable seed production is late October, and optimal plant density is 70 and 80 hills per 3.3 m2. A stable interplanting number before wintering will contribute to the seed yield.

Human Mind Within and Beyond the Culture - Toward a Better Encounter between East and West - (문화속의 인간심성과 문화를 넘어선 인간심성 - 동과 서의 보다 나은 만남을 위하여 -)

  • Bou-Yong Rhi
    • Sim-seong Yeon-gu
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    • v.28 no.2
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    • pp.107-138
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    • 2013
  • The purpose of this article is to awaken our colleagues to the culture and mind issues that have been forgotten or neglected by contemporary psychiatry under the prevalence of materialistic orientation. Cultural psychiatry too, though it has been contributed a great deal to widen the mental vision of psychiatry, has revealed several limitations in its approach. In the course of one sided search for culture specific factors in relation to mental health, conventional cultural psychiatry has neglected an effort to explore the common root underlying the different cultures and the common foundation of human mind. Cross sectional comparisons of the cultures alone have inevitably prevented the global considerations to culutre and mind in historical aspects and the dynamic interactions between mind and culture more in depth. The author suggested that the total view of mind and total approach of analytical psychology of C.G. Jung might be capable to replenish those limitations. Author explained the ways of C.G. Jung's observations and experiences of non-western culture and his concepts of culture and mind. The author demonstrated Jung's view of culture with the example of Filial Piety, Hyo, the Confucian moral norm which can be regarded as components of the collective consciousness though connected with archetypal patterns of behavior of intimacy between parent and child. In regard to the coexistence of multi-religious cultures in Korea the author made a proposal of 'culture spectrum' model for understanding value orientations of person in religious cultures. He identified in case of the Korean 4 types of cultural spectrums: Person with predominantly the Buddhist culture; with the Confucian; with the Shamanist; and with the Christian culture. The author also made an attempt to depict the dynamic interactions of different religious cultures in historical perspectives of Korea. Concepts of mind from the Eastern thoughts were reviewed in comparison with Jung's view of mind. The Dao of Lao Zi, One Mind by Wonhyo, the Korean Zen master from the 7th century, the Diagram of the Heaven's Decree by Toegye, a renowned Neo-Confucianist of Korea from the 16th century and his theory of Li-Ki, were explored and came to conclusion that they represent certainly the symbol of the Self in term of C.G. Jung. The goal of healing is 'the becoming whole person'. Becoming whole person means bringing the person as an individual to live not only within the specific culture but also to live in the world beyond the culture which is deeply rooted in the primordial foundation of human mind.