• Molecules and Cells
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• v.38 no.12
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• pp.1054-1063
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• 2015

Mitochondria play a crucial role in eukaryotic cells; the mitochondrial electron transport chain (ETC) generates adenosine triphosphate (ATP), which serves as an energy source for numerous critical cellular activities. However, the ETC also generates deleterious reactive oxygen species (ROS) as a natural byproduct of oxidative phosphorylation. ROS are considered the major cause of aging because they damage proteins, lipids, and DNA by oxidation. We analyzed the chronological life span, growth phenotype, mitochondrial membrane potential (MMP), and intracellular ATP and mitochondrial superoxide levels of 33 single ETC component-deleted strains during the chronological aging process. Among the ETC mutant strains, 14 ($sdh1{\Delta}$, $sdh2{\Delta}$, $sdh4{\Delta}$, $cor1{\Delta}$, $cyt1{\Delta}$, $qcr7{\Delta}$, $qcr8{\Delta}$, $rip1{\Delta}$, $cox6{\Delta}$, $cox7{\Delta}$, $cox9{\Delta}$, $atp4{\Delta}$, $atp7{\Delta}$, and $atp17{\Delta}$) showed a significantly shorter life span. The deleted genes encode important elements of the ETC components succinate dehydrogenase (complex II) and cytochrome c oxidase (complex IV), and some of the deletions lead to structural instability of the membrane-$F_1F_0$-ATP synthase due to mutations in the stator stalk (complex V). These short-lived strains generated higher superoxide levels and produced lower ATP levels without alteration of MMP. In summary, ETC mutations decreased the life span of yeast due to impaired mitochondrial efficiency.

• International Journal of Automotive Technology
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• v.8 no.2
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• pp.203-209
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• 2007

As the vehicle electronic control technology quickly grows and becomes more sophisticated, a more efficient means than the traditional in-vehicle driving test is required for the design, testing, and tuning of electronic control units (ECU). For this purpose, the hardware-in-the-loop simulation (HILS) scheme is very promising, since significant portions of actual driving test procedures can be replaced by HIL simulation. The HILS incorporates hardware components in the numerical simulation environment, and this yields results with better credibility than pure numerical simulations can offer. In this study, a HILS system has been developed for ESP (Electronic Stability Program) ECUs. The system consists of the hardware component, which that includes the hydraulic brake mechanism and an ESP ECU, the software component, which virtually implements vehicle dynamics with visualization, and the interface component, which links these two parts together. The validity of HIL simulation is largely contingent upon the accuracy of the vehicle model. To account for this, the HILS system in this research used the commercial software CarSim to generate a detailed full vehicle model, and its parameters were set by using design data, SPMD (Suspension Parameter Measurement Device) data, and data from actual vehicle tests. Using the developed HILS system, performance of a commercial ESP ECU was evaluated for a virtual vehicle under various driving conditions. This HILS system, with its reliability, will be used in various applications that include durability testing, benchmarking and comparison of commercial ECUs, and detection of fault and malfunction of ESP ECUs.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2006.05a
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• pp.159-162
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• 2006

In ubiquitous computing environments, which can be connected to the networks any time any where, wearable computers frequently will be changed their network connection point. Therefore, the demand of the mobility support service becomes more important. The mobility support mechanism allows a wearable computer to continue the existing services without the modification for the network configuration of wearable computer even if wearable computer changes the network connection point during its moving. In this paper, we design the component based middlewear for the mobility supports of wearable computers, propose the method of the mobility support service. This method tunnels the existing data to wearable computer using Mobile IP protocol even if a wearable computer moves to other network after recomposing dynamically the mobility support component in wearable middlewear.

• Journal of KIISE:Computing Practices and Letters
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• v.16 no.11
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• pp.1126-1130
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• 2010

Research on intelligent robot is in active progress as the next generation IT education area. Since intelligent robots are closely related to the real human world, they should provide human behaviors or judging ability as their functions. For this reason, research is recently done not only on diverse hardware of robot education but also on service component architecture which includes various functions. In this paper we propose a study on learning to creative solve problems using RDS(Robotics Developer Studio). RDS is a software tool to control or program intelligence robot as a software module. Using service component framework which considers standardization of the integrated development of intelligent robot, we expect to provide 3-dimensional visual simulation environment, and save time and costs in education the environment for the intelligence robot experiment.

• Nuclear Engineering and Technology
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• v.41 no.6
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• pp.785-796
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• 2009

A KALIMER-600 concept which is a type of sodium-cooled fast reactor, has been developed at KAERI. It uses sodium as a primary coolant and is a pool-type reactor to enhance safety. Also, a supercritical carbon dioxide ($CO_2$) Brayton cycle is considered as an alternative to an energy conversion system to eliminate the sodium water reaction and to improve efficiency. In this study, a simplified model for analyzing the thermodynamic performance of the KALIMER-600 coupled with a supercritical $CO_2$ Brayton cycle was developed. To develop the analysis model, a commercial modular modeling system (MMS) was adopted as a base engine, which was developed by nHance Technology in USA. It has a convenient graphical user interface and many component modules to model the plant. A new user library for thermodynamic properties of sodium and supercritical $CO_2$ was developed and attached to the MMS. In addition, some component modules in the MMS were modified to be appropriate for analysis of the KALIMER-600 coupled with the supercritical $CO_2$ cycle. Then, a simplified performance analysis code was developed by modeling the KALIMER-600 plant with the modified MMS. After evaluating the developed code with each component data and a steady state of the plant, a simple power reduction and recovery event was evaluated. The results showed an achievable capability for a performance analysis code. The developed code will be used to develop the operational strategy and some control logics for the operation of the KALIMER-600 with a supercritical $CO_2$ Brayton cycle after further studies of analyzing various operational events.

• Journal of Korean Society of Transportation
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• v.21 no.4
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• pp.57-66
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• 2003

Because the Logit model easily calculates probabilities for choice alternatives and estimates parameters for explanatory variables, it is widely used as a traffic mode choice model. However, this model includes an assumption which is independently and identically distributed to the error component distribution of the mode choice utility function. This paper is a study on the estimation of the Heteroscedastic Logit Model. which mitigates this assumption. The purpose of this paper is to estimate a Logit model that more accurately reflects the mode choice behavior of passengers by resolving the homoscedasticity of the model choice utility error component. In order to do this, we introduced a scale factor that is directly related to the error component distribution of the model. This scale factor was defined so as to take into account the heteroscedasticity in the difference in travel time between using public transport and driving a car, and was used to estimate the travel time parameter. The results of the Logit Model estimation developed in this study show that Heteroscedastic Logit Models can realistically reflect the mode choice behavior of passengers, even if the difference in travel time between public and private transport remains the same as passenger travel time increases, by identifying the difference in mode choice probability of passengers for public transportation.

• Journal of Korea Water Resources Association
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• v.52 no.11
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• pp.895-904
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• 2019

It has been well recognized that extreme rainfall process often features a nonstationary behavior, which may not be effectively modeled within a stationary frequency modeling framework. Moreover, extreme rainfall events are often described by a two (or more)-component mixture distribution which can be attributed to the distinct rainfall patterns associated with summer monsoons and tropical cyclones. In this perspective, this study explores a Mixture Distribution based Nonstationary Frequency (MDNF) model in a changing rainfall patterns within a Bayesian framework. Subsequently, the MDNF model can effectively account for the time-varying moments (e.g. location parameter) of the Gumbel distribution in a two (or more)-component mixture distribution. The performance of the MDNF model was evaluated by various statistical measures, compared with frequency model based on both stationary and nonstationary mixture distributions. A comparison of the results highlighted that the MDNF model substantially improved the overall performance, confirming the assumption that the extreme rainfall patterns might have a distinct nonstationarity.

• The Korean Journal of Food And Nutrition
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• v.34 no.2
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• pp.174-180
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• 2021

The purpose of this study was to determine the optimum extraction method suitable for the availability of biological activities in unripe apples known to be rich in functional components. Unripe apples 'Hongro' picked on May 28th, 2019 were extracted by various extraction methods (hot water, ethanol, enzymatic pre-treatment, ultrasonic wave, and subcritical water) and their extracts were investigated yield, effective component contents, and antioxidant activities. Overall, the yields by the extraction solvent were higher in water than in organic solvent(ethanol) because water-soluble compounds were eluted from a polar solvent. Total phenol contents of the ultrasonic wave (ethanol) extracts were significantly higher in 6 times than hot water extract. Contents of flavonoid were highest in the ethanol extract at 29.14 mg QE/g. Contents of tannin and ursolic acid were also significantly higher in the ultrasonic wave (ethanol) extract. The DPPH radical and ABTS radical scavenging activities were the strongest in the ultrasonic wave (ethanol) extract. Correlation between effective components and antioxidant activities was high in the total phenol content with ABTS and the ursolic acid content with DPPH (p<0.01). The above results suggested that ultrasonic wave (ethanol) extract of unripe apples has the potential to act as a functional material.

• Journal of the Korean Institute of Gas
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• v.23 no.4
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• pp.19-27
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• 2019

The consumption of liquefied natural gas (LNG) has increased annually due to the strengthening of international environmental regulations. In order to produce stable and efficient LNG, it is essential to divide the global (overall) operating condition and construct a quick and accurate monitoring system for each operation condition. In this study, multi-mode monitoring system is proposed to the LNG plant fractionation process. First, global normal operation data is divided to local (subdivide) normal operation data using global principal component analysis (PCA) and k-means clustering method. And then, the data to be analyzed were matched with the local normal mode. Finally, it is determined the state of process abnormality through the local PCA. The proposed method is applied to 45 fault case and it proved to be more than 5~10% efficient compared to the global PCA and univariate monitoring.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.23 no.5
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• pp.516-522
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• 2019

In this paper, we designed the editing function size and position adjustment, hiding and displaying, style editing, edit by device type etc. for each device type so that contents can be dynamically converted according to resolution or screen size according to various devices. and to be able to respond to various devices by storing device information in a component created through editing function. To improve the viewer of the web application and to improve the processing speed of the server, a component using the lazy loading technique was designed. in this paper, responsive web functionality and improve server throunghput results show that the response function of the Web function and the improvement of the processing speed of the server are improved by the monitoring tool, and the processing speed is improved in most browsers.