• Molecules and Cells
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• v.44 no.3
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• pp.168-178
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• 2021

The retinal pigment epithelium (RPE) forms a monolayer sheet separating the retina and choroid in vertebrate eyes. The polarized nature of RPE is maintained by distributing membrane proteins differentially along apico-basal axis. We found the distributions of these proteins differ in embryonic, post-natal, and mature mouse RPE, suggesting developmental regulation of protein trafficking. Thus, we deleted tumor susceptibility gene 101 (Tsg101), a key component of endosomal sorting complexes required for transport (ESCRT), in embryonic and mature RPE to determine whether ESCRT-mediated endocytic protein trafficking correlated with the establishment and maintenance of RPE polarity. Loss of Tsg101 severely disturbed the polarity of RPE, which forms irregular aggregates exhibiting non-polarized distribution of cell adhesion proteins and activation of epidermal growth factor receptor signaling. These findings suggest that ESCRT-mediated protein trafficking is essential for the development and maintenance of RPE cell polarity.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.21 no.3
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• pp.29-34
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• 2021

For the purpose of Application to the small radar sensor, the MMIC Chips, which are the core component of the W-band, was designed in Korea according to the characteristics of the transceiver and manufactured by 60nm GaN and 0.1㎛ GaAs pHEMT process. The output power of PA is 28 dBm at center frequency of W-band and Noise figure is 6.7 dB of switch and LNA MMIC. Output power and Noise figure of MMIC chips developed in domestic was applied to the transmitter and receiver module through W-band waveguide low loss transition structure design and impedance matching to verify the performance after the fabrication are 26.1~27.7 dBm and 7.85~10.57 dB including thermal testing, and which are close to the analysis result. As a result, these are judged that the PA and Switch and LNA MMICs can be applied to the small radar sensor.

• Journal of the Korean Society for Library and Information Science
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• v.55 no.3
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• pp.321-342
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• 2021

The purpose of this study is to develop the research support service model of a university library, which prepares for the changing research environment and supports the entire research process. In particular, components of the research support service at each stage of research are developed based on 'the research lifecycle' to support the entire research process. First, constructed elements of research support services that should be supported at each stage of the study through literature reviews and surveys of service demand. Next, a survey and in-depth interview were conducted with service providers to ensure effective service operation. This research support service model developed through the processes above are proposed as 'the research support service component model' that consists of six steps and 50 components including 20 core elements and as 'the research support service operation system model' that is composed of the organic system among government and related organizations, university libraries and organizations inside universities.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.39 no.2
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• pp.113-122
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• 2021

Urban expansion, particularly converting sub-urban areas to residential and commercial land use in metropolitan areas, has been considered as a significant signal of regional economic development. However, this results in urban climate change. One of the key impacts of rapid urbanization on the environment is the effect of UHI (Urban Heat Island). Understanding the effects of urban land cover change on UHI is crucial for improving the ecology and sustainability of cities. This research reports an application of remote sensing data, GIS (Geographic Information Systems) for assessing effects of urban land cover change on the LST (Land Surface Temperature) and heat budget components in Ho Chi Minh City, where is one of the fastest urbanizing region of Vietnam. The change of urban land cover component and LST in the city was derived by using multi-temporal Landsat data for the period of 1998 - 2020. The analysis showed that, from 1998 to 2020 the city had been drastically urbanized into multiple directions, with the urban areas increasing from approximately 125.281 km² in 1998 to 162.6 km² in 2007, and 267.2 km² in 2020, respectively. The results of retrieved LST revealed the radiant temperature for 1998 ranging from 20.2℃ to 31.2℃, while that for 2020 remarkably higher ranging from 22.1℃ to 42.3℃. The results also revealed that given the same percentage of urban land cover components, vegetation area is more effective to reduce the value of LST, meanwhile the impervious surface is the most effective factor to increase the value of the LST.

• KIPS Transactions on Software and Data Engineering
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• v.10 no.6
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• pp.223-234
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• 2021

Recent advances in the 4th Industrial Revolution have accelerated the change of the shopping behavior from offline to online. Search queries show customers' information needs most intensively in online shopping. However, there are not many search query research in the field of search, and most of the prior research in the field of search query research has been studied on a limited topic and data-based basis based on researchers' qualitative judgment. To this end, this study defines the type of search query with data-based quantitative methodology by applying machine learning to search research query field to define the 15 topics of search query by conducting topic modeling based on search query and clicked document information. Furthermore, we present a new classification system of new search query types representing searching behavior characteristics by extracting key variables through principal component analysis and analyzing. The results of this study are expected to contribute to the establishment of effective search services and the development of search systems.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.50 no.7
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• pp.455-463
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• 2022

As the need for R&D for high reliability cameras, such as satellite cameras, increases, the reliability of the bonding strength properties between an opto-mechanical structure and an optical component has been secured through specimen tests. However, the widely used specimen shape is not suitable for the application of glass and glass-ceramic material, which is fragile, making it difficult to obtain accurate bonding properties due to stress concentration in glass parts before reaching the bonding strength limit. In this study, the stress distribution characteristics in the shear test condition for various specimen shapes were studied analytically, based on the test results of the glass material's own fracture. Through this, the shape characteristics capable of relieving the stress concentration of the glass part were derived, and the range of the bonding shear strength verifiable by the specimen test was improved.

• Journal of Korea Foundry Society
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• v.41 no.6
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• pp.516-520
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• 2021

During sand casting, the binders produces gases in cores because high temperature molten metals dissolve the binders into gases and causes gas defects in the casting products. In the present study, quantitative analysis of inorganic binder gas generation was performed using Thermo Gravimetry (TG) and Mass Spectrometer (MS) analyses. The specimen was prepared using organic binders in liquid and solid state, and a mixture of sand and binders. Moisture loss by catalysts was calculated by TG results from liquid and solid binder specimens; it was found that components of gases were different. Quantitative analysis was discussed for generated gases with individual gas component results obtained using TG and MS. It is expected that gas generation can be predicted in the casting simulation using the technique proposed in the present study.

• International Journal of Computer Science & Network Security
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• v.22 no.1
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• pp.105-112
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• 2022

The development and spread of IT-technologies has raised interest in teaching programming pupils. The article deals with problems related to programming and ways to overcome them. The importance of programming skills is emphasized, as this process promotes the formation of algorithmic thinking of pupils. The authors determined the level of pupils' interest to programing learning depending on the age. The analysis has showed that the natural interest of younger pupils in programming is decreasing over the years and in the most productive period of its study is minimized. It is revealed that senior school pupils are characterized by low level of interest in the study of programming; lack of motivation; the presence of psychological blocks on their own abilities in the context of programming; law level of computer science understanding. To overcome these problems, we conducted the second stage of the experiment, which was based on a change in the approach to programing learning, which involved pupils of non-specialized classes of senior school (experimental group). During the study of programming, special attention was paid to the motivational and psychological component, as well as the use of game technologies and teamwork of pupils. The results of the pedagogical experiment on studying the effectiveness of teaching programming for pupils of nonspecialized classes are presented. Improvement of the results provided the use of social and cognitive motives; application of verbal and non-verbal, external and internal means; communicative attacks; stimulation and psychological setting; game techniques, independent work and reflection, teamwork. The positive effect of the implemented methods is shown by the results verified by the methods of mathematical statistics in the experimental and control groups of pupils.

• KEPCO Journal on Electric Power and Energy
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• v.7 no.2
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• pp.329-333
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• 2021

V2G (Vehicle to Grid) technology for an EV (Electric Vehicle) has been assumed as so promising in a near future for its useful energy resource concept but still yet to be developed around the world for specific service purposes through various R&BD projects. Basically, V2G returns power stored in vehicle at a cheaper or unused time to the grid at more expensive or highly peaked time, and is accordingly supposed to provide such roles like peak shaving or load levelling according to customer load curve, frequency regulation or ancillary reserves, and balancing power fluctuation to grid from the weather-sensitive renewable sources like wind or solar generations. However, it has recently been debated over its prominent usage as diffusing EVs and the required charging/discharging infrastructure, partially for its addition of EV ownership costs with more frequent charging/discharging events and user inconvenience with a relative long-time participation in the previously engaged V2G program. This study suggests that a Korean DR (Demand Response) service integrated V2G system especially based upon a dynamic charge/pause/discharge scheme newly proposed to ISO/IEC 15118 rev. 2 can deal with these concerns with more profitable business model, while fully making up for the additional component (ex. battery) and service costs. It also indicates that the optimum economic, environmental, and grid impacts can be simulated for this V2G-DR service particularly designed for EV aggregators (V2G service providers) by proposing a specific V2G engagement program for the mediated DR service providers and the distributed EV owners.

• Journal of Microbiology and Biotechnology
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• v.32 no.6
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• pp.730-739
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• 2022

Methicillin-resistant Staphylococcus aureus (MRSA) causes severe infections and poses a global healthcare challenge. The utilization of novel molecules which confer synergistical effects to existing MRSA-directed antibiotics is one of the well-accepted strategies in lieu of de novo development of new antibiotics. Thymol is a key component of the essential oil of plants in the Thymus and Origanum genera. Despite the absence of antimicrobial potency, thymol is known to inhibit MRSA biofilm formation. However, the anti-MRSA activity of thymol analogs is not well characterized. Here, we assessed the antimicrobial activity of several thymol derivatives and found that 4-chloro-2-isopropyl-5-methylphenol (chlorothymol) has antimicrobial activity against MRSA and in addition it also prevents biofilm formation. Chlorothymol inhibited staphyloxanthin production, slowed MRSA motility, and altered bacterial cell density and size. This compound also showed a synergistic antimicrobial activity with oxacillin against highly resistant S. aureus clinical isolates and biofilms associated with these isolates. Our results demonstrate that chlorinated thymol derivatives should be considered as a new lead compound in anti-MRSA therapeutics.