• IMMUNE NETWORK
• /
• v.22 no.5
• /
• pp.38.1-38.24
• /
• 2022

Exosomes, which are well-known nanoscale extracellular vesicles, are multifunctional biomaterials derived from endosomes and perform various functions. The exosome is a critical material in cell-cell communication. In addition, it regulates the pathophysiological conditions of the tumor microenvironment in particular. In the tumor microenvironment, exosomes play a controversial role in supporting or killing cancer by conveying biomaterials derived from parent cells. Innate immunity is a crucial component of the host defense mechanism, as it prevents foreign substances, such as viruses and other microbes and tumorigenesis from invading the body. Early in the tumorigenesis process, the innate immunity explicitly recognizes the tumor via Ags and educates the adaptive immunity to eliminate it. Recent studies have revealed that exosomes regulate immunity in the tumor microenvironment. Tumor-derived exosomes regulate immunity against tumor progression and metastasis. Furthermore, tumor-derived exosomes regulate polarization, differentiation, proliferation, and activation of innate immune cells. Exosomes produced from innate immune cells can inhibit or support tumor progression and metastasis via immune cell activation and direct cancer inhibition. In this study, we investigated current knowledge regarding the communication between tumor-derived exosomes and innate immune cell-derived exosomes (from macrophages, dendritic cells, NK cells, and neutrophils) in the tumor microenvironment. In addition, we discussed the potential development of exosomal immunotherapy using native or engineered exosomes against cancer.

• Transactions of Materials Processing
• /
• v.33 no.1
• /
• pp.5-11
• /
• 2024

The development of a next-generation hydrogen compressor, a key component in the expansion of hydrogen charging infrastructure, is in progress. In order to improve compression efficiency and durability, it is important to optimize the precision forming and shearing processes of the diaphragm, which is the bellows unit cell, as well as the optimization of diaphragm shape itself. In this study, we aim to show that die and process design technology that can synchronize the inner and outer shearing points of the diaphragm for the precision forming of product can be constructed based on a numerical simulation. First, the damage model that can predict the fracture points will be determined using the shear load and shear zone measurements obtained by performing a blanking test of AISI-633 stainless steel. Next, we will explain the overall procedure based on numerical analysis model how to determine the shearing points according to the deformation pattern of urethane die for various shearing die design.

• Journal of the Korean Society for Heat Treatment
• /
• v.37 no.1
• /
• pp.23-28
• /
• 2024

As global warming accelerates, the transportation industry is increasing the use of lightweight materials with the goal of reducing carbon emissions. Magnesium is a suitable material, but its poor formability limits its use, so research is needed to improve it. Rare-earth elements are known to effectively control texture development, but their high cost limits commercial. In this study, changes in microstructure and texture were investigated by adding Pb, which is expected to have a similar effect as rare-earth elements. The material used is Mg-15wt%Pb alloy. Initial specimens were obtained by rolling at 773 K to a rolling reduction of 25% and heat treatment. Afterwards, plane strain compression was performed at 723 K with a strain rate of 5×10^-2s^-1 and a strain of -0.4 to -1.0. As a result, recrystallized grains were formed within the microstructure, and the main component of the texture changed from (0,0) to (30,26). The maximum axial density was initially 10.01, but decreased to 4.23 after compression.

• Current Photovoltaic Research
• /
• v.12 no.1
• /
• pp.17-23
• /
• 2024

Photovoltaic (PV) power generation is the world's best and largest renewable energy that generates electricity with infinite sunlight. Solar cell modules are a component of photovoltaic power generation and must have a long-term durability of at least 25 years. The development of processes and equipment that can be recovered through the recycling of metals and valuable metals when the solar module's lifespan is over has been completed to the level of commercialization, but few processes have been developed that require repair due to initial defects. This is mainly due to the economic problems caused by remaking. However, if manufacturing processes such as repairing solar cell modules that have been proven to be early defects are established and the technical review of long-term reliability and durability reaches a certain level, it is considered that it will be a recommended process technology for environmental economics. In this paper, assuming that a defective solar cell module occurs artificially, a manufacturing process for replacement of solar cells was developed, and a technical verification of the manufacturing technology was conducted through long-term durability evaluation in accordance with KS C 8561. Through this, it was determined that remanufacturing technology for solar cell replacement of solar cell modules that occurred in a short period of time after installation was possible, and the research results were announced through a journal to commercialize solar modules using manufacturing technology in the solar market in the future.

• Journal of the Korean Society of Industry Convergence
• /
• v.27 no.1
• /
• pp.39-46
• /
• 2024

As the development of hydrogen vehicles has accelerated in recent years, it is necessary to develop a storage tank for hydrogen fueling stations capable of high-pressure charging, and for this purpose, a new system with a compressor-embedded refueling tank is required. In this study, the parametric study of shape design based on strength performance evaluation was carried out to find the optimal shape design of bellows, the core component of compressor-embedded refueling tank for a newly developed hydrogen refueling station capable of high-pressure charging above 1,000 bar. The design factors for parametric study were contour shape and radius of bellows, and the performance factors were the maximum stress and the gap distance in the contact direction. In the shape design of the compressor bellows for hydrogen refueling station considered in this study, it was found that adjusting the contour radius is an appropriate design method to improve the compression performance and structural safety.

• Journal of the Korean Society for Heat Treatment
• /
• v.37 no.2
• /
• pp.66-72
• /
• 2024

To investigate the effect of deformation condition on microstructure and texture formation behaviors of AZ91 magnesium alloy with three kinds of initial texure during high-temperature deformation, plane strain compression tests were carried out at high-temperature deformation conditions - temperature of 673 K~723 K, strain rate of 5 × 10^-3s^-1, up to a strain of -1.0. To clarify the texture formation behavior and crystal orientaion distribution, X-ray diffraction and EBSD measurement were conducted on mid-plane section of the specimens after electroltytic polishing. As a result of this study, it is found that the main component and the accumulation of pole density vary depending on initial texture and deformation caondition, and the formation and development basal texture components ({0001} <$10\bar{1}0$>) were observed regardless of the initial texure in all case of specimens.

• Wind and Structures
• /
• v.38 no.5
• /
• pp.355-366
• /
• 2024

Severe natural multi-hazard events can cause damage to infrastructure and economic losses of billions of dollars. The challenges of modeling these losses include dependency between hazards, cause and sequence of loss, and lack of available data. This paper presents and explores multi-hazard loss modeling in the context of the combined wind and rain vulnerability of mid/high-rise buildings during hurricane events. A component-based probabilistic vulnerability model provides the framework to test and contrast two different approaches to treat the multi-hazards: In one, the wind and rain hazard models are both decoupled from the vulnerability model. In the other, only the wind hazard is decoupled, while the rain hazard model is embedded into the vulnerability model. The paper presents the mathematical and conceptual development of each approach, example outputs from each for the same scenario, and a discussion of weaknesses and strengths of each approach.

• Journal of Ecology and Environment
• /
• v.48 no.2
• /
• pp.144-151
• /
• 2024

Background: This study focused on the diet of Clithon retropictum, level II endangered species in Korea. Since the development of brackish water zones has led to a decline in the population of this species, to obtain information on the ecology of C. retropictum required for its conservation and restoration. To investigate the actual preys of C. retropictum in south coast of Korea, we conducted high-throughput sequencing and metabarcoding techniques to extract DNA from gut contents and periphyton in their habitats. Results: Total 118 taxonomic groups were detected from periphyton samples. 116 were Chromista and Cyanobacteria dominated in the most samples. In gut contents samples, 98 taxonomic groups were detected. Similar to the results of periphyton, 96 were Chromista and Cyanobacteria dominated in the most samples. In the principal component analysis based on the presence/absence of taxonomic groups, gut content composition showed more clustered patterns corresponding to their habitats. Bryophyta was the most crucial taxonomic group explaining the difference between periphyton and gut contents compositions of C. retropictum. Conclusions: Our finding suggests that C. retropictum may not randomly consume epilithic algae but instead, likely to supplement their diet with Bryophyta.

• Nuclear Engineering and Technology
• /
• v.56 no.6
• /
• pp.2395-2403
• /
• 2024

With the rapid development of DC high voltage accelerator, higher requirements have been raised for the design of DC high voltage power supply, requiring more stable high voltage with lower output ripple. Therefore, it also puts forward higher requirements for the parameter design of the voltage doubling rectifier circuit, which is the core component of the DC high voltage power supply. In order to obtain output voltage with better performance, the effects of the working frequency, the stage capacitance and the load resistance on the output voltage of the voltage doubling rectifier circuit are studied in detail by simulation. It can be concluded that the higher the working frequency of the transformer, the larger the stage capacitance, the larger the load resistance and the better the output voltage performance in a certain range. Based on this, a 2.5 MV voltage doubling rectifier circuit driven by a 120 kHz frequency transformer is designed, developed and tested for the power supply of the neutron source device towards BNCT. Experimental results show that this voltage doubling rectifier circuit can satisfy the design requirements, laying a certain foundation for the engineering design of DC high voltage power supply of neutron source device.

• KOREAN JOURNAL OF CROP SCIENCE
• /
• v.60 no.2
• /
• pp.190-196
• /
• 2015

We evaluated the morphological characteristics in 100 super sweet corn inbred lines, which were developed to breeding super sweet corn variety at Gyeongsangbuk-do Agricultural Research and Extension Services, by examining six quantitative and two qualitative characteristics. On the result of evaluation of two qualitative traits, most of inbred lines showed yellow (91 inbred lines) at seed color (QL1) and weak (68 inbred lines) at seedling vigor (QL2). In the survey of six quantitative traits, the average value for each trait indicated as follows: days of tasseling (QN1, 41.0 to 55.0 days), days of silking (QN2, 44.0 to 59.0 days), anthesis-silking interval (QN3, 2.0 to 7.0 days), tillering (QN4, 0.0 to 2.0), plant height (QN5, 96.0 to 187.0 cm) and ear height (QN6, 30.0 to 86.0 cm). In PCAs (principal component analysis) for 8 morphological characteristics, seedling vigor (QL2) and tillering (QN4) greatly contributed in negative direction and the days of tasseling (QN1) and days of silking (QN2) greatly contributed in positive direction on the first principal component. While, ear height (QN6) and plant height (QN5) contributed in positive direction on the second principal component. Thus these morphological traits, which were greatly contributed in the first and second principal components, might be considered to be useful for discrimination in 100 super sweet corn inbred lines. In our study, the results of morphological variation and PCAs for 100 super sweet corn inbred lines will be helpful for super sweet corn breeding programs such activities as planning crosses for hybrid and line development.