• YAKHAK HOEJI
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• v.49 no.5
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• pp.428-436
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• 2005

DNA topoisomerase I(TOP1) helps the control of DNA replication, transcription and recombination by assist­ing breaking and rejoining of DNA double strand. Camptothecin (CPT) and its derivative, topotecan, are known to inhibit TOP1 by intercalating into TOP1-DNA complex. Recently various non-CPT intercalators are synthesized for a new class of TOP1 inhibitors. In this study, six compounds isolated from Poria cocos were investigated for their interaction with TOP1­DNA complex using the flexible docking program, FlexiDock. The binding modes were analyzed and compared with the TOP1 inhibition activities. The compounds that showed potent activity were intercalated between the + 1/-1 base pairs of DNA, located near the active site phosphotyrosine723 and formed hydrogen bonds with active site residues. On the other hand, compounds with no activity were not docked at all. The binding modes were well correlated with the inhibition activity, suggesting the possibility that potent inhibitors can be designed from the information presented by the docking study.

• The Journal of the Korean dental association
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• v.55 no.12
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• pp.828-840
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• 2017

In recent years, many researchers and clinicians found interest in regenerative medicine using induced pluripotent stem cells (iPSCs) with biomaterials due to their pluripotency, which is able to differentiate into any type of cells without human embryo, which of use is ethically controversial. However, there are limitations to make iPSCs from adult somatic cells due to their low stemness and donor site morbidity. Recently, to overcome above drawbacks, dental tissue-derived iPSCs have been highlighted as a type of alternative sources for their high stemness, easy gathering, and their complex (ectomesenchymal) origin, which easily differentiate them to various cell types for nerve, vessel, and other dental tissue regeneration. In other part, utilizing biomaterials for regenerative medicine using cell is recently highlighted because they can modulate cell adhesion, proliferation and (de)differentiation. Therefore, this paper will convey the overview of advantages and drawbacks of dental tissue-derived iPSCs and their future application with biomaterials.

• Journal of applied mathematics & informatics
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• v.27 no.5_6
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• pp.1493-1499
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• 2009

Let $A_1$ and $A_2$ be nonzero complex idempotent and tripotent matrix, respectively. Denote a linear combination of the two matrices by A = $c_1A_1$ + $c_2A_2$, where $c_1,\;c_2$ are nonzero complex scalars. In this paper, under an assumption of $A_1A_2$ = $A_2A_1$, we characterize all situations in which the linear combination is tripotent. A statistical interpretation of this tripotent problem is also pointed out. Moreover, In [2], Baksalary characterized all situations in which the above linear combination is idem-potent by using the property of decomposition of a tripotent matrix, i.e. if $A_2$ is tripotent, then $A_2$ = $B_1-B_2$, where $B^2_i=B_i$, i = 1, 2 and $B_1B_2=B_2B_1=0$. While in this paper, by utilizing a method different from the one used by Baksalary in [2], we prove the theorem 1 in [2] again.

• Korean Journal of Crystallography
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• v.8 no.2
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• pp.119-123
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• 1997

The complex [Ni(L)]I2 (1) (L:3,5,10,12-Tetramethly-1,4,8,11-tetraazacyclotetradecane) has been prepared and characterized by X-ray diffraction methods. The complex 1 crystallized in the orthorhombic system, space group Pcab with cell parameters a=13.293(1) Å, b=28.550(7) Å, c=10.804(1) Å, z=8. Least-squares refinement of 1 led to a R(Rw) factor of 0.043 (0.046) for 1851 observed reflections of Fo>3o (Fo). The crystal structure of 1 has a slightly distorted square-planar geometry and adopts the trans-III conformation.

• Mass Spectrometry Letters
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• v.12 no.4
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• pp.152-158
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• 2021

Electrospray ionization (ESI) and ion mobility spectrometry-mass spectrometry (IMS-MS) were employed to investigate the solvated structures of ionic species in the lithium iodide electrolyte solution in the gas phase. The Li⁺I^-Li⁺ triple ion and single standalone Li+ ions solvated by 1,4-dioxane were successfully generated and observed by ESI-MS under the influence of dioxane vapor at the inlet region. Under the present experimental condition, (1,4-dioxane)_m·Li⁺ complex ions (m = 1, 2, and 3) and a (1,4-dioxane)·Li⁺I^-Li⁺ complex ion were observed, which were further examined by IMS to investigate their structures. The presence of multiple structural isomers was confirmed, which accounts for the endothermic conformational transition of 1,4-dioxane from a chair to a boat to achieve bidentate O-donor binding to Li⁺ and Li⁺I^-Li⁺. Further structural details critical for the ion-solvent interactions were also examined and discussed with the help of density functional theory calculations.

• Bulletin of the Korean Chemical Society
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• v.27 no.5
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• pp.713-717
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• 2006

$S_2O$-donor macrocyclic isomers incorporating a xylyl group in o- ($L^1$), m- ($L^2$) and p-positions ($L^3$) extract no metal ions except silver(I) from aqueous to chloroform phase. And the magnitudes of %Ex for silver(I) are in the order of $L^1$ > $L^2$ > $L^3$. Taking this result into account, $L^1$-$L^3$ were utilized as membrane active components to prepare potentiometric silver(I)-selective electrodes. The proposed macrocycles-based electrodes E1 ($L^1$), E2 ($L^2$) and E3 ($L^3$) exhibited comparable results which show considerable selectivity toward silver(I) over alkali, alkali earth and other transition metal ions. Comparative NMR study on $L^1$-$L^3$ and their complexes with silver(I) in solution was also accomplished. In addition, a unique sandwich-type complex $[Ag(L^1)_2]CIO_4$ was prepared from the assembly reaction of $L^1$ with $AgClO_4$ and structurally characterized by an X-ray diffraction analysis.

• Analytical Science and Technology
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• v.18 no.5
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• pp.391-395
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• 2005

The title complex, $[Cd(N_3)_2(2-ethylimidazole)_2]$, I, has been prepared and characterized by X-ray single crystallography. The complex I crystallizes in the monoclinic system, Cc space group with a = 16.200(3), b = 12.926(3), $c=7.007(1){\AA}$, ${\beta}=102.29(3)^{\circ}$, $V=1433.7(5){\AA}^3$, Z = 4, $R_1=0.0239$ and ${\omega}R_2=0.0604$ for 1874 independent reflections. Cd(II) atom has a slightly distorted octahedral coordination geometry, with four end-on (${\mu}-1$,1) bridging azido ligands and two 2-ethylimidazole ligands bonding through nitrogen atom. The central cadmium(II) atoms are run in parallel to the c-axis and are doubly bridged with neighboring cadmium(II) atoms by the end-on (${\mu}-1$,1) bridging azido ligands. Thus, this complex has a one-dimensional zigzag chain structure in which the 2-ethylimidazole is in the cis conformation.

• Journal of the Korea Organic Resources Recycling Association
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• v.30 no.1
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• pp.23-32
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• 2022

In this study, rainfall water outlet water quality monitoring was performed on the C industrial complex to evaluate the characteristics of non-point pollutant runoff from the industrial complex during rainfall and to use it as basic data for calculating the load and unit of non-point pollutant. As a result of the IETD analysis, it was selected as a representative rainfall event for simulating non-point pollutants when the rainfall duration was about 21 hours and the rainfall was 26.44mm. Also as a result of monitoring the flow and water quality survey, the first rainfall was 12.2 mm, the rainfall duration was 12 hr, the number of preceding dry days was 3 days, the second rainfall was 22.1 mm, the rainfall duration was 12 hr, and the number of preceding dry days was 7 days.

• Journal of the Chungcheong Mathematical Society
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• v.28 no.3
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• pp.451-463
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• 2015

A continuous and non-decreasing function ${\psi}$ and another continuous function ${\phi}$ with ${\phi}(z)=0{\Leftrightarrow}z=0$ defined on $\mathbb{C}^+=\{x+yi:x,y{\geq}0\}$ are introduced, the ${\psi}-{\phi}$-contractive or expansive type conditions are considered, and the existence theorems of common fixed points for two mappings defined on a complex valued metric space are obtained. Also, Banach contraction principle and a fixed point theorem for a I-expansive type mapping are given on complex valued metric spaces.

• Journal of Environmental Science International
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• v.1 no.2
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• pp.69-80
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• 1992

Effects of light on leaf senescence of Phseolus vulgaris were investigated by measuring the disassembly of chlorophyll-protein complexes in detached leaves which had been kept in the dark or under light. The loss of chlorophyll accompanied by degradation of chlorophyll- protein complexes. PSI (photosystem I) complex containing LHCI (light harvesting complex of PSI) apoproteins was rapidly decreased after the early stage of dark-induced senescence. RC(reaction center)-Cores was slightly increased until 4 d and slowly decreased thereafter. As disassembly of LHCII trimer progressed after the late stage of senescence, there was a steady increase in the relative amount of SC(small complex)-2 containing LHCII monomer. On the other hand, white and red light adaptation caused the structural stability of chlorophyll-protein complexes during dark-induced senescence. Particularly, red light was more effective in the retardation of LHCII breakdown than white light, whereas white light was slightly effect in protecting the disassembly of PSI complex compared to red light. These results suggest, therefore, that light may be a regulatory factor for stability of chlorophyll-protein complexes in the senescent leaves.