• 대한수학회논문집
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• 제9권4호
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• pp.825-830
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• 1994

This paper is concerned with the zeros of successive derivatives of real entire functions. In order to state our results, we introduce the following notations : An entire function which assumes only real values on the real axis is said to be a real entire function. Thus, if a complex number is a zero of a real entire function, then its conjugate is also a zero of the same function.

• Journal of the Optical Society of Korea
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• 제8권4호
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• pp.182-187
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• 2004

We synthesized and analyzed the optical transfer function(OTF) of the modified triangular interferometer (MTI) using two-pupil synthesis method. Also, we presented the optimal MTI, which can obtain any bipolar function by combining two wave plates and a linear polarizer. By using the proposed MTI, we can obtain the complex hologram without bias and conjugate image.

• 한국전산구조공학회논문집
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• 제24권4호
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• pp.405-412
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• 2011

본 논문에서는 켤레구배법을 이용해 전체-국부 확장함수를 지닌 일반유한요소법을 해석하는 방식을 제안한다. 이 기법은 편미분방정식의 해에 대한 정보가 충분하지 않은 경우에도 수치해석적인 방법으로 일반유한요소법의 확장함수를 구성할 수 있으며, 해석과정 중 약간의 추가적인 연산만으로 좋은 성능을 지닌 전처리행렬 및 초기 추측치를 구성할 수 있어 국부적으로 복잡한 거동을 보이는 문제의 해석에 효과적이다. 본 논문에 포함된 수치해석 예제의 결과는 제안된 기법이 가우스 소거법과 같은 직접 솔버를 이용하는 경우보다 수치해석적으로 더 효율적임을 보여준다.

• 한국유체기계학회 논문집
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• 제18권2호
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• pp.60-66
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• 2015

Conjugate heat transfer analysis was performed to investigate the flow and cooling performance of the high pressure turbine nozzle of gas turbine engine. The CHT code was verified by comparison between CFD results and experimental results of C3X vane. The combination of k-${\omega}$ based SST turbulence model and transition model was used to solve the flow and thermal field of the fluid zone and the material property of CMSX-4 was applied to the solid zone. The turbine nozzle has two internal cooling channels and each channel has a complex cooling configurations, such as the film cooling, jet impingement, pedestal and rib turbulator. The parabolic temperature profile was given to the inlet condition of the nozzle to simulate the combustor exit condition. The flow characteristics were analyzed by comparing with uncooled nozzle vane. The Mach number around the vane increased due to the increase of coolant mass flow flowed in the main flow passage. The maximum cooling effectiveness (91 %) at the vane surface is located in the middle of pressure side which is effected by the film cooling and the rib turbulrator. The region of the minimum cooling effectiveness (44.8 %) was positioned at the leading edge. And the results show that the TBC layer increases the average cooling effectiveness up to 18 %.

• 대한의생명과학회지
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• 제9권2호
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• pp.67-74
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• 2003

Viral and non-viral vectors have been used in the delivery of genetic materials into animal cells and tissues, with each approach having pros and cons. Non-viral vectors have many useful merits such as easy preparation, low immunity and size tolerance of a transgene when compared to those of viral vectors. Delivery specificity may be achieved by complex formation between receptor ligands and a non-viral vector. In the present study, non-viral vector systems are investigated in an effort to find a practical delivery means for gene therapy, Receptor-ligand interaction between transferrin-receptor and transferrin was utilized for efficient gene transfer into cancer cells. A plasmid vector, pcDNA3 (LacZ) was ligated with a small duplexed oligo fragment in which a Biotin- VN$^{TM}$ phosphoramidite was placed in the middle of the oligo. The plasmid vector labeled by biotin was then conjugated with biotin-labeled transferrin via streptavidin. This trimeric conjugates were delivered to a hepatoma cell line, HepG2. The delivery efficiency of the trimeric conjugate was 2-fold higher than that of cationic liposomes used for transfection of a plasmid vector. These results demonstrate that a plasmid vector can be efficiently transferred into cells by forming a trimeric complex of plasmid vector-linker-ligand.

• 한국전자파학회논문지
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• 제16권8호
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• pp.797-802
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• 2005

본 논문에서는 UHF 대 역용(911 MHz) 태그로 금속체 부착 가능한 태그로써 PIFA 형태 를 채택하여, $50{\times}30{\times}4$ mm의 크기로 칩의 임피던스(77-j100 ${\Omega}$)와 공액 정합이 되는 태그 안테나를 설계 및 제작하였다. RFID 태그로부터 backscattering 되는 필드, 즉 RCS(Radar Cross Section)을 통해 태그 안테나의 성능을 평가하였다. 제안된 태그 안테나는 칩의 임피던스에 쉽게 정합시킬 수 있는 간단한 구조이고, foam을 이용하여 저가에 생산할 수 있는 장점을 가지고 있다. RCS값이 칩이 단락일 때 RCS 값은 $-21\;dBm^2$이고, 정합일 때는 $-10.2\;dBm^2$로 효율적인 RCS 특성을 가지고 있다.

• Clinical and Experimental Pediatrics
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• 제49권3호
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• pp.235-241
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• 2006

Streptococus pneumoniae is an important cause of invasive infections as well as non-invasive infections such as acute otitis media and sinusitis both in children and adults. Resistance of S. pneumoniae to multiple antimicrobials is increasing and poses therapeutic challenges, and prevention became more important. 23-valent polysaccharide vaccine has been used for the last several decades, but is not effective in children <2 years of age, the highest risk group of invasive diseases. Recently, a 7-valent pneumococcal protein conjugate vaccine(PCV) which is effective in infants and young children has been developed. The efficacy of PCVs against invasive pneumococcal disease and pneumonia is well established and is documented in several well-conducted studies. However, the effect of PCVs on otitis media is less obvious and more complex. PCVs clearly reduce diseases caused by vaccine-type(VT) pneumococci, but replacement of VT serotypes by non-VT serotypes in nasopharyngeal carriage of S. pneumoniae is responsible for the increase in acute otitis media caused by non-VT serotypes. Three years after introduction of PCV in the US, some increase of invasive infections with serotype 19A possibly due to serotype switching within certain vaccine type strains has been noted. Since most antibiotic-resistance in S. pneumoniae is confined to VT serotypes, vaccine use also reduces antibiotic resistance. With development of PCV, there was a great advance in the prevention of pneumococcal diseases, but replacement with potential virulent organisms and development of antibiotic resistance in non-VT pneumococci is a possibility that needs careful monitoring.

• 한국국방경영분석학회지
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• 제34권1호
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• pp.1-11
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• 2008

본 연구에서는 다양하고 복잡한 변수간의 비선형적인 관계를 분석할 수 있는 신경망의 특성을 이용하여 곡사화기를 사용하는 포병의 모의훈련체계를 향상시킬 수 있는 방안을 제시하였다. 신경망 모델은 Conjugate Gradient 학습알고리즘을 사용하였고, 모델의 신뢰성은 모의실험을 통해 수학적 회귀분석모델과 신경망 모델의 예측오차를 비교하여 입증하였다. 신경망모델을 곡사화기 모의훈련체계 개선에 활용한다면, 보다 실전적인 모의훈련을 가능하게 하여 전투력 향상 및 예산절감에도 크게 기여할 것이다.

• 폴리머
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• 제32권6호
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• pp.544-548
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• 2008

본 연구에서는 키틴의 알칼리 가수분해를 통해 탈아세틸화도가 조절된 세 가지 조건의 키토산을 제조하였고, 이 키토산이 수용성을 지니게 화학적 분해법을 이용해 분자량을 조절하였다. 이렇게 제조된 분자량이 조절된 세 가지 조건의 탈아세틸화도를 가지는 키토산 각각에 항산화제인 리포산을 합성하여 항산화 능력을 가지는 생체 적합성 나노 구조체를 형성하였다. 키토산-리포산의 합성을 확인하기 위하여 분광학적 분석 방법을 사용하여 분석하였다. 키토산-리포산 합성체는 수용액 상태에서 자기조립체를 형성하며 이렇게 형성된 자기조립체 나노 입자는 약 135 nm 정도의 크기를 가지고 있음을 알 수 있었다.

• Journal of Pharmaceutical Investigation
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• 제25권2호
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• pp.145-152
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• 1995

The superoxide dismutase (SOD) mimetic activity of copper complex of 3,5-disopropylsalicylic acid (Cu(II)-DIPS) was tested and compared to those of human recombinant SOD (hrSOD) and its conjugate form with polyethyleneglycol (PEG) using fer- ricytochrome c reduction assay. Stability constant of Cu(II)-DIPS was measured po- tentiometrically using SCOGS2 program. In the presence of 10 g/L albumin, Cu(II)-DIPS lost most of its SOD mimetic activity. HrSOD was modified with polyethylene glycol (PEG) of M.W. 5000. These conjugates have markedly prolonged plasma half-lives of enzymatic activity (15.5 hr) compared to native hrSOD (5 min). In summary, efficient SOD mimetics should be stable enough not to dissociate in blood by serum protein. HrSOD could have longer half-life by conjugation with inert PEG for sustained SOD effect.