• Radiation Oncology Journal
• /
• 제11권2호
• /
• pp.295-301
• /
• 1993

절제 불가능한 제 3기 비소세포 폐암에서의 MVP(Mitomycin C 6 $mg/m^2$, Vinblastine 6 $mg/m^2$, Cisplatin 60 $mg/m^2$) 복합 항암요법과 다분할 방사선 치료의 효과를 판정하기 위하여 1991년 1월부터 전향성 임의 선택연구(prospective randomized study)를 시작하였다. 본 연구는 제 III기의 비소세포 폐암중 절제가 불가능한 환자를 대상으로 하여 MVP 항암요법을 3 회 시행한 후 다분할 방사선 치료 (120 cGy/fx, BID)를 6480 cGy까지 시행하였다. 방사선 치료가 끝난 1개월 후 유도 항암요법에 부분 관해 이상의 반응을 보였던 환자를 대상으로 추가 항암요법을 시행하는 군과 계속 관찰하는 군으로 임의 분류하였다. 1992년 12월까지 48명의 환자가 등록되었으며, 이중 3명은 항암요법후 치료를 중단하였으며, 6명은 방사선 치료중 치료를 중단하거나, 개인적 사정으로 다분할 방사선 치료를 시행받지 못하여 39명의 환자에 대한분석을 시행하였다. 유도 항암요법을 마친 환자중 2명은 완전 관해를 보였으며, 21명은 부분 관해를 보여 MVP 유도항암요법에 대한 관해율은 $58\%$ (23/39)이었다. 항암요법에 부분관해를 보인 21명중 1명은 방사선 치료후 완전관해를 보였으며, 10명은 부분관해를 보였으나, 나머지 10명은 방사선 치료에 반응을 보이지 않았다. 항암요법에 반응을 보이지 않았던 16명의 환자중 9명은 방사선 치료에도 전혀 반응을 보이지 않았다. 유도항암 요법과 다분할 방사선 치료후의 관해율은 $64\%$이었다. 방사선 치료후 19명의 환자에 대하여 추가 항암요법에 대한 임의 선택을 시행하여 이중 9명은 추가 항암요법 군으로 분류되어, 3회의 추가 항암요법을 시행하였다. 아직까지는 추가 항암요법군과 관찰군 사이에 원격전이나 생존율의 차이가 관찰되지 않았다. 전체 환자의 중앙 생존은 13개월이었고, 6개월과 12개월의 생존율은 각각 $84.6\%$와 $53.7\%,\;40.3\%$이었다. 특히 유도항암요법에 부분관해 이상의 반응을 보였던 환자들은 무반응환자에 비하여 통계적으로 유의하게 증가된 생존율을 보였다(p=0.0287). 아직까지 추적 관찰기간이 짧으나, $64\%$의 높은 치료 관해율과 증가된 생존율, 그리고 합병증의 증가가 관찰되지 않는 점으로 보아 본 연구를 계속 진행함으로써 더 좋은 결과를 얻을 수 있을 것으로 기대된다.

• Journal of Chest Surgery
• /
• 제16권1호
• /
• pp.115-120
• /
• 1983

We implanted pacemakers using screw-in sutureless myocardial electrode in 40 patients between February, 1980 and November, 1982 at Seoul Nation University Hospital. Mean age of total patient who received the pacemaker implantation was 39.9 years, but excluding the patient who received the open heart surgery, mean age was 49.3 years. Cause of pacemaker implantation was complete A-V block in 13 patients, symptomatic sick sinus syndrome in 12 patients, complete A-V block after open heart surgery in 12 patients, second degree A-V block with dizziness in one patient, and atrial fibrillation with slow ventricular response in two patients. In thirty nine cases, electrodes were implanted by subxiphoid approach, on the diaphragmatic surface of right ventricle. I n one case, electrode was implanted through the left anterior thoracotomy. Acute stimulation threshold, measured in 35 patients, varied from 0.1 to 2.5 mA [mean 0.85 mA.], and R-wave amplitude [sensitivity], measured in 19 patients, varied from 2.9 mV to 11.5 mV [mean 7.6 mV]. There was no hospital death. The postoperative complications included wound seroma in two patients [5%], wound hematoma in three patients [7.5%], and pacing failure in one patient [2.5%]. The subxiphoid implantation of the pacemaker using sutureless myocardial lead was valuable in obtaining safe, reliable and long-term impulse generation.

• 산업공학
• /
• 제16권2호
• /
• pp.229-239
• /
• 2003

The On-Line Analytical Processing (OLAP) tools access data from the data warehouse for complex data analysis, such as multidimensional data analysis, and decision support activities. Current research has lead to new developments in all aspects of data warehousing, however, there are still a number of problems that need to be solved for making data warehousing effective. View maintenance, one of them, is to maintain view in response to updates in source data. Keeping the view consistent with updates to the base relations, however, can be expensive, since it may involve querying external sources where the base relations reside. In order to reduce maintenance costs, it is possible to maintain the views using information that is strictly local to the data warehouse. This process is usually referred to as "self-maintenance of views". A number of algorithm have been proposed for self maintenance of views where they keep some additional information in data warehouse in the form of auxiliary views. But those algorithms did not consider a consistency of materialized views using view self-maintenance. The purpose of this paper is to research consistency problem when self-maintenance of views is implemented. The proposed "conveyor algorithm" will resolved a complete consistency of materialized view using self-maintenance with considering network delay. The rationale for conveyor algorithm and performance characteristics are described in detail.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권12호
• /
• pp.7193-7196
• /
• 2013

Ovarian cancer patients need a surveillance program for the detection of tumor progression after completion of treatment. The methods generally consist of history taking, physical examination, tumor marker monitoring and imaging. However, the details of recurrence detection with each method are not well defined. To clarify this issue, ovarian cancer patients who achieved complete or partial responses and developed tumor progression at the follow up time between January 2004 and December 2010 in University Hospital Chiang Mai, Thailand, were reviewed. Clinical data, CA 125 level and imaging results at the tumor progression time were recorded and analyzed. There were 144 ovarian cancer patients meeting the inclusion criteria with the mean age of 51 years and 62.5% of them were in an advanced stage. Complete response was achieved in 89 patients (61.8%) after primary treatment. The median progression free survival and overall survival were 15.5 months and 37.5 months, respectively. Abnormal symptoms presented in 49.3% of the studied patients and 59.7% developed physical examination abnormalities. In addition, CA 125 was elevated in 89.6% while in 74.3% of tumor progression was identified by CT-scan. Short treatment time period and a high level of CA 125 were significant independent prognostic factors in these patients. In conclusion, careful history taking, physical examination and monitoring of CA 125 levels are important methods for tumor progression detection in a surveillance program for epithelial ovarian cancer patients.

• Tuberculosis and Respiratory Diseases
• /
• 제52권6호
• /
• pp.633-639
• /
• 2002

저자들은 소세포폐암과 막성신증이 동시에 발견된 60세 남자 환자에서 수술 및 전신항암치료 후 폐암의 완전관해와 더불어 단백뇨가 소실되었던 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• 한방안이비인후피부과학회지
• /
• 제28권4호
• /
• pp.196-207
• /
• 2015

Purpose : To observe effects of Korean Medicine treatment for genital warts.Methods : In a single private clinic from February 2014 to February 2015, we did retrospective chart review for 326 patients with genital warts who had been treated by Korean Medicine. Korean Medicine treatment included herbal treatment and herbal ointment.Results : A total of 326 patients were enrolled in this study: 62.7%(n=219) male, 32.8%(n=107) female. In the type of diagnosis, new diagnosis was 45.4%(n=148) and recurrent disease was 54.6%(n=178). Complete clearance was achieved 63.2%(n=206) and treatment period was 3.5 months(range:1-9). Partial clearance-good was 15%(n=49), partial clearance-poor was 4.9%(n=16), non response was 16.9%(n=55) and the average treatment period was 4.3 months(range:1-14). In complete clearance group, female and the prevalence of less than 1 year were statistically significant(p<0.05). There was no recurrence of genital warts after TKM treatment during follow-up period(4-13months).Conclusion : This study suggest that Korean Medicine may be an effective treatment for genital warts.

• 한국임상수의학회지
• /
• 제34권2호
• /
• pp.119-122
• /
• 2017

Calcinosis cutis is a chronic condition characterized by insoluble calcified deposits in the skin and subcutaneous tissue. Although there is no uniformly effective treatment for calcinosis cutis, minocycline therapy has demonstrated varying degrees of benefit in humans. Five client-owned dogs with calcinosis cutis were included. Minocycline was administered orally in a dose of 10 mg/kg bodyweight twice a day. Treatment was repeated every day until complete remission. The efficacy of minocycline was evaluated within this period. The side effects of minocycline were monitored and reported by the owners and veterinarians. Of the 5 dogs with calcinosis cutis, which was classified as the dystrophic form, four dogs had a complete remission of calcinosis cutis and one dog had a partial response. The major improvement was a reduction in the size of the calcified deposits and reduction in inflammation associated with them. The duration of remission was $9.1{\pm}2.2$ weeks. The adverse effects, observed in one dog, were anorexia and vomiting. Minocycline may be effective in the control of calcinosis cutis in dogs.

• 대한간학회지
• /
• 제24권4호
• /
• pp.424-429
• /
• 2018

Hepatocellular carcinoma (HCC) is the sixth most common cause of death worldwide and the main cause of primary liver cancer. The principle problem of HCC is the poor prognosis, since advanced HCC reportedly has a median survival of only 9 months. The standard therapies are sorafenib and regorafenib, but the outcomes remain unclear. We report a 60-year-old man with advanced HCC with right adrenal gland metastasis and portal vein tumor thrombosis, who showed a complete response to multiple applications of an interdisciplinary therapy.

• Nuclear Engineering and Technology
• /
• 제54권9호
• /
• pp.3488-3493
• /
• 2022

Accelerator driven subcritical systems have long been discussed as facilities which can be used for solving the nuclear waste problem. The physics of these systems is very different from conventional reactors and new techniques had to be developed for reactivity monitoring. One such technique is the Area Ratio Method which studies the response of a subcritical system upon insertion of a large number of neutron pulses. An issue associated with this technique is the spatial dependence of measured reactivity which is intrinsic to the sub criticality of the system since the reactor does not operate on the fundamental mode and measured reactivity depends on the detector position. This is generally addressed by defining Bell-Glasstone spatial correction factor. This factor upon multiplication with measured reactivity gives the correct reactivity which is independent of detector location. Monte Carlo Methods are used for evaluating these factors. This paper presents a complete three dimensional map of spatial correction factors for BRAHMMA subcritical system. In addition, the dataset obtained also helps in identifying detector locations where the correction factor is close to unity, thereby implying no correction if the detector is used at those locations.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권2호
• /
• pp.617-619
• /
• 2012

The aim of this study was to investigate the early outcome of the taxotere and cisplatin chemoradiotherapy for advanced cervical cancer. Fifty-six cases (FIGO II b to IVa) were divided randomly into two groups: radiotherapy alone (28 cases) and radiation plus chemotherapy (TP) group. There was no difference in radiotherapy between the two groups. The RT+C cases who received TP regimen during the radiation, and DDP once weekly injection of vain, according to 20$mg/m^2$ and taxotere once weekly iv according to 35 $mg/m^2$. These regimens were given for 4~5weeks, and some medicines to control vomiting were available for the RT+C cases. The two groups received an oral medicine MA 160mg every day during the treatment. Regarding early outcome, the complete remission rate was 64.3% and partial remission rate was 35.7% in RT+C. The complete remission rate was 32.1% and partial remission rate was 39.3% in RT. The total response rate and complete remission in the RT+C group were higher than that in the RT group. We conclude that taxotere and cisplatin chemoradiotherapy can improve the early outcome of the advanced cervical cancer, the adverse effects being endurable.