• 제목/요약/키워드: Complete response

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Waldeyer's Ring 비호치킨 림프종의 병합요법 (Combined Modality Therapy of Non-Hodgkin's Lymphoma of Waldeyer's Ring)

  • 박인규;윤상모;박준식;김재철
    • 대한두경부종양학회지
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    • 제15권1호
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    • pp.22-28
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    • 1999
  • Purpose: We performed this study retrospectively to evaluate local control, survival, prognostic factors, and failure patterns in patients with non-Hodgkin's lymphoma of Waldeyer's ring. Materials and Methods: From April 1984 to November 1996,41 patients with non-Hodgkin's lymphoma of Waldeyer's ring were treated with combined chemotherapy and radiation therapy. Age was ranged from 19 to 73 years old with a median age of 55 years, and there were 26 male and 15 female patients. Primary site was tonsil in 26 and base of the tongue in 7 and nasopharynx in 8, and stage distribution showed stage I in 12 and stage II in 29 patients. Pathologic classification was done according to Working Formulation. There were 1 with follicular mixed small cleaved and large cell, 8 with diffuse small cleaved cell, 7 with diffuse mixed small and large cell, and 25 cases with diffuse large cell. All patients were treated with combination of chemotherapy and radiation therapy. Chemotherapy regimen consisted of either CHOP-Bleo(cyclophosphamide, adriamycin, vincristine, prednisolone, bleomycin) or COP-BLAM III(cyclophosphamide, vincristine, prednisolone, bleomycin, adriamycin, procarbazine). Radiation dose ranged from 3600cGy to 6620cGy with a median dose of 5040cGy. Follow-up time was ranged from 15 months to 159 months(median 55 months). Results: The complete response was achieved in 98%(40/41) and partial response in 2%(1/41). The complete response rate were the followings: 66.7% for stage I and 51.7% for stage II after chemotherapy, 100% for stage I and 96.6% for stage II after overall treatment respectively. The overall survival rate and disease-tree survival rates at 5 years were 82.6% and 79.5%, respectively. Prognostic factors for overall survival were age(p=0.007), stage(p=0.03), nodal status(p=0.006) and radiation dose(p=0.003). The factors associated with disease-tree survival were stage(p=0.04), nodal status(p=0.004) and radiation dose(p=0.009). The failure patterns were analized in evaluable 35 patients with complete response. Locoregional failure was noted in 2 patients and distant metastasis in 5 patients. Conclusion: Our results suggest that combined modality therapy is the appropriate treatment for stage I-II intermediate grade non-hodgkin's lymphoma of the Waldeyer's ring. However, our material is small and the analysis is retrospective. Randomized prospective studies for combined therapy, radiation therapy alone and chemotherapy alone are needed.

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Scaling laws for vibration response of anti-symmetrically laminated plates

  • Singhatanadgid, Pairod;Ungbhakorn, Variddhi
    • Structural Engineering and Mechanics
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    • 제14권3호
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    • pp.345-364
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    • 2002
  • The scaling laws for vibration response of anti-symmetrically laminated plates are derived by applying the similitude transformation to the governing differential equations directly. With this approach, a closed-form solution of the governing equations is not required. This is a significant advantage over the method employed by other researchers where similitude transformation is applied to the closed-form solution. The scaling laws are tested by comparing the similitude fundamental frequencies to the theoretical fundamental frequencies determined from the available closed-form solutions. In case of complete similitude, similitude solutions from the scaling laws exactly agree with the theoretical solutions. Sometimes, it may not be feasible to select the model which obeys the similarity requirement completely, therefore partial similitude is theoretically investigated and approximate scaling laws are recommended. The distorted models in stacking sequences and laminated material properties demonstrate reasonable accuracy. On the contrary, a model with distortion in fiber angle is not recommended. The derived scaling laws are very useful to determine the vibration response of complex prototypes by performing the experiment on a model with required similarities.

Coupled buffeting response analysis of long-span bridges by the CQC approach

  • Ding, Quanshun;Chen, Airong;Xiang, Haifan
    • Structural Engineering and Mechanics
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    • 제14권5호
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    • pp.505-520
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    • 2002
  • Based on the modal coordinates of the structure, a finite-element and CQC (complete quadratic combination) method for analyzing the coupled buffeting response of long-span bridges is presented. The formulation of nodal equivalent aerodynamic buffeting forces is derived based on a reasonable assumption. The power spectral density and variance of nodal displacements and elemental internal forces of the bridge structure are computed using the finite-element method and the random vibration theory. The method presented is very efficient and can consider the arbitrary spectrum and spatial coherence of natural winds and the multimode and intermode effects on the buffeting responses of bridge structures. A coupled buffeting analysis of the Jiangyin Yangtse River Suspension Bridge with 1385 in main span is performed as an example. The results analyzed show that the multimode and intermode effects on the buffeting response of the bridge deck are quite remarkable.

Probabilistic shear-lag analysis of structures using Systematic RSM

  • Cheng, Jin;Cai, C.S.;Xiao, Ru-Cheng
    • Structural Engineering and Mechanics
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    • 제21권5호
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    • pp.507-518
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    • 2005
  • In the shear-lag analysis of structures deterministic procedure is insufficient to provide complete information. Probabilistic analysis is a holistic approach for analyzing shear-lag effects considering uncertainties in structural parameters. This paper proposes an efficient and accurate algorithm to analyze shear-lag effects of structures with parameter uncertainties. The proposed algorithm integrated the advantages of the response surface method (RSM), finite element method (FEM) and Monte Carlo simulation (MCS). Uncertainties in the structural parameters can be taken into account in this algorithm. The algorithm is verified using independently generated finite element data. The proposed algorithm is then used to analyze the shear-lag effects of a simply supported beam with parameter uncertainties. The results show that the proposed algorithm based on the central composite design is the most promising one in view of its accuracy and efficiency. Finally, a parametric study was conducted to investigate the effect of each of the random variables on the statistical moment of structural stress response.

Precise response time measurement and analysis of liquid crystal displays

  • Glinel, David;Boher, Pierre;Leroux, Thierry
    • 한국정보디스플레이학회:학술대회논문집
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    • 한국정보디스플레이학회 2006년도 6th International Meeting on Information Display
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    • pp.723-728
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    • 2006
  • In this paper, we present a new system, OPTISCOPE SA, especially designed for precise measurement of temporal behavior of LCD displays. We show that gray to gray level response time measurement requires a very sensitive and precise instrument and also that the capacity to measure luminance levels and gamma curve can be useful. Quite often, precise evaluation of LCD response time needs also use of low pass and stop band filters to suppress noise and flicker. Low pass filters affect the results but can be corrected for simple temporal behaviors. For complex temporal behaviors like those observed for overdriven LCDs, we show that direct adjustment of theoretical responses is much more efficient to get a complete picture of the temporal behavior of such displays.

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펄스응답 순환행렬의 특이치 분해를 이용한 강인한 차수감소 모델예측제어기의 설계 (Design of Robust Reduced-Order Model Predictive Control using Singular Value Decomposition of Pulse Response Circulant Matrix)

  • 김상훈;문혜진;이광순
    • 제어로봇시스템학회논문지
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    • 제4권4호
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    • pp.413-419
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    • 1998
  • A novel order-reduction technique for model predictive control(MPC) is proposed based on the singular value decomposition(SVD) of a pulse response circulant matrix(PRCM) of a concerned system. It is first investigated that the PRCM (in the limit) contains a complete information of the frequency response of a system and its SVD decomposes the information into the respective principal directions at each frequency. This enables us to isolate the significant modes of the system and to devise the proposed order-reduction technique. Though the primary purpose of the proposed technique is to diminish the required computation in MPC, the clear frequency decomposition of the SVD of the PRCM also enables us to improve the robustness through selective excitation of frequency modes. Performance of the proposed technique is illustrated through two numerical examples.

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단일추진제 추진시스템의 비정상 마찰을 고려한 과도기유체 해석 (A FLUID TRANSIENT ANALYSIS FOR THE PROPELLANT FLOW WITH AN UNSTEADY FRICTION IN A MONOPROPELLANT PROPULSION SYSTEM)

  • 채종원
    • 한국전산유체공학회지
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    • 제11권1호
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    • pp.43-51
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    • 2006
  • A fluid transient analysis on the Koreasat 1 & 2 pipeline system is conducted through numerical parametric studies in which unsteady friction results are compared with quasi-steady friction results and show relatively accurate prediction of the response curve with the unsteady friction. The code developed and used in this analysis has finished verification through comparing with the original Zielke model, the full and recursive convolution model and quasi-steady model as a reference. The unsteady friction is calculated by the recursive convolution Zielke model in which a complete evolution history of velocity field is no longer required so that it makes the fluid transient analysis on the complicated system possible. The results show that the application of quasi-steady friction to model cannot predict the entire response curve properly except the first peak amplitude but the application of unsteady friction to model can predict reasonably the response curve, therefore it is to know the characteristics of the propulsion system.

A fluid transient analysis for the propellant flow with an unsteady friction in a monopropellant propulsion system

  • Chae Jong-Won;Han Cho-Young
    • 한국전산유체공학회:학술대회논문집
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    • 한국전산유체공학회 2006년도 PARALLEL CFD 2006
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    • pp.320-323
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    • 2006
  • A fluid transient analysis on the Koreasat 1 & 2 pipeline system is conducted through numerical parametric studies in which unsteady friction results are compared with quasi-steady friction results and show relatively accurate prediction of the response curve with the unsteady friction. The code developed and used in this analysis has finished verification through comparing with the original Zielke model, the full and recursive convolution model and quasi-steady model as a reference. The unsteady friction is calculated by the recursive convolution Zielke model in which a complete evolution history of velocity field is no longer required so that it makes the fluid transient analysis on the complicated system possible. The results show that the application of quasi-steady friction to model cannot predict the entire response curve properly except the first peak amplitude but application of unsteady friction to model can predict reasonably he response curve, therefore it is to know the characteristics of the propulsion system.

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축소된 유한요소모델을 이용한 하드디스크 구동부의 고유치 및 주파수응답 해석 (Eigenvalue and Frequency Response Analyses of a Hard Disk Drive Actuator Using Reduced Finite Element Models)

  • 한정삼
    • 대한기계학회논문집A
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    • 제31권5호
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    • pp.541-549
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    • 2007
  • In the case of control for mechanical systems, it is highly useful to be able to provide a compact model of the mechanical system to control engineers using the smallest number of state variables, while still providing an accurate model. The reduced mechanical model can then be inserted into the complete system models and used for extended system-level dynamic simulation. In this paper, moment-matching based model order reductions (MOR) using Krylov subspaces, which reduce the number of degrees of freedom of an original finite element model via the Arnoldi process, are presented to study the eigenvalue and frequency response problems of a HDD actuator and suspension system.

Characterization of one Time-Sequential Stereoscopic 3D Display - Part I: Temporal Analysis -

  • Pierre, Boher;Thierry, Leroux;Collomb-Patton, Veronique
    • Journal of Information Display
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    • 제11권2호
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    • pp.57-62
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    • 2010
  • A method of characterizing time-sequential stereoscopic 3D displays based on the measurement of the temporal behavior of the systems vs. the grey levels is proposed. An Nvidia 3D vision kit with a 3D-ready SAMSUNG 2233RZ LCD display is characterized in the paper. OPTISCOPE SA especially designed for the precise measurements of the luminance and temporal behavior of LCD displays was used. The transmittance and response time of the shutter glasses was first evaluated. Then the grey-to-grey response times of the display were measured. The 2D and 3D behaviors of the display were then compared. Finally, the temporal behavior of the complete system was modeled, and the grey-level variations on one view were deduced as a function of the synchronization and level of the other eye. The main sources of imperfection were identified and quantified, and a full computation of the system performances was done.