• Title/Summary/Keyword: Competitively

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Inhibitory Effect of Phosphorylcholine on Photophosphorylation of Isolated Chloroplasts from Barley (Phosphorylcholine이 보리 엽록체의 광인산화활성에 미치는 저해효과에 대하여)

  • 유경희
    • Journal of Plant Biology
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    • v.29 no.3
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    • pp.157-165
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    • 1986
  • The onset of photophosphorylation at the various stages of greening showed different patterns with varying concentrations of Pi. With further greening, ATP formation occurred at the lower concentration of Pi (48 hrs; 0.05 mM). At early stages of greening, more Pi was required for photophosphorylation (6 hrs; 5.0 mM). The addition of cell-free extracts of etiolated barley seedlings resulted in the competitive inhibition of photophophorylation. The apparent inhibition by cell-free extracts were gradually decreased during greening of etiolated barley seedlings. We found that the inhibitors of photophosphorylation in cell-free extracts were some organic phosphates and most of them was P-choline. P-choline inhibited photophosphorylation competitively with Pi and its content was decreased considerably in greening. It is likely that P-choline partly delay the photophorylation in early stages of greening.

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Influence Maximization Scheme against Various Social Adversaries

  • Noh, Giseop;Oh, Hayoung;Lee, Jaehoon
    • Journal of information and communication convergence engineering
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    • v.16 no.4
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    • pp.213-220
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    • 2018
  • With the exponential developments of social network, their fundamental role as a medium to spread information, ideas, and influence has gained importance. It can be expressed by the relationships and interactions within a group of individuals. Therefore, some models and researches from various domains have been in response to the influence maximization problem for the effects of "word of mouth" of new products. For example, in reality, more than two related social groups such as commercial companies and service providers exist within the same market issue. Under such a scenario, they called social adversaries competitively try to occupy their market influence against each other. To address the influence maximization (IM) problem between them, we propose a novel IM problem for social adversarial players (IM-SA) which are exploiting the social network attributes to infer the unknown adversary's network configuration. We sophisticatedly define mathematical closed form to demonstrate that the proposed scheme can have a near-optimal solution for a player.

Mechanism of Electropolymerization of Pyrrole in Acidic Aqueous Solutions

  • Kim, Kang-Jin;Song, Hyung-Soo;Kim, Jin-Doo;Chon, Jung-Kyoon
    • Bulletin of the Korean Chemical Society
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    • v.9 no.4
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    • pp.248-251
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    • 1988
  • Mechanism of electrochemical polymerization of pyrrole (Py) on a Pt electrode in acidic aqueous solutions was studied by means of potentiostatic measurements, cyclic voltammetry and chronopotentiometry. Pyrrole molecule appeared to be initially oxidized via two-electron transfer step to produce oxidized pyrrole ion ($Py^+$), which was coupled with a non-oxidized pyrrole to yield a dimerized species, Py-Py. The Py-Py thus formed was further oxidized again via two-electron transfer step, which was followed by coupling with non-oxidized monomer and by concomitant expulsion of a $H^+$. Then the latter chain extension process was repeated. The chain extension and polypyrrole oxidation reactions occurred competitively.

Kinetics and Mechanism of the Hydrolysis of N-(Benzenesulfonyl) benzimidoyl Chlorides

  • Kim, Tae-Rin;Kwon, Hyo-Shik
    • Bulletin of the Korean Chemical Society
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    • v.9 no.3
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    • pp.157-160
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    • 1988
  • The rates of hydrolysis of N-(benzenesulfonyl) benzimidoyl chlorides (p-H, $p-CH_3,\;p-CH_3,\;p-NO_2\;and m-NO_2$) have been measured by UV spectrometry in 60% methanol-water at $25^{\circ}C$ and a rate equation which can be applied over wide pH range was obtained. Below pH 7.00, the substituent effect on the hydrolysis rate of N-(benzenesulfonyl) benzimidoyl chloride was found to conform to the Hammett ${\sigma}$ constant with ${\rho}$ = -0.91, whereas above pH 9.00, with ${\rho}$ = 0.94. On the basis of the rate equation obtained and the effect of solvent, substituents and salt, the following reaction mechanism were proposed; below pH 7.00, the hydrolysis of N-(benzenesulfonyl) benzimidoyl chloride proceeds by $S_N1$ mechanism, however, above pH 9.00, the hydrolysis is initiated by the attack of the hydroxide ion and in the range of pH 7.00-9.00, these two reactions occur competitively.

STATCOM Helps to Guarantee a Stable System

  • Andersen, B.R;Gemmell, B.D.;Horwill, C.;Hanson, D.J.
    • Journal of Power Electronics
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    • v.1 no.2
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    • pp.65-70
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    • 2001
  • Transmission System Operators are governed by operational security standards that are applied in real time. During system disturbances, the System Operators must rely on the installed protection and control equipment, prior to human intervention. New power electronic solutions bring rapid and repeatable responses to disturbances, which will help System Operators to guarantee a stable system. Last year, Alstom completed the world's first competitively bid STATCOM to support the voltage on National Grid's 400kV network that supplies London and the Southeast from the north of the UK. It is rated ${\pm}75MVAr$ and forms part of a Static Var System (SVS) with a total rating of 0 to 225MVAr. This paper will describe the reasons for its size, location, its chain-link configuration and give examples of its operating performance. The paper will also describe the features that allow this STATCOM to deliver much more than reactive compensation in support of a wider transmission service objective, as system conditions require.

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THE PRICE OF RISK IN CONSTRUCTION PROJECTS: CONTINGENCY APPROXIMATION MODEL (CAM)

  • S. Laryea;E. Badu;I. K. Dontwi
    • International conference on construction engineering and project management
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    • 2007.03a
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    • pp.106-118
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    • 2007
  • Little attention has been focussed on a precise definition and evaluation mechanism for project management risk specifically related to contractors. When bidding, contractors traditionally price risks using unsystematic approaches. The high business failure rate our industry records may indicate that the current unsystematic mechanisms contractors use for building up contingencies may be inadequate. The reluctance of some contractors to include a price for risk in their tenders when bidding for work competitively may also not be a useful approach. Here, instead, we first define the meaning of contractor contingency, and then we develop a facile quantitative technique that contractors can use to estimate a price for project risk. This model will help contractors analyse their exposure to project risks; and also help them express the risk in monetary terms for management action. When bidding for work, they can decide how to allocate contingencies strategically in a way that balances risk and reward.

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Volumetric 3D Display: Features and Classification

  • Joonku Hahn;Woonchan Moon;Hosung Jeon;Minwoo Jung;Seongju Lee;Gunhee Lee;Muhan Choi
    • Current Optics and Photonics
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    • v.7 no.6
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    • pp.597-607
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    • 2023
  • Volumetric 3D displays generate voxels to enable users to watch three-dimensional virtual objects from various angles, and they have a significant advantage over other types of 3D displays in terms of realism and the absence of vergence-accommodation conflict (VAC). By virtue of these advantages, various volumetric 3D display technologies incorporating novel approaches have been introduced competitively. As a result, the conventional classification criteria for volumetric 3D technology often fall short in categorizing these innovative methods. In this study, we present an improved classification framework capable of accommodating these new technologies. We expect that a new classification may offer some intuition to identify areas of technical deficiency and contribute to improving the technology.

Identification of Biologically Effect and Chemical Structure of Polyphenol Compounds from the Leaves of Korea Persimmon (Diospyrus kaki L. Folium) (한국산 감잎의 Polyphenol 화합물의 생리활성물질의 화학구조 및 효소저해효과)

  • An, Bong-Jeon;Choi, Hee-Jin;Son, Jun-Ho;Woo, Hee-Seob;Han, Ho-Suk;Park, Jung-Hye;Son, Gyu-Mok;Choi, Cheong
    • Journal of the Korean Society of Food Culture
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    • v.18 no.5
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    • pp.443-456
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    • 2003
  • The lyophilization of the solution extracted from 60 percent of acetone applied to persimmon leaves, the compounding process in accordance with the solution's concentration, and the gel filteration through Sephadex G-50 of biologically activated substances obstructing enzyme activity, such as tyrosinase, xanthine oxidase, and angiotesin converting enzyme (ACE) led to the assumption that polyphenol was the compound serving as biologically activated substances obstructing enzyme activity. Xanthine oxidase involved in pruine metabolism oxidizes hypoxanthine to xanthine and xanthine to uric acid. In the continuous study for natural compound, nine flavan-3-ols have been isolated from the persimmon leaves. The structures of (+)-catechin, (+)-gallocatechin, procyanidin B-1, pyrocyanidin C-1, prodelphinidin B-3, gallocatechin-$(4{\alpha}{\rightarrow}8)$-catechin, procyanidin B-7-3-O-gallate, procyanidin C-1-3'-3'-3'-O-trigallate and (-)-epigallocatechin-$(4{\alpha}{\rightarrow}8)$-epigallocatechin-$(4{\alpha}{\rightarrow}8)$-catechin were established by NMR and their inhibitory effect on xanthine oxidase activity was investigated. Procyanidin B-7-3-O-gallate, (-)-epigallocatechin-$(4{\alpha}{\rightarrow}8)$-epigallocatechin-$(4{\alpha}{\rightarrow}8)$-catechin and procyanidin C-1-3'-3'-3'-O-trigallate showed 94%, 90.69%, 80.90% inhibition at $100\;({\mu})M$ and inhibited on the angiotensin converting enzyme respectively. Procyanidin B-7-3-O-gallate and procyanidin C-1-3'-3'-3'-O-trigallate showed 66%, 63% inhibition at $100\;({\mu})M$ and inhibited on the xanthine oxidase competitively. Procyanidin C-1-3'-3'-3'-O-trigallate showed 70% inhibition at $100\;({\mu})M$ and inhibited on the tyrosinase competitively.

Inhibition of Human Neutrophil Elastase by Tetracyclines and Mechanism of the Inhibition (Tetracycline계 항균제에 의한 호중구 Elastase의 효소 활성도 억제 및 그 작용 기전)

  • Kim, Woo-Mi;Kang, Koo-Il
    • The Korean Journal of Pharmacology
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    • v.29 no.1
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    • pp.131-137
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    • 1993
  • Human neutrophil elastase (HNE, EC 3,4,21, 11), a mediator of tissue breakdown, was inhibited by tetracycline, oxytetracycline and demeclocycline. Among them, oxytetracycline showed the most potent inhibitory effect on the activity of HNE. IC50 of this drug at our specific condition was less than 1 mM. Tetracycline inhibited human neutrophil elastase non-competitively, and oxytetracycline inhibited competitively. Ki values of tetracycline and oxytetracycline were 4.9 mM and 0.39 mM, respectively. Structural modified tetracycline, de-dimethylaminotetracycline, which showed no antibiotic activity since the active dimethylamino radical was removed from the position #4 of the tetracycline, showed similar inhibition effect on the activity of human neutrophil elastase to that of tetracycline. Thus, we speculated that inhibition of human neutrophil elastase by tetracyclines was not depended on the dimethylamino radical which is a critical active site for antibiotic effect, rather it was depended on the hydoxyl radical of tetracyclines. Therefore, the property of inhibiting elastase may be an additional molecular biochemical mechanism of action of these drugs at the inflammatory sites.

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Drug Delivery into the Blood-Brain Barrier by Endogenous Substances-A Role of Amine and Monocarboxylic Acid Carrier Systems for the Drug Transport- (내인성물질의 수송계를 이용한 혈액-뇌관문에의 약물송달V-약물의 혈액-뇌관문 투과성에 대한 염기성 아민 및 모노카르본산 수송계의 역할-)

  • Kang, Young-Sook
    • Journal of Pharmaceutical Investigation
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    • v.20 no.4
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    • pp.223-228
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    • 1990
  • The contribution of endogenous transport systems to the blood-brain barrier (BBB) transport of basic and acidic drugs was studied by using a carotid injection technique in rats and an isolated bovine cerebrovascular disease state were compared between the normotensive rats (WKY) and stroke-prone spontaneously hypertensive rats (SHRSP) which have been well established as an animal model with pathogenic similarities to humans. Basic drugs such as eperisone, thiamine and scopolamine inhibited, in a concentration dependent manner the in vivo uptake of $[{^3}H]choline$ through BBB, whereas amino acids and acidic drugs such as salicylic acid and valproic acid did not inhibit the uptake. The uptake of $[^3H]choline$ by B-CAP increased with time and showed a remarkable temperature dependency. The uptake of $[^3H]choline$ by B-CAP showed the very similar inhibitory effects as observed in the in vivo brain uptake, and was competitively inhibited by a basic drug, eperisone. The in vivo BBB uptakes of $[^3H]acetic$ acid and $[^{14}C]salicylic$ acid were dependent on pH of the injectate and the concentration of drugs. Several acidic drugs such such as salicylic acid, benzoic acid and valproic acid inhibited the in vivo uptake of $[^3H]acetic$ acid, whereas amino acid, choline and a basic drug such as eperisone did not inhibit the uptake. The uptake of acetic acid by B-CAP was competitively inhibited by salicylic acid. The permeability surface area product (PS) through BBB for $[^3H]choline$ in SHRSP was significantly lower than that in WKY. The concentration of choline in the brain dialysate in SHRSP was about half of that in WKY, while no significant difference was observed in the plasma concentration of choline between SHRSP and WKY. No significant difference was observed in the transport of monocarboxylic acids, glucose and neutral amino acid through BBB between SHRSP and WKY. From these results, it was concluded that BBB transport system of choline contributes to the transport of basic drugs through BBB, that acidic drugs can be transported via a moncarboxylic acid BBB transport system and that the specific dysfuntion of the BBB choline transport in SHRSP was ascribed to the reduction of the maximum velocity of choline concentration in the brain interstitial fluids.

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