• Journal of Chest Surgery
• /
• 제18권1호
• /
• pp.111-121
• /
• 1985

A clinical analysis was performed on 312 cases of the chest trauma experienced at department of thoracic surgery, Chosun University Hospital during the past 6 years 10 months period from January 1978 to October 1984. 1. The ratio of male to female patient of the chest trauma was 3.1:1 in male predominance and age from 20 to 50 occupied 71.2% of the total cases. 2. The most common cause of the chest trauma was traffic accidents [45.5%] in this series. 244 cases [78.2%]were injured due to non-penetrating injuries and the remainders [68 cases, 21.8%] were injured due to penetrating injuries. 3. The frequently injured site of the chest trauma was left side of the chest [56.4%], the right side was 33% and the both side was 10.6%. 4. The most common symptoms were chest pain and dyspnea, and common signs were diminished breathing sound and subcutaneous emphysema. 5. The Hemothorax, Pneumothorax, Hemopneumothorax, and Hemopericardium were observed in 190 cases [60.9%] of the total cases, and etiologic distribution revealed 76.5% due to penetrating injuries and 56.6% due to non-penetrating injuries. 6. The rib fractures were observed in 210 cases [67.3%] of the total cases and the most common site of the rib fracture was 6th rib 140 cases [19.2%]. The common site of the rib fracture was from 4th rib to 7th rib [63.8%]. 7. The lung injuries were observed in 150 cases [48.1%] and the other organ injuries were observed in 260 cases [83.3%]. 8. Conservative treatment including thoracentesis were performed in 153 cases [49.1%], Closed thoracotomy with water seal drainage were performed in 112 cases [35.9%], and open thoracotomy were performed in 45 cases [14.4%]. 9. The complications of the chest trauma were developed in 63 cases [20.2%] and the common complications were atelectasis, wound infection and pneumonitis etc. 10. Overall mortality was 0.96% [3 cases] and the cause of death was bacteremia, hypovolemic shock, heart failure and pulmonary edema.

• 산업경영시스템학회지
• /
• 제16권27호
• /
• pp.11-19
• /
• 1993

본 논문에서는 여러 가지 형태의 고장을 갖는 동일한 두 요소로 구성된 병렬 시스템의 신뢰도를 평가하는 마코프 모형을 제시하였다. 여기서 고려하는 고장형태는 인간의 오류에 의한 고장, 하드웨어에 의한 고장, 하나의 원인에 의해서 여러개의 구성요소가 동시에 고장나는 Common cause 고장형태로 나누었다. 시스템은 임의의 시점에서 예방보수를 받을수 있고, 고장률과 예방 보수률은 일정하다고 가정했다. 또한 수리률이 임의의 분포를 따를 경우 시스템 신뢰도 및 평균 고장시간을 구했다.

• 산업공학
• /
• 제10권2호
• /
• pp.41-50
• /
• 1997

This paper considers the reliability computation of the network with dependent components and a software system is developed for supporting the reliability analysis and improvement of the system reliability. At first, We propose the common cause failure and load sharing models as the typical models considering the dynamic behaviors of networks with dependent components. Secondly, the algorithm is proposed to obtain the network reliability and reliability importance of component. The software, Delphi, is used to develop the our reliability analysis system.

• Clinical and Experimental Pediatrics
• /
• 제50권12호
• /
• pp.1180-1187
• /
• 2007

Systemic lupus erythematosus (SLE) is an episodic, multi-system, autoimmune disease characterized by widespread inflammation of blood vessels and connective tissues and by the presence of antinuclear antibodies (ANAs), especially antibodies to native (double-stranded) DNA (dsDNA). Its clinical manifestations are extremely variable, and its natural history is unpredictable. Untreated, SLE is often progressive and has a significant fatality rate. The most widely used criteria for the classification of SLE are those of the American College of Rheumatology (ACR), which were revised in 1982 and modified in 1997. The presence of four criteria have been diagnosed as a SLE. Rashes are common at onset and during active disease. The oral mucosa is the site of ulceration with SLE. Arthralgia and arthritis affect most children and these symptoms are short in duration and can be migratory. Lupus nephritis may be more frequent and of greater severity in children than in adults. The initial manifestation of nephritis is microscopic hematuria, followed by proteinuria. The most common neuropsychiatric symptoms are depression, psychosis(hallucination and paranoia) and headache. CNS disease is a major cause of morbidity and mortality. Pericarditis is the most common cardiac manifestation. Libman-Sacks endocarditis is less common in children. The most frequently described pleuropulmonary manifestations are pleural effusions, pleuritis, pneunonitis and pulmonary hemorrhage. During the active phase ESR, CRP, gamma globulin, ferritin and anti-dsDNA are elevated. Antibodies to dsDNA occur in children with active nephritis. Antibodies to the extractable nuclear antigens (Sm, Ro/SS-A, La/SS-B) are strongly associated with SLE. Specific treatment should be individualized and based on the severity of the disease. Sepsis has replaced renal failure as the most common cause of death.

• 한국콘텐츠학회논문지
• /
• 제17권7호
• /
• pp.265-275
• /
• 2017

본 연구는 장례식장에서 사망자를 위생적으로 관리하기 위해 사망의 장소, 종류 및 원인 등 사망자들의 유형에 따라 체액 분출 등 사후 어떤 변화가 있는지 알아보고자 하였다. 사망자 858명을 대상으로 조사한 결과 평균 연령은 68.6세이며, 주요 사망의 원인은 83.0%가 병사이며, 사망 장소는 79.5%가 의료기관에서 발생되었다. 사망자에서 발생되는 체액 분출율은 전체 사망자의 46.2%에서 조사되었고, 사망의 종류에 따라서는 사고사가 78.8%로 가장 높고, 노화사는 10.8%로 가장 낮았다. 사망의 장소에 따른 의료기관 사망자는 46.3%, 주택 사망자는 38.6%인데 반해 기타 장소는 77.4%로 높았다. 사망의 원인으로 직접, 중간 및 선행 사인이 기록된 사망자 수는 크게 다르지만 체액 분출 비율은 비슷하였다. 장기 및 계통별 사망자 수는 직접, 중간 및 선행 사인 모두 호흡기질환과 심장질환 사망자 수가 가장 많고, 체액 분출은 직접 사인은 간질환 사망자가 가장 높고 소화기 및 혈액순환계 순이며, 중간 및 선행 사인에서는 기타 및 사고사가 가장 높은 비율을 보였다. 사망의 원인에 기록된 질병을 기준으로 한 사망자 수는 직접 사인은 심폐부전이 96명으로 가장 많고 폐렴 및 패혈증 순이며, 체액 분출은 사망자 수가 15명 이상 기준으로 담관암(73.3%)이 가장 높고, 췌장암, 중증뇌손상 및 간암 순으로 많았다. 따라서 사망자의 위생적 관리를 위해서는 보다 정확한 질병명과 발병기간을 명시하도록 하여야 하고, 사망자 이송과정에서는 관련 정보가 문서화 되고 체계적인 전달 시스템이 될 수 있도록 제도화 하여야 할 것이다.

• Korean Circulation Journal
• /
• 제52권4호
• /
• pp.251-264
• /
• 2022

Heart failure with preserved ejection fraction (HFpEF) accounts for approximately half of all heart failure (HF) cases. The prevalence of HFpEF is increasing due to an aging population with hypertension, diabetes mellitus, and obesity. HFpEF remains a challenging clinical entity due to a lack of effective treatment options. Traditional HF medications have not been shown to reduce mortality of patients with HFpEF, and an implantable cardioverter-defibrillator is not indicated due to normal ejection fraction. Sudden death is the most common mode of death in patients with HFpEF; however, the underlying mechanisms of sudden death are not fully elucidated. Although ventricular arrhythmias are responsible for the majority of sudden deaths in general, their contribution to sudden deaths in HFpEF patients is likely less significant. The mechanisms of ventricular arrhythmias in HFpEF are 1) reduced conduction velocity due to ventricular hypertrophy, 2) delayed repolarization due to potassium current down-regulation, 3) calcium leakage due to altered excitation-contraction coupling, and 4) increased ventricular fibrosis caused by systemic inflammation. Hypertension and subsequent ventricular hypertrophy reduce the conduction velocity in HFpEF hearts via heterogeneous distribution of connexin 43. Delayed repolarization caused by potassium current down-regulation in HFpEF hearts provides a window for early afterdepolarization to trigger ventricular arrhythmias. Altered excitation-contraction coupling in HFpEF can cause calcium to leak and trigger delayed afterdepolarization. Increased systemic inflammation and subsequent ventricular fibrosis provide substrates for re-entry. Further research is warranted to investigate the detailed mechanisms of ventricular arrhythmias in HFpEF.

• Nuclear Engineering and Technology
• /
• 제55권12호
• /
• pp.4367-4381
• /
• 2023

Nuclear power plants are increasingly being equipped with digital I&C systems. Although some probabilistic safety assessment (PSA) models for the digital I&C of nuclear power plants have been constructed, there is currently no specific internationally agreed guidance for their modeling. This paper presents an initiative by the OECD Nuclear Energy Agency called "Digital I&C PSA - Comparative application of DIGital I&C Modelling Approaches for PSA (DIGMAP)", which aimed to advance the field towards practical and defendable modeling principles. The task, carried out in 2017-2021, used a simplified description of a plant focusing on the digital I&C systems important to safety, for which the participating organizations independently developed their own PSA models. Through comparison of the PSA models, sensitivity analyses as well as observations throughout the whole activity, both qualitative and quantitative lessons were learned. These include insights on failure behavior of digital I&C systems, experience from models with different levels of abstraction, benefits from benchmarking as well as major contributors to the core damage frequency and those with minor effect. The study also highlighted the challenges with modeling of large common cause component groups and the difficulties associated with estimation of key software and common cause failure parameters.

• 품질경영학회지
• /
• 제33권3호
• /
• pp.19-30
• /
• 2005

Recently many organization to become survival in changing marketplace, they must commit to implementing tools, systems, and quality management techniques. In this paper we develop process method of Team's problem-solving to reduce in failure costs. This paper suggest the step process how to measure quality cost reasonably that works in all types organizations. Or what is continuous improvement? Continuous improvement can be described as the continuous reduction of variation. Variation has many sources(machines, methods, materials, measurements, people, and environments) and cause(special & common in organization). As quality cost are not the answer to every organization financial, or quality-related problem, it's real results are designing & implementing quality cost system might be the answer.

• 의료법학
• /
• 제8권1호
• /
• pp.61-105
• /
• 2007

The Hospitalized Acquired Infection is defined as the case where the hidden infection or not found at the time of hospitalization occurs during the hospitalized period or, within 30 days to those who performed the surgery operation and then left the hospital. About 2/3 of the Hospitalized Acquired Infection are found as having the internal infection cases that are occurred by the patients' own virus due to the lowered immune system, while about 1/3 are found as having the external infection. The latter 1/3 of the external infection cases can be prevented through the infection management. And in case the new Hospitalized Acquired Infection case occur to the patient who was treated in the hospital, its responsibility issue will matter. As well in the disputes over the Hospitalized Acquired Infection cases, the cause-result relation between the damages and the medical staff's fault and as to whether there is failure of the medical staff or not. personnel should be proved in the medical-malpractice cases. In addition, the difficulties in proving such as expertise, secrecy propensity, discrete propensity and incompleteness will be considered to ease the burden of patient side's proving. Probability theory, Fact based assumption theory, Most adequate plaintiff preassumption or Expressed evidence theories are being discussed as the theories of eased burden of proof. In the result of gathering and reviewing Korea's precedent cases concerning the Hospitalized Acquired Infection, there are only a few accumulated prece dent cases and the attitude of the court also are also not consistent. Therefore, there are the precedents where the cause-result relation and the failure are immediately assumed when (1) timely proximity between the medical behavior and malpractice results, (2) proximity between the medical behavior-applied parts and the malpractice results-found parts, and (3) lack of other causes are separately evidenced; while the are the precedents only when 'the existence of the medical faults based on the common sense' is separately evidenced. It was found that the former and latter cases coexisted. The former is considered as based on the theory that separates the fault and cause-result relation not to consider them together, or regarded as based on the doubts that assumes the medical staff's neglect even though the Hospitalized Acquired Infection might be completely prevented by their efforts. However, the modern medical technology has the limitation as far as the prevention of the Hospitalized Acquired Infection. In conclusion, the assumption of the cause-result relation and that of the fault should be separately reviewed. Therefore, the latter precedents are considered as more reasonable, in the point the faulty behavior may be proved based on the common sense.

• Journal of Genetic Medicine
• /
• 제15권2호
• /
• pp.87-91
• /
• 2018

X-linked dominant mutations in lysosome-associated membrane protein 2 (LAMP2) gene have been shown to be the cause of Danon disease, which is a rare disease associated with clinical triad of cardiomyopathy, skeletal myopathy, and mental retardation. Cardiac involvement is a common manifestation and is the leading cause of death in Danon disease. We report a case of a 24-month-old boy with hemizygous LAMP2 mutation who presented with failure to thrive and early-onset hypertrophic cardiomyopathy. We applied targeted exome sequencing and found a novel hemizygous c.692del variant in exon 5 of the LAMP2 gene, resulting a frameshift mutation p.Thr231Ilefs*11. Our study indicates that target next-generation sequencing can be used as a fast and highly sensitive screening method for inherited cardiomyopathy.