• 융합경영연구
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• 제7권1호
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• pp.1-14
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• 2019

Purpose - Currently, the economic globalization has become a common channel for China's enterprise to perform the international economic activities. Due to this background, this paper tries to analyze the influence of internationalization level on operation performance of enterprises. Research design, data, and Methodology - This paper aims at 296 companies going listed in Shanghai Stock Exchange and Shenzhen Stock Exchange. The data about the listed companies during the 12 years from 2005 to 2016 have been collected. Relevant theories, including the theory of comparative advantage, monopolistic advantage and product life cycle in developed countries as well as the small scale technology and state on localized technological capacities in developing countries, have been summarized to provide theoretical basis for the influence of international operation on operation performance of the enterprises. Moreover, the current status of international operation of China's enterprises, including the dynamic cause of the internationalization of China's enterprises, its competitive advantage and disadvantage as well as the interest and potential risk of the internationalization, have been also analyzed. Results - Via adopting the panel data to conduct an empirical analysis, It can be found that the relationship between international operation level and operation performance of China's enterprises can be expressed as the S-curve of declining, rising and declining again. Conclusions - This paper has taken the lead in using Ohlson corporate value model to fill the gap in the relevant researches in China. It can also provide guidance for the international operation of China's enterprises. Meanwhile, the two systems for international operation and performance evaluation index have been put forward. The performance of international operation can be classified as financial performance or corporate value so that the operation effect of those China's enterprises going abroad can be better evaluated.

• 대한건축학회논문집:계획계
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• 제35권4호
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• pp.3-14
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• 2019

The purpose of this study is to analyze the distribution characteristics of the agency-managed shared housings in Seoul and draw the possible implications from it. The needed data for the study was obtained from an on-line shared housing portal service which provides housing information from various shared housing management agencies. By mapping out the locations and other related data into a GIS(Geographic Information System) program, this study shows that shared housings in Seoul can be sorted into four large clusters. Each cluster has a different ratio of housing types and room capacities reflecting each regional circumstance and common causes. Women-only shared housing takes up 79% of the overall shared housing ratio and, while multi-family housing type has the most count, the apartment type has a noticeably high ratio in women-only housing compared to the apartment type ratio among the other gender-specific housings. Given the high crime rate against the single-person household of young adult women, the reason for the popularity of shared-apartment housing among young women can be deduced. However, the potential tenants' practical choices and their concern for safety are not the only causes that drive the current shared housing market. The young adults in their 20's and 30's choose to live in popular places where they can engage social activities. A new tier of shared housing market has also appeared in places where young adults could not have afforded if they lived alone. Choosing where we live is no longer about just meeting the requirements for a house based on what she/he needs but also about satisfying the preferences for a living based on what she/he desires. This paper indicates that although there is an undeniable premise that 'sharing a house' revolves around the realm of housing welfare and is not a typical topic for the upper-income households, the way we live and how we choose our place to live is shifting.

• 한국정보통신학회논문지
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• 제23권11호
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• pp.1428-1433
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• 2019

국내 재난 사고의 기술동향 중 산악사고에 대한 관심 또한 지속적으로 증가 추세에 있다. 사고 발생 시 보편적인 방법으로는 스마트폰을 이용한 위치 추적 및 사고신고 등이며, 이를 이용하여 구조 활동을 진행 하고 있으나, 산악지역의 특성상 음영현상의 발생하는 구역에 대한 해결책이 요구되고 있는 실정이다. 이에 본 논문에서는 447 MHz 대역 FSK방식을 이용한 무선 통신 기반 산행 안전 휴대 시스템을 제시하였다. 447 MHz 대역 송·수신기를 이용하여 이상 현상 발생 시 위치 전송 및 구조 신호 전송을 통한 위치좌표 전송 및 데이터를 축적하며, 송신자가 설정된 구역범위의 임계치를 벗어날 경우 위험 경고 알림을 발생하여 위험지역을 신속히 벗어날 수 있는 서비스를 제공한다. 또한 송신자의 건강 상태를 지속적으로 체크하여, 지정된 임계치를 상위 할 경우 수신자에게 경고를 함으로, 송신자의 재난에 대응할 수 있을 것이라고 사료된다.

• Journal of Ginseng Research
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• 제45권2호
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• pp.273-286
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• 2021

Background: Prostate carcinoma is the second most common cancer among men worldwide. Developing new therapeutic approaches and diagnostic biomarkers for prostate cancer (PC) is a significant need. The Chinese herbal medicine Panax quinquefolius saponins (PQS) have been reported to show anti-tumor effects. We hypothesized that PQS exhibits anti-cancer activity in human PC cells and we aimed to search for novel biomarkers allowing early diagnosis of PC. Methods: We used the human PC cell line DU145 and the prostate epithelial cell line PNT2 to perform cell viability assays, flow cytometric analysis of the cell cycle, and FACS-based apoptosis assays. Microarray-based gene expression analysis was used to display specific gene expression patterns and to search for novel biomarkers. Western blot and quantitative real-time PCR were performed to demonstrate the expression levels of multiple cancer-related genes. Results: Our data showed that PQS inhibited the viability of DU145 cells and induced cell cycle arrest at the G1 phase. A significant decrease in DU145 cell invasion and migration were observed after 24 h treatment by PQS. PQS up-regulated the expression levels of p21, p53, TMEM79, ACOXL, ETV5, and SPINT1 while it down-regulated the expression levels of bcl2, STAT3, FANCD2, DRD2, and TMPRSS2. Conclusion: PQS promoted cells apoptosis and inhibited the proliferation of DU145 cells, which suggests that PQS may be effective for treating PC. TMEM79 and ACOXL were expressed significantly higher in PNT2 than in DU145 cells and could be novel biomarker candidates for PC diagnosis.

• 한국콘텐츠학회논문지
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• 제21권5호
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• pp.581-591
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• 2021

본 연구는 대규모 협동조합형 임대주택의 입주예정자가 느끼는 공동체 의식과 공동체 프로그램의 요구를 파악하여 대규모 협동조합형 임대주택의 건축계획방향을 설정하는데 목적이 있다. 이를 위하여 위스테이별내 모델하우스 방문자와 입주예정자를 대상으로 설문조사를 실시하였다. 분석결과, 모델하우스 방문자는 20대와 30대가 가장 많았으나, 입주예정자는 30대가 가장 많았다. 모델하우스 방문자 대부분은 현재 공동체 활동에 참여하지 않으나, 입주예정자는 주1회 정도 이웃과 교류하기를 원하고 있었다. 입주예정자들은 운동시설과 육아관련 시설에 대한 요구가 높았으며, 생활협동조합 및 아이돌봄 서비스에 대한 요구가 가장 많았다. 다만, 연령별로 요구하는 이웃의 범위, 만남정도, 공동시설 및 요구 프로그램이 달랐다. 본 연구는 방문자와 입주예정자가 동일한 설문을 실시하지 않은 점, 수도권에 한정된 하나의 사례만을 분석한 점이 한계이며, 입주 후의 공동체 의식과 운영 중인 공동체 프로그램 등에 대한 추가적인 연구가 필요하다.

• Journal of Microbiology and Biotechnology
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• 제32권1호
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• pp.15-26
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• 2022

Luteolin is a common dietary flavone possessing potent anti-inflammatory activities. However, when administrated in vivo, luteolin becomes methylated by catechol-O-methyltransferases (COMT) owing to the catechol ring in the chemical structure, which largely diminishes its anti-inflammatory effect. In this study, we made a modification on luteolin, named LUA, which was generated by the chemical reaction between luteolin and 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH). Without a catechol ring in the chemical structure, this new flavone could escape from the COMT-catalyzed methylation, thus affording the potential to exert its functions in the original form when administrated in the organism. Moreover, an LPS-stimulated RAW cell model was applied to detect the anti-inflammatory properties. LUA showed much more superior inhibitory effect on LPS-induced production of NO than diosmetin (a major methylated form of luteolin) and significantly suppressed upregulation of iNOS and COX-2 in macrophages. LUA treatment dramatically reduced LPS-stimulated reactive oxygen species (ROS) and mRNA levels of pro-inflammatory mediators such as IL-1β, IL-6, IL-8 and IFN-β. Furthermore, LUA significantly reduced the phosphorylation of JNK and p38 without affecting that of ERK. LUA also inhibited the activation of NF-κB through suppression of p65 phosphorylation and nuclear translocation.

• International Journal of Computer Science & Network Security
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• 제22권2호
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• pp.63-74
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• 2022

Repressive measures in the Crimea against the Ukrainian media and the ban on the entry of international and Ukrainian monitoring missions created the conditions for the function of providing information to be performed by representatives of civil society. Such a phenomenon was called Crimean citizen journalism and became a post-occupation phenomenon characteristic of the Crimean information sphere. The journalists' activities are aimed at reporting on human rights violations and repression against Ukrainian citizens who find themselves in conditions of information bans and restrictions. Crimean citizen journalism, which connects the peninsula with the mainland of Ukraine, is monothematic in nature, and its emergence has become a form of nonviolent resistance to the occupation of Crimea. The purpose of the study is to cover the characteristic features, the development of common Crimean citizen journalistic movement features as a social phenomenon, a phenomenon that arose after the occupation through the identification of a modern journalist portrait. The study uses the general scientific method of empirical research as the main one, the sociological method of a questionnaire survey, as well as the methods of classification, generalisation, observation, statistical calculation. An analysis of a survey of Crimean citizen journalists demonstrates the existence of an active, mobile community in Crimea that seeks to provide information and human rights nonviolent resistance to the occupation.

• 한국엔터테인먼트산업학회논문지
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• 제15권2호
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• pp.47-57
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• 2021

본 연구의 목적은 코로나 19의 타의적인 상황으로 인간관계 및 소통이 단절되어 버린 상황에 대처하기 위한 새로운 소통방법으로서 연구자가 전통적인 한지 재료를 이용하여 소통과 관계를 목적으로 창작한 작품에 대한 해석을 통해 언택트 시대에 소통을 위한 함의가 무엇인지를 알아보고자 함에 있다. 본 연구는 연구자의 경험, 지식, 직관적인 통찰을 통해 계랑화가 어려운 연구자의 동기, 의도, 의미에 대한 심층적 해석방법을 사용했다. 한국의 전통미를 대표하는 한지 재료를 이용하여 인관관계와 소통을 목적으로 창작 전시했던 작품과 해석을 통한 함의는 다음과 같다. 첫째, 코로나 19와 같은 언택트 시대의 한계 상황 극복을 통해 인간관계와 소통을 위해 전통 재료를 활용하는 창작 활동은 상호 이해하기와 의미 찾기에 도움이 된다. 둘째, 동일한 민족과 언어, 공간에서 사람들 간의 관계 형성과 소통을 위한 전통 재료의 활용 방안은 공동인식을 형성하는 매개체가 될 수 있다. 본 연구 결과는 재난재해 상황에서 발생하는 인간관계와 소통에 대한 연구에서 기초자료로 활용과 확대를 위한 동기를 제공할 것이다.

• Journal of Microbiology and Biotechnology
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• 제32권7호
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• pp.877-884
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• 2022

Probiotics are microorganisms that can benefit host health when ingested in a live state, and lactic acid bacteria are the most common type. Among fungi, Saccharomyces boulardii (SB) is the only strain known to have a probiotic function with beneficial effects on colitis; however, information on other probiotic yeast strains is limited. Therefore, this study aimed to discover yeast strains expressing intestinal anti-inflammatory activities by exhibiting probiotic properties in dextran sodium sulfate (DSS)-induced colitis mice model. Nuruk (Korean traditional fermentation starter) containing various microbial strains was used as a source for yeast strains, and S. cerevisiae 28-7 (SC28-7) strain was selected with in vitro and in vivo characteristics to enable survival in the intestines. After 14 days of pretreatment with the yeast strains, DSS was co-administered for six days to induce colitis in mice. The results revealed that the disease activity index score was lowered by SC28-7 treatment compared to the DSS group, and the colon length and weight/length ratio were recovered in a pattern similar to that of the normal group. SC28-7 administration significantly reduced the secretion of pro-inflammatory cytokines in the serum and modified the mRNA expression of inflammatory cytokines (interleukin-1β, transforming growth factor-β, and interferon-γ) and proteins involved in gut barrier functions (mucin 2, mucin 3, zonula occludens-1, and occludin) in colon tissues. These results indicate that SC28-7 attenuates DSS-induced colon damage and inflammation, supporting its future use as a probiotic yeast for treating and preventing intestinal inflammatory diseases such as inflammatory bowel disease.

• 한국콘텐츠학회논문지
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• 제22권3호
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• pp.296-308
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• 2022

코로나-19 사태에서 60세 이상 노인들은 우울, 불안,공포 등 다양한 심리건강 문제가 생겼고, 커뮤니티는 노인 활동의 유일한 공간이 되었다. 이를 위해 본 연구는 이론적 고찰, FGI 인터뷰와 계층 분석법 AHP를 활용하여 치유적 고령친화 커뮤니티 환경디자인 평가체계를 제시하였다. 평가체계는 3차원 공간, 10개 상위 계층과 68개 하위 계층이다. 또한 전문가 설문조사와 SPSS 프로그램 분석를 통해 평가체계의 각 지표의 가중치를 배분하였다. 첫째, 물질 공간 환경디자인은 노인들의 일상생활에 대한 공용공간 활동시 쾌적성과 건강성을 충족시켜야 한다. 둘째, 사회적 공간환경 디자인은 노인들의 교류와 사회적 연계를 촉진한다는 취지로 디자인을 한다. 셋째, 운영 공간 환경디자인은 커뮤니티 운영회사의 운영체제를 중요하게 고려하고 있다. 이를 통해 노인의 주거환경 발전을 위한 체계적인 기술적 근거와 행동지침을 제공하여 고령자 심리의 건강 향상을 기대해 본다.