• BMB Reports
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• 제53권5호
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• pp.254-259
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• 2020

Increasing evidence suggests the role of miR-449a in the regulation of tumorigenesis and autophagy. Autophagy plays an important role in the malignancy of T-cell lymphoma. However, it is still unknown whether miR-449a is associated with autophagy to regulate the malignancy of T-cell lymp homa. In this study, we for the first time demonstrated that miR-449a enhanced apoptosis of T-cell lymphoma cells by decreasing the degree of autophagy. Further, miR-449a downregulated autophagy-associated 4B (ATG4B) expression, which subsequently reduced the autophagy of T-cell lymphoma cells. Mechanistically, miR-449a decreased ATG4B protein level by binding to its mRNA 3'UTR, thus reducing the mRNA stability. In addition, studies with nude mice showed that miR-449a significantly inhibited lymphoma characteristics in vivo. In conclusion, our results demonstrated that the "miR-449a/ATG4B/autophagy" pathway played a vital role in the malignancy of T-cell lymphoma, suggesting a novel therapeutic target.

• 문화기술의 융합
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• 제9권5호
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• pp.409-413
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• 2023

오늘날 군은 조직구성원의 특성변화에 맞추어 조직 효과성을 달성하기 위해 많은 노력을 하고 있다. 현재 한국군에서 행동으로 움직이는 여단급 이하 조직구성원은 우리가 흔히 이야기하는 MZ세대가 주축을 이루고 있다. 이와 같은 MZ세대는 개인의 만족과 가치관을 중요시하는 특성으로 타인이 자신의 취향과 의견을 인정해 주지 않으면 공정하지 않다고 생각한다. 따라서 군에서도 이와 같은 조직구성원들의 특성에 맞추어 다양한 지휘 방법과 조직문화를 개선할 필요가 있다. 본 연구에서는 군사 선진국인 독일군의 임무형 지휘의 특성 및 핵심요소를 분석하였으며 이러한 독일군의 사례를 고찰하여 우리나라 군 조직의 주축인 MZ세대의 관점에서 군 조직 실정에 맞는 '임무형 지휘' 시스템을 도입해야 할 것이다.

• Journal of Advanced Marine Engineering and Technology
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• 제25권1호
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• pp.199-208
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• 2001

In this paper, an automatic route tracking algorithm using the position variables and the yaw angle of a ship is suggested, Since most autopilot systems paly only a role of course-keeping by integrating the gyrocompass output, they cannot cope with position errors between the desired route and real route of the ship resulted from a drifting and disturbances such as wave, wind and currents during navigation. In order for autopilot systems to track the desired route, a method which can reduce such position errors is required and some algorithms have been proposed[1,2]While such were turned out effective methods, they have a shortage that the rudder control actions for reducing the position errors are occurred very frequently. In order to improve this problem it is necessary to convert that error into the corresponding yaw angle and necessary to treat only yaw angle control problem. To do this a command generation algorithm which converts the rudder angle command reducing the current position error into they yaw angle command is suggested. To control the ship under disturbances and nonlinearities of the ship dynamics, the adaptive fuzzy controller is developed. Finally, through computer simulations for two ship models, the effectiveness of the suggested method and the possibility of the automatic route tracking are assured.

• 제어로봇시스템학회논문지
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• 제10권9호
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• pp.809-815
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• 2004

Researches on mobile robots have been mainly focused on the autonomous navigation and a lot of interesting results have been published so far. Most of applications are, however, fancy, unpractical, and very expensive to be used for 'UN-expensive' purpose. Well-known soccer robot may be an example of unpractical application. Un-autonomous mobile robot has, however, potential for a lot of practical applications. Especially, tele-operation of the un-autonomous mobile robot may the central issue of research. Major research topics for the tele-operated un-autonomous mobile robot include development of a force reflecting joystick for tele-operation and development of a sophisticated algorithm for smooth tele-operation. A new concept named fuzzy command smoothing algorithm is proposed in this paper in order to provide smooth motion to a tele-operated mobile robot. It gives smooth motion command to the mobile robot from possibly abrupt quick turn motion command of the joystick using fuzzy logic. Simulation results verify the usefulness of the proposed algorithm.

• 한국독어학회지:독어학
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• 제4집
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• pp.81-107
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• 2001

Ziel dieser Arbeit ist es, die Probleme der semantischen Interpretationen der heutigen deutschen Anaphern im $oberfl\"{a}chenstrukturell$ einfachen Satz mit Hilfe von Langackers 'C-Command' und Chomskys 'Government and Binding Theorie' zu $l\"{o}sen$. Bis Anfang der 70er Jahren wurden die koreferentiellen Erscheinungen zwischen NPs meist durch den von Langacker eingefuhrten 'precede and command' Begriff $gel\"{o}st$. Aber dieser Begriff ist $h\"{o}chst\;abitr\"{a}r$ auf theoretischen $Gr\"{u}nden$ und empirisch $inad\"{a}quat$. Reinhart versuchte, einige Schwierigkeiten mit Bezug auf Koreferenz-Beziehungen zwischen NPs zu $l\"{o}sen$, indem er command durch c-command ersetzte. Mit Hilfe von 'c-command'-Relationen werden manche Probleme, die bisher theoretisch nicht $erkl\"{a}rt$ werden konnten, befriedigend $gel\"{o}st$. Chomsky schlagt 'Binding Conditions' vor, um die semantischen Interpretationen der Anaphern im einfachen Satz zu behandeln. Die von ihm vorgeschlagenen 3 Bedingungen sind: (i) Eine Anapher $mu\ss$ in ihrer 'governing' Kategorie gebunden sein, (ii) Eine pronominale NP $mu\ss$ in ihrer 'governing' Kategorie frei sein, (iii) Eine lexikalische NP $mu{\ss}\;\"{u}berall$ frei sein. Dabei versteht man Anapher unter Reflexivpronomen, die pronominale NP unter Personalpronomen, und die lexikalische NP unter Referenz- Ausdruck. Aber in der vorliegenden Arbeit fassen ein Reflexivpronomen und ein Personalpronomen zu einer Anapher zusammen. Aufgrund der 'Binding Conditions' werden viele Fragen der semantischen Interpretationen, vor allem der komplementaren Verteilungen von den im einafchen Satz erscheinenden Anaphern erschlossen.

• 한국화재소방학회논문지
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• 제33권3호
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• pp.128-137
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• 2019

본 연구의 목적은 대형재난이 발생할 때 효과적인 재난대응을 위하여 긴급구조통제단의 운영 개선방안을 제시하는 데 있다. 연구의 결과 긴급구조통제단 운영 개선방안에 대한 인식에 영향을 미치는 정도에 유의수준 5%에서 유의미한 변수는 운영예산 확보, 유관기관 협력, 재난자원 지원, 전문가 양성이 긴급구조통제단 운영에 영향력이 있는 변수로 나타났다. 변수의 상대적 영향력을 보면 전문가 양성, 유관기관 협력, 재난자원 지원, 운영예산 확보의 순으로 긴급구조통제단 운영에 유의미한 영향력이 있는 변수로 나타났다.

• 한국산업융합학회 논문집
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• 제17권4호
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• pp.217-226
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• 2014

Since the world has changed to a society of 21st century high-tech industries, the modern people have become reluctant to work in a difficult and dirty environment. Therefore, unmanned technologies through robots are being demanded. Now days, effects such as voice, control, obstacle avoidance are being suggested, and especially, voice recognition technique that enables convenient interaction between human and machines is very important. In this study, in order to conduct study on the stable motion control of the robot system that has mobile-manipulator structure and is voice command-based, kinetic interpretation and dynamic modeling of two-armed manipulator and three-wheel mobile robot were conducted. In addition, autonomous driving of three-wheel mobile robot and motion control system of two-armed manipulator were designed, and combined robot control through voice command was conducted. For the performance experiment method, driving control and simulation mock experiment of manipulator that has two-armed structure was conducted, and for experiment of combined robot motion control which is voice command-based, through driving control, motion control of two-armed manipulator, and combined control based on voice command, experiment on stable motion control of voice command-based robot system that has mobile-manipulator structure was verified.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제10권5호
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• pp.2267-2285
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• 2016

Information Centric Networking that uses content name instead of IP address as routing identifier can handle challenges such as traffic explosion and user mobility, but it also suffers from scalability and incompatibility problems. In this paper by combining the concept of software defined networking and Internet end to end arguments, we propose a wide area deployable software defined information centric networking service model named SD-ICN. SD-ICN employs a dual space structure that separates edge service network and core transmission network. The enhanced SDN techniques are used in edge service network in order to implement intelligent data routing and caching, while traditional IP technique is reserved in core transmission network so as to provide wide area high speed data transmission. Besides, a distributed name resolution system based on the cooperation of different controllers is also presented. The prototype experiments in our campus network show that SD-ICN can be deployed in a scalable and incremental way with no modification of the core network, and can support typical communication modes such as multicast, mobility, multihoming, load balancing, and multipath data transmission effectively.

• 한국인터넷방송통신학회논문지
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• 제15권3호
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• pp.125-130
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• 2015

본 논문에서는 네트워크에뮬레이터를 활용한 지휘통제시스템의 시험환경 구성, 결과 및 설계반영사항에 대해 다룬다. 정보통신기술의 발달에 의한 정보교환능력과 연산능력의 강화는 네트워크중심전이라는 개념을 가져오게 되었는데, 네트워크중심전에서 무기체계사용자가 빠른 상황판단을 내려 적합한 명령을 내릴 수 있게 지원하는 것이 지휘통제 체계이다. 본문에서는 소프트웨어 기반 네트워크 에뮬레이터중 하나인 dummynet을 활용한 시험환경 구축을 설명하고, 개발된 지휘통제시스템의 운용개념을 요약하였다. 더 나아가 시험 케이스 및 결과에 대해 설명하고, 목표 통신망에서의 제약사항을 극복할 운용개념을 제시하였다. 제안한 방식을 활용하면 항적메시지와 같이 여러 단말기가 같은 데이터를 빠른 주기로 공유할 때 유통 데이터를 크게 감소시킬 것으로 기대된다.

• 융합보안논문지
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• 제20권1호
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• pp.69-75
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• 2020

지휘통제체계는 인간의 두뇌와 신경 조직처럼 정보·감시·정찰(ISR)에서 정밀타격체계(PGR)를 연결하는 링커이며 전투력의 중심이다. 미래 한국군의 지휘통제체계 구축시 기술적 문제뿐만 아니라 제도적 문제를 함께 고려해야 한다. 미국 국방부는 지휘 통제체계 개발에 앞서 보안 정책을 수립하고 이를 구체화하여 아키텍처 문서로 정리하며, 이를 토대로 보안 정책의 일관성과 지속을 유지한다. 본 논문에서는 미군의 지휘통제체계 구축시 적용하는 보안 아키텍처를 살펴보고 현행 한국군의 보안 관련 정책(규정)을 분석하여 미래 지휘통제체계 구축 시 보안 요구사항을 식별한다. 식별된 보안 요구사항을 그룹핑하여 현행 보안 관련 규정의 분야별 개선사항을 도출하여 제시하고자 한다.