• Radiation Oncology Journal
• /
• 제7권1호
• /
• pp.1-13
• /
• 1989

Effects of ionizing radiation alone and combined with chemotherapy on tumor growth and it's clonal specificity monitored by changes in distribution of chromosome number were studies in A549 ceil line originated from human adenocarcinoma of the lung. Radiation (300 rad, 600 rad and 900 rad) were delivered with or without 5-FU. Forty eight hours later, 57.5% of growth inhibition of cell w8s seen in cells treated with 5-FU concentration of $0.4{\mu}g/ml$ for 24hr exposure. Cell survival curves after radiation with and without 5-FU were made. Chromosomal analysis of cells in metaphase in control, and in cells treated with 300 rad of radiation, or $0.4{\mu}g/ml$ of 5-FU treatment, and combined treatment of both were done to examine the changes in ploidy and number of chromosome. Radiation combined with S-FU enhanced growth inhibition of A549 cells. However, no evidence of synergegic effects in growth. inhibition was observed in the cells treated with the combination therapy. Pattern of chromosomal distribution of survived cells were shifted from hyperploidy to hypoploidy by single dose of radiation (300 rad). As radiation dose increased a large number of hypoploidy cells were observed. Following treatment of cells with 5-FU, chomosomal distribution of survived cells were also shifted to hypodiploidy which were seen in cells treated with radiation, The ceil treated with 5-FU and fellowed by radiation within 24 hrs had cell with increased number of hypodiploidy cells. Almost same type of chromosomal changes were reproduced in cells treated with combined treatment with radiation and 5-FU. Minor differences were that cells with fewer number of chromosome were more frequent in cells treated with combined therapy. Further increase in cells of hypoploidy (93%) having 1-10 chromosome were induced by additional radiation. Therefore, the enhanced therapeutic effect of 5-FU combined with radiation of A549 cells appeared to be additive rather than synergistic.

• 대한기계학회논문집A
• /
• 제34권11호
• /
• pp.1587-1592
• /
• 2010

복합하중 하에서의 샌드위치 시편내의 응력분포에 시편의 형상과 하중조건이 미치는 영향을 수치해석을 통하여 고찰하였다. 상용 유한요소해석 프로그램인 NASTRAN 을 사용하여 세 종류의 형상계수를 가지는 시편들에 대하여 평면변형률, 2 차원 해석을 수행하였으며, 각각의 시편에 대하여 각각 다른 복합변위각을 가지는 네 종류의 복합변위를 적용하였다. 수치해석의 결과는 복합변위각이, 즉 전단변위의 수직변위에 대한 상대적인 크기가, 응력 불균일분포영역의 크기에 미치는 영향이 전단응력과 폰 미세스(von Mises)응력의 경우에만 나타나고 수직응력의 경우에는 나타나지 않음을 보여준다. 또한 복합변위각이 증가함에 따라 전단응력의 불균일분포영역의 크기는 감소함에 비해서 폰 미세스 응력의 불균일분포영역의 크기는 증가한다. 추가로, 형상계수가 증가함에 따라, 즉, 시편의 길이의 높이에 대한 상대적 크기가 커질수록, 복합변위 하에서의 응력 불균일분포영역의 크기는 현격하게 감소한다.

• 대한물리의학회지
• /
• 제18권3호
• /
• pp.39-45
• /
• 2023

PURPOSE: This study aimed to provide the basic data necessary for rehabilitation by identifying the effects of complex balance exercises combined with self-observation training on balance and gait improvement in stroke patients. METHODS: This study assigned 20 people randomly into two groups: the control and experimental groups. The experimental group (10 subjects) underwent self-observation training-combined complex balance exercise. The control group (10 subjects) underwent complex balance exercises. A pretest of the balance ability and walking ability of both groups was performed. The interventions were conducted for 30 minutes three times a week for four weeks, and post-tests were conducted four weeks after all interventions were completed. RESULTS: There was a significant difference between the experimental and control groups according to the increase in Berg Balance Sale within the group and a statistically significant difference by a decrease in 10MWT (p < .01). On the other hand, there was a significant difference only in the change in Berg Balance Sale between the two groups (p < .05). CONCLUSION: Combined balance exercise combined with self-observation training and combined balance exercise alone positively affected the Berg Balance Sale and 10MWT in both groups. On the other hand, in the results between groups, there was a statistically significant difference in Berg Balance Sale in complex balance exercise combined with self-observation training. Therefore, self-observation training should be used for the rapid social rehabilitation of stroke patients.

• 생명과학회지
• /
• 제16권7호
• /
• pp.1214-1218
• /
• 2006

페놀성 화합물들의 병용투여가 rat의 진정효과에 미치는 영향을 조사하였다. 천마성분으로서 positive GABAergic neuromodulation을 보이는 4-hydroxy-3-methoxybenzaldehyde와 강력한 항산화물질인 2,3-dihydroxlrbenzaldehyde를 동량 투여한 결과, pentyleneterazole에 의해 유발된 사망률이 유의하게 감소되었으며 pentobarbital에 의해 유도된 수면시간은 유의하게 연장되었으나 항불안효과와 근육이완효과는 나타나지 않았다. 이러한 결과로 보아 항경련효과를 가진 화합물과 항산화 효과를 가진 화합물을 병용투여 함으로서 경련이나 불면 등의 신경증상을 효과적으로 억제할 수 있을 것으로 사료된다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권9호
• /
• pp.4019-4023
• /
• 2014

Metformin has been shown to be useful in reducing insulin resistance by restoring sensitivity. Recent evidence suggests that metformin might also possess anti-tumour activity. This study aimed to investigate the effects of cisplatin combined with metformin on the proliferation, invasion and migration of HNE1/DDP human nasopharyngeal carcinoma (NPC) cells, and to provide a new target for treating metastasis. The MTT assay was used to assess viability of HNE1/DDP cells after exposure to different concentrations of 2, 5-diaminopyrimidine-4, 6-diol (DDP; 2, 4, 8, 16, and $32{\mu}mol{\cdot}L^{-1}$), metformin (5, 10, 15, 20, and $25{\mu}mol{\cdot}L^{-1}$), and $4{\mu}mol{\cdot}L^{-1}$ of DDP combined with metformin. Wound healing and transwell migration assays were performed to assess cell migration and invasion, and expression of E-cadherin and MMP-9 was detected using Western blotting. MTT assay results showed that DDP could inhibit the proliferation of HNE1/DDP cells in a time- and concentration-dependent manner, with an IC50 of $32.0{\mu}mol{\cdot}L^{-1}$ at 24 h (P < 0.05), whereas low concentrations of DDP had almost no inhibitory effects on cell invasion and migration. DDP combined with metformin significantly inhibited cell invasion and migration. In addition, genes related to migration and invasion, such as those of E-cadherin and MMP-9, showed differential expression in the NPC cell line HNE1/DDP. In the present study, with an increasing concentration of metformin, the expression of MMP-9 was downregulated whereas that of E-cadherin was significantly upregulated. Taken together, our results show that cisplatin combined with metformin has effects on proliferation, invasion, and migration of human NPC cells.

• Journal of Acupuncture Research
• /
• 제24권1호
• /
• pp.179-193
• /
• 2007

Objectives: It has been demonstrated that acupuncture treats diseases while that the widespread use of that clinically and experimentally. It also has shown that electro-acupuncture(EA) is more effective than manual-acupuncture (MA). The purpose of this study was to investigate effect of EA and MA at combined acupoints on sex and age in rats. Methods: This study measured the effects of acupuncture treatment on small intestinal motility in rats. MA and EA(intensity, 5 times muscle twitch threshold) was applied for 30 minutes to the combined left and right sides acupoints on ST36, ST37, ST39 under enflurane anesthesia. EA and MA applied to the ST36, ST37, ST39 acupoints produced an elevation of small intestinal motility. Results: In experimental groups of combined left and right sides acupoints, only specified groups show elevation of small intestinal motility in male rats, 5 weeks age. Furthermore, combined left and right sides acupoints in EA and MA show differences effects according to the sex, male and female, and the age as 5, 6, 7, 8 weeks. Conclusion : Although these different according to the sex and age in rats do not have a established tendency, the present study suggest that effect of EA and MA are experimentally dependent upon the sex and age on small intestinal motility in rats.

• 동의생리병리학회지
• /
• 제19권5호
• /
• pp.1238-1242
• /
• 2005

Shangwan(CV13), Zhongwan(CV12), Xiawan(CV10), Hefu(L14) and Taichong(LR3) which belong to Conception Vessel and stomach meridian are acupuncture points frequently used for healing gastrointestinal desease in oriental medicine. The present study was conducted to see the effects produced by combined acupuncture(A), electro-acupuncture(EA) and moxibustion using five acupoints which belongs to different meridians on serum gastrin level in rats. Electro-acupuncture (2 Hz, intensity; 10 times muscle twitch threshold) was applied for 30 minutes to Hefu(LI4), Taichong(LR3) under halothane anesthesia. Moxibustion ($1.6{\pm}0.3\;mg$, 5 times of a day) was applied during 3 days to CV10, CV12, CV13 under halothane anesthesia. Combined stimuli of acupuncture at Hefu(LI4), Taichong(LR3) and moxibustion at CV13, CV12 increased serum gastrin level significantly eventough combined simulus of moxibustion on CV 10 was not shown any change. And combined stimul of EA and moxibustion at experimental all groups were not shown any effects. These data suggest that effects of acupuncture and moxibustion are depentent with used acupoints and combination stimuli method.

• 한방재활의학과학회지
• /
• 제21권4호
• /
• pp.191-203
• /
• 2011

Objectives: The purpose of this study is to investigate the clinical effects of heating-conduction therapy on lateral ligament injury induced by ankle sprain grade II. Methods: The 67 outpatients who were diagnosed as ankle sprain grade II were performed heating-conduction acupuncture therapy on lateral ligament injury. To evaluate the efficiency of heating-conduction acupuncture therapy, pain threshold with pressure algometer and visual analogue scale(VAS) were applied pretreatment and after 1st, 2nd treatment. Results: 1. The pain threshold and VAS score after 1st and 2nd treatment with an isolated injury of the anterior talofibular ligament showed statistically significant improvement compared with pretreatment. 2. The VAS score after 1st and 2nd treatment with an combined injury to the anterior talofibular and the calcaneofibular ligament showed statistically significant improvement compared with pretreatment. 3. The VAS score after 1st and 2nd treatment with an combined injury to the anterior talofibular, calcaneofibular and posterior talofibular ligament showed statistically significant improvement compared with pretreatment. 4. After 1st and 2nd treatment on the posterior talofibular ligament and after 2nd treatment on the anterior taofibular and calcaneofibular ligament with an combined injury to the anterior talofibular, calcaneofibular and posterior talofibular ligament the pain threshold showed statistically significant improvement compared with pretreatment. 5. Between isolated injury and combined injury of lateral ligament, the difference in pain threshold and VAS score was not statistically significant. Conclusions: Heating-conduction acupuncture therapy has clinical effects of pain reduction on patient with an isolated injury and combined injury of lateral ligament induced by ankle sprain grade II.

• 한국해양공학회지
• /
• 제3권2호
• /
• pp.577-577
• /
• 1989

In this paper, a detail evaluation of ultimate strength of offshore unstiffened tubular members with bending and local denting damage which are subjected to combined axial force and bending moment and to component load is presented through theoretical and experimental approaches. Based upon the results obtained here, the damage effect on the ultimate strength of tubular member under combined loads and component load is investigated.

• 한국해양공학회지
• /
• 제3권2호
• /
• pp.77-86
• /
• 1989

In this paper, a detail evaluation of ultimate strength of offshore unstiffened tubular members with bending and local denting damage which are subjected to combined axial force and bending moment and to component load is presented through theoretical and experimental approaches. Based upon the results obtained here, the damage effect on the ultimate strength of tubular member under combined loads and component load is investigated.