• 한국과학교육학회지
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• 제14권3호
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• pp.312-320
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• 1994

The purpose of this study is to analyze the relationship of logical thinking skills and integrated process skills, and to investigate the differences in general tendency of subskills by grade level and gender between Korean middle school students and Japanese one. The performance level of skills was measured using GALT and TIPS II. The results are compared with those of Japan (Mattheis et al., 1992). Summary of the results are as follow. 1. Percentages of formal and transitional stage of males are more than females in developmental level. It has been found out that the males attained significantly higher scores of logical thinking skills than the females in middle school stage. The significant differences in scores by gender show a good correlation with those for Japanese middle school students. Developmental level of Korean middle school students shows a remarkable improvement as they move up from 8th grade to 9 one. The significant differences in developmental level by grade also show a good correlation with those for Japanese middle school students. Total scores of GALT for Japanese middle school students are higher than Korean one, but it has been found nearly same scores for 9th grade in both countries. Scores of subskills of logical thinking skills, except correlational reasoning, for Korean students show lower than those for Japanese students. It could be noted that the combinatorial reasoning is considered to be easiest and the correlational reasoning to be most difficult in both countries. 2. It also has been found out similar pattern for integrated process skills in both countries because the males and females did not examplify significant differences, although males gain somewhat higher scores than females in Korea. Scores of subskills of integrated process skills for Japanese middle school students show higher them Korean one. It could be noted that the identifying variables is considered to be easiest and stating hypothesis to be most difficult in both countries. 3. There was a significant relationship (r= .65) between logical thinking skills and integrated process skills, and there were statistically significant differences of the integrated process skills for developmental level. In integrated process skills, the students who belong to the higher grade levels acquired better score than who belong to the lower grade level. It has been also found remarkable improvement between 8th and 9th grade, and there are significant differences for grade level in both countries.

• Biomolecules & Therapeutics
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• 제18권1호
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• pp.39-47
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• 2010

Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor involved in neuronal differentiation, plasticity, survival and regeneration. BDNF draws massive attention mainly due to the potential as a therapeutic target in neurological diseases such as depression and Alzheimer's disease. In a primary screening for the natural compounds enhancing BDNF release from cultured rat primary cortical neuron, we found that compounds such as baicalein, tanshinone IIa, cinnamic acid, epiberberine, genistein and wogonin among many others increased BDNF release. All the compounds at $0.1{\mu}M$ of concentration barely showed stimulatory effect on BDNF induction, however, their combination (mixture 1; baicalein, tanshinone IIa and cinnamic acid, mixture 2; epiberberine, genistein and wogonin) showed synergistic increase in BDNF release as well as mRNA and protein expression. The level of BDNF expression was comparable to the maximum BDNF stimulation attainable by a positive control oroxylin A ($20{\mu}M$) without cell toxicity as determined by MTT analysis. Both mixtures synergistically increased the phosphorylation of extracellular signal-regulated kinase (ERK) as well as cAMP response element binding protein (CREB), an immediate and essential regulator of BDNF expression. Similar to these results, mixture of these compounds synergistically inhibited the up-regulation of inducible nitric oxide synthase (iNOS) induced by lipopolysaccharide treatments in rat primary astrocytes. These results suggest that the combinatorial treatment of natural compounds in lower concentration might be a useful strategy to obtain sufficient BDNF stimulation in neurological disease condition such as depression, while minimizing potential side effects and toxicity of higher concentration of a single compound.

• 컴퓨터교육학회논문지
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• 제13권2호
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• pp.1-14
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• 2010

지금까지의 정보 교과에서의 논리적 사고력 향상에 관한 연구는 대부분 일반적인 논리적 사고력 검사지를 바탕으로 이루어졌으며, 프로그래밍 학습 결과를 통한 논리적 사고력의 향상에 한정되어 있다. 본 연구에서는 일반적인 논리적 사고력의 특성 및 타 교과에서 논리적 사고력의 특성과 달리 정보 교과의 문제 해결 과정에서의 논리적 사고력의 조작적 정의를 제시하였다. 먼저, 정보 교과의 문제 해결 과정에서 요구되는 논리적 사고력의 구성요소를 선정하고, 각각에 대한 조작적 정의를 개방형식의 전문가 설문과 연구자 숙의 과정을 통하여 제시하였다. 또한, 각각의 조작적 정의를 바탕으로 중등 정보 교과 '문제 해결 방법과 절차' 영역의 내용요소와 연관성을 제시하고, 그에 따른 평가 문항을 개발하였다. 연구 결과, 정보 교과의 문제해결과정에서 요구되는 논리적 사고력의 구성요소는 서열화 논리, 명제 논리, 상관 논리, 변인 통제 논리, 조합 논리, 비례 논리이며, 조작적 정의와 정보교과 내용요소를 바탕으로 논리적 사고력 평가문항을 개발하여 그 실효성을 알아보았다. 본 연구 결과는 정보 교과의 논리적 사고력 신장을 위한 교수학습방법과 평가 방안의 가이드라인을 제공하는 데에서 의의를 찾을 수 있을 것이다.

• Genomics & Informatics
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• 제5권1호
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• pp.10-18
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• 2007

Numerous studies have reported that genes with similar expression patterns are co-regulated. From gene expression data, we have assumed that genes having similar expression pattern would share similar transcription factor binding sites (TFBSs). These function as the binding regions for transcription factors (TFs) and thereby regulate gene expression. In this context, various analysis tools have been developed. However, they have shortcomings in the combined analysis of expression patterns and significant TFBSs and in the functional analysis of target genes of significantly overrepresented putative regulators. In this study, we present a web-based A Functional Clustering Analysis Tool for Predicted Transcription Regulatory Elements and Gene Ontology Terms (FCAnalyzer). This system integrates microarray clustering data with similar expression patterns, and TFBS data in each cluster. FCAnalyzer is designed to perform two independent clustering procedures. The first process clusters gene expression profiles using the K-means clustering method, and the second process clusters predicted TFBSs in the upstream region of previously clustered genes using the hierarchical biclustering method for simultaneous grouping of genes and samples. This system offers retrieved information for predicted TFBSs in each cluster using $Match^{TM}$ in the TRANSFAC database. We used gene ontology term analysis for functional annotation of genes in the same cluster. We also provide the user with a combinatorial TFBS analysis of TFBS pairs. The enrichment of TFBS analysis and GO term analysis is statistically by the calculation of P values based on Fisher’s exact test, hypergeometric distribution and Bonferroni correction. FCAnalyzer is a web-based, user-friendly functional clustering analysis system that facilitates the transcriptional regulatory analysis of co-expressed genes. This system presents the analyses of clustered genes, significant TFBSs, significantly enriched TFBS combinations, their target genes and TFBS-TF pairs.

• 한국정보과학회논문지:시스템및이론
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• 제26권9호
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• pp.1166-1176
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• 1999

연속 매체, 특히 비디오 데이타에 대한 일반 사용자 연산에는 재생뿐만 아니라 임의 속도 탐색 연산, 정지 연산, 그리고 그 외 다양한 연산이 있다. 이 연산 중에서 원하는 화면을 빨리 찾는 데에 유용한 고속 전진(FF: fast-forward)과 고속 후진(FB: fast-backward)은 재생 연산과는 달리 비순차적인 디스크 접근을 요구한다. 이러한 경우에 디스크 부하가 균등하지 않으면 일부 디스크에 접근이 편중되어 서비스 품질이 떨어진다. 본 논문에서는 디스크 배열을 이용한 저장 시스템에서 디스크 접근을 고르게 분산시키기 위하여 '소수 라운드 로빈(PRR: Prime Round Robin)' 방식으로 연속 매체를 디스크에 배치하는 기법에서 문제가 됐던 낭비된 디스크 저장 공간을 신뢰도 향상을 위해서 사용하는 '그룹화된 패리티를 갖는 소수 라운드 로빈(PRRgp: PRR with Grouped Parities)' 방식을 제안한다. 이 기법은 PRR 기법처럼 임의 속도 검색 연산에 있어서 디스크 배열을 구성하는 모든 디스크의 부하를 균등하게 할뿐만 아니라 낭비됐던 디스크 저장 공간에 신뢰도를 높이기 위한 패리티 정보를 저장함으로서 신뢰도를 향상시킬 수 있다. 신뢰도 모델링 방법으로 조합 모델과 마르코프 모델을 이용해서 결함발생율과 결함복구율을 고려한 신뢰도를 산출하고 비교.분석한다. PRR 기법으로 연속 매체를 저장하고 낭비되는 공간에 패리티 정보를 저장할 경우에 동시에 두 개 이상의 결함 발생 시에 그 결함으로부터 복구가 불가능하지만 PRRgp 기법에서는 약 30% 이상의경우에 대해서 동시에 두 개의 결함 발생 시에 저장한 패리티 정보를 이용한 복구가 가능할 뿐만 아니라 패리티 그룹의 수가 두 개 이상인 경우에는 두 개 이상의 결함에 대해서도 복구가 가능하다.Abstract End-user operations on continuous media (say video data) consist of arbitrary-rate search, pause, and others as well as normal-rate play. FF(fast-forward) / FB(fast-backward) among those operations are desirable to find out the scene of interest but they require non-sequential access of disks. When accesses are clustered to several disks without considering load balance, high quality services in playback may not be available. In this paper, we propose a new disk placement scheme, called PRRgp(Prime Round Robin with Grouped Parities), with enhanced reliability by using the wasted disk storage space in an old one(PRR: Prime Round Robin), in which continuous media are placed on a disk array based storage systems to distribute disk accesses uniformly. The PRRgp can not only achieve load balance of disks consisting of a disk array under arbitrary-rate search like PRR, but also improve reliability by storing parity information on the wasted disk space appropriately. We use combinatorial and Markov models to evaluate the reliability for a disk array and to analyze the results. When continuous media like PRR are placed and parity information on the wasted disk space is stored, we cannot tolerate more than two simultaneous faults. But they can be recovered by using stored parity information for about 30 percent as a whole in case of PRRgp presented in this paper. In addition, more than two faults can be tolerated in case there are more than two parity groups.

• 영재교육연구
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• 제5권2호
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• pp.139-156
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• 1995

The purpose of the study is to examine the effects of Gifted Education Isnstitute of Korea (GEIK) programs for gifted children especially in the areas of reasoning skills and creativity, thereby proving the effectiveness of the program. The subjects are 136 (103 boys and 33 girls) fourth, fifth, and sixth grade gifted children, who have participated in GEIK programs for more than six moths. They were stratified by the length of participation in GEIK programs. Ninety four children have participated for more than one year. Forty-two children have participated for less than one year. Both groups are rather homogeneous in IQ scores and school achievement levels at the time of enterance into GEIK programs. Both a Group Assessment of Logical Thinking (GAIT) and a Creativity test were used for the study on reasoning skills and creativity. GALT, developed by V. Roadranka, R. H. Yeany and M. J. Padilla in 1983, consists of 12 questions. It is classified into six subscales: conservation, proportional reasoning, controlling variables, provability reasoning, correlational reasoning, and combinatorial reasoning. The reliability of this test is .85. This test recommends to classify the stages of child development as follows according to the total test score. 0-4 point: Concrete Stage, 5-7 points: Transitional Stage, and 8 and above points: Formal stage. The Creativity Test was developed by Y. Lee and W. Chung (1971). It consists of four components: fluency, flexibility, originality, and openness. Only both fluency and openness were used in this study. In order to analyze data, T-Test, Intercorrelational Analyses, ANOVA, and Nultiple Regression were used. Followings are the results deduced from the above analoyses of the data. First, 43.48% of the subjects were on Concrete Stage, 36.78% were on the Transitional Stage, and 19.86% were on the Formal Stage in the developmental level classified by Piaget. Second, the students who have participated in GEIK programs more than one year acquired significantly higher score in GALT than the students who have participated in GEIK programs less than one year. Third, boys showed higher score in GALT than girls did. Fourth, there were statistically significant intercorrelations between six subscales of GALT. Fifth, the students who have participated in GEIK programs more than one year acquired significantly higher score in openness of creativity test than the students who have participated in GEIK programs less than one year. There were no significant differences in openness of creativity test between boys and girls. Sixth, the students who have participated in GEIK programs more than one year acquired significantly higher score in fluency of creativity test than the students who have participated in GEIK programs less than one year. Girls showed higher score in fluency of creativity test than boys did. Seventh, the students who acquired higher score in GALT showed higher score in both openness and fluency of creativity test. Followings are the conclusions deduced form the above results. First, the developmental level of reasoning skills of the fourth grade students participationg in GEIK programs is the same as that of 7th grade of normal Korean students and the same as those of 10th grade of U.S.A. and Philipoine students. Second, the GEIK programs are effective in improving reasoning skills. Third, the GEIK programs are effective in improving creativity. Fouth, reasoning skills and creativity can be improved by well planned programs. In conclusion, this study suggests that beyond reasoning skills and creativity, other areas such as areas in science skills, mathmatical skills, or verbal skills, etc., should be studied in the future.

• 대한교통학회지
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• 제23권3호
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• pp.35-47
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• 2005

버스 대중교통은 정해진 노선, 운행시간표에 의해 정류장을 경유하여 운행하므로 버스 노선망 설계 문제(BTRNDP: Bus Transit Route Network Design Problem)는 승용차위주의 가로망 설계 문제와 다른 접근방법이 요구된다. 버스 노선망 설계 문제의 적용모형은 설계방법의 역사적발전과정에 따라 매뉴얼 및 지침, 시장분석기법, 시스템해석모형, 휴리스틱모형, 하이브리드모형, 경험기반모형, 시뮬레이션모형, 수리최적화모형 등 크게 8가지 분류할 수 있다. BTRNDP는 이용자비용과 운영자비용의 조합인 총비용을 최소화하는 목적함수를 획득하기 위한 일련의 현실적 제약조건하에서 버스노선집합과 배차횟수를 결정하는 문제이다. BTRNDP는 조합최적화문제로 일반적 수리최적화문제로 가능해 공간을 정의하는 것이 어렵기 때문에 모든 가능해로 구성된 큰 탐색공간으로부터 최적해를 탐색해야하는 NP-Hard라는 특성을 가진다. BTRNDP의 목적함수는 이용자와 운영자관점을 모두 고려한 다목적함수(Multi-Objective Function)를 이용하며 수요는 고정수요를 이용하였으나 최근에는 가변수요를 고려한 방법론이 연구되고 있다. 해알고리즘으로 최적 버스 노선망을 구성하게 될 모든 가능한 후보노선집합(Candidate Route Set)을 생성하고 노선집합의 최적조합을 찾는 메타휴리스틱(Meta-heuristic) 알고리즘을 이용하여 전역최적 노선집합을 찾는 방법이 적용되고 있다. 최적 버스 노선망의 배차횟수를 결정하기 위해서 대중교통 통행배분모형이 필요한데 BTRNDP에 적용되는 통행배분모형은 다중경로 통행배분모형이 주로 활용되었다. 국내외 BTRNDP를 고찰한 결과 주요 시사점으로는 BTRNDP에서 가장 중요한 고려사항은 세분화된 버스정류장 기반 기종점통행량 구축, 버스 노선망 평가 모형 및 대중교통 통행 배분모형의 개발, 탐색 해알고리즘의 개발 등의 향후 연구내용이 포함될 수 있다.

• 대한화학회지
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• 제46권4호
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• pp.336-345
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• 2002

본 연구에서는 조합화학을 이용하여 $CaO-Gd_2O_3-Al_2O_3$계에서 $Eu^{3+}$와 $Tb^{3+}$활성 적색 및 녹색 PDP용 형광체를 탐색하였으며 탐색된 형광체의 합성온도, 최적조성,발광 특성 등을 조사하였다. $CaO-Gd_2O_3-Al_2O_3$의 삼성분계의 형광특성 라이브러리를 작성하기 위하여 210개의 다른 조성을 가진 시료를 고분자 착체 중합법으로 합성하였다. 합성된 형광체 분말을 VUV PL로 측정하여 형광 특성 라이브러리를 작성하였고 발광특성이 잘 나타난 시료를 XPD를 이용하여 결정 구조를 확인하였다. 적색 형광체로서 탐색된 $Ca_{\alpha}$G$d_{0.95-\alpha-\beta}$$Al_\beta$$O_\delta$ : Eu(0.02< $\alpha+\beta$ <0.04)형광체는 색순도 면에서 상용형광체보다 개선된 특성을 보였으며 녹색 형광체로서 탐색된 $CaGdAl_3O_7$ : Tb, Ca$Al_{12}$$O_{19}$ : Tb, $Gd_4Al_2$$O_9$ : Tb, $Gd_3Al_5$$O_{12}$ : Tb 형광체 중에서 $CaGdAl_3O_7$ : Tb, Ca$Al_{12}$$O_{19}$ : Tb형광체는 상용 형광체에 비해 잔광시간이 짧은 특성을 보였다

• 대한한의학회지
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• 제28권1호통권69호
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• pp.224-236
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• 2007

Background : Chunghyul-dan is a combinatorial herbal medicine; previous studies reported it had therapeutic effects for microangiopathy, a major part in the progression of small vessel disease, as well as having anti-hypertensive, anti-hyperlipidemic, anti-apoptotic, anti-oxidative, and anti-inflammatory activities. Therefor, we examined the inhibitory effect of Chunghyul-dan on stroke recurrence in patients with small vessel disease. Methods : We prescribed Chunghyul-dan at 600 mg a day to patients with small vessel disease, and monitored stroke recurrence, drug compliances, and adverse effect for 1 year. We then performed follow-up brain MRI to find new vascular lesions after 1 year of Chunghyul-dan medication. For the subjects lost to follow-up, we assessed their prognosis after 1 year by telephone. Results : There were 73 subjects treated with Chunghyul-dan for 1 year; new vascular events were found in 3. Of the 85 subjects lost to follow-up, fifty four could be contacted, and eight of them had stroke recurrence. One year of Chunghyul-dan medication reduced the odds ratio of stroke recurrence by 75% compared to the subjects lost to follow-up and the rate increased to 88%, when adjusted for other relevant risk factors for stroke recurrence. These reductions were much higher than those of aspirin and other kinds of conventional anti-platelets. There was no adverse effect in any of the study subjects. Conclusions : We suggest Chunghyul-dan could be useful for inhibition of stroke recurrence. Further study with a randomized controlled trial is needed to confirm this suggestion.

• Animal cells and systems
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• 제14권4호
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• pp.275-282
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• 2010

Chunghyul-dan (CHD) is a combinatorial drug known to exert anti-inflammatory effects in endothelial cells. In this study, we employed global transcriptional profiling using cDNA microarrays to identify molecular mechanisms responsible for the anti-inflammatory activity of CHD in endothelial cells. An analysis of the microarray data revealed that transcript levels of monocyte chemotactic protein-1 (MCP-1), vascular cell-adhesion molecule-1 (VCAM-1) and activated leukocyte cell-adhesion molecule were dramatically altered in CHD-treated endothelial cells. These changes in gene expression were confirmed by RT-PCR, Western blotting and ELISA. Chronic CHD treatment also appeared to decrease MCP-1 secretion, probably as a result of decreased MCP-1 expression. In addition, we determined that chronic CHD treatment inhibited lipopolysaccharide-stimulated adhesion of THP-1 leukocytes to endothelial cells. The inhibitory effect of CHD on LPS-stimulated adhesion resulted from downregulation of VCAM-1 expression. Transmigration of THP-1 leukocytes through endothelial cells was also inhibited by chronic CHD treatment. In conclusion, CHD controls a variety of inflammatory activities by regulating MCP-1 and VCAM-1 gene expression.