• Korean Journal of Clinical Pharmacy
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• v.30 no.1
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• pp.1-10
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• 2020

Objective: The aim of the study was to perform a meta-analysis of randomized clinical trials to compare the clinical efficacy and safety between combination of cyclin-dependent kinase (CDK) 4/6 inhibitors with aromatase inhibitors (AIs) and AIs alone in patients with hormone receptor+/human epidermal growth factor receptor type2-(HR+/HER2-) advanced breast cancer. Methods: Published clinical studies were identified through electronic database searches until February 2019. Literature qualities were assessed by the Scottish Intercollegiate Guidelines Network Checklist. Key endpoints of efficacy were progression-free survival (PFS), objective response rate (ORR), and clinical benefit (CB). Endpoints of safety were adverse events (AEs) (neutropenia, leukopenia, any grade 3/4 AEs, and serious AEs) and on-treatment death. Meta-analysis was performed using the RevMan 5.3 software. Results: The selected five studies were evaluated as "good" in quality assessment. Compared to AIs alone, the combination therapy significantly improved PFS (pooled hazard ratio=0.55; 95% confidence interval (CI) 0.49-0.62), ORR (odds ratio=1.78; 95% CI=1.49-2.13), and CB (odds ratio=1.86; 95% CI=1.51-2.28). The prevalence of AEs was significantly higher in the combination group than in the AIs alone group. On-treatment death was greater in the combination group than in the AIs alone group, although insignificant. Conclusion: The combination therapy of CDK4/6 inhibitors with AIs was more effective for the treatment of HR+/HER2- advanced breast cancer, but less safe than AIs alone. The combination therapy should be effectively managed through patient monitoring, and further studies are needed to reduce AEs in the combination therapy of CDK4/6 inhibitors with AIs.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2014.05a
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• pp.270-271
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• 2014

In this study, a replacement ratio of blast furnace slag coarse aggregate and a water binder ratio by an optimum combination of PHC file was investigated. As a results, the target strength 78.5MPa was altogether satisfied in a mix proportion 28-G100-SG0 and W/B ratio 26 %. The surface rupture was generated in 28-G0-SG100 combination after curing with the autoclave. According to the result of measuring the ingredient, the majority were the MgOH2 hydrate.

• Journal of Distribution Science
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• v.12 no.3
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• pp.33-41
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• 2014

Purpose - The purpose of this study was to predict the selection of independent auditors in the companies listed on the Tehran Stock Exchange (TSE) using a combination of PSO algorithm and CART. This study involves applied research. Design, approach and methodology - The population consisted of all the companies listed on TSE during the period 2005-2010, and the sample included 576 data specimens from 95 companies during six consecutive years. The independent variables in the study were the financial ratios of the sample companies, which were analyzed using two data mining techniques, namely, PSO algorithm and CART. Results - The results of this study showed that among the analyzed variables, total assets, current assets, audit fee, working capital, current ratio, debt ratio, solvency ratio, turnover, and capital were predictors of independent auditor selection. Conclusion - The current study is practically the first to focus on this topic in the specific context of Iran. In this regard, the study may be valuable for application in developing countries.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2017.05a
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• pp.88-89
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• 2017

Due to the increase in the usage of explosive materials and terrorism, the interest towards the superior explosion protective HPFRCC has risen. In existing research, the optimum ratio for solving the problematic problems such as the optimum fiber incorporation rate and the self-shrinkage crack of HPFRCC had been derived. However, there had been few or even no research upon how effective HPFRCC would perform protective explosion-proof in actual explosion. Therefore, this research compared the explosion-proof performance of HPFRCC according to fiber commination and mixing ratio. As a result, the combination of steel fiber and organic fiber showed excellent flow and strength, and it also improved the explosion resistance.

• The Transactions of the Korean Institute of Electrical Engineers P
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• v.59 no.3
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• pp.330-334
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• 2010

We tried to combine a transformer with a superconducting element and investigated the current limiting characteristics. When a superconducting element was connected to third winding of the transformer, the fault current was limited to about 90 % effectively. The fault current and consumption power were able to be controlled by the turn's ratio of secondary and third windings. It gives flexibility of the rating of a transformer in the power grid. As a result, power burden of a superconducting element was reduced by the decrease of turn's ratio in third winding of a transformer. It was because the voltage behavior of a superconducting element was dependent on turn's ratio of a transformer while the current characteristic was independent.

• Biomolecules & Therapeutics
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• v.20 no.1
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• pp.62-67
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• 2012

TNF-related apoptosis-inducing ligand (TRAIL) is a promising agent for management of cancer because of its selective cytotoxicity to cancer cells. However, some cancer cells have resistance to TRAIL. Accordingly, novel treatment strategies are required to overcome TRAIL resistance. Here, we examined the synergistic apoptotic effect of apigenin in combination with TRAIL in Huh-7 cells. We found that combined treatment of TRAIL and apigenin markedly inhibited Huh-7 cell growth compared to either agent alone by inducing apoptosis. Combined treatment with apigenin and TRAIL induced chromatin condensation and the cleavage of poly (ADP-ribose) polymerase (PARP). In addition, enhanced apoptosis by TRAIL/apigenin combination was quantified by annexin V/PI flow cytometry analysis. Western blot analysis suggested that apigenin sensitizes cells to TRAIL-induced apoptosis by activating both intrinsic and extrinsic apoptotic pathway-related caspases. The augmented apoptotic effect by TRAIL/apigenin combination was accompanied by triggering mitochondria-dependent signaling pathway, as indicated by Bax/Bcl-2 ratio up-regulation. Our results demonstrate that combination of TRAIL and apigenin facilitates apoptosis in Huh-7 cells.

• Korea journal of population studies
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• v.7 no.1
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• pp.78-123
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• 1984

This study is attempting to examine the possible determinants of the rise of the sex ratio at birth from 106 to 110 in past decade in Taiwan. The basic hypothesis for the sudden rise of the sex ratio at birth is due to a combination of prenatal sex determination and abortion. The reasoning for this hypothesis involves three types of considerations - motivation, norm, and access. The theory is evaluated by analyzing data from birth registration and a large and representative sampie of Taiwanese wives of childbearing age. The empirical data seem to support the theoretical preposition and the basic hypothesis that the rise of the sex ratio at birth in Taiwan is due to a combination of prenatal sex determination and abortion. There is striking evidence of son-preference in the rise of the sex ratio at birth in higher birth order. In 1990 the sex ratio was 119 for third births and 128 for fourth and fifth births compared to the expected 106. Also, the 1991 KAP data indicated that women who have only daughters but no any son are more likely to make prenatal sex screening and terminate their pregnancies in male live births at higher birth order. Obviously, genetic diagnosis through chorionic villus sampling which was available in recent years was misused for prenatal sex determination and sex selective abortion.

• Asian-Australasian Journal of Animal Sciences
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• v.20 no.2
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• pp.252-256
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• 2007

This study was carried out to determine the effect of vitamin E and vitamin C on the performance of Japanese quails (Coturnix coturnix japonica) reared under heat stress during the growth and egg production period. A total of 810 seven-day-old Japanese quails were used in the trial. The birds received a diet with either three levels of vitamin E (DL-${\alpha}$Tocopheryl acetate) (60, 120 and 240 mg/kg of diet) and vitamin C (ROVIMIX STAY-C 35) (60, 120 and 240 mg/kg of diet). Live weight on day 35 and weight gain were the lowest in the group of chicks on a combination of 60 mg of vitamin E and 60 mg of vitamin C, whereas the highest live weight was demonstrated in chicks on a combination of 240 mg of vitamin E and 240 mg of vitamin C (p<0.01). The effects of treatments on cumulative feed consumption, feed conversion ratio, age at 5% lay, sexual maturity weight, rate of lay and mean egg weight values were found to be significant (p<0.01). The highest feed consumption, feed conversion ratio, age at 5% lay, sexual maturity weight, rate of lay and mean egg weight values were found in the group on a combination of 240 mg of vitamin E and 240 mg of vitamin C. The effect of treatments on the mortality ratio was found to be insignificant (p>0.01). The cost of supplementing diets with vitamin E and vitamin C is very low. Therefore such a combination of supplement can offer a potential protective management practice in preventing heat stress related losses in performance of Japanese quails.

• Journal of the Korea institute for structural maintenance and inspection
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• v.14 no.5
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• pp.87-92
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• 2010

This study set up 25, 35% for silica fume, SFFB's 2 level and water-combination material ratio, silica fume 10% for substitution ratio, and 4 level of SFFB 5, 10, 15(%) in order to compare and analyze the quality characteristic of ultra high strength concrete according to the substitution ratio of silica fume free binder (SFFB) that can be utilized as a substitute material for silica fume. As a result of an experimentation, the lower water-combination material ratio was, the higher addition ratio of high performance water-reducing agent for securing target liquidity increased, and it indicated the tendency that addition ratio of high performance water-reducing agent decreases because of material characteristic that SFFB has a lower absorptiveness than silica fume. The best strength was shown when SFFB substitution ratio is 10% at compressive strength and when substitution ratio is 15% at tensile strength, and it was indicated that at autogenous shrinkage contraction decreases compared to Plain(SF) regardless of substitution ratio of W/B and SFFB.

• The Journal of the Korea Contents Association
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• v.19 no.12
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• pp.517-526
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• 2019

The purpose of this study is to find the optimal method for clinical application by analyzing image quality and radiation output according to parameter combination when using the Automatic Exposure Control (AEC). The experimental method combines 70, 81 kVp with sensitivity S200, S400, S800 and S1000 of the Automatic Exposure Control for Entrance Surface Dose (ESD), current volume, Signal to Noise Ratio (SNR), Contrast to Noise Ratio (CNR), Time-to-Radiation Dose Curve in abdomen and pelvis. And then, image quality and radiation output stability were evaluated. As a results, Entrance Surface Dose, current volume, Signal to Noise Ratio, Contrast to Noise Ratio decreased as the tube voltage and sensitivity were set higher. In addition, the higher tube voltage and sensitivity, the Time-to-Radiation Dose Curve showed a poor output stability. In conclusion, the higher the combination of tube voltage and sensitivity in the use of Automatic Exposure Control, the more problems can be seen in image quality and stability of the radiation output. Therefore, a relatively low combination of tube voltage and sensitivity showed that the image quality and radiation output stability could be optimized by minimizing the error range that would occur when the detector recognized a combination of parameters.