• Journal of Communications and Networks
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• v.14 no.1
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• pp.91-103
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• 2012

Network mobility (NEMO) based on mobile IP version 6 has been proposed for networks that move as a whole. Route optimization is one of the most important topics in the field of NEMO. The current NEMO basic support protocol defines only the basic working mode for NEMO, and the route optimization problem is not mentioned. Some optimization schemes have been proposed in recent years, but they have limitations. A new NEMO route optimization scheme-involving a combination of the optimized route cache protocol (ORC) and reverse routing header (RRH) and the use of a quota mechanism for optimized sessions (OwR)-is proposed. This scheme focuses on balanced performance in different aspects. It combines the ORC and RRH schemes, and some improvements are made in the session selection mechanism to avoid blindness during route optimization. Simulation results for OwR show great similarity with those for ORC and RRH. Generally speaking, the OwR's performance is at least as good as that of the RRH, and besides, the OwR scheme is capable of setting up optimal routing for a certain number of sessions, so the performance can be improved and the cost of optimal routing in nested NEMO can be decreased.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.10 no.10
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• pp.4977-4996
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• 2016

The existence of excessively large and too filled network buffers, known as bufferbloat, has recently gained attention as a major performance problem for delay-sensitive applications. Researchers have made three types of suggestions to solve the bufferbloat problem. One is End to End (E2E) congestion control, second is deployment of Active Queue Management (AQM) techniques and third is the combination of above two. However, these solutions either seem impractical or could not obtain good bandwidth utilization. In this paper, we propose a Transmission Control Protocol（TCP）delayed window update mechanism which uses a congestion detection approach to predict the congestion level of networks. When detecting the network congestion is coming, a delayed window update control strategy is adopted to maintain good protocol performance. If the network is non-congested, the mechanism stops work and congestion window is updated based on the original protocol. The simulation experiments are conducted on both high bandwidth and long delay scenario and low bandwidth and short delay scenario. Experiment results show that TCP delayed window update mechanism can effectively improve the performance of the original protocol, decreasing packet losses and queuing delay while guaranteeing transmission efficiency of the whole network. In addition, it can perform good fairness and TCP friendliness.

• Journal of Microbiology and Biotechnology
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• v.28 no.11
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• pp.1771-1781
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• 2018

The emergence of multidrug-resistant microorganisms, as well as fungal infectious diseases that further threaten health, especially in immunodeficient populations, is a major global problem. The development of new antifungal agents in clinical trials is inferior to the incidence of drug resistance, and the available antifungal agents are restricted. Their mechanisms aim at certain characteristics of the fungus in order to avoid biological similarities with the host. Synthesis of the cell wall and ergosterol are mainly targeted in clinical use. The need for new approaches to antifungal therapeutic agents or development alternatives has increased. This review explores new perspectives on mechanisms to effectively combat fungal infections and effective antifungal activity. The clinical drug have a common feature that ultimately causes caspase-dependent cell death. The drugs-induced cell death pathway is associated with mitochondrial dysfunction, including mitochondrial membrane depolarization and cytochrome c release. This mechanism of action also reveals antimicrobial peptides, the primary effector molecules of innate systems, to highlight new alternatives. Furthermore, drug combination therapy is suggested as another strategy to combat fungal infection. The proposal for a new approach to antifungal agents is not only important from a basic scientific point of view, but will also assist in the selection of molecules for combination therapy.

• Journal of Internet Computing and Services
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• v.12 no.2
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• pp.1-8
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• 2011

In this paper, we propose an effective method for cooperative spectrum sensing in cognitive radios where cognitive user(CR) with the highest reliability sensing data is only selected and allowed to report its local decision to FC as only decision making node. The proposed scheme enables CR users to implicitly compare their sensing data reliabilities based on their likelihood ratio, without any collaboration among cognitive radio users. Due to the mechanism, the proposed cooperative scheme can achieves a high spectrum sensing performance while only requiring extremely low cooperation resources such as signaling overhead and cooperative time in comparison with other existing methods such as maximum ratio combination (MRC) based, equal gain combination (EGC) based and conventional hard combination based cooperative sensing methods.

• Journal of Microbiology and Biotechnology
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• v.26 no.8
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• pp.1490-1503
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• 2016

Colorectal cancer (CRC) is the third most common cancer in the world. Although 5-fluorouracil (5-FU) is the representative chemotherapy drug for colorectal cancer, it has therapeutic limits due to its chemoresistant characteristics. Colorectal cancer cells can develop into cancer stem cells (CSCs) with self-renewal potential, thereby causing malignant tumors. The human gastrointestinal tract contains a complex gut microbiota that is essential for the host's homeostasis. Recently, many studies have reported correlations between gut flora and the onset, progression, and treatment of CRC. The present study confirms that the most representative symbiotic bacteria in humans, Lactobacillus plantarum (LP) supernatant (SN), selectively inhibit the characteristics of 5-FU-resistant colorectal cancer cells (HT-29 and HCT-116). LP SN inhibited the expression of the specific markers CD44, 133, 166, and ALDH1 of CSCs. The combination therapy of LP SN and 5-FU inhibited the survival of CRCs and led to cell death by inducing caspase-3 activity. The combination therapy of LP SN and 5-FU induced an anticancer mechanism by inactivating the Wnt/β-catenin signaling of chemoresistant CRC cells, and reducing the formation and size of colonospheres. In conclusion, our results show that LP SN can enhance the therapeutic effect of 5-FU for colon cancer, and reduce colorectal cancer stem-like cells by reversing the development of resistance to anticancer drugs. This implies that probiotic substances may be useful therapeutic alternatives as biotherapeutics for chemoresistant CRC.

• Geomechanics and Engineering
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• v.6 no.5
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• pp.455-467
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• 2014

As the traffic increased, the original capacity of the tunnel has been unable to meet the needs, so it must be expanded. Based on the features of tunnel, the intermittent trough method must be supposed for tunnel enlarging. Under the situation on the buried deep of the tunnel, it could be used the reasonable arch axis model to descript the past covered rock pressure for mechanism calculating of self-bearing arch. Then establish the three-arch combination effectible model for the analysis which is relied on the tunneling enlarging to Chongqing Yu-Zhou tunnel. It has determined the proper width for the intermittent trough in shallow buried tunnel enlarging.

• Proceedings of the Korea Concrete Institute Conference
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• 2004.05a
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• pp.28-31
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• 2004

This paper discusses the role of micro and macrofibers in the workability, compressive strength, and failure of cementitious composites. Workability(flow), compressive strength, splitting strength and fracture mechanism of hybrid fiber reinforced cement composites(HFRCC) have been investigated by means of Korean Standard (KS). The specific blend pursued in this investigation is a combination of polyvinyl alcohol(PVA) and steel cord. It was demonstrated that a hybrid combination of steel and PVA enhances fiber dispersion compared to only steel cord reinforced cement composites and that the brittle and wide cracking was much reduced in HFRCC as expected because in the matrix containing the PVA fiber around the steel cord, a multiple microcracking occurred and the steel cord could sufficiently work for bridging the cracked surface.

• Journal of the Institute of Electronics and Information Engineers
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• v.51 no.12
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• pp.204-209
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• 2014

This paper has described a QoS mechanism and management for multimedia object transport protocol. Resource manager reports the system resource information to the QoS manager. Based on the combination of two informations, the more effective QoS management can be achieved by organic combination between them on the protocol time domain. Therefore, it is possible for QoS manager to decide call admission control quickly and detect and react the performance fluctuations in protocol time domain.

• The Transactions of the Korean Institute of Electrical Engineers P
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• v.59 no.3
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• pp.330-334
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• 2010

We tried to combine a transformer with a superconducting element and investigated the current limiting characteristics. When a superconducting element was connected to third winding of the transformer, the fault current was limited to about 90 % effectively. The fault current and consumption power were able to be controlled by the turn's ratio of secondary and third windings. It gives flexibility of the rating of a transformer in the power grid. As a result, power burden of a superconducting element was reduced by the decrease of turn's ratio in third winding of a transformer. It was because the voltage behavior of a superconducting element was dependent on turn's ratio of a transformer while the current characteristic was independent.

• Toxicological Research
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• v.26 no.2
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• pp.109-115
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• 2010

The purpose of this study was to elucidate the mechanism underlying enhanced radiosensitivity to $^{60}Co\;{\gamma}$-irradiation in human prostate PC-3 cells pretreated with berberine. The cytotoxic effect of the combination of berberine and irradiation was superior to that of berberine or irradiation alone. Cell death and Apoptosis increased significantly with the combination of berberine and irradiation. Additionally, ROS generation was elevated by berberine with or without irradiation. The antioxidant NAC inhibited berberine and radiation-induced cell death. Bax, caspase-3, p53, p38, and JNK activation increased, but activation of Bcl-2, ERK, and HO-1 decreased with berberine treatment with or without irradiation. Berberine inhibited the anti-apoptotic signal pathway involving the activation of the HO-1/NF-${\kappa}B$-mediated survival pathway, which prevents radiation-induced cell death. Our data demonstrate that berberine inhibited the radioresistant effects and enhanced the radiosensitivity effects in human prostate cancer cells via the MAPK/caspase-3 and ROS pathways.