• The Journal of Korean Medical History
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• v.27 no.2
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• pp.99-120
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• 2014

Purpose : There are two types of sleep disturbance: inability to sleep (不眠) and somnolence (多眠). This study is to examine treatments of the two types of sleep disturbance in the Books of Cold Damage and how those theories were established and formed. Methods : 1. Verses including the words related to inability to sleep and somnolence were extracted from "Treatise on Cold Damage Diseases" (傷寒論). 2. Among the Books on Cold Damages that are classified according to the symptoms, 17 books with contents related to inability to sleep and somnolence were selected to collect and classify data in three perspectives: mechanism of disease (病機), method of treatment (治法) and disease pattern (病證). 3. Data collected through the above methods were compared and diagramed. Results & Conclusions : 1. On Cold Damage, inability to sleep is mostly rooted when human body lacks yin energy while having excessive yang energy (陽盛陰虛) due to fire and heat (火熱). The reason could be misuse of perspiration inducing method (汗法) or purgation (下法) on the doctors' part. 2. On Cold Damage, somnolence is rooted when pathogen (邪氣) is spread to yin meridians (陰經) and the human body lacks yang while having excessive yin energy (陰盛陽虛) or when heat (熱邪) is invaded into interior parts (裏部). 3. Many scholars of Cold Damage in later periods had copied the "Treatise on Cold Damage Diseases" for treatments of sleep disturbance but many others have applied the verses from "Treatise on Cold Damage Diseases" or added new treatments. Do jeol-am (陶節庵) and Wang Geung-dang (王肯堂) particularly had deep understanding on "Treatise on Cold Damage Diseases" and utilized the content freely or suggested new remedies because they had thorough knowledge on relating formula as well.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.19 no.3
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• pp.141-149
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• 2015

Objectives Recently the fuzzy logic is widely used in the decision making, identification, pattern recognition, optimization in various fields. In this study, we propose the fuzzy logic as the objective method of distinguishing hot and cold, the basis of diagnosis in Korean medicine. Methods We developed fuzzy inference system to distinguish whether the subjects had hot or cold. The cold and hot questionnaire of Korean traditional university textbook, the pulse rate and the DITI value of face used in the system. These three kinds of information were defined as 'fuzzy sets,' and 54 fuzzy rules were established on the basis of clinical practitioners' knowledge. The fuzzy inference was performed by using the Mamdani's method. To evaluate the usefulness of the fuzzy inference system, 200 cases of data measured in the Woosuk university hospital of oriental medicine were used to compare the determining hot, normal, cold results obtained from the experts and from the proposed system. Results As a result, 100 cases of "cold", 54 cases of "normal", and 34 cases of "hot" were matched between the experts and the proposed system. This fuzzy system showed the conformity degree of 94%(${\kappa}=0.853$). Conclusions In this study, we could express the process of distinguishing hot-cold using the fuzzy logic for objectification and quantification of hot-cold identification. This is the first study that introduce a fuzzy logic for distinguish pattern identification. The degree of the heat characteristic of the patients inferred by this system could provide a more objective basis for diagnosing the hot-cold of patients.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.6
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• pp.1094-1098
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• 2010

With the high prevalence of functional dyspepsia in the world, it was difficult to get objective diagnosis, treatment and assessment for the reason that there were many different symptoms and signs. The purpose of this study is to develop a standard instrument of pattern identification for functional dyspepsia which will be applied to clinical research. The items and structure of the instrument were based on review of published literature. The advisor committee on this study was organized by 11 oriental division of gastroenterology professors of oriental medical colleges nationwide. The experts discussed developing the instrument, and we also took professional advices by e-mail. We divided the symptoms and signs of functional dyspepsia into 6 pattern identification, such as disharmony of liver and stomach, retention of undigested food, damp-heat in the spleen and stomach, simultaneous occurrence of cold and heat syndromes, deficiency and cold of the spleen and the stomach, and insufficiency of stomach eum. We got the mean weights to each symptom of six pattern identification which had been scored on a 5-point scale ranging from 1 to 5 by the 11 experts. We made out the Korean instrument of the pattern identification composed of 45 questions for functional dyspepsia. Although there are some limitations in our study, the instrument is meaningful and certain worth of its own. We hope to improve the instrument through the further clinical studies and discussions.

• The Journal of Internal Korean Medicine
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• v.39 no.4
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• pp.495-510
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• 2018

Objective: This study was designed to investigate the possibility of quantification of the diagnosis of abdominal coldness (AC) in patients with functional dyspepsia (FD). Methods: Forty-four patients with FD were enrolled in this study. Three Korean medicine doctors each randomly examined all abdomens. Diagnosis of AC was made by consensus of at least two of the doctors. Body temperature (oral by digital oral thermometer) and skin temperature (by digital infrared thermal imaging [DITI]) were measured, followed by administration of the Cold and Heat questionnaire (CHQ) and the Instrument of Pattern Identification for Functional Dyspepsia (IPIFD). Results: Of the 44 patients with FD, 22 were assigned to the AC group and 22 to the non-AC group. The concordance rate of diagnosis among the three doctors was 63.6% (28/44), with a ${\kappa}$ of 0.504, indicating means moderate agreement). Neither the oral nor the skin temperatures showed statistically significant differences between the AC and non-AC groups. However, the CHQ scores and 'Simultaneous Occurrence of Cold and Heat Syndromes pattern' scores of the IPIFD were higher in AC group and showed statistically significant differences (p=0.010 and 0.009). Conclusions: This is the first study conducting quantitative measurements of abdominal coldness in patients with FD. Although oral and skin temperature showed no statistical significance between AC and non-AC groups, the concordance rate of diagnosis of AC among the three Korean Medicine doctors was moderate. The CHQ scores and 'Simultaneous Occurrence of Cold and Heat Syndromes pattern' scores of the IPIFD also suggest that diagnosis of AC is relevant to cold and heat patterns, and these questionnaires could be utilized as supportive data for the diagnosis of AC. Further studies should be conducted for the purpose of quantifying and standardizing abdominal examinations in Korean Medicine.

• Tunnel and Underground Space
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• v.9 no.1
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• pp.27-35
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• 1999

The characteristics of heat conduction for the heat source boundary like an arch shape cavern are different from those for the semi-infinite or circular boundary which can be driven theoretically. A new form of transient heat conduction equation in rock mass around the arch shape cavern is evaluated with analyzing the pattern of the rock temperature distribution measured at the cold storage pilot plant. The new equation, which is driven by adopting a shape function, $SF=\sqrt{logx_0/log(x_0+x)}$ to the solution for a semi-infinite boundary, has the semi-radial form of temperature variation with distance. And, thermal properties of rock mass are estimated by comparing the rock temperature distributions by this equation with those by measurement. Thermal conductivity and specific heat of rock mass are estimated as giving the difference of 20~25% compared to those of laboratory scale. This difference seems to be caused by discontinuity like joint and water content in rock mass.

• Journal of Applied Biological Chemistry
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• v.54 no.4
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• pp.244-251
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• 2011

Galactinol and rafinose accumulation in plants is associated with stressful environmental conditions such as cold, heat, or dehydration by the action of galactinols synthase (GolS) in the raffinose family of oligosaccharides biosynthetic pathway from UDP-galactose. Moreover, several reports mentioned that GolS transcription is up regulated by various environmental stresses like cold, heat, dehydration. Therefore, to determine whether MoGolS1 was induced with the abiotic stress we analyzed the expression pattern of the gene under various abiotic stresses like heat, cold, abscisic acid, sucrose and salt concentration in the lemon balm plants grown in standard MS medium. The MoGolS1 gene was 981-bp in length encoding 326 amino acids in its sequence and shared 77 and 76% sequence similarity with Arabidopsis thaliana galactinol synthase4 (AtGolS4) and AtGolS1 genes respectively. The MoGolS1 gene was strongly expressed by the abiotic stress induced by sucrose, ABA or heat shock. It was also expressed in responses to cold, Identification and Functional Characterization of the GALACTINOL SYNTHASgene induction with various stresses may be possible for itscrucial function in abiotic stress tolerance in plants, providing a good engineering target for genetic engineering.

• Journal of Korean Medical classics
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• v.34 no.1
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• pp.47-65
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• 2021

Objectives : An accurate judgment of prognosis when treating diseases is crucial. While the 『Shanghanlun(傷寒論)』 deals with the prognosis of the Three Yin Diseases with great importance, full-scale studies have been lacking. This paper aims to study the Three Yin Diseases with a focus on prognosis analysis. Methods : Among the Three Yin Disease verses, those that could provide clues to prognosis were selected and analysed. Conclusions & Results : When Yang pulse patterns such as long(長脈)·floating(浮脈)·rapid(數脈) pulses and Yang symptoms such as fever, vexing heat, mild perspiration, thirst, warmth in hands and feet are present in Yin disease, it could be taken as signs of Yang Qi restoration. In these situations, Yin Cold pattern such as diarrhea and reversal cold disappear and the prognosis is positive. However, despite Yang pulse patterns and symptoms, there are cases where diarrhea happens as a result of cold dampness being eliminated due to Yang Qi restoration. Also, when Yang Qi starts communicating smoothly after its restoration in the Three Yin Diseases, perspiration can happen. When diarrhea and reversal cold, which are patterns of Yin Cold get worse, with pulse patterns such as unfelt(脈不至)·replete(實脈)·fulminating(脈暴出) pulses, false heat symptoms such as fever and hot flashes happen, accompanied with Yang Qi depleted symptoms such as inability to lie down due to agitation, continuous perspiration, sore throat, dyspnea, and exaggerated breathing happen. When fast pulse, fever, and perspiration are present due to depression and stagnation of ministerial fire, symptoms such as bloody stool with pus, purulent abscess, sore throat, and inability to lie down due to agitation show, which signal negative prognosis. In bad cases of Reverting Yin Disease, there is continuous diarrhea and bloody stool with pus, which can be due to either Kidney Yang deficiency or depression and stagnation of ministerial fire. It could also be caused by excessive heat.

• Journal of Society of Preventive Korean Medicine
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• v.18 no.3
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• pp.81-90
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• 2014

Objective : We performed a clinical study to investigate pattern characteristics in persistent allergic rhinitis depending on Korean Medicine pattern questionnaire items as a pattern identification diagnostic tool. Method : 32 patients with persistent allergic rhinitis were asked to interview with doctor of Korean Medicine and perform the 4 pattern questionnaires(Cold-Heat Pattern, Phlegm Pattern, Yin Deficiency pattern, bloodstasis pattern). Then, we analyzed the response rate of each pattern questionnaires. Results : After diagnosis of Korean Medicine Doctor's pattern identification, 17 individual items have higher response rate, 7 of 17 items have a common tendency in allergic rhinitis. The other 8 of 10 items belong to Lung qi deficiency cold and Lung-spleen qi deficiency group, these have higher tendency of deficiency. In bloodstasis pattern questionnaires, we don't decide the tendency of patients with allergic rhinitis. Conclusion : The result may provide that we don't use Korean Medicine pattern questionnaires as a major tool in the pattern identification of allergic rhinitis. Continuous studies are needed to develop the standardized pattern identification diagnostic tool.

• The Journal of Internal Korean Medicine
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• v.45 no.3
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• pp.415-428
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• 2024

Objective and Methods: This study examined Cheng Guopeng (程國彭)'s understanding of Shanghan Disease (傷寒病) through <Yixue xinwu (醫學心悟)>, created tables based on this, and these tables were compared with <Shiyong zhongyi neike biaodian (實用中醫內科表典)>'s table on Six Meridian Pattern Identification (六經辨證). Results and Conclusion: 1. <Yixue xinwu> and <Shiyong zhongy neike biaodian> were mostly similar regarding the pathology and the Six Meridian Pattern Identification of Shanghan Disease. However, <Shiyong zhongyi neike biaodian> selected terms that encompass internal medical diseases rather than terms that refer only to infectious diseases. 2. About Taiyang meridian disease (太陽 經病), <Yixue xinwu> recognized the existence of Wen bing (溫病) and Re bing (熱病), but did not regard them as True Shanghan Disease (正傷寒), and differentially diagnosed them as Similar Shanghan Disease (類傷寒). 3. About Yangming meridian disease (陽明 經病), <Yixue xinwu> understood this as a meridian transmitted heat-syndrome in the interior (傳經 裏熱證), and created a new Radix Puerariae Decoction (葛根湯). This prescription has the same name as the <Shanghanlun (傷寒論)>, but it has a different drug composition and indications. 4. About three-In meridian disease (3陰 經病), <Yixue xinwu> always divided it into two categories: meridian transmitted heat-syndrome in the interior (傳經 裏熱證) and meridian stroked cold-syndrome in the interior (直中 裏寒證). However, <Shiyong zhongyi neike biaodian> described Taiin disease (太陰病) as Spleen-stomach deficiency cold-syndrome (脾胃虛寒證). This means that meridian transmitted heat-syndrome in the interior (傳經 裏熱證) does not exist among Taiin disease.

• Herbal Formula Science
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• v.25 no.2
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• pp.253-270
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• 2017

Ojectives : To indicate source of prescriptions in "Wenbingtiaobian" and draw pathologic consideration for differences between prescription and source. Methods : Analysed cause and mechanism of disease, pattern identification, treatment, prescriptions and medicinal herbs based on "Translation of Wenbingtiaobian", "Modern Shanhanlun", "Jinkuiyaolueyishi", "Medical collection of Yetianshi" and "Herbal Formula Science". Results : 64.5% of prescriptions in "Wenbingtiaobian" are derived from "Linzhengzhinanyian", "shanghanlun" or "Jinkuiyaolue". Prescriptions from "shanghanlun" or "Jinkuiyaolue" have been modified to fit for heat pattern differentiations, to expand or reduce their medicinal scope, to build up efficacy by adding cold herbs, herbs of nourishing yin, engendering fluid or outthrusting through the exterior, to diffuse water-dampness or warm yang by adding warm herbs. Prescriptions from "Linzhengzhinanyian" have been modified to eliminate cold-dampness, disperse and outthrust with lightness, tonify yin. Conclusions : Wenbingtiaobian" inherited "Linzhengzhinanyian", "shanghanlun" nd "Jinkuiyaolue" andchanged and developed them to cure the febrile disease in the aspect of prescription, mechanism of disease, pattern differentiation and treatment.