• 가정과삶의질연구
• /
• 제27권5호
• /
• pp.69-76
• /
• 2009

This study aimed to develop cognitive-behavioral group counseling program for social problem-solving and career decision-making self-efficacy in incoming university freshman and to examine its efficacy through pre- and post-test. The program included cognitive restructuring, problem-solving and social skill training. The program consisted of 12 weekly sessions, approximately 1.5~2 hours in duration. Pre- and post-tests were administered to both a treatment group(n=48) and a control group(n=48). The collected data were statistically analyzed through ANCOVA. The main results of the study were as follows : The students in the treatment group showed a significant increase in both social problem-solving and career decision-making self-efficacy in comparison with those in the control group.

• 동의신경정신과학회지
• /
• 제15권2호
• /
• pp.191-201
• /
• 2004

The purpose of this study was to evaluate the effects and limitations of cognitive & behavioral therapy that applied to the social phobia. In this case, a female patient, 25 old, who had been treated distantly by her friends, was trained to catch her dysfunctional belief and maladaptive automatic thoughts. In this training, we used homework and counselling for 2months. And we diagnosed her state as SimDamHeoGup(心膽虛怯), so we used acupuncture treatment and herbs, for example HaChulBoShimTang(夏朮補心湯) and GuiBiWonDamTang(歸脾溫膽湯). In result, she could recover social relationship slowly. Conclusionally, cognitive & behavioral therapy can be very effective methods to treat social phobia, because patients with social phobia have maladaptive automatic thoughts, based on dysfunctional beliefs like 'I'm infelicitous' or 'I'm ineffective'.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• 제32권2호
• /
• pp.51-62
• /
• 2021

Objectives: Tic disorder is a neurodevelopmental disorder characterized by multiple involuntary movements of muscles or vocalization. Although tic symptoms subside as the patient ages, some patients suffer from significant functional impairments related to severe tic symptoms. This manuscript aimed to review the latest scientific evidences for the effect of cognitive-behavioral interventions on tic disorder. Methods: The relevant studies were identified by searching medical research databases. We focused our search on studies published between 2000 and 2020 in order to reflect the latest scientific evidence. A total of 821 articles were identified in the initial database search and 27 articles were finally included for the review after the exclusion of duplicated and irrelevant articles. Results: Behavioral therapies including habit reversal training, Comprehensive Behavioral Intervention for Tics, and exposure and response prevention were the most widely studied interventions for tic disorder and are recommended as first-line treatments for tic disorders with high confidence. Cognitive psychophysiologic approaches were also reported to be effective. Conclusion: Further studies are needed to support the future treatment of tics with low-cost and more widely available treatments, in order to ensure better treatment outcomes.

• 생물정신의학
• /
• 제13권2호
• /
• pp.82-94
• /
• 2006

Objectives : In order to explore effects of board-game therapy for cognitive rehabilitation in patients with schizophrenia, we investigated the change of executive cognitive function over a 2-month period of board-game therapy in patients with schizophrenia. Methods : Two groups of chronic schizophrenic inpatients were participated in this study. One group(n=21) were treated with board-game therapy for 2 months and the other control group(n=19) were not treated. For the evaluation of the executive cognitive function, a Wisconsin Card Sorting Test(WCST) was administered before and after the introduction of the board-game therapy. PANSS score change was also evaluated. Result : At the beginning of this study, there was no significant difference in performance of cognitive function tests, demographical data or clinical severity between both patient groups. After 2 months of treatment with the board-game therapy, the board-game therapy group showed significant improvements of executive cognitive function without any significant change of their schizophrenic symptoms. On the contrary, there was no change in control group. Conclusion : This study showed that a board-game therapy is effective for the enhancement of executive cognitive function in patients with chronic schizophrenia. A board-game therapy could be introduced with ease into psychiatric fields, such as inpatients' or outpatients' clinic wards and day hospital. Our result indicates that the board-game therapy is a promising tool for the enhancement of cognitive function, especially executive cognitive function and helpful for cognitive rehabilitation for schizophrenic patients.

• 대한약침학회지
• /
• 제27권2호
• /
• pp.70-81
• /
• 2024

Objectives: Cognitive impairments, ranging from mild to severe, adversely affect daily functioning, quality of life, and work capacity. Despite significant efforts in the past decade, more than 200 promising drug candidates have failed in clinical trials. Herbal remedies are gaining interest as potential treatments for dementia due to their long history and safety, making them valuable for drug development. This review aimed to examine the mechanisms behind the effect of Polygonum multiflorum on cognitive function. Methods: This study focused primarily on the effects of Polygonum multiflorum and its chemical constituents on cognitive behavioral outcomes including the Morris water maze, the passive avoidance test, and the Y maze, as well as pathogenic targets of cognitive impairment and Alzheimer's disease (AD) like amyloid deposition, amyloid precursor protein, tau hyperphosphorylation, and cognitive decline. Additionally, a thorough evaluation of the mechanisms behind Polygonum multiflorum's impact on cognitive function was conducted. We reviewed the most recent data from preclinical research done on experimental models, particularly looking at Polygonum multiflorum's effects on cognitive decline and AD. Results: According to recent research, Poligonum multiflorum and its bioactive components, stilbene, and emodin, influence cognitive behavioral results and regulate the pathological target of cognitive impairment and AD. Their mechanisms of action include reducing oxidative and mitochondrial damage, regulating neuroinflammation, halting apoptosis, and promoting increased neurogenesis and synaptogenesis. Conclusion: This review serves as a comprehensive compilation of current experiments on AD and other cognitive impairment models related to the therapeutic effects of Polygonum multiflorum. We believe that these findings can serve as a basis for future clinical trials and have potential applications in the treatment of human neurological disorders.

• The Journal of Korean Physical Therapy
• /
• 제26권6호
• /
• pp.436-441
• /
• 2014

Purpose: The objective of this study was to offer clinical primary data that it's aims to examine effects of transcranial direct current stimulation (tDCS) on cognitive function and biochemical change of rat with alzheimer's disease(AD) induced by injecting scopolamine. Methods: Subjects were instructed cognitive dysfunction model, rat of Sprague-Dawley system was injected with scopolamine and each experimental group was classified into three; group I (n=16) is non-treatment groups; group II (n=16) is applied with the tacrine; group III (n=16) is applied with the tDCS. The ziggurat task test was conducted to observe behavioral changes and cognitive function ability and 7, 14, 21, 28 days after the model. Acetylcholine Esterase (Ach E) activity was examined for biochemical assessment of which the results are followed. Results: Participants showed as to behavioral change, tacrine application group was the most significantly responded, following tDCS application group. As to biochemical change, same as above, tacrine application group was the most significantly responded, following tDCS application group. Conclusion: From these results, confirm that tDCS application to rat with alzheimer's disease leads to positive effects on behavioral, cognitive function changes, and biochemical changes, lasting for certain period of time. This study, in particular, tDCS, which can change excitability of brain cells non-invasively, could provide basic data that is useful as a new treatment way for the patients with cognitive dysfunction.

• 한국융합학회논문지
• /
• 제10권9호
• /
• pp.167-172
• /
• 2019

본 연구는 초기 치매환자를 대상으로 전산화 인지재활프로그램이 전두엽 집행기능 중 생성 이름대기에 미치는 효과를 파악하고, 치매 환자의 조기 언어중재에 관한 기초자료를 제공하였다. 분석 대상은 경증치매환자 29명으로서 전산화 인지재활프로그램(CoTras)을 중재하는 실험군 21명과 지필과 테이블활동 등 전통적인 면대면 언어재활을 중재하는 대조군 8명으로 분류되었다. 실험집단과 대조집단은 모두 12주 동안 순차적 언어 회상 기억훈련, 연합회상 기억훈련, 언어 범주화 기억훈련, 언어통합 기억훈련을 진행하였다. 의미유창성과 음소유창성의 사전검사점수를 공변량으로 통제한 Welch's robust ANCOVA분석 결과, 실험집단과 대조집단은 의미유창성과 MMSE-K의 변화에서 유의미한 차이가 있었다(p<0.05). 반면에, 음소유창성은 실험군과 대조군 모두 기초선단계에 비해서 12주간의 치료 후 유의미하게 증가하였지만 통계적으로 치료방법에 따른 유의미한 차이는 없었다. 본 연구의 결과는 전산화 인지재활프로그램이 전통적인 인지재활에 비해서 의미유창성의 향상에 효과적일 가능성을 시사한다.

• 한국임상약학회지
• /
• 제28권4호
• /
• pp.285-292
• /
• 2018

Background: Long-term levodopa therapy relieves the motor dysfunction associated with Parkinson's disease (PD), but has various effects on non-motor symptoms, including cognitive dysfunction, hallucinations, and affective disorders, and can exacerbate certain aspects of dementia-like cognitive dysfunction. Here, we investigated the relationship between levodopa treatment and development of dementia in patients with PD. Methods: This retrospective study analyzed 76 consecutive patients with PD who had taken levodopa between 2011 and 2015. The participants were initially free of dementia and had initial daily levodopa doses of below 600 mg. Patients who did and did not develop comorbid dementia were compared in terms of potential predictor variables, including PD onset age, sex, levodopa doses, and non-dementia comorbidities. Results: Of the 76 patients, 21 (27.6%) developed dementia, which was followed by hallucinations and insomnia. The independent predictors of incident dementia were PD onset age and second-year and third-year average levodopa doses that were higher than the first-year average levodopa dose. Patients who developed dementia had significantly higher average daily levodopa doses and levodopa dose increases over the 6-year treatment period than those who did not develop dementia. In addition, patients with higher levodopa doses were more likely to experience hallucinations. Conclusion: These results suggest that increases in levodopa doses may be associated with a greater risk of cognitive impairment in patients with PD. Therefore, motor and cognitive functions and levodopa dose increases should be evaluated regularly during long-term levodopa therapy in patients with PD.

• 한국콘텐츠학회논문지
• /
• 제22권3호
• /
• pp.529-537
• /
• 2022

본 연구는 인구 고령화 및 1인가구의 증가 등의 사회문제를 고려하여 1인가구 중고령자의 사회참여활동, 인지기능, 우울의 관계를 분석하고 이 관계에 대하여 인지저하 및 치매의심 집단과 일반집단에 따른 집단비교 분석을 실시하는 데 목적을 두었다. 분석을 위해 경로분석 및 다집단분석을 실시하였고, 분석결과 1인가구 중 고령자의 사회참여활동은 인지기능 증가를 통해 우울을 감소시키는 것으로 나타났고, 사회참여활동의 긍정적 효과는 인지저하 및 치매의심 집단에서 더 강한 것으로 확인되었다. 이러한 결과를 토대로 사회참여활동과 사회참여활동을 촉진할 수 있는 방안, 인지기능이나 정신건강에 도움이 될 수 있는 프로그램 개발에 대한 시사점을 논의하였고, 특히 인지기능이 저하되어 있는 집단에서 사회참여활동의 효과가 더 긍정적이었다는 점을 감안하여, 요양시설 등에서 고립된 치료보다는 사회성 증진을 함께 도모할 수 있는 프로그램이나 치료방법의 필요성 등을 제언하였다.

• 대한조현병학회지
• /
• 제21권2호
• /
• pp.74-80
• /
• 2018

Objectives : This study investigated whether long-acting injectable (LAI) paliperidone is different from its oral form in terms of the effect on cognitive function in schizophrenia spectrum and other psychotic disorders. Methods : We reviewed the medical records of patients in Seoul National University Bundang Hospital who were diagnosed as having schizophrenia and/or other psychotic disorders based on DSM-5 from 2016 to 2017. Seven patients were treated with oral paliperidone and 11 were treated with paliperidone palmitate. All patients underwent clinical and neuropsychological assessment, including the Korean version of the MATRICS Consensus Cognitive Battery (MCCB) at their first visit or within one month of their initial treatment. MCCB was repeated within three to 12 months after the initial assessment. Results : There was no significant difference between the two groups in most cognitive domains including speed of processing, attention and vigilance, working memory, verbal learning, visual learning and reasoning and problem solving domain. However, patients treated with paliperidone palmitate showed better improvement in social cognition domain than those taking oral paliperidone. The standardized values of social cognition domain scores had significantly improved over time in patients under paliperidone palmitate, demonstrating a significant time-by-group interaction. Conclusion : Our results show that long-acting injectable paliperidone could be helpful in some aspects of improving cognitive function in schizophrenia spectrum and other psychotic disorders. Further studies with other antipsychotics are necessary to generalize the results.