• The Journal of Korean Academy of Sensory Integration
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• v.5 no.1
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• pp.31-40
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• 2007

Objective: The purpose of this study was to get the cognitive reaction time according to the intensity of auditory stimuli in older people and to differentiate the cognitive reaction time between older people and adults. Method: 49 subjects consisted of 32 older people and 17 adults. Cognitive reaction time was assessed with Simple Auditory Reaction of Foundation I in PSS CogReHab. Analysis of the data was done by using independent t-test. Results: The results were as follows: 1. There was a significant difference of the mean of cognitive reaction time to the intensity of auditory stimuli. 2. There was no significant difference from older people regardless of sexual distinction in mean of cognitive reaction time. However, there was a significant difference of the mean of cognitive reaction time in adults. 3. There was a significant difference between older people who got a job or not in 90 dB of auditory stimuli. 4. The mean of cognitive reaction time to the intensity of auditory stimuli in older people was slower than adults. There was a significant difference of the mean of cognitive reaction time between older people and adults in 70 dB of auditory stimuli. 5. The mean of cognitive reaction time to the intensity of auditory stimuli in older people did not have the significant difference in scholastic ability. Conclusions: The results of the study showed slowing of the cognitive reaction time in auditory stimuli to aging in older people. Therefore, applying silver industry and development of equipment for older people may maintain independent life.

• BMB Reports
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• v.54 no.6
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• pp.295-304
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• 2021

Olfactory neuropathology is a cause of olfactory loss in Alzheimer's disease (AD). Olfactory dysfunction is also associated with memory and cognitive dysfunction and is an incidental finding of AD dementia. Here we review neuropathological research on the olfactory system in AD, considering both structural and functional evidence. Experimental and clinical findings identify olfactory dysfunction as an early indicator of AD. In keeping with this, amyloid-β production and neuroinflammation are related to underlying causes of impaired olfaction. Notably, physiological features of the spatial map in the olfactory system suggest the evidence of ongoing neurodegeneration. Our aim in this review is to examine olfactory pathology findings essential to identifying mechanisms of olfactory dysfunction in the development of AD in hopes of supporting investigations leading towards revealing potential diagnostic methods and causes of early pathogenesis in the olfactory system.

• Proceedings of the Korean Society for Cognitive Science Conference
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• 2005.05a
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• pp.228-232
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• 2005

최근의 연구에서 Li. Brenner, Cornelissen과 Kim (2002)은 추적 눈 운동 동안의 2차원 모양지각이 망막에 형성된 이미지 내용을 그대로 반영한다는 것을 보여 주었는데, 이러한 연구는 2차원 모양판단에 있어서 눈 운동 정보가 전혀 고려되지 않았음을 시사한다. 이와 같은 실험실 연구와 달리, 실제 생활에서 2차원 모양지각의 왜곡은 대부분의 경우에 발생하지 않는데, 가능한 한 가지 이유는 실험실 연구에서 사용된 자극의 경우에 참조대상이 존재하지 않는데 비하여, 실제 생활에서는 다양한 참조대상이 목표대상의 주변에 존재하기 때문이다. 목표대상과 참조대상의 상대적인 위치관계는 추적 눈 운동 동안에 망막에서도 그대로 유지되는데 시각체계가 이러한 안정적인 관계를 목표 대상의 모양을 지각할 때에 이용할 가능성이 있다. 본 연구에서는 다양한 참조대상을 이용하여 이러한 가능성을 검증하였다. 특히, 피험자의 눈 운동을 눈 운동 측정기를 이용하여 측정하였으며, 적절한 눈 운동을 수행한 시행에서의 데이터만 분석에 사용하였다.

• Proceedings of the Korean Society for Cognitive Science Conference
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• 2005.05a
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• pp.151-153
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• 2005

We investigated the brain substrate of repetition priming on the implicit memory taskusing low-resolution electromagnetic tomography (LORETA) with high-density 128 channel EEG and individual MRI as a realistic head model. Thirteen right-handed, healthy subjects performed a word/nonword discrimination task, in which the words and nonwords were presented visually,and some of the words appeared twice with a lag of one or five items. All of the subjects exhibited repetition priming with respect to the behavioral data, in which a faster reaction time was observed to the repeated word (old word) than to the first presentation of the word (new word). The old words elicited more positive-going potentials than the new words, beginning at 200 ms and lasting until 500 ms post-stimulus. We conducted source reconstruction using LORETA at a latency of 400 ms with the peak mean global field potentials and used statistical parametric mapping for the statistical analysis. We found that the source elicited by the old words exhibited a statistically significant current density reduction in the left inferior frontal gyrus. This is the first study to investigate the generators of repetition priming using voxel-by-voxel statistical mapping of the current density with individual MRI and high-density EEG.

• Journal of Korean Medical classics
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• v.31 no.1
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• pp.57-78
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• 2018

Objectives : The paper uses recitation test, one of the study and evaluation methods in the Korean Medical Classics, to provide a basis upon which thoughts can be given to the education of Korean Medicine, and furthermore the essence of education itself. Methods : 1. The paper reviewed how recitation tests were performed in Goryeo and Joseon. 2. The paper introduces the methods of applying recitation test to the education of the Korean Medical Classics and their results. The paper furthermore discussed possible improvements. 3. The paper pondered on the traditional aspects of the significances (principles) of recitation tests and their cognitive neuroscience aspects. Results : 1. The imperial examinations for medical officers during Goryeo and Joseon both performed recitation tests, and the subject of these tests were given more weight than other subjects. 2. Recitation test is a form of education that revolves around the learners. It requires a detailed plan of execution for it to be effective. 3. The significances (principles) of recitation test are reviewed from the aspect of cognitive neuroscience, and the deductions from the traditional aspects are made into "conceptual abstract, come to things & run out knowledge, and flash back." Conclusions : Recitation test was the humanity's way of conserving and conveying knowledge & wisdom from the times before the invention of letters. This method is the oldest education method of acquiring concepts that are generalized and made abstract through indirect experiences. This method is still effective today. In the education of the Korean Medical Classics, this method was used to supplement the public education method and create an education method that revolves around individual learner in a way that utilizes the strengths of education in apprenticeship.

• Science of Emotion and Sensibility
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• v.21 no.4
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• pp.77-90
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• 2018

Behavioral studies of emotion recognition in autism spectrum disorders (ASD) have yielded mixed results. Most of the studies focused on emotion recognition abilities with regard to ASD using stimuli with unisensory modality, making it difficult to determine difficulties in real life emotion perception in ASD. Herein, we review the recent behavioral and cognitive neuroscience studies on emotion recognition functions in ASD, including both unisensory and multisensory emotional information, to elucidate the possible difficulties in emotion recognition in ASD. In our study, we discovered that people with ASD have problems in the process of integrating emotional information during emotion recognition tasks. The following four points are discussed: (1) The restrictions of previous studies, (2) deficits in emotion recognition in ASD especially in recognizing multisensory information, (3) possible compensation mechanisms for emotion recognition in ASD, and (4) the possible roles of attention and language functions in emotion recognition in ASD. The compensatory mechanisms proposed herein for ASD with regard to emotion recognition abilities could contribute to a therapeutic approach for improving emotion recognition functions in ASD.

• Journal of Korean Critical Care Nursing
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• v.1 no.1
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• pp.19-31
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• 2008

Purpose: This study was conducted to exam the effects of the Abbreviated Cognitive Behavioral Therapy(ACBT) on chronic insomnia. Methods: Study was one-group interrupted time series study that involved 13 adults(mean age=51.7, aged 25-77 years) with chronic primary insomnia who visited sleep disorder clinic of S Hospital from November 2004 to October 2005. The subjects received 2-session individual ACBT with 2 week-interval($1^{st}$: 1.5- 2hrs, $2^{nd}$: 20-30min). To measure the subjective insomnia severity and sleep patterns, 3 times of insomnia severity index and sleep logs were completed(before ACBT, after ACBT, and 3-month after ACBT). The main outcomes were subjective insomnia severity and sleep patterns(sleep onset latency, waking after sleep onset, and total sleep time, sleep efficiency). The data were analyzed with SPSS 10.0 version program by Friedman test, Wilcoxon signed rank test with Bonferroni correction. Results: There were statistically significant decrease in insomnia severity index, sleep onset latency, and waking after sleep onset, and increase total sleep time and sleep efficiency. Conclusion: ACBT was effective in reducing subjective insomnia severity and improving sleep patterns. Sleep improvement was better sustained over time with ACBT.

• Smart Media Journal
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• v.5 no.1
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• pp.30-37
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• 2016

In recent decades, the study of human brain function has dramatically increased thanks to the advent of Functional Magnetic Resonance Imaging. This is a powerful tool which provides a deep view of the activities of the brain. From fMRI data, the neuroscientists analyze which parts of the brain have responsibility for a particular action and finding the common pattern representing each state involved in these tasks. This is one of the most challenges in neuroscience area because of noisy, sparsity of data as well as the differences of anatomical brain structure of each person. In this paper, we propose the use of appropriate discriminant methods, such as Fisher Discriminant Ratio and hypothesis testing, together with strong boosting ability of Adaboost classifier. We prove that discriminant methods are effective in classifying cognitive states. The experiment results show significant better accuracy than previous works. We also show that it is possible to train a successful classifier without prior anatomical knowledge and use only a small number of features.

• Safety and Health at Work
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• v.2 no.2
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• pp.176-182
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• 2011

Objectives: Previous investigations have presented some evidence of late cognitive effects in dental personnel exposed to metallic mercury. We wanted to examine if Norwegian dentists have an increased prevalence of symptoms consistent with neurological and/or cognitive malfunction. Methods: The study group consisted of 406 dentists from central Norway and 217 controls from the general population, all under the age of 70. They had responded to a standardised postal questionnaire (Euroquest) inquiring about seven symptoms in regard to neurology, psychosomatics, memory, concentration, mood, sleep disturbances, and fatigue. A score was calculated for each symptom based on 4 to 15 single questions scored on a scale from 1 (seldom or never) to 4 (very often). Results: The dentists and controls had a participation rate of 57.2 % and 42.9 % respectively. The dentists reported no more cognitive symptoms than the controls, with low average symptom scores from 1.16 for neurological symptoms in males to 1.73 for fatigue in females. Corresponding figures for the controls were 1.22 and 1.77. There were a total of 1.2 % of the dentists and 1.8 % of the controls who reported having three or more of the seven symptoms "often" or more frequently. Conclusion: Norwegian dentists do not report more cognitive and neurological symptoms than controls from the general population.

• Journal of Oriental Neuropsychiatry
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• v.30 no.1
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• pp.31-38
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• 2019

Objectives: To identify the cost effectiveness of early dementia diagnosis using the 2014 Health Insurance Review & Assessment Service-National Patients Sample (HIRA-NPS). Methods: The medical costs of dementia between Western medical care and Korean medical care were compared through the reimbursement and non-reimbursement item code for dementia examination. In addition, the medical expenses of patients with dementia and mild cognitive impairment were compared and analyzed with respect to Western and Korean medical care. Results: There were 87,434 claims, of which 16,101 patients were diagnosed with dementia and 38,680,789,560 won was found to be the medical expenses. 12,881 patients (80.0%) with dementia, 3,144 patients (19.5%) with mild cognitive impairment, and 76 patients (0.5%) progressing from mild cognitive impairment to dementia. The proportion of medical expenses was 97.6% for dementia patients, 2.3% for mild cognitive impairment, and 1% for patients progressing from mild cognitive impairment to dementia. 86,070 claims (98.4%) were from Western medical care, with16,824 patients (98.2%), and the medical expenses was 38,546,895,400 won (99.7%). 1,361 claims (1.6%) were from Korean medical care, with 303 patients (1.8%), and the medical expenses was 133,894,160 won (0.3%). Conclusions: This study compared and analyzed the medical costs of dementia patients and the diagnosis of both Korean and Western medical care. The results of this study are expected to be used as basic research data for investigating cost effectiveness of developing early diagnosis of dementia.