• 동의생리병리학회지
• /
• 제25권1호
• /
• pp.37-47
• /
• 2011

This study was aimed to investigate the memory enhancing effect of Jeongjihwan against scopolamine-induced amnesia in C57BL/6 mice. To determine the effect of Jeongjihwan on the memory and cognitive function, we have injected scopolamine (1 mg/kg, i.p.) into C57BL/6 mice 30 min before beginning of behavior tests. We have conducted Y-maze, Morris water-maze, passive avoidance and fear conditioning tests to compare learning and memory functions. Scopolamine-induced behavior changes of memory impairment were significantly restored by oral administration of Jeongjihwan (100 or 200 mg/kg/day). To elucidate the molecular mechanism underlying the memory enhancing effect of Jeongjihwan, we have examined the antioxidant defense system and neurotrophic factors. Jeongjihwan treatment attenuated intracellular accumulation of reactive oxygen species and up-regulated mRNA and protein expression of antioxidant enzymes as assessed by RT-PCR and western blot analysis, respectively. Jeongjihwan also increased protein levels of brain-derived neurotrophic factor (BDNF) compared with those in the scopolamine-treated group. Furthermore, as an upstream regulator, the activation of cAMP response element-binding protein (CREB) via phosphorylation was assessed by Western blot analysis. Jeongjihwan elevated the phosphorylation of CREB (p-CREB), which seemed to be mediated partly by extracellular signal-regulated kinase1/2 (ERK1/2) and protein kinase B/Akt. These findings suggest that Jeongjihwan may have preventive and therapeutic potential in the management of amnesia.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권3호
• /
• pp.957-962
• /
• 2012

Objective: Rapidly increasing colorectal cancer (CRC) incidence in Malaysia and the introduction of cutting edge new treatments, which prolong survival, mean that treatment outcome measures meed to be evaluated, including consideration of patient's quality of life (QoL) assessment. There are limited data on QoL in CRC patients, especially in Malaysia. Therefore, this study was performed focusing on cancer stages and age groups. Methods: The cross sectional study was conducted from June to September 2011 at three public tertiary hospitals with the EORTC QLQ C-30 questionnaire in addition to face to face interview and review of medical records of 100 respondents. Results: The mean age was 57.3 (SD 11.9) years with 56.0% are males and 44.0% females, 62% of Malay ethnicity, 30% Chinese, 7% Indian and 1% Sikh. Majority were educated up to secondary level (42%) and 90% respondents had CRC stages III and IV. Mean global health status (GHS) score was 79.1 (SD 21.4). Mean scores for functional status (physical, emotional, role, cognitive, social) rangeds between 79.5 (SD 26.6) to 92.2 (SD 13.7). Mean symptom scores (fatigue, pain, nausea/vomiting, constipation, diarrhea, insomnia, dyspnoea, loss of appetite) ranged between 4.00 (SD 8.58) to 20.7 (SD 30.6). Respondents role function significantly deteriorates with increasing stage of the disease (p=0.044). Females had worse symptoms of pain (p=0.022), fatigue (p=0.031) and dyspnoea (p=0.031). Mean insomnia (p=0.006) and diarrhea (p=0.024) demonstrated significant differences between age groups. Conclusion: QOL in CRC patients in this study was comparable to that in other studies done in developed countries. Pain, fatigue and dyspnoea are worse among female CRC patients. Given that functions deteriorates with advanced stage of the disease at diagnosis, a systematic screening programme to detect cases as early as possible is essential nationwide.

• 한국실내디자인학회논문집
• /
• 제19권3호
• /
• pp.119-127
• /
• 2010

This study investigates the examples of artistic intervention especially on the surface of architecture as a meeting place of art and architecture. Artistic intervention demonstrates the possibilities for the meaningful integration of arts into architectural spaces. This study summarizes the characteristics of artistic intervention on the surfaces of architectures as follow; first, the artistic intervention is applied to the broad ranges of designs including public art, architectural design and sign design that establish identities and unique characters to the spaces. Second, the artistic intervention on the surfaces is conducted by the participation of the various fields of artists, i.e. painters, installation artists, graphic designers and landscape designers. The artistic intervention is also conducted by individual collaboration between artists and architects as well as by the forms of public art of art-in-architecture program. Third, the artistic intervention on the surfaces is expressed using the complex combination of images, colors, patterns, and texts. They are applied to enhance the aesthetic and symbolic characters of buildings in public arts, to improve the visual characters of architectural design with graphics, colors, and patterns, as well as to increase communication skills and cognitive effects of sign design with letters and colors on walls and floor surfaces. Fourth, the artistic intervention is also applied on the surfaces to encourage people to communicate historic and symbolic meanings related to the locations and functions. Thus, graphics on the architectural surfaces could provide a public space, with which people could share common feeling on public arts. As a conclusion, the study finds that artistic intervention either as artworks or as elements of architectural design can not only enhance the aesthetic quality of architectural space but also expand the techniques of design representation. In addition, the artistic intervention can contribute to create a new realm of design where artists and architects work together to enrich our surroundings.

• Mass Spectrometry Letters
• /
• 제5권4호
• /
• pp.104-109
• /
• 2014

Nonmedical use of prescription stimulants such as methylphenidate (MPH) and amphetamine (AP) by normal persons has been increased to improve cognitive functions. Due to high potential for their abuse, reliable analytical methods were required to detect these prescription stimulants in biological samples. A direct injection liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was developed and implemented for simultaneous determination of MPH, AP and their metabolites ritalinic acid (RA) and 4-hydroxyamphetamine (HAP) in human urine. Urine sample was centrifuged and the upper layer ($100{\mu}L$) was mixed with $800{\mu}L$ of distilled water and $100{\mu}L$ of internal standards ($0.2{\mu}g/mL$ in methanol). The mixture was then directly injected into the LC-MS/MS system. The mobile phase was composed of 0.2% formic acid in distilled water (A) and acetonitrile (B). Chromatographic separation was performed by using a Capcell Pak MG-II C18 ($150mm{\times}2.0mm$ i.d., $5{\mu}m$, Shiseido) column and all analytes were eluted within 5 min. Linear least-squares regression with a 1/x weighting factor was used to generate a calibration curve and the assay was linear from 20 to 1500 ng/mL (HAP), 40-3000 ng/mL (AP and RA) and 2-150 ng/mL (MPH). The intra- and inter-day precisions were within 16.4%. The intra- and inter-day accuracies ranged from -15.6% to 10.8%. The limits of detection for all the analytes were less than 4.7 ng/mL. The suitability of the method was examined by analyzing urine samples from drug abusers.

• 감성과학
• /
• 제8권3호
• /
• pp.277-290
• /
• 2005

본 연구는 미래병사의 전투복 설계를 위한 기초 연구로 미래병사체계의 한 부분인 스마트 전투복의 디자인 프로토타입을 개발하는 것을 목적으로 한다 미래 전장은 정보의 습득과 전달이 승패의 핵심이 되는 정보전장이 될 것으로 생각되며, 미래병사를 위한 스마트 전투복은 전투력을 상승시키기 위한 각종 디지털 기기를 내장한 스마트 의류로서 전투복으로서 갖추어야 하는 착용성과 기기를 편안하게 사용할 수 있는 사용성을 모두 갖추어야 한다. 파라서 인체와 의복, 디지털 기기와의 관계를 연구하여 전투력을 상승시킬 수 있는 기기를 병사 특유의 동작에 방해되지 않도록 배치하기 위한 연구가 필요하다. 따라서 본 연구에서는 미래병사의 체형을 예측하고, 미래 병사에게 필요할 것으로 생각되는 각종 디지털 장치의 특성을 탐색하고, 동작과 인체의 구조를 연구하여 스마트 전투복의 최적 설계안이 도출되었다

• Journal of Gastric Cancer
• /
• 제14권1호
• /
• pp.47-53
• /
• 2014

Purpose: Electrogastrography is a method of measuring action potentials of the stomach. The purpose of this study was to investigate early postoperative changes in the electrogastrography and determine the correlation between electrogastrography and quality of life of patients with stomach cancer who underwent distal gastrectomy. Materials and Methods: This study analyzed 20 patients with stomach cancer who underwent electrogastrography and quality of life was measured 1, 12, and 24 weeks after the operation. Quality of life-C30 version 3.0 and quality of life-STO22, were used. Results: Fasting and postprandial mean dominant frequency at 1 week after the operation was 2.7 and 2.7 cycles per minute, and 2.8 and 2.7 cycles per minute at 12 weeks, 2.6 and 2.8 cycles per minute at 24 weeks. Fasting and postprandial mean dominant power at 1 week was 36.5 and 36.4 dB, 36.3 and 40.1 dB at 12 weeks and 40.9 and 42.3 dB at 24 weeks. The percentage of tachygastria was increased whereas the percentage of bradygradia was decreased during the postoperative periods (P<0.05). Global health, physical, emotional and social functioning scales were improved, but role and cognitive functioning were not changed. Pain, insomnia, diarrhea and financial difficulties were significantly improved according to the postoperative periods (P<0.05). The correlation between the STO22 and electrogastrography parameters was not significant (P>0.05). Conclusions: These may suggest that electrogastrography is a simple and noninvasive method and may be applicated for evaluating motility and autonomic functions of the remnant stomach.

• 수면정신생리
• /
• 제8권2호
• /
• pp.138-143
• /
• 2001

Sleepiness is associated with many different conditions and, as a neglected topic, it can be the cause of serious psychological and social disadvantages. In the aspect of learning, additional problems may arise from poor progress in school caused by the effect of sleepiness on concentration, memory, and other cognitive functions. Narcolepsy is by no means the most common cause of excessive sleepiness. Nonetheless, it is not a rarity, especially in young people. The non-specific nature of early features of narcolepsy, combined with very limited awareness that the condition can start in various ways, leads to many misinterpretations. Misinterpretation of narcolepsy symptoms is not confined to the medical profession. Teachers may well be critical of a student with narcolepsy because of their perception of narcolepsy symptoms as laziness, poor motivation, or difficult behavior and dull learning ability. Inappropriate reactions by parents, teachers, and peers, based on misinterpretation of narcolepsy symptoms or the patient's reactions to them, make a difficult situation worse. Especially in Korea, where schooling is focused on college entrance examinations, the problem is very serious and intensified by inappropriate or delayed diagnosis and treatment. Therefore, psychiatrists should be aware that narcolepsy in young adolescents is not rare and that they need to be familiar with its clinical features in both its classic and less obvious forms. Narcolepsy should be suspected if a adolescent's excessive sleepiness can not be explained in other ways. Therefore, we report on two patients who portray the tendency of dull learning ability and are mistaken as idle students. We diagnosed narcolepsy through polysomnography and multiple sleep latency testing. We treated the students with methylphenidate and pemolin. The students showed improvement in learning ability and were able to adapt better to school.

• 한국지능시스템학회논문지
• /
• 제27권2호
• /
• pp.157-163
• /
• 2017

경제적 발전과 의학의 발달로 인해 고령인구의 비율이 높아지는 고령 사회가 도래하고 있다. 우리나라의 고령화 진입 속도는 다른 선진국들에 비해 매우 빠른 편이다. 고령으로 인한 노인들의 신체적 능력은 점점 더 악화되어 가고 있으며, 이를 예방하기 위해 신체적, 정신적 장애를 위한 보조 시스템의 개발이 요구되고 있다. 이러한 보조 시스템은 노약자의 삶의 질 향상에 크게 기여할 수 있으며, 대표적인 시스템으로 재활 훈련 장비를 들 수 있다. 특히, 근력 강화, 인지능력 강화, 그리고 균형 능력을 강화시킬 수 있는 기능이 포함된 장비는 대부분의 노약자들에게 도움이 된다. 본 논문에서는 이들 기능을 강화시키는 휴먼 케어 콘텐츠 기반의 재활 훈련 장비의 개발을 소개하고, 본 장비의 사용성 평가를 제시한다. 사용성 평가는 예비 사용자는 물론 재활전문의 등의 전문가를 대상으로 실시하고, 그 결과를 분석하였다.

• 한국컴퓨터정보학회논문지
• /
• 제12권5호
• /
• pp.303-311
• /
• 2007

대량생산 체제를 기초로 한 교수 학습은 물질적 풍요를 가져오는데 기여했지만, 전인적 인간계발이라는 교육본연의 목표를 상실하고 자연과 타인을 자기욕구 충족을 위한 수단으로 간주하는 파괴적인 인간을 양산하게 되었다. 이에 대한 대안적 교육방법으로 인지적 측면 뿐만 아니라 정서적 측면에서도 학습자를 지원하는 멘토링(mentoring)이 새롭게 주목을 받고 있다. 한편, 면대면 멘토링이 가지는 시간과 공간적인 제약을 극복하려는 노력의 일환으로 전자멘토링(e-mentoring)이 요구되고 있다. 이 연구는 방과 후 학교 운영의 일환으로 예비교사가 멘토로서 참여하고 중등학교 학생들이 멘티가 되는 전자멘토링 시스템 설계방안을 제시하는데 목적이 있다. 이를 위해 멘토링 관련 선행연구 분석을 토대로, 전자멘토링 시스템 설계 방향을 설정하고 필수 기능을 도출하였다. 연구결과로 제시된 전자멘토링 설계방안은 멘토링 프로그램의 효과성과 효율성 증진에 관심있는 실천가들에게 새로운 지침을 제공해 줄 것이며, 이 설계방안을 토대로 시스템 개발과 그것의 효과성 검증을 위한 실증적 후속연구가 요청된다.

• 대한인간공학회지
• /
• 제28권4호
• /
• pp.51-59
• /
• 2009

These days mobile phone which were used mainly by grown-up persons are now widely used among children as well due to new social demands. Despite this trend, existing mobile phones are still being designed and produced according to the taste of people in their 20s and 30s, even the elderly, not satisfying physical, emotional and cognitive characteristics raised by children. This study aimed to extract the design factors of mobile phones for children by reflecting functional factors requested by children and parents in QFD's customer demands. First, functional and design factors requested in mobile phones for children were extracted from existing products and documentary records and some functional factors were selected through a process of integration and omission. The survey research was conducted on children and parents, based on the selected functional factors. Based on the survey research, functional factors were analyzed using AHP, and key functional factors considered by children and parents in mobile phones for children were investigated. Finally, in order to reflect the results in QFD, the correlation between functional factors and design factors was constructed as HOQ through experts' evaluation. The results showed that both children and parents recognized the basic functions such as telephoning, text messaging and phone directory as high priority functional factors, even though the relative importance was different between children and parents. Therefore, it is likely to satisfy the desires of both children and parents by designing mobile phones for children in consideration of design factors such as menu depth, button independence and button arrangement. It is expected that this study will promote experiments on design factors and propose basic data for and guidelines to mobile phone design for children.