• The Journal of Korean Medicine
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• v.26 no.3 s.63
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• pp.27-42
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• 2005

Objectives : Alzheimer's disease (AD) is a progressive and fatal neurodegenerative disease characterized by amyloid plaques and neurofibrillary tangles. These plaques are associated with degenerating neuronal processes and consist primarily of fibrillary aggregates of beta-amyloid$ protein, generated from amyloid precursor protein (APP). Another amyloidogenic fragment, the carboxyl terminus (CT) of APP, which is composed of 99-105 amino acid residues containing the complete $A{\beta}$ sequence, also appears to be toxic to neurones. Recent evidence suggest that CT105, carboxy terminal 105 amino acids peptide fragment of APP, may be an important factor causing neurotoxicity in AD. Methods : Although a variety of oriental prescriptions including Pinelliae rhizoma have traditionally been utilized for the treatment of AD, their pharmacological effects and action mechanisms have not yet been fully elucidated. In the present study, we investigated effects of the dichloromethane extract of Pinelliae rhizoma (PINR) on neurotoxicity and the formation of reactive oxygen species (ROS) and nitric oxide (NO) in SK-N-SH cells overexpressed with CT105. In addition, we evaluated its radical scavenging activity and effects on acetylcholinesterase (AChE) activity. Furthermore, effects on cognitive deficits induced by scopolamine treatment in rats were evaluated. Results ; We found in this study that PINR significantly inhibited apoptotic neuronal death induced by CT105 overexpression in SK-N-SH cells. Based on morphological examinations by phase-contrast microscopy, PINR reversed apoptotic changes of CT105-expressed cells. It was also found that PINR significantly promoted neurite outgrowth and inhibited formation of ROS nd NO. PINR was shown to scavenge DPPH radicals and noncompetitively inhibit AChE activity. Furthermore, it reduced scopolamine-induced memory impairment in rata, assessed by passive avoidance test. Conclusions : Taken together, these results demonstrate that PINR exhibits neuroprotective, antioxidant, and memory enhancing effects, and therefore may bs beneficial for the treatment of AD.

• Journal of the Korean Institute of Landscape Architecture
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• v.35 no.6
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• pp.84-96
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• 2008

This research investigated the landscape characteristics of the skyline and the cognitive characteristics of Mt. Mudeung (1,186m) from various viewpoints. Mt. Mudeung, the representative landscape of Gwangju City, has been recognized as a natural landmark and theme of paintings. By analyzing the perspective from 32 points with a digital terrain model, some landscape indices of the skyline were derived and the relationships are discussed. Assessment of the semantic differential scale with 21 adjective variables and representativeness to 15 landscape photographs of the mountain were accomplished. 1. Through regression analysis of the skyline indices, significant relationships were found between them the angle from the visual axis and number of skyline jumps, the vertical angle fluctuation and number of jumps per degree, the visual depth fluctuation and vertical angle fluctuation of skyline, and between the vertical angle mean and number of jumps per degree. Meaningful relations were found between the number of jumps of skyline to number of jumps per degree and the angle from visual axis to visual distance. However, in the representative assessment no difference was found on the angle from visual axis of viewpoints. On the other hand, it seemed to relate representativeness with visual clarity based on visual distance. 2. We found 4 factors "familiarity", "fluctuation of skylines", "openness", and "feeling of texture" in the results of factor analysis of semantic differential assessment. When considering the results of assessment for representativeness, adjective words for familiarity and openness seemed to have a close assessment. Specifically, the research showed that the landscape representation was highly assessed in a view which could be seen from the higher parts to the lower part of hills. This result indicates that the management of viewpoints which could get a scene from intermediate to distant, and locating a high elevation is important. 3. In the picturesque expression of Mt. Mudeung, various impressions from the different points, a skyline based on the top of Mt. Mudeung and a mono structure by overlapping hills were common characteristics. These common characteristics were also partially found through the analysis of topographical landscape indices and landscape images. Therefore, the viewpoints for the representative landscape management should be selected in natural or open spaces.

• Asia pacific journal of information systems
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• v.18 no.4
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• pp.1-26
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• 2008

Rapid progress of information technology and widespread use of the personal computers have brought various conveniences in our life. But this also provoked a series of problems such as hacking, malicious programs, illegal exposure of personal information etc. Information security threats are becoming more and more serious due to enhanced connectivity of information systems. Nevertheless, users are not much aware of the severity of the problems. Using appropriate password is supposed to bring out security effects such as preventing misuses and banning illegal users. The purpose of this research is to empirically analyze a research model which includes a series of factors influencing the effectiveness of passwords. The research model incorporates the concept of risk based on information systems risk analysis framework as the core element affecting the selection of passwords by users. The perceived risk is a main factor that influences user's attitude on password security, security awareness, and intention of security behavior. To validate the research model this study relied on questionnaire survey targeted on evening class MBA students. The data was analyzed by AMOS 7.0 which is one of popular tools based on covariance-based structural equation modeling. According to the results of this study, while threat is not related to the risk, information assets and vulnerability are related to the user's awareness of risk. The relationships between the risk, users security awareness, password selection and security effectiveness are all significant. Password exposure may lead to intrusion by hackers, data exposure and destruction. The insignificant relationship between security threat and perceived risk can be explained by user's indetermination of risk exposed due to weak passwords. In other words, information systems users do not consider password exposure as a severe security threat as well as indirect loss caused by inappropriate password. Another plausible explanation is that severity of threat perceived by users may be influenced by individual difference of risk propensity. This study confirms that security vulnerability is positively related to security risk which in turn increases risk of information loss. As the security risk increases so does user's security awareness. Security policies also have positive impact on security awareness. Higher security awareness leads to selection of safer passwords. If users are aware of responsibility of security problems and how to respond to password exposure and to solve security problems of computers, users choose better passwords. All these antecedents influence the effectiveness of passwords. Several implications can be derived from this study. First, this study empirically investigated the effect of user's security awareness on security effectiveness from a point of view based on good password selection practice. Second, information security risk analysis framework is used as a core element of the research model in this study. Risk analysis framework has been used very widely in practice, but very few studies incorporated the framework in the research model and empirically investigated. Third, the research model proposed in this study also focuses on impact of security awareness of information systems users on effectiveness of password from cognitive aspect of information systems users.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.2
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• pp.228-235
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• 2010

This study was performed to investigate the memory enhancing effect of Poria cocos Wolf (Hoelen cum radix) against scopolamine-induced amnesia in Sprague-Dawley (SD) rats. To induce amnesia, scopolamine (0.75 mg/kg) was intraperitonically injected into SD rats 30 min before starting behavior tests. We have conducted Morris water-maze and Y-maze tests to monitor learning and memory functions. Poria cocos effectively reversed scopolamine-induced memory impairment in SD rats which was represented by an improvement of mean escape latency in water-maze test and spontaneous alterations in Y-maze test. To elucidate possible molecule mechanism, we have measured mRNA as well as protein expression of acetylcholine esterase (AchE), choline acetyltransferase (ChAT), muscarinic acetylcholine receptor (mAchR), and brain-derived neurotrophic factor (BDNF) using RT-PCR and Western blot analysis, respectively. Poria cocos increased mRNA levels of ChAT and mAchR in rat hippocampus compared with those in the scopolamine-injected amnesic group. In addition, protein expression of ChAT and BDNF was also elevated by Poria cocos intake. Furthermore, as an upstrem regulator, the activation of cAMP response element-binding protein (CREB) was assessed by immunohistochemistry. In this immunohistochemical analysis, the phosphorylation of CREB (p-CREB) was reduced by scopolamine injection, which was restored back to control levels by administration of Poria cocos. These results suggest that Poria cocos may improve memory and cognitive deficit in amnesia and have therapeutic potentials through up-regulation of ChAT, mAchR, and BDNF, which seemed to be mediated by activation of CREB.

• Journal of KIISE:Computing Practices and Letters
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• v.10 no.2
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• pp.174-188
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• 2004

In the life environment changed with not only the quality and the price of the products but also the material abundance, it is the most crucial factor for the strategy of product sales to investigate consumer's sensibility and preference degree. In this perspective, it is necessary to design and merchandise the products in cope with each consumer's sensibility and needs as well as its functional aspects. In this paper, we propose the Fashion Design Recommender Agent System (FDRAS-pro) for textile design applying collaborative filtering personalization technique as one of the methods of material development centered on consumer's sensibility and preference. For a collaborative filtering system based on textile, Representative-Attribute Neighborhood is adopted to determine the number or neighbors that will be used for preferences estimation. Pearson's Correlation Coefficient is used to calculate similarity weights among users. We build a database founded on the sensibility adjectives to develop textile designs by extracting the representative sensibility adjectives from users' sensibility and preferences about textile designs. FDRAS-pro recommends textile designs to a customer who has a similar propensity about textile. To investigate the sensibility and emotion according to the effect of design factors, fertile designs were analyzed in terms of 9 design factors, such as, motif source, motif-background ratio, motif variation, motif interpretation, motif arrangement, motif articulation, hue contrast, value contrast, chroma contrast. Finally, we plan to conduct empirical applications to verify the adequacy and the validity of our system.

• The Mathematical Education
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• v.31 no.2
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• pp.109-119
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• 1992

The primary purpose of the present study is to provide the sources to improve the mathematical problem solving performance by analyzing the effects of the belief systems and the misconceptions of the middle school students in solving the problems. To attain the purpose of this study, the reserch is designed to find out the belief systems of the middle school students in solving the mathematical problems, to analyze the effects of the belief systems and the attitude on the process of the problem solving, and to identify the misconceptions which are observed in the problem solving. The sample of 295 students (boys 145, girls 150) was drawn out of 9th grade students from three middle schools selected in the Kangdong district of Seoul. Three kinds of tests were administered in the present study: the tests to investigate (1) the belief systems, (2) the mathematical problem solving performance, and (3) the attitude in solving mathematical problems. The frequencies of each of the test items on belief systems and attitude, and the scores on the problem solving performance test were collected for statistical analyses. The protocals written by all subjects on the paper sheets to investigate the misconceptions were analyzed. The statistical analysis has been tabulated on the scale of 100. On the analysis of written protocals, misconception patterns has been identified. The conclusions drawn from the results obtained in the present study are as follows; First, the belief systems in solving problems is splited almost equally, 52.95% students with the belief vs 47.05% students with lack of the belief in their efforts to tackle the problems. Almost half of them lose their belief in solving the problems as soon as they given. Therefore, it is suggested that they should be motivated with the mathematical problems derived from the daily life which drew their interests, and the individual difference should be taken into account in teaching mathematical problem solving. Second. the students who readily approach the problems are full of confidence. About 56% students of all subjects told that they enjoyed them and studied hard, while about 26% students answered that they studied bard because of the importance of the mathematics. In total, 81.5% students built their confidence by studying hard. Meanwhile, the students who are poor in mathematics are lack of belief. Among are the students accounting for 59.4% who didn't remember how to solve the problems and 21.4% lost their interest in mathematics because of lack of belief. Consequently, the internal factor accounts for 80.8%. Thus, this suggests both of the cognitive and the affective objectives should be emphasized to help them build the belief on mathematical problem solving. Third, the effects of the belief systems in problem solving ability show that the students with high belief demonstrate higher ability despite the lack of the memory of the problem solving than the students who depend upon their memory. This suggests that we develop the mathematical problems which require the diverse problem solving strategies rather than depend upon the simple memory. Fourth, the analysis of the misconceptions shows that the students tend to depend upon the formula or technical computation rather than to approach the problems with efforts to fully understand them This tendency was generally observed in the processes of the problem solving. In conclusion, the students should be taught to clearly understand the mathematical concepts and the problems requiring the diverse strategies should be developed to improve the mathematical abilities.

• Journal of The Korean Association For Science Education
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• v.20 no.4
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• pp.491-504
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• 2000

Recent research has shown that students' interest in learning physics is not a simple one. In this study the dimensions of students' interest in learning physics have been identified. These are the topic being taught, the activity in which the students are involved, and the motive of the students for learning physics. A Likert-style pilot questionnaire was constructed for identifying these dimensions and given to 13 year-old 162 students. A factor analysis of the results indicates that there are meaningful sub-dimensions in interest. In other words, while there were no specific sub-dimensions in topic dimension, motive dimension could be divided into intrinsic motive and extrinsic motive, and activity dimension could also be divided into receptive, experiential, high cognitive, and interactive activity.

• Journal of Digital Convergence
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• v.12 no.5
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• pp.435-442
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• 2014

This study investigated many factors which had to be considered importantly in space planning for the cultural contents exhibition hall on the basis of establishment cases at this time that cultural contents were considered very importantly in the national economy. It must be a priority to set up the concept of the exhibition space which can encompass exhibition spaces, exhibits, the approach to experience exhibitions and others for the effective planning for exhibition spaces showing cultural contents. Visitors' moving lines should be planned based on that concept setting. It is necessary to reflect human attributes that people detect environmental information and perceive the environment through their sensory organs and plan moving lines considering visitors' cognitive, emotional and psychological factors which they can feel according to the temporal order. In addition, this study led visitors to respond exhibits through their five senses and increased the effects that visitors appreciated exhibition spaces, actively getting out of the way that visitors experienced exhibitions, which might be limited to sight. This study will be able to provide specific space planning methods related to the establishment of cultural industry-based professional exhibition halls which have been increased day by day at this time that culture-based industries are considered to be important. Moreover, it will be helpful in reducing the trial and effort factor in the exhibition hall establishment project.

• Journal of Korean Academy of Nursing
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• v.26 no.3
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• pp.632-652
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• 1996

It has been noted that a genetic alteration of cells influenced by unhealthy lifestyle in addition to a series of other carcinogens increases the incidence of various neoplasmic diseases. Therefore the importance of a lifestyle that minimizes such an impact on health should be emphasized. Since stomach cancer, the most common neoplasmic disease in Korea, is related to personal lifestyle and as there is a possibility of its recurrence, patients with stomach cancer need to lead a healthy lifestyle. Also the quality of life which patients experience is negatively affected by the side effects of treatments and the possibility of recurrence. Therefore an effective nursing intervention to enhance quality of life and encourage healthy lifestyle is needed. The purpose of this study is to provide a basis for nursing intervention strategies to promote health and thus enhance quality of life. A hypothetical model for this purpose was constructed based on Pender's Health Promotion Model and Becker's Health Belief Model, with the inclusion of some influential factors such as hope for quality of life and health promoting behavior. The aims of study were to : 1) evaluate the effectiveness of patient's cognitive-perceptual factors on health promoting behaviors and quality of life ; 2) examine the causal relationships among perceived benefit, perceived barrier, perceived susceptibility and severity, internal locus of control, perceived health status, hope, health concept, self efficacy, self esteem health promoting behaviors & quality of life ; 3) build and test a global hypothetical model. The subjects for this study were 164 patients who were being treated for stomach cancer were approached in the outpatient clinic on a University Hospital. The data from the completed questionnaires were analyzed using Linear Structural Relationships (LISREL). The results of research are as follows : 1) Hypothetical model and the modified model showed a good fit to the empirical data, revealing considerable explanational power for health promoting behaviors(54.9%) and quality of life(87.6%) 2) Self efficacy and hope had significant effects on health promoting behaviors. Of these, hope was affected indirectly through self efficacy and self esteem. 3) Perceived health status, hope and self esteem had significant direct effect on the quality of life. Of these variables, perceived health status was the most essential factor affecting general satisfaction in life. 4) Self-efficacy, as a mediating variable, was positively affected by perceived benefit and hope. 5) Self-esteem, as a mediating variable, was positively affected by perceived health status and hope. 6) Hope was the main variable affecting self efficacy, self esteem, health promoting behaviors and quality of life. The derived model in this study could effectively be used as a reference model for further study and could suggests a direction for nursing practices

• Korean Journal of Social Welfare
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• v.61 no.2
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• pp.277-301
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• 2009

The purpose of this study is to examine those factors affecting Male Abusive Behavior on Intimate Female Partner Violence. The primary aim of this study is to determine the association between Intimate Partner Violence and coping strategies of male abusive behavior. The sample included 121 male abusive behavior who are referred by Counsel for Family Violence. For statistical analysis, descriptive statistical methods and hierarchical multiple regression were employed. Results indicated that male abusive behavior expressed more aggressive cognitive biases and irrational beliefs than nonviolent men. Both of problem-solving and avoidance coping to deal with relationship conflicts were related to abusive behavior of male. Specially, men who used higher levels of avoidance coping strategies was more likely related to physical abuse, less use of problem-solving coping was related to psychological abuse. Hostility and low marital satisfaction have also been associated with Intimate Partner Violence. Drinking is a risk factor for psychological abuse. Results are discussed implication for developing theoretical and interventional meanings of social welfare practice.