• Journal of Korea Society of Digital Industry and Information Management
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• v.6 no.1
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• pp.69-81
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• 2010

Physical manifestations of aging due to the lack of exercise include the slowing down of motor learning, cardiopulmonary degradation, and the increasing difficulty to adapt to the environment. Aging is manifested with the lack of aerobic exercise work, decrease in muscular endurance, decline in skeletal and muscular strength, flexibility and agility, and the decrease in reaction speed and balance. Added to those are aging-related physiological changes, including the reduction of muscle bulk, increased body fat, decrease in total body water and basic metabolic rate as activities are reduced, and a decrease in cell and Lean Body Mass (LBM). These changes are known to cause problems. Interest and participation in appropriate physical activities among the elderly is needed to help them increase stamina, avoid diseases, maintain a clear intellect, and basically enable the elderly to live their daily lives as easy as possible. Therefore, physical activities are necessary for the elderly to enhance health-related factors. Special exercises should be performed for the enhancement of muscle function, muscle endurance, flexibility, agility, and balance. An accurate measurement of cardio-respiratory endurance and stamina through basic physical and cognitive characteristics of older adults is also required to ensure safety. Also, the development of a more scientific resistance exercise prescription system for the elderly is desperately needed.

• Journal of mucopolysaccharidosis and rare diseases
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• v.4 no.2
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• pp.42-44
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• 2018

Prader-Willi syndrome (PWS) is a multisystemic complex disorder characterized by hyperphagia and impaired satiety which lead to severe and early obesity. In infancy, hypotonia and poor suck are main problems, and a child goes through Failure-to-thrive. During childhood, clinical manifestations change to food seeking as well as excessive weight gain, short stature, developmental delay, cognitive disability and behavioral problems. Also, growth hormone insufficiency is frequent. Most patients receive the recombinant growth hormone (rGH) therapy that provides improvement in growth, body composition, and physical attributes. The clinical care guideline for rGH therapy in PWS had been noticed in 2013. The rGH therapy helps in body fat, lean body mass, height SDS and head circumference. Also, the rGH therapy helps motor function, psychomotor development and cognition and behavioral issues.In Samsung medical center, there are clinical care guidelines for rGH therapy in PWS and an useful application for the patients. 'Living with PWS', the name of an moblie application for PWS patients, was introduced in the lecture. The application revised to version 2. It was made more convenient to users than in version 1. It helps caregivers to schedule the rGH therapy and to monitor height and weight.

• The Journal of Korean Physical Therapy
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• v.15 no.2
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• pp.75-84
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• 2003

The purpose of this study was to review of mechanism and application methodology about mental practice. The mental practice is symbolic rehearsal of physical activity in the absence of any gross muscular movements. Human have the ability to generate mental correlates of perceptual and motor events without any triggering external stimulus, a function known as imagery, Practice produces both internal and external sensory consequences which are thought to be essential for learning to occur, It is for this reason that mental practice, rehearsal of skill in imagination rather than by overt physical activity, has intrigued theorists, especially those interested in cognitive process. Several studies in sport psychology have shown that mental practice can be effective in optimizing the execution of movements in athletes and help novice learner in the incremental acquisition of new skilled behaviors. There are many theories of mental practice for explaining the positive effect In skill learning and performance. Most tenable theories are symbolic learning theory, psyconeuromuscular theory, Paivio's theory, regional cerebral blood flow theory, motivation theory, modeling theory, mental and muscle movement nodes theory, insight theory, selective attention theory, and attention-arousal set theory etc.. The factors for influencing to effects of mental practice are application form, application period, time for length of the mental practice, number of repetition, existence of physical practice.

• The Korean Journal of Rehabilitation Nursing
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• v.1 no.1
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• pp.73-82
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• 1998

This study, whose subjects are forty stroke patients in discharging who have been using FIM Western medical (Neurology, Neurosurgery, Rehabilitation Medicine) and Chinese herb medical base of D Hospital in Pusan from the first of May to the eleventh of July, has been made to evaluate the patients' functional conditions and analyze the factors affecting them. The result of study is as followings: FIM total score in discharging is avarage $85.83{\pm}28.96$; the motor FIM score is $57.55{\pm}24.40$ and the cognitive FIM score $29.95{\pm}6.99$. The items recorded the highest score reveal the eating bowel management; the former is $5.68{\pm}1.73$, the latter $5.33{\pm}2.23$. The item recorded the lowest score reveal bathing and stairs, each $2.35{\pm}1.69$ and $3.23{\pm}2.13$. Analysis reveal it is in the case of age(p=.005) and durations of admission(p=.01) that there is significant difference of FIM score when stroke patients in discharging.

• Proceedings of the Korea Information Processing Society Conference
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• 2020.11a
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• pp.971-974
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• 2020

Infants express their physical and emotional needs to the outside world mainly through crying. However, most of parents find it challenging to understand the reason behind their babies' cries. Failure to correctly understand the cause of a baby' cry and take appropriate actions can affect the cognitive and motor development of newborns undergoing rapid brain development. In this paper, we propose an infant cry recognition system based on deep transfer learning to help parents identify crying babies' needs the same way a specialist would. The proposed system works by transforming the waveform of the cry signal into log-mel spectrogram, then uses the VGGish model pre-trained on AudioSet to extract a 128-dimensional feature vector from the spectrogram. Finally, a softmax function is used to classify the extracted feature vector and recognize the corresponding type of cry. The experimental results show that our method achieves a good performance exceeding 0.96 in precision and recall, and f1-score.

• Biomolecules & Therapeutics
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• v.28 no.6
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• pp.512-518
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• 2020

Stroke is a leading cause of long-term disability in ischemic survivors who are suffering from motor, cognitive, and memory impairment. Previously, we have reported suppressing LPA₅ activity with its specific antagonist can attenuate acute brain injuries after ischemic stroke. However, it is unclear whether suppressing LPA₅ activity can also attenuate chronic brain injuries after ischemic stroke. Here, we explored whether effects of LPA₅ antagonist, TCLPA5, could persist a longer time after brain ischemic stroke using a mouse model challenged with tMCAO. TCLPA5 was administered to mice every day for 3 days, starting from the time immediately after reperfusion. TCLPA5 administration improved neurological function up to 21 days after tMCAO challenge. It also reduced brain tissue loss and cell apoptosis in mice at 21 days after tMCAO challenge. Such long-term neuroprotection of TCLPA5 was associated with enhanced neurogenesis and angiogenesis in post-ischemic brain, along with upregulated expression levels of vascular endothelial growth factor. Collectively, results of the current study indicates that suppressing LPA₅ activity can provide long-term neuroprotection to mice with brain ischemic stroke.

• Therapeutic Science for Rehabilitation
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• v.5 no.1
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• pp.23-32
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• 2016

Objective : To investigate the current international researches which identify the effect of stroke with hemiplegia after dual-task training Methods : We systematically examined journals published from 2007 to 2015, searching PubMed. Total 5 researches were selected for the analyses. Results : Selected studies were all in international journal and they used two group experimental design. In addition, all the paper got PEDro scores above 6. They conducted gait task for motor task, at the same time used various domain of cognitive task such as from sustain attention to working memory. The outcome measure tools used for evaluation by the standardized assessment tool and operational definition, further also included the assessment tool designed for the dual-task training such as a variety of tools make possible to assess various aspects of effect. Discussion : Dual-task training in this study was found to give a positive effect on the dual-task performance, as well as improving the motor and cognitive function in patients with stroke. However there were also limitation to the studies conducted so far. In order to apply the occupational therapy, this results can consider as the preliminary data which suggest supplement point and can be a evidence for effective treatment for stroke with hemiplegia.

• Molecules and Cells
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• v.43 no.4
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• pp.360-372
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• 2020

The basal ganglia network has been implicated in the control of adaptive behavior, possibly by integrating motor learning and motivational processes. Both positive and negative reinforcement appear to shape our behavioral adaptation by modulating the function of the basal ganglia. Here, we examined a transgenic mouse line (G2CT) in which synaptic transmissions onto the medium spiny neurons (MSNs) of the basal ganglia are depressed. We found that the level of collaterals from direct pathway MSNs in the external segment of the globus pallidus (GPe) ('bridging collaterals') was decreased in these mice, and this was accompanied by behavioral inhibition under stress. Furthermore, additional manipulations that could further decrease or restore the level of the bridging collaterals resulted in an increase in behavioral inhibition or active behavior in the G2CT mice, respectively. Collectively, our data indicate that the striatum of the basal ganglia network integrates negative emotions and controls appropriate coping responses in which the bridging collateral connections in the GPe play a critical regulatory role.

• Biomolecules & Therapeutics
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• v.30 no.4
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• pp.320-327
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• 2022

Neurodevelopmental disorders are complex conditions that pose difficulty in the modulation of proper motor, sensory and cognitive function due to dysregulated neuronal development. Previous studies have reported that an imbalance in the excitation/inhibition (E/I) in the brain regulated by glutamatergic and/or GABAergic neurotransmission can cause neurodevelopmental and neuropsychiatric behavioral deficits such as autism spectrum disorder (ASD). NMDA acts as an agonist at the NMDA receptor and imitates the action of the glutamate on that receptor. NMDA however, unlike glutamate, only binds to and regulates the NMDA receptor subtypes and not the other glutamate receptors. This study seeks to determine whether NMDA administration in mice i.e., over-activation of the NMDA system would result in long-lasting behavioral deficits in the adolescent mice. Both gender mice were treated with NMDA or saline at early postnatal developmental period with significant synaptogenesis and synaptic maturation. On postnatal day 28, various behavioral experiments were conducted to assess and identify behavioral characteristics. NMDA-treated mice show social deficits, and repetitive behavior in both gender mice at adolescent periods. However, only the male mice but not female mice showed increased locomotor activity. This study implies that neonatal exposure to NMDA may illicit behavioral features similar to ASD. This study also confirms the validity of the E/I imbalance theory of ASD and that NMDA injection can be used as a pharmacologic model for ASD. Future studies may explore the mechanism behind the gender difference in locomotor activity as well as the human relevance and therapeutic significance of the present findings.

• Journal of Korea Multimedia Society
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• v.20 no.12
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• pp.1980-1991
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• 2017

Many stroke patients undergoing rehabilitation therapy require a quantitative indicator for the evaluation of body function in paretic and non-paretic regions. In this study, the impedance parameters were acquired to assess the physical status in the upper extremity of thirty six stroke patients with hemiplegia caused by cerebral hemorrhage (10 patients) and cerebral infarction (26 patients), using bioelectrical impedance. Prediction marker (PM), phase angle (PA), PM/PA, and resistance (R) versus reactance ($X_c$) were utilized to evaluate the functional status of the paretic and non-paretic regions. In addition, the hand grip strength (HGS) and the pinch strength (lateral, palmer, tip) were measured on the upper extremity of hemiplegic stroke patients. PM was distributed in inversely proportional to HGS, but PA was distributed in proportional to HGS. However, there were a number of patients with HGS of 0, regardless of the impedance parameters (PM, PA, R vs. $X_c$). Paretic and non-paretic status in upper extremity of these patients could not be analyzed using impedance parameters. At the rehabilitation therapist's instructions, they were unable to move the hand and fingers of the paretic upper extremity by cranial nerve damage, motor nerve damage, and severe cognitive decline.