• International Journal of Computer Science & Network Security
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• 제21권2호
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• pp.142-147
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• 2021

The main idea of the work is to address issues related to the activation of incentives in students of educational institutions, as an integral part of motivation in pedagogy, which is one of the priorities of higher education, in turn, the correct and timely application of motivational factors allows qualitative analysis, on the activation of cognitive interest in training. The purpose of the article is to study and qualitatively assess the methods and ways to stimulate students while studying in higher education. In solving the set tasks, a qualitative analysis of the known literature on the definition and application of motivation in the educational process. Definitely a stimulating process as a factor of psychological motivation. It is concluded that neither in understanding the essence of the stimulus, its role in the regulation of behavior, nor in understanding the relationship between stimulation and stimulus does not exist.

• 대한의용생체공학회:의공학회지
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• 제29권6호
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• pp.477-483
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• 2008

The observations of difference and similarity in brain activities involved in processing different languages have fundamental importance in cognitive neuroscience. The purpose of this study was to investigate the difference and similarity in temporal brain activation patterns due to the language difference during visual perception of Korean and English words under priming. Especially, we tried to find the difference in evoked spectral power in gamma-band, which is known to reflect feature binding. The stimulation was visually presented as word pairs belonging to same or different categories so that N400 event-related potential(ERP) was evoked. Average ERP analysis and spectral analysis of gamma-band activity(GBA) were performed on 12 normal Korean subjects. Several ERP components such as P1, N1, N400, and P600 could be identified consistently, and the differences in N1, N400, and P600 were observed. From the spectral analysis, we found that the evoked GBA(eGBA) was significantly larger for English at ${\sim}100$ ms poststimulus. The latency of the eGBA was also considerably delayed for English. Overall, the results on the ERP components and eGBA analyses seem to be commensurate with subjects' familiarity of each language, and the difficulty of perceiving words of each language. The methods of this study can also be applied for clinical purposes considering that the language-related processing can be greatly altered for the patients with neurological or psychiatric diseases.

• Journal of Neurogastroenterology and Motility
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• 제24권4호
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• pp.512-527
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• 2018

This review provides a comprehensive overview of brain imaging studies of the brain-gut interaction in functional gastrointestinal disorders (FGIDs). Functional neuroimaging studies during gut stimulation have shown enhanced brain responses in regions related to sensory processing of the homeostatic condition of the gut (homeostatic afferent) and responses to salience stimuli (salience network), as well as increased and decreased brain activity in the emotional response areas and reduced activation in areas associated with the top-down modulation of visceral afferent signals. Altered central regulation of the endocrine and autonomic nervous responses, the key mediators of the brain-gut axis, has been demonstrated. Studies using resting-state functional magnetic resonance imaging reported abnormal local and global connectivity in the areas related to pain processing and the default mode network (a physiological baseline of brain activity at rest associated with self-awareness and memory) in FGIDs. Structural imaging with brain morphometry and diffusion imaging demonstrated altered gray- and white-matter structures in areas that also showed changes in functional imaging studies, although this requires replication. Molecular imaging by magnetic resonance spectroscopy and positron emission tomography in FGIDs remains relatively sparse. Progress using analytical methods such as machine learning algorithms may shift neuroimaging studies from brain mapping to predicting clinical outcomes. Because several factors contribute to the pathophysiology of FGIDs and because its population is quite heterogeneous, a new model is needed in future studies to assess the importance of the factors and brain functions that are responsible for an optimal homeostatic state.

• 한국산학기술학회논문지
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• 제22권4호
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• pp.466-472
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• 2021

본 연구는 치매노인에게 적용되고 있는 다양한 비약물적 중재 방법과 효과에 대해 알아보고, 치매의 임상적 증상에 따른 비약물적 중재의 효과성을 분석하여 치매노인을 치료하고 관리하는 전문가들에게 도움을 주고자 한다. 이를 위해 RISS를 비롯한 5개의 데이터베이스를 사용하여 치매노인의 비약물적 중재에 대한 연구들을 검색한 후, 선정 및 배제기준에 따라 14편의 연구들을 분석하였다. 대상자 특성과 연구 특성으로 나누어 코딩을 진행하였고, 공통되는 증상별로 분류하여 메타분석을 실시하였다. 공통되는 종속변수는 인지기능, 기억력, 일상생활수행능력, 삶의 질, 우울, 행동심리증상등 6개의 하위영역으로 분류되었으며, 메타분석 결과 인지기능에서는 홀니스 프로그램, 기억력에서는 제과제빵 활동, 일상생활수행능력에서는 복합중재 프로그램, 삶의 질에서는 클라이언트 중심적 인지자극치료, 우울과 행동심리증상에서는 리듬움직임 활동이 가장 효과가 좋은 것으로 나타났다. 본 연구결과를 보아 치매노인에게 적용되고 있는 비약물적 중재는 매우 다양하며 중재들이 나타내는 효과성에서도 서로 다른 차이를 나타내고 있음을 알 수 있었다. 따라서 증상별로 중재에 대한 효과의 차이를 구별하여 적용한다면 보다 효율적인 중재가 제공될 수 있을 것으로 사료된다.

• BMB Reports
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• 제49권9호
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• pp.520-525
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• 2016

We investigated the effects of two antimicrobial peptides (AMPs) isolated from Scolopendra subspinipes mutilans on neutrophil activity. Stimulation of mouse neutrophils with the two AMPs elicited chemotactic migration of the cells in a pertussis toxin-sensitive manner. The two AMPs also stimulated activation of ERK and Akt, which contribute to chemotactic migration of neutrophils. We found that AMP-stimulated neutrophil chemotaxis was blocked by a formyl peptide receptor (FPR) 1 antagonist (cyclosporin H); moreover the two AMPs stimulated the chemotactic migration of FPR1-expressing RBL-2H3 cells but not of vector-expressing RBL-2H3 cells. We also found that the two AMPs stimulate neutrophil migration in vivo, and that this effect is blocked in FPR1-deficient mice. Taken together, our results suggest that the two AMPs stimulate neutrophils, leading to chemotactic migration through FPR1, and the two AMPs will be useful for the study of FPR1 signaling and neutrophil activation.

• The Korean Journal of Physiology and Pharmacology
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• 제23권1호
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• pp.47-54
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• 2019

Estrogen withdrawal in post-menopausal women leads to overactivation of osteoclasts, which contributes to the development of osteoporosis. Inflammatory cytokines are known as one of mechanisms of osteoclast activation after estrogen deficiency. SPA0355 is a thiourea derivative that has been investigated for its antioxidant and anti-inflammatory activities. However, its efficacy in bone resorption has not been previously investigated. The aim of this study was to investigate the impact of SPA0355 on the development of osteoporosis and to explore its mode of action. In vitro experiments showed that SPA0355 inhibited receptor activator of $NF-{\kappa}B$ ligand (RANKL)-induced osteoclastogenesis in primary bone marrow-derived macrophages. This effect appears to be independent of estrogen receptor activation as ICI 180,782 failed to abrogate its effects on osteoclasts. Further signaling studies revealed that SPA0355 suppressed activation of the MAPKs, Akt, and $NF-{\kappa}B$ pathways. SPA0355 also increased osteoblastic differentiation, as evidenced by its effects on alkaline phosphatase activity and mineralization nodule formation. Intraperitoneal administration of SPA0355 to ovariectomized mice prevented bone loss, as verified by three-dimensional images and bone morphometric parameters derived from ${\mu}CT$ analysis. Noticeably, SPA0355 did not show hepatotoxicity and nephrotoxicity and also had little effect on hematological parameters. Taken together, the results indicate that SPA0355 may protect against bone loss in ovariectomized mice by stimulation of osteoblast differentiation and by inhibition of osteoclast resorption. Therefore, SPA0355 is a safe and potential candidate for management of postmenopausal osteoporosis.

• Investigative Magnetic Resonance Imaging
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• 제14권2호
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• pp.115-120
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• 2010

목적 : 활성자극 파라다임을 사용한 기능적 자기공명영상 데이터에서 자발적 요동에 해당하는 저주파 BOLD 신호의 존재여부를 규명해 보고자 하였다. 대상 및 방법 : 20명의 여자 양궁선수들과 양궁 경험이 없는 23명의 여자들을 대상으로 finger-tapping 파라다임은 30초간의 운동기와 휴지기를 3회 반복하였다. 혈액산소수준의존(BOLD) fMRI 영상은 3.0 T MR 기기에서 경사자장 반향 EPI 영상을 해부학적 영상은 3차원 T1 강조영상을 사용하였다. 뇌활성화 차이는 SPM-5를 사용하여 분석하였고 저주파 요동성분을 찾기 위해 GIFT 프로그램을 사용하였다. 결과 : 두군 모두에서 finger-tapping에 따라 대뇌좌측의 주운동영역과 보조운동영역 그리고 우측 소뇌에서의 활성화가 관찰되었다. GIFT를 사용한 ICA 분석에서 피검자들의 반측 감각운동망, 동측 감각운동망 그리고 인지기능과 연관된 신경망에 해당하는 독립적인 성분들이 구별되었다. 결론 : Finger-tapping fMRI 데이터에서 BOLD 신호의 자발적 요동에 해당하는 저주파 신호 성분들을 ICA 기법을 사용하여 분리해 낼수 있었고 이러한 독립성분들이 일차운동감각 신경망 그리고 운동 인지기능을 담당하는 신경망의 휴지기 신경활동을 나타낸다는 사실을 규명할 수 있었다.

• Molecules and Cells
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• 제38권9호
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• pp.796-805
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• 2015

Gintonin is a novel ginseng-derived lysophosphatidic acid (LPA) receptor ligand. Oral administration of gintonin ameliorates learning and memory dysfunctions in Alzheimer's disease (AD) animal models. The brain cholinergic system plays a key role in cognitive functions. The brains of AD patients show a reduction in acetylcholine concentration caused by cholinergic system impairments. However, little is known about the role of LPA in the cholinergic system. In this study, we used gintonin to investigate the effect of LPA receptor activation on the cholinergic system in vitro and in vivo using wild-type and AD animal models. Gintonin induced $[Ca^{2+}]_i $ transient in cultured mouse hippocampal neural progenitor cells (NPCs). Gintonin-mediated $[Ca^{2+}]_i $ transients were linked to stimulation of acetylcholine release through LPA receptor activation. Oral administration of gintonin-enriched fraction (25, 50, or 100 mg/kg, 3 weeks) significantly attenuated scopolamine-induced memory impairment. Oral administration of gintonin (25 or 50 mg/kg, 1 2 weeks) also significantly attenuated amyloid-${\beta}$ protein ($A{\beta}$)-induced cholinergic dysfunctions, such as decreased acetylcholine concentration, decreased choline acetyltransferase (ChAT) activity and immunoreactivity, and increased acetylcholine esterase (AChE) activity. In a transgenic AD mouse model, long-term oral administration of gintonin (25 or 50 mg/kg, 3 months) also attenuated AD-related cholinergic impairments. In this study, we showed that activation of G protein-coupled LPA receptors by gintonin is coupled to the regulation of cholinergic functions. Furthermore, this study showed that gintonin could be a novel agent for the restoration of cholinergic system damages due to $A{\beta}$ and could be utilized for AD prevention or therapy.