• KSII Transactions on Internet and Information Systems (TIIS)
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• v.12 no.1
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• pp.204-226
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• 2018

Big data processing applications have been migrated into cloud gradually, due to the advantages of cloud computing. Hadoop Distributed File System (HDFS) is one of the fundamental support systems for big data processing on MapReduce-like frameworks, such as Hadoop and Spark. Since HDFS is not aware of the co-location of virtual machines in the cloud, the default scheme of block allocation in HDFS does not fit well in the cloud environments behaving in two aspects: data reliability loss and performance degradation. In this paper, we present a novel location-aware data block allocation strategy (LDBAS). LDBAS jointly optimizes data reliability and performance for upper-layer applications by allocating data blocks according to the locations and different processing capacities of virtual nodes in the cloud. We apply LDBAS to two stages of data allocation of HDFS in the cloud (the initial data allocation and data recovery), and design the corresponding algorithms. Finally, we implement LDBAS into an actual Hadoop cluster and evaluate the performance with the benchmark suite BigDataBench. The experimental results show that LDBAS can guarantee the designed data reliability while reducing the job execution time of the I/O-intensive applications in Hadoop by 8.9% on average and up to 11.2% compared with the original Hadoop in the cloud.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.44 no.4
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• pp.103-109
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• 2007

This paper presents behavioral models using SIMULINK and Verilog-a for a PLL based fractional-N frequency synthesizer. By adopting a top-down approach along with the traditional bottom-up transistor level design in parallel, the design time is greatly shortened, and a co-verification method for both the digital and the analog part is considered. Under this consideration, the SIMULINK modeling reduces simulation time and easily estimates the PLL's performance on the top level. Verilog-a is able to verify the feasibility of each blocks at first hand because it is compatible with transister level circuits. Then, an efficient way of the design is presented by comparing the results of both models.

• The Journal of Advanced Prosthodontics
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• v.9 no.4
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• pp.257-264
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• 2017

PURPOSE. To evaluate the adhesion to CAD/CAM feldspathic blocks by failure analysis and shear bond strength test (SBSt) of different restorative systems and different surface treatments, for purpose of moderate chipping repair. MATERIALS AND METHODS. A self-adhering flowable composite (Vertise Flow, Kerr) containing bi-functional phosphate monomers and a conventional flowable resin composite (Premise Flow, Kerr) applied with and without adhesive system (Optibond Solo Plus, Kerr) were combined with three different surface treatments (Hydrofluoric Acid Etching, Sandblasting, combination of both) for repairing feldspathic ceramics. Two commercial systems for ceramic repairing were tested as controls (Porcelain Repair Kit, Ultradent, and CoJet System, 3M). SBSt was performed and failure mode was evaluated using a digital microscope. A One-Way ANOVA (Tukey test for post hoc) was applied to the SBSt data and the Fisher's Exact Test was applied to the failure analysis data. RESULTS. The use of resin systems containing bi-functional phosphate monomers combined with hydrofluoric acid etching of the ceramic surface gave the highest values in terms of bond strength and of more favorable failure modalities. CONCLUSION. The simplified repairing method based on self-adhering flowable resin combined with the use of hydrofluoric acid etching showed high bond strength values and a favorable failure mode. Repairing of ceramic chipping with a self-adhering flowable resin associated with hydrofluoric acid etching showed high bond strength with a less time consuming and technique-sensitive procedure compared to standard procedure.

• The Journal of Advanced Prosthodontics
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• v.12 no.1
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• pp.33-37
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• 2020

PURPOSE. The purpose of this study is to evaluate the effects of type of magnet attachment and implant angulation in two implant overdenture models. MATERIALS AND METHODS. Magnet attachments used in this study were flat and dome types (MGT5515, MGT5520D, Dentium Co., Seoul, Korea). Two implants with keepers were inserted in the resin blocks at a distance of 24 mm. For the first model, the implants were parallel to the vertical and perpendicular to the horizontal; for the second model, both were angulated 5 degrees to the mesial; for the third model, both were angulated 10 degrees toward the mesial. The retentive force was measured in both vertical and lateral directions. Statistical analyses were performed using SPSS software version 22.0 (α=.05). RESULTS. The flat type magnet attachment showed the highest lateral retentive force in the 20° divergent group (P<.05) and the dome type magnet attachment showed the highest lateral retentive force in the parallel group (P<.05). The vertical and lateral retentive force of the dome type magnet attachment was greater than that of the flat type magnet attachment in every direction (P<.05). CONCLUSION. Within the limitations of this study, the dome shape magnet attachment can resist vertical and lateral retentive force more superiorly than the flat type magnet attachment, regardless of angle, in the mandibular two implant model.

• The Journal of Advanced Prosthodontics
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• v.12 no.5
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• pp.251-258
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• 2020

PURPOSE. The bond strengths between resin denture teeth with various compositions and denture base resins including conventional and CAD/CAM purposed materials were evaluated to find influence of each material. MATERIALS AND METHODS. Cylindrical rods (6.0 mm diameter × 8.0 mm length) prepared from pre-polymerized CAD/CAM denture base resin blocks (PMMA Block-pink; Huge Dental Material, Vipi Block-Pink; Vipi Industria) were bonded to the basal surface of resin teeth from three different companies (VITA MFT^®; VITA Zahnfabrik, Endura Posterio^®; SHOFU Dental, Duracross Physio^®; Nissin Dental Products Inc.) using resin cement (Super-Bond C&B; SUN MEDICAL). As a control group, rods from a conventional heat-polymerizing denture base resin (Vertex™ Rapid Simplified; Vertex-Dental B.V. Co.) were attached to the resin teeth using the conventional flasking and curing method. Furthermore, the effect of air abrasion was studied with the highly cross-linked resin teeth (VITA MFT^®) groups. The shear bond strengths were measured, and then the fractured surfaces were examined to analyze the mode of failure. RESULTS. The shear bond strengths of the conventional heat-polymerizing PMMA denture resin group and the CAD/CAM denture base resin groups were similar. Air abrasion to VITA MFT^® did not improve shear bond strengths. Interfacial failure was the dominant cause of failure for all specimens. CONCLUSION. Shear bond strengths of CAD/CAM denture base materials and resin denture teeth using resin cement are comparable to those of conventional methods.

• Biomedical Science Letters
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• v.13 no.4
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• pp.279-285
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• 2007

Although retinoic acid has been known as either anti-inflammatory or pro-inflammatory molecule, depending on the cell type, its exact role in mature human neutrophils has not been fully explored. In this study, we investigate the effects of retinoic acid on neutrophil apoptosis and the associated mechanism and found that 9-cis retinoic acid (9CRA) significantly inhibits the spontaneous apoptosis of neutrophils. Its effect is increased by co-treatment with $TNF-\alpha$ (P<0.05). The 9CRA-induced inhibition is blocked by the following enzyme inhibitors: Ly 294002, phosphoinoside (PI)-3 kinase inhibitor, U73122, a phospholipase C (PLC) inhibitor, PP2, Src family protein inhibitor, SB202190, p38 MAPK inhibitor, and BAY-11-7085, NF-kB inhibitor. This study also demonstrates that all-trans retinoic acid suppresses spontaneous apoptosis, similar to the mechanism of inhibition exhibited by 9CRA. Phosphorylation of p38 MAPK decreases by 9CRA treatment. $Ik-B{\alpha}$ is degraded until 30 minutes after a time-dependent 9CRA treatment, but degradation can be inhibited by Ly 294002. These results indicate that 9CRA decreases p38 MAPK activation, induces NF-kB activation via PI-3 kinase, and also blocks cleavage of caspase 3. As these findings suggest, 9CRA has a molecular mechanism which may help pro-inflammatory response by blocking neutrophil apoptosis.

• KIEAE Journal
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• v.15 no.5
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• pp.107-112
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• 2015

Purpose: This study desires to investigate an effect of indoor temperature, humidity, and illuminance targeting a planting system of double-skin facade and cavity space adjacent to the outside within a certain period of winter. Through this, the study suggests a basic material about an energy conservation effect of double window system using planting to reduce heating load of a building in winter, so desires to contribute to indoor thermal comfort effect and illuminance correction study of double window and indoor plant. Method: Considering effects such as day and night climatic elements and air conditions in winter, illuminance measurement was conducted through a double-skin facade of space, a subject of the measurement, on the basis of practical residence time of a resident, and this study analyzed characteristics of indoor illuminance about this. The study measured and compared a change of insolation, dry-bulb temperature, and relative humidity at each indoor-outdoor measuring point, so measured and compared characteristics of an indoor temperature effect by elements of double-skin facade and indoor plant. Result: Through this study, the researcher could determine that indoor plant within double window in winter not only blocks solar radiation but also photosynthesizes, so is somewhat disadvantageous to winter thermal comfort reducing heating load. In addition, solar radiation going through interior plays a role to bring down somewhat high humidity to about 50% of reasonable humidity, so plays a direct role of maintenance of comfortable indoor space. Although there are effects such as blocking of solar radiation and temperature reduction, this has a positive influence on humidity control and proper illuminance distribution. The researcher could determine that illuminance, temperature, and humidity by solar radiation penetration for the whole measuring time play a role to supplement indoor environment mutually.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2008.04a
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• pp.33-45
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• 2008

Auditory fear memory is thought to be maintained by fear conditioning-induced potentiation of synaptic efficacy. The conditioning-induced potentiation has been shown to be maintained, at least in part, by enhanced expression of surface AMPA receptor (AMPAR) at excitatory synapses in the lateral amygdala (LA). Depotentiation, reversal of conditioning-induced potentiation, has been proposed as a cellular mechanism for fear extinction. However, a direct link between depotentiation and extinction has not yet been tested. To address this, we applied both ex vivo and in vivo approaches to rats in which fear memory had been consolidated. We found a novel form of ex vivo depotentiation; the depotentiation reversed conditioning-induced potentiation at thalamic input synapses onto the LA (T-LA synapses) ex vivo, and it could be induced only when both NMDA and metabotropic glutamate receptors were co-activated. Extinction returned the enhanced T-LA synaptic efficacy observed in conditioned rats to baseline and occluded the depotentiation. Consistently, extinction reversed conditioning-induced enhancement of surface expression of AMPAR subunits in LA synaptosomal preparations. A GluR2-derived peptide that blocks regulated AMPAR endocytosis inhibited depotentiation, and microinjection of a cell-permeable form of the peptide into the LA attenuated extinction. Our results are consistent with the use of depotentiation to weaken potentiated synaptic inputs onto the LA during extinction, and they provide strong evidence that AMPAR removal at excitatory synapses in the LA underlies extinction. The results described here are in line with previous findings. Neural activity in the LA has been shown to decrease after extinction in the rat and human. The NMDAR dependency of the depotentiation fits nicely with a large body of evidence that fear extinction depends upon amygdala NMDARs. Similarly, blockade of metabotropic glutamate recepotrs in the LA has recently been shown to attenuate fear extinction.

• Proceedings of the Korean Geotechical Society Conference
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• 1998.05a
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• pp.3-34
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• 1998

The stability condition of rock slopes is greatly affected by the geometry and strength parameters of discontinuities in the rock masses. Rock slopes Involving movement of rock blocks on discontinuities are failed by one or combination of the three basic failure modes-plane, wedge, and toppling. In rock mechanics, practically all the parameters such as the joint set characteristics, the rock strength properties, and the loading conditions are always subject to a degree of uncertainty. Therefore, a reasonable assessment of the rock slope stability has to include the excavation of the multi-failure modes, the consideration of uncertainties of discontinuity characteristics, and the decision on stabilization measures with favorable cost conditions. This study was performed to provide a new numerical model of the deterministic analysis, reliability analysis, and reliability-based optimization for rock slope stability. The sensitivity analysis was carried out to verify proposed method and developed program; the parameters needed for sensitivity analysis are design variables, the variability of discontinuity properties (orientation and strength of discontinuities), the loading conditions, and rock slope geometry properties. The design variables to be optimized by the reliability-based optimization include the cutting angle, the support pressure, and the slope direction. The variability in orientations and friction angle of discontinuities, which can not be considered in the deterministic analysis, has a greatly influenced on the rock slope stability. The stability of rock slopes considering three basic failure modes is more influenced by the selection of slope direction than any other design variables. When either plane or wedge failure is dominant, the support system is more useful than the excavation as a stabilization method. However, the excavation method is more suitable when toppling failure is dominant. The case study shows that the developed reliability-based optimization model can reasonably assess the stability of rock slopes and reduce the construction cost.

• YAKHAK HOEJI
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• v.42 no.5
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• pp.513-518
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• 1998

Fluoxetine is a nontricyclic antidepressant which blocks serotonin reuptake selectively. Its N-demethyl metabolite, norfluoxetine is also selective inhibitor of serotonin uptake . This study was carried out to compare the bioavailability of Myung-in fluoxetine (20mg/cap.) with that of Prozac$^{\circde{R}}$. The bioavailability was conducted on 24 healthy volunteers who received a single dose (80mg) of each drug in the fasting state, in a randomized balanced 2-way crossover design. After closing, serial blood samples were collected for a period of 48 hours, Plasma was analyzed for fluoxetine and norfluoxetine by a sensitive and validated HPLC assay. The major pharmacokinetic parameters ($AUC_{0-48\;hr}$, Cmax, Tmax , $AUC_{inf.}$, MRT. $T_{1/2}$, Vd and Cl) were, calculated from the plasma fluoxetine concentration-time data of each volunteer. The microcomputer program, 'WinNonlin' was used for compartmental analysis. A two-compartment model with first-order input, first-order output and no lag time was chosen as the most appropriate pharmacokinetic model. The data were best described by using a weighting factor of $1/y^2$. Though the plasma fluoxetine concentrations of Myung-in fluoxetine were higher than those of Prozac$^{\circde{R}}$ at all observed time from 7.9% to 16.9% (P<0.05 at 6.7 and 10 hr), the bioavailability of Myung-in fluoxetine appeared to be bioequivalent with that of Prozac$^{\circde{R}}$. There were no statistical significant differences between the two drugs in all pharmacokinetic parameters including $AUC_{0-48\;hr}$ of norfluoxetine.