• Macromolecular Research
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• v.16 no.8
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• pp.695-703
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• 2008

Nanoparticles have tremendous potential in cancer prevention, detection and augmenting existing treatments. They can target tumors, carry imaging capability to document the presence of tumors, sense pathophysiological defects in tumor cells, deliver therapeutic genes or drugs based on the tumor characteristics, respond to external triggers to release an appropriate agent, document the tumor response, and identify the residual tumor cells. Nanoparticles < 30 nanometers in diameter show unexpected and unique properties. Furthermore, particles < 5 nanometers in size can easily penetrate cells as well as living tissues and organs. This study evaluated the safety of nano materials in a living body and the relationship between the living tissue and synthetic nano materials by examining the in-vitro cytotoxicity of poly(lactic-co-glycolic) acid (PLGA) nano-spheres and fluorescein isothiocynate(FITC)-labeled dendrimers as polymer nanoparticles. PLGA was chosen because it has been used extensively for biodegradable nanoparticles on account of its outstanding bio-compatibility and its acceptance as an FDA approved material. The dendrimer was chosen because it can carry a molecule that recognizes cancer cells, a therapeutic agent that can kill those cells, and a molecule that recognizes the signals of cell death. Cytotoxicity in L929 mouse fibroblasts was monitored using MTT assay. Microscopic observations were also carried out to observe cell growth. All assays yielded meaningful results and the PLGA nanoparticles showed less cytotoxicity than the dendrimer. These nano-particles ranged in size from 10 to 100 nm according to microscopy and spectroscopic methods.

• Journal of the Korean Society of Food Culture
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• v.10 no.3
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• pp.185-200
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• 1995

In this survey, we investigated the way of thinking about meal management of housewives including the sincerity to meal preparation, the eating practices and cronic degenerative diseases related dietary behaviors, and studied the effects of above factors on the real food intakes. We also investigated the trends of health-foods and nutrient supplements usage. The results obtained from 506 housewives in Seoul were summarized as follows. Although our subjects prepared their meals habitually without special concern, they did not prefer the use of convenient foods. The food prefrence of housewivess who had more child and refered higher life status was similar with other family members. The dietary attitudes were good in large family, the higher income and the more child group. The highly educated group skipped breakfast more frequently. The mealmanagers with better education career and good living status considered for the restriction of salty foods, sweet foods, animal fats and pungent foods, and for the nutritionally balanced diet. The high income group showed great concerns about weight gain at meal times. The nutritional qualities expressed by the frequency of food group intakes were high in the better educated and living status groups, and their eating frequencies of animal protein foods and calcium sources were significantly high. Mealmanagers who had no job intaked vegetable oils through frying foods frequently. The use of health-foods and nutrient supplements was influenced by age, educational and economic level and self-estimated living status, but the trends in prevalence of both were not consistent. Health-foods were prefered by the groups of high educational career, affluent income and advanced living status, and low educational career, low income and low living status groups favored the nutrient supplements. The restrictive intake of animal fat and the use of health-food were positively correlated, which seemed that the subjects used health-foods as supplements in compensation for nutritional unbalance caused by the avoidance of animal protein foods.

• Physical Therapy Rehabilitation Science
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• v.6 no.4
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• pp.202-207
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• 2017

Objective: The self-decisions of the client regarding the meaningful work as a therapeutic approach of client-orientation. The Cognitive Orientation to daily Occupational Performance (CO-OP) is an occupation-oriented problem-solving approach. The purpose of this study was to describe the goals and intervention protocols of CO-OP in those affected by stroke. Design: A systematic review. Methods: Using EBSCOhost, PubMed, and ProQuest databases, we searched studies published in the past decade that utilized the CO-OP intervention. An initial search revealed 71,171 potential articles. After applying our search criteria to screen the titles, abstracts, and full-text, we included 7 articles that met our inclusion and exclusion criteria. In this study, we used the patient, intervention(s), comparison, outcome method to analyze the 7 selected studies. We analyzed the frequency of goals and intervention protocols. Results: Seven articles met our selection criteria; these studies included participants with an almost normal cognitive function from inpatient and outpatient rehabilitation facilities. CO-OP was used for 237 goals; the most used goal was the instrumental activities of daily living. The training procedure used 3 types of self-selecting goals in the activities. One of the goals was not trained, but was only evaluated to determine the generation effect. The most common outcome measurements included the Canadian Occupational Performance Measure and the Performance Quality Rating Scale. Conclusions: This research provided information about the effectiveness of CO-OP and selecting the correct evaluation tool to assess the efficiency of the intervention. This study suggests that treatment with CO-OP in occupational therapy is effective and that it outlines common protocols.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.27 no.1
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• pp.43-52
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• 2001

Living systems constantly suffer from atmospheric reactive oxygen species and also produce inevitably them by the course of metabolism. Therefore, antioxidants play important roles in protecting the systems from various diseased caused by them. In this study, we investigated various tinged autumnal leaves as antioxidant sources. Among the, the red leaf extracts of Acer Palmatum THUNBERG.(Aceraceae: maple tree) and Prunus Donarioum Sieb. Var. spontanea Makino(Rosaceae : cherry trees) showed the highest anti-oxidativities. The major antioxidants in their red leaves were isolated and identified as vitexin from maple leaves and isoscutellarein-4'-O-$\beta$-glucopyranoside from cherry leaves. Finally, we evaluated the efficacy of skin care products containing the extracts by human use study. As a result, the tinged leaves of maple and cherry trees were evaluated as good antioxidant sources on the bases of antioxidativities, cytotoxicities, cell proliferation effects and human use study.

• Proceedings of the KIEE Conference
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• 2007.04a
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• pp.55-57
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• 2007

$CO_2$ laser sees that is most suitable to get this effect through minimum formation damage and advantage that is root enemy of effect that happen in minimum cellular tissue depth of 0.1mm is stable living body organization or internal organs institution. Formation damage by ten can be related in formation's kind or energy density, length of evaporation time. If shorten evaporation time, surroundings cellular thermal damage 200 - because happen within 400ums laser beam in rain focus sacred ground surroundings cellular, tissue without vitiation me by evaporation Poe of very small floor as is clean steam can. Application is possible to vulva cuticle cousins by a paternal aunt quantity, uterine cancer, cuticle tumor by laser system that $CO_2$ laser gets into standard in obstetrics and gynecology application. Because effect that super pulse output is ten enemies of laser if uniformity one pulse durations are short almost is decreased, most of all pulse module special quality of pulse style $CO_2$ laser for obstetrics and gynecology mode stabilization by weight very, in this research to get into short pulse duration and higher frequency density, do switching by high frequency in DC-DC Converter output DC's ripple high frequency to be changed, high frequency done current ripple amount of condenser for output filter greatly reduce can. Ripple of output approximately to Zero realization applying possible inductor realization through a special quality experiment do.

• Nuclear Engineering and Technology
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• v.49 no.8
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• pp.1772-1777
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• 2017

Korean nuclear power plants (NPPs) periodically evaluate the radioactive gaseous and liquid effluents released from power reactors to protect the public from radiation exposure. This paper provides a comprehensive overview of the release of radioactive effluents from Korean NPPs and the effects on the annual radiation doses to the public. The amounts of radioactive effluents released to the environment and the resulting radiation doses to members of the public living around NPPs were analyzed for the years 2011-2015 using the Korea Hydro & Nuclear Power Co., Ltd's annual summary reports of the assessment of radiological impact on the environment. The results show that tritium was the primary contributor to the activity in both gaseous and liquid effluents. The averages of effective doses to the public were approximately on the order of $10^{-3}mSv$ or $10^{-2}mSv$. Therefore, even though Korean NPPs discharged some radioactive materials into the environment, all effluents were within the regulatory safety limits and the resulting doses were much less than the dose limits.

• Journal of Korean Academy of Rural Health Nursing
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• v.8 no.1
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• pp.33-41
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• 2013

Purpose: The study was done to explore relationships between residential areas and smoking rates and to identify related factors contributing to smoking in Korea adolescents. Methods: An analysis was done of smoking rates and socioeconomic position indicators by city size based on a 2012 cross-sectional nationwide online survey conducted with 74,186 Korean middle and high school students aged 12-18 years old. Data were analyzed using x2-test and multiple logistic regression with the SPSS/WIN18.0 program. Results: Analyses revealed that rural boys were more likely to be current smokers compared to metropolitan boys (odds ratio 1.18, 95%-confidence interval 1.01; 1.38) but residential areas and smoking rates among girls were not related. After adjusting for covariates, results showed that city size, Family affluence score, economic status, parents' education level, living with parents, school type, and school achievement were related to increased an proportion of adolescents who smoked. Conclusion: In conclusion, rural living is a determinant of smoking among boys. Tobacco control programs should recognize differences in living conditions between rural and urban areas.

• BMB Reports
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• v.51 no.10
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• pp.526-531
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• 2018

Protein-Protein Interactions (PPIs) play essential roles in diverse biological processes and their misregulations are associated with a wide range of diseases. Especially, the growing attention to PPIs as a new class of therapeutic target is increasing the need for an efficient method of cell-based PPI analysis. Thus, we newly developed a robust PPI assay (SeePPI) based on the co-translocation of interacting proteins to the discrete subcellular compartment 'processing body' (p-body) inside living cells, enabling a facile analysis of PPI by the enriched fluorescent signal. The feasibility and strength of SeePPI (${\underline{S}}ignal$ ${\underline{e}}nhancement$ ${\underline{e}}xclusively$ on ${\underline{P}}-body$ for ${\underline{P}}rotein-protein$ ${\underline{I}}nteraction$) assay was firmly demonstrated with FKBP12/FRB interaction induced by rapamycin within seconds in real-time analysis of living cells, indicating its recapitulation of physiological PPI dynamics. In addition, we applied p53/MDM2 interaction and its dissociation by Nutlin-3 to SeePPI assay and further confirmed that SeePPI was quantitative and well reflected the endogenous PPI. Our SeePPI assay will provide another useful tool to achieve an efficient analysis of PPIs and their modulators in cells.

• Journal of Korean society of Dental Hygiene
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• v.14 no.4
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• pp.555-561
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• 2014

Objectives : The aim of this study was to investigate the factors related to stress perception. Methods : A self-reported questionnaire was filled out by 109 people living in Gimpo city from January 16 to April 15, 2013. The data were analyzed using SPSS window ver. 19.0(IBM CO., Armonk, NY, USA) for t-test, one-way ANOVA, and multiple linear regression analysis. Results : Men and group of 59 years old tended to have higher stress perception than women and those who over 60 years old, but the results were not statistically significant. Stress perception was higher among the group with systemic dryness and oral dryness(each${\geq}1$) and the group reporting high difficulty in daily living due to oral problem(${\geq}2$)(p<0.05). Especially, the factor that was most correlated to stress perception was systemic dryness(${\beta}$=0.347) followed by problem of daily living for oral problem(${\beta}$=0.278, p<0.01). Conclusions : Systemic dryness and oral problem can increase the level of stress perception, mouth dryness and oral problems are a part of stress responses. Therefore, the regular health checkup must be done and early treatment to reduce stress perception as well as negative aspects caused by stress. It will contribute to the enhancement of public health and life of quality.

• Human Ecology Research
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• v.54 no.3
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• pp.263-278
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• 2016

Recently in South Korea, family-friendly living environment in resident communities have emerged as an important issue in addressing problems created by personalized and fragmented family in urban areas. Since their foundation in 2005, Healthy Family Support Centers provided a variety of community activities for both parents and children through the Co-Child Care Sharing Programs. That being said, it is certain that the Healthy Family Support Centers play a central role in making a family-friendly environment. This study surveyed the physical environment of the co-child care sharing space and suggested further improvement. The content of this survey represents the characteristics of co-child care sharing space in Incheon such as operation status, physical space, prepared facilities, and preference for facilities. This study also explored the field of two co-child sharing spaces (Bupyung-gu and Seo-gu) as an example case. The subject of this study was 14 co-child sharing spaces of nine Healthy Family Support Centers in Incheon investigated from July 2014 to October 2014. This study indicated three results: first, the size of the co-child care spaces, their composition and facilities are very different from each center and require standards and guidelines for the co-child sharing space in regards to physical space, composition, and facilities. Second, co-child sharing space should be provided with individual special programs and diversified activities in addition to playing activities. Third, many healthy family support centers operate over two co-child sharing spaces along with an out-located co-child sharing space that require mutual organizing and operational networking between each co-child sharing space to effectively share programs.