• Asian-Australasian Journal of Animal Sciences
• /
• v.28 no.8
• /
• pp.1075-1083
• /
• 2015

Adipose tissue deposited within muscle fibers, known as intramuscular fat (IMF or marbling), is a major determinant of meat quality and thereby affects its economic value. The biological mechanisms that determine IMF content are therefore of interest. In this study, 48 genes involved in the bovine peroxisome proliferator-activated receptor signaling pathway, which is involved in lipid metabolism, were investigated to identify candidate genes associated with IMF in the longissimus dorsi of Hanwoo (Korean cattle). Ten genes, retinoid X receptor alpha, peroxisome proliferator-activated receptor gamma (PPARG), phospholipid transfer protein, stearoyl-CoA desaturase, nuclear receptor subfamily 1 group H member 3, fatty acid binding protein 3 (FABP3), carnitine palmitoyltransferase II, acyl-Coenzyme A dehydrogenase long chain (ACADL), acyl-Coenzyme A oxidase 2 branched chain, and fatty acid binding protein 4, showed significant effects with regard to IMF and were differentially expressed between the low- and high-marbled groups (p<0.05). Analysis of the gene co-expression network based on Pearson's correlation coefficients identified 10 up-regulated genes in the high-marbled group that formed a major cluster. Among these genes, the PPARG-FABP4 gene pair exhibited the strongest correlation in the network. Glycerol kinase was found to play a role in mediating activation of the differentially expressed genes. We categorized the 10 significantly differentially expressed genes into the corresponding downstream pathways and investigated the direct interactive relationships among these genes. We suggest that fatty acid oxidation is the major downstream pathway affecting IMF content. The PPARG/RXRA complex triggers activation of target genes involved in fatty acid oxidation resulting in increased triglyceride formation by ATP production. Our findings highlight candidate genes associated with the IMF content of the loin muscle of Korean cattle and provide insight into the biological mechanisms that determine adipose deposition within muscle.

• Journal of KIISE:Computer Systems and Theory
• /
• v.34 no.9
• /
• pp.416-424
• /
• 2007

The Bio-Inspired system is a computing model that emulates the objects in ecosystem which are evolving themselves and cooperate each other to perform some tasks. Since it could be used to solved the complex problems that have been very difficult to resolve with previous algorithms, there have been a lot of researches to develop an application based on the Bio-Inspired system. However, since this computing model requires the process of evolving and cooperating with a lot of objects and this process takes a lot of times, it has been very hard to develop an application based on this computing model. This paper presents a parallel simulator for a Bio-Inspired system that is designed and implemented with OMNeT++ on PC clusters, and proves its usefulness by showing its simulation performance for a couple of applications. In the proposed parallel simulator, the functions required in the ERS platform for evolving and cooperating between objects (called Ecogent) are mapped onto the functions of OMNeT++, and they are simulated on PC clusters simultaneously to reduce the total simulation time. The simulation results could be monitored with a GUI In realtime, and they are also recorded into DBMS for systematic analyses afterward. This paper shows the usefulness of the proposed system by analyzing its performances for simulating various applications based on Bio-Inspired system on PC clusters with 4 PCs.

• Journal of the Korean Regional Science Association
• /
• v.6 no.2
• /
• pp.123-147
• /
• 1990

This paper examines the changing geography of producer service industries in the 1980s. The foci of this study are to analyze the regional distribution of each producer services, and to reveal the spatial linkage of producer services. Further this paper asserts the potential role of producer services for reducing the potential endogenous development in the periphery. During the 1981-86 period, producer service industries grew more rapidly than other service sectors and manufacturing sector. The main reason of the raid growth of producer services is attributable to an increase in demand for intermediate services from manufacturing firms. In order to compete an increasingly complex business environment, firms have expanded the amount of effort devoted to activities such as planning, coordination and control, and consequently have increased their use of producer services. The most distinctive feature of the location of producer services is spatial concentration into Seoul and surrounding region. Especially the degree of the concentration o business services into the Capital Region has been accelerating during the 1990s. The pattern of employment growth and regional distribution of producer services show a clear core / periphery disparity. Much of the regional inequality in producer services is largely due to variation in demand associated with the pattern of corporation headquarters with the pattern of corporation headquarters and branch plants location with large manufacturing firms. The analysis of spatial division of labor reflects that producer services are related to the location of headquarters in manufacturing industry. Headquarters in manufacturing firms and business service firms tend to cluster each other. Most of the headquarters spatially separated from branch offices are clustered heavily in Seoul. Especially headquarters of business services and insurance services are overwhelmingly concentrated into Seoul. The firms whose headquarters are located in Seoul have a linkage pattern on a nationwide scale. It is viewed have little potential for generating local multiplier effects and regional development. In the light of the result of this study, producer services are not likely to disperse soon to peripheral regions. Consequently the absence of policies directed at enhancing producer sevice in the periphery, concentration tendency would continue to reinforce the core's dominance at the expense of peripheral regions. From a regional perspective, the quality of a region's producer service sector is a key determinant of economic growth, since manu industrial location decisions are influenced by the differential availability of producer services among regions. Poor performance of producer services in peripheral regions seemed to be linked to the region's manufacturing base. Low-wage, standardized branch plants are not likely to induce the growth in knowledge intensive services associated with high-technology corporate headquarters. Producer services may help to create and attract new business including manufacturing firms, and also to enhance the productivity and competitiveness of local firms. Therefore the provision of service producing activities would be lead not only to generate and retain endogenous development but also to attract external firms, especially small and medium sized firms which have a lower propensity of internalized services. Hence, it may be more efficient to create and expanse new locally owned producer services rather than to attract branch plants of mult-locational firms in order to make indigenous economic development.

• Microbiology and Biotechnology Letters
• /
• v.34 no.2
• /
• pp.101-108
• /
• 2006

YNB54 strain which shows inhibitory activities specific to the plant pathogenic Phytophthora sp. on potato dextrose agar medium was screened among lots of strains isolated from Korean soils. To identify taxonomy of the Phytophthora specific antagonistic bacteria YNB54, 165 rDNA sequence, MIDI fatty acid composition, DNA-DNA hybridization, GC content, and commercial multitest systems such as API 20E and Biolog GN were performed. Results of commercial kits including lots of biochemical and physiological reactions showed that this strain was closely related to taxa including Enterobacter cloacae and Enterobacter cancerogenus species than other genera(Citerobacter Klebsiella, Leclercia). Also, analysis of its MIDI, G+C contents, and DNA-DNA hybridization suggests that this strain was more similiar to the Genus Enterobacter than other genera (Citerobacter Klebsiella, Leclercia). This strain was potentially identified as Enterobacter sp. by these results. But our 16S ribosomal DNA sequences (rDNA) analysis confirmed that it was more closely related to the cluster of Citerobacter freundii ATCC 29935 than any other Enterobacter species. In the absence of defined phylogenetic critia for delineating genera, the results observed with Citrobacter and Enterobacter species suggest that further studies are needed to clarify their relationships. This investigation demonstrates that YNB54 strain is genetically diverse and potentially more taxonomically complex than hitherto realized. Further study is necessary to confirm their taxonomic positions.

• Journal of the Korean Society for information Management
• /
• v.36 no.4
• /
• pp.279-300
• /
• 2019

This study aims to analyze and to demonstrate the research trends and intellectual structure in the field of catalog in the 2000s and 2010s through co-word analysis. The field of catalog had firmly established its own research area and Many differences were found in research trends and intellectual structures in the 2000s and 2010s. First, the average number of articles decreased by 4.2 in the 2010s compared to the 2000s, but the number of author keywords was not significantly different. Only 22.2% of keywords appeared more than three times in both periods, and 77.8% of keywords appeared more than three times in one period. Second, in terms of intellectual structure, the 2000s, represented by three-level clusters, formed a more complex network than the 2010s, represented by two-level clusters. Third, as a result of examining the changes in the characteristics of each cluster, there were some research topics with few changes, but many research topics were more actively progressed or subdivided, and decreased. The results of this study are meaningful in that they can visually grasp the intellectual structure along with the trend of the age of catalogue, and can prepare for related education and research by predicting the future.

• Molecules and Cells
• /
• v.26 no.6
• /
• pp.566-575
• /
• 2008

Twenty-five chipmunk species occur in the world, of which only the Siberian chipmunk, Tamias sibiricus, inhabits Asia. To investigate mitochondrial cytochrome b sequence variations and population structure of the Siberian chipmunk in northeastern Asia, we examined mitochondrial cytochrome b sequences (1140 bp) from 3 countries. Analyses of 41 individuals from South Korea and 33 individuals from Russia and northeast China resulted in 37 haplotypes and 27 haplotypes, respectively. There were no shared haplotypes between South Korea and Russia - northeast China. Phylogenetic trees and network analysis showed 2 major maternal lineages for haplotypes, referred to as the S and R lineages. Haplotype grouping in each cluster was nearly coincident with its geographic affinity. In particular, 3 distinct groups were found that mostly clustered in the northern, central and southern parts of South Korea. Nucleotide diversity of the S lineage was twice that of lineage R. The divergence between S and R lineages was estimated to be 2.98-0.98 Myr. During the ice age, there may have been at least 2 refuges in South Korea and Russia - northeast China. The sequence variation between the S and R lineages was 11.3% (K2P), which is indicative of specific recognition in rodents. These results suggest that T. sibiricus from South Korea could be considered a separate species. However, additional information, such as details of distribution, nuclear genes data or morphology, is required to strengthen this hypothesis.

• Journal of Korea Spatial Information System Society
• /
• v.10 no.2
• /
• pp.63-79
• /
• 2008

With the recent development of advanced GIS and complex spatial analysis technologies, the more sophisticated technologies are being required to support the advanced knowledge for solving geographical or spatial problems in various decision support systems. In addition, necessity for research on scientific crime investigation and forensic science is increasing particularly at law enforcement agencies and investigation institutions for efficient investigation and the prevention of crimes. There are active researches on geographic profiling to predict the base location such as criminals' residence by analyzing the spatial patterns of serial crimes. However, as previous researches on geographic profiling use simply statistical methods for spatial pattern analysis and do not apply a variety of spatial and temporal analysis technologies on serial crimes, they have the low prediction accuracy. Therefore, this paper identifies the typology the spatio-temporal patterns of serial crimes according to spatial distribution of crime sites and temporal distribution on occurrence of crimes and proposes STA-BLP(Spatio-Temporal Analysis based Base Location Prediction) algorithm which predicts the base location of serial crimes more accurately based on the patterns. STA-BLP improves the prediction accuracy by considering of the anisotropic pattern of serial crimes committed by criminals who prefer specific directions on a crime trip and the learning effect of criminals through repeated movement along the same route. In addition, it can predict base location more accurately in the serial crimes from multiple bases with the local prediction for some crime sites included in a cluster and the global prediction for all crime sites. Through a variety of experiments, we proved the superiority of the STA-BLP by comparing it with previous algorithms in terms of prediction accuracy.

• Journal of Korea Soil Environment Society
• /
• v.1 no.1
• /
• pp.89-102
• /
• 1996

An integrated model is presented to describe underground flow and mass transport, using a multicomponent multiphase approach. The comprehensive governing equation is derived considering mass and force balances of chemical species over four phases(water, oil, air, and soil) in a schematic elementary volume. Compact and systemati notations of relevant variables and equations are introduced to facilitate the inclusion of complex migration and transformation processes, and variable spatial dimensions. The resulting nonlinear system is solved by a multidimensional finite element code. The developed code with dynamic array allocation, is sufficiently flexible to work across a wide spectrum of computers, including an IBM ES 9000/900 vector facility, SP2 cluster machine, Unix workstations and PCs, for one-, two and three-dimensional problems. To reduce the computation time and storage requirements, the system equations are decoupled and solved using a banded global matrix solver, with the vector and parallel processing on the IBM 9000. To avoide the numerical oscillations of the nonlinear problems in the case of convective dominant transport, the techniques of upstream weighting, mass lumping, and elementary-wise parameter evaluation are applied. The instability and convergence criteria of the nonlinear problems are studied for the one-dimensional analogue of FEM and FDM. Modeling capacity is presented in the simulation of three dimensional composite multiphase TCE migration. Comprehesive simulation feature of the code is presented in a companion paper of this issue for the specific groundwater or flow and contamination problems.

• Asian-Australasian Journal of Animal Sciences
• /
• v.33 no.9
• /
• pp.1507-1519
• /
• 2020

Objective: The current research was aimed to profile the transcriptomic picture of the peripheral blood lymphocytes (PBLs) associated with immunity in Chinese Holsteins supplemented orally with coated folic acid during the periparturient period. Methods: The total of 123 perinatal cows were selected for this study and divided into three groups; group A (n = 41, 240 mg/500 kg cow/d), group B (n = 40, 120 mg/500 kg cow/d) and group C (n = 42, 0 mg/cow/d) based on the quantity of folic acid fed. Three samples of PBLs were selected from each folic acid treated group (high, low, and control) and RNA sequencing method was carried out for transcriptomic analysis. Results: The analysis revealed that a higher number of genes and pathways were regulated in response to high and low folic acid supplementation compared to the controls. We reported the novel pathways tumor necrosis factor (TNF) signaling, antigen processing and presentation, Staphylococcus aureus infection and nuclear factor (NF)-kappa B signaling pathways) and the key genes (e.g. C-X-C motif chemokine ligand 10, TNF receptor superfamily member 1A, cluster difference 4, major histocompatibility complex, class II, DQ beta, NF-kappa-B inhibitor alpha, and TNF superfamily 13) having great importance in immunity and anti-inflammation in the periparturient cows in response to coated folic acid treatment. Conclusion: Collectively, our study profiled first-time transcriptomic analysis of bovine lymphocytes and compared the involved cytokines, genes, and pathways between high vs control and low vs control. Our data suggest that the low folic acid supplementation (120 mg/500 kg) could be a good choice to boost appropriate immunity and anti-inflammation as well as might being applied to the health improvement of perinatal dairy cows.

• Journal of Digital Convergence
• /
• v.18 no.9
• /
• pp.277-283
• /
• 2020

The purpose of this study was to identify the risk factors influencing stroke. The research method was used two-stage stratified cluster sampling using data from the National Health and Nutrition Survey (2016-2018). This study subjects performed a complex sample logistic regression analysis on adults aged 19 or older. Risk factors affecting stroke were shown as follows: in age groups, odds ratio were conformed when people are in their 70s, the rate is 8.861 times higher; when they are in their subjective health conditions, the odds ratio are 4.501 times higher in the bad groups; odds ratio was 3.158 times higher in the group diagnosed with hypertension and 1.598 times higher in the group diagnosed with diabetes. The result of this study found that chronic diseases such as high blood pressure and diabetes and the management of senior citizens are important because stroke is dangerous and can be managed through prevention.