• BMB Reports
• /
• 제51권4호
• /
• pp.188-193
• /
• 2018

Caffeoylserotonin (CaS), one derivative of serotonin (5-HT), is a secondary metabolite produced in pepper fruits with strong antioxidant activities. In this study, we investigated the effect of CaS on proliferation and migration of human keratinocyte HaCaT cells compared to that of 5-HT. CaS enhanced keratinocyte proliferation even under serum deficient condition. This effect of CaS was mediated by serotonin 2B receptor (5-HT2BR) related to the cell proliferation effect of 5-HT. We also confirmed that both CaS and 5-HT induced G1 progression via 5-HT2BR/ERK pathway in HaCaT cells. However, Akt pathway was additionally involved in upregulated expression levels of cyclin D1 and cyclin E induced by CaS by activating 5-HT2BR. Moreover, CaS and 5-HT induced cell migration in HaCaT cells via 5-HT2BR. However, 5-HT regulated cell migration only through ERK/AP-1/MMP9 pathway while additional Akt/NF-${\kappa}B$/MMP9 pathway was involved in the cell migration effect of CaS. These results suggest that CaS can enhance keratinocyte proliferation and migration. It might have potential as a reagent beneficial for wound closing and cell regeneration.

• 상하수도학회지
• /
• 제32권6호
• /
• pp.507-515
• /
• 2018

The results of the survey on water utilization status, the wasted water factor, the awareness, and the education and promotional activities of water saving in Daejeon City are as follows: The percentage of using tap valve with a closure was 66% when showering. 74% of water was used with closing the tap valve when washing faces with no water needed, it was still considered that there existed a wasting water. The most wasting reasons of water were found to be shower, bath, and laundry in order. In the awareness of practicing tap water saving, 9.1% of respondents acted actively, 53.4% of them were trying to practice it, and more than 63% had a positive awareness. In the contents of practicing saving water, locking water when soaping while showering, non-laundry of small quantity, and using cups when brushing teeth were top priorities. About 50% of the reasons for saving water was to practice purely saving water, when saving for economic help was excluded. The level of water saving awareness was not high when considering that the ratio of usage without water saving equipment and installation, and using method was relatively high when moving in. In order to make usage of water saving equipment more common, it was deemed necessary to provide information on the purchase of water saving equipment and to promote and educate the efficiency of saving of related products. More than about 90% of the respondents responded that water saving education or promotional activities had an effect of improving water saving awareness. The most effective method of education and promotional activities was found to be 40.4% by mass media activities, and 21.7% by promotions through mobile devices.

• 농업과학연구
• /
• 제44권4호
• /
• pp.595-603
• /
• 2017

Crop growth and production cost are greatly influenced by management of environmental factors such as ambient temperature, humidity, and $CO_2$, especially in protected horticulture. Opening and closing of greenhouses is the most important operation for control of these ambient environmental factors, and precise and stable operation requires high performance window motors. In this study, a 400 W precise window motor was constructed, and its performance was evaluated for plastic and glass greenhouses. First, the motor was designed and fabricated by benchmarking of an advanced foreign product. Then, the performance was evaluated through vibration, PCB (Process Control Block), and load tests. Vibration tests resulted in averaged vibration displacement and velocity of the developed motor of 0.002 mm and 0.2267m/s, which were statistically significantly different from those of the target motor. Average vibration acceleration ($0.26m/s^2$) of the developed motor was also significantly different from that ($0.51m/s^2$) of the target motor. PCB tests showed 2 - 4 mm deviation from the target values, and confirmed the operating status and precision of the control. Load tests with a 300 kg load also showed acceptable operating status and durability. Current values were $1.31{\pm}0.06A$ and RPMs were in the range of 2.9 - 3.0. Considering the above results, the developed window motor would be competitive to the target foreign product.

• 대한치과기공학회지
• /
• 제41권4호
• /
• pp.295-301
• /
• 2019

Purpose: This study is for the prosthesis of dogs. Observe the occlusal relation between the dog's canine and carnassial teeth. The strength and the direction of the occlusal by 3D FEM analysis. Methods: The mandibular canine and carnassial of dogs were tested. The dog's skull was contact point confirmed by dental CAD. The skull of the dog was 3D modeled by CT. The 3D model was analyzed by ABAQUS. Opening and closing movement has been a force of 100N, 200N, 300N, 500N, 1000N, 1,500N. The peak von Mises stress distribution was confirmed. Results: As occlusal force increased, stress appeared to 1.34 MPa, 3.32 MPa, 5.00 MPa, 6.19 MPa, 5.58 MPa, 5.47 MPa in left canine. and Stress was seen at 2.10 MPa, 3.08 MPa, 3.89 MPa, 5.50 MPa, 7.04 MPa, 7.18 MPa in the right canine. Stress appeared at 2.41 MPa, 3.53 MPa, 5.15 MPa, 7.28 MPa, 31.26 MPa, 67.22 MPa in the left carnassial. and Stress was seen at 1.57 MPa, 2.96 MPa, 3.76 MPa, 6.01 MPa, 20.94 MPa, 64.38 MPa in the right carnassial. Conclusion: Peak von Mises stress values were found at the peak of the canine, the buccal of the central cusp of the carnassial, and the occlusal surface of the distal cusp.

• 한국포장학회지
• /
• 제19권2호
• /
• pp.61-65
• /
• 2013

Modified atmosphere (MA) of reduced $O_2$ and elevated $CO_2$ concentrations has been used for keeping the quality of fresh produce and extending the shelf life. As a way to attain the beneficial MA package around the produce, a gas diffusion tube or perforation can be attached onto the container and controlled on real time in its opening/closing responding to $O_2$ and $CO_2$ concentrations measured by gas sensors. The timely-controlled opening of the gas diffusion tube can work in harmony with the produce respiration and help to create the desired MA. By use of the mathematical modeling, the effect of tube dimension on the controlled container atmosphere was figured out in this study. Spinach and king oyster mushroom were used as typical commodities for designing the model container system (0.35 and 0.9 kg in 13 L, respectively) because of their respiration characteristics and the optimal MA condition ($O_2$ 7~10%/$CO_2$ 5~10% for spinach; $O_2$ 2~5%/$CO_2$ 10~15% for mushroom). With a control logic for the gas composition to stay as close as possible to optimum MA window without invading injurious low $O_2$ and/or high $CO_2$ concentrations, the atmosphere of the sensor-controlled container could stay at its lower $O_2$ boundary or upper $CO_2$ limit under certain tube dimensional conditions. There were found to be the ranges of the tube diameter and length allowing the beneficial MA. The desired range of the tube dimension for spinach consisted of combinations of larger diameter and shorter length in the window of 0.3~2 cm diameter and 0.2~10 cm length. Similarly, that for king oyster mushroom was combinations of larger diameter and shorter length in the window of 0.9~2 cm diameter and 0.2~3 cm in length. Clear picture on generally affordable tube dimension range may be formulated by further study on a wide variety of commodity and pack conditions.

• Steel and Composite Structures
• /
• 제27권5호
• /
• pp.577-598
• /
• 2018

The imperfect steel-concrete interface bonding is an important deficiency of the concrete-filled double skin tubular (CFDST) columns that led to separating concrete and steel surfaces under lateral loads and triggering buckling failure of the columns. To improve this issue, it is proposed in this study to use longitudinal and transverse steel stiffeners in CFDST columns. CFDST columns with different patterns of stiffeners embedded in the interior or exterior surfaces of the inner or outer tubes were analyzed under constant axial force and reversed cyclic loading. In the finite element modeling, the confinement effects of both inner and outer tubes on the compressive strength of concrete as well as the effect of discrete crack for concrete fracture were incorporated which give a realistic prediction of the seismic behavior of CFDST columns. Lateral strength, stiffness, ductility and energy absorption are evaluated based on the hysteresis loops. The results indicated that the stiffeners had determinant role on improving pinching behavior resulting from the outer tube's local buckling and opening/closing of the major tensile crack of concrete. The lateral strength, initial stiffness and energy absorption capacity of longitudinally stiffened columns with fixed-free end condition were increased by as much as 17%, 20% and 70%, respectively. The energy dissipation was accentuated up to 107% for fixed-guided end condition. The use of transverse stiffeners at the base of columns increased energy dissipation up to 35%. Axial load ratio, hollow ratio and concrete strength affecting the initial stiffness and lateral strength, had negligible effect of the energy dissipation of the columns. It was also found that the longitudinal stiffeners and transverse stiffeners have, respectively, negative and positive effects on ductility of CFDST columns. The conclusions, drawn from this study, can in turn, lead to the suggestion of some guidelines for the design of CFDST columns.

• Journal of Mechanical Science and Technology
• /
• 제17권7호
• /
• pp.1073-1082
• /
• 2003

Many researchers have investigated the blood flow characteristics through bileaflet mechanical heart valves using computational fluid dynamics (CFD) models. Their numerical approach methods can be classified into three types; steady flow analysis, pulsatile flow analysis with fixed leaflets, and pulsatile flow analysis with moving leaflets. The first and second methods have been generally employed for two-dimensional and three-dimensional calculations. The pulsatile flow analysis interacted with moving leaflets has been recently introduced and tried only in two-dimensional analysis because this approach method has difficulty in considering simultaneously two physics of blood flow and leaflet behavior interacted with blood flow. In this publication, numerical calculation for pulsatile flow with moving leaflets using a fluid-structure interaction method has been performed in a three-dimensional geometry. Also, pulsatile flow with fixed leaflets has been analyzed for comparison with the case with moving leaflets. The calculated results using the fluid-structure interaction model have shown good agreements with results visualized by previous experiments. In peak systole. calculations with the two approach methods have predicted similar flow fields. However, the model with fixed leaflets has not been able to predict the flow fields during opening and closing phases. Therefore, the model with moving leaflets is rigorously required for advanced analysis of flow fields.

• 대한치과보철학회지
• /
• 제29권2호
• /
• pp.161-175
• /
• 1991

To understand the biomechanics of the mandibular movement of the patients with T.M.J. disorder, it is necessary to analyze the mandibular movement by the least moving points of instantaneous center of rotation on computer screen. In this study, two subjects without T.M.J. disorder and with normal occlusion and few patients with T.M.J. disorder were selected for obtaining the processing data. The habitual opening and dosing movements were recorded by image recognition system of video and computer and then the mandibular movement and the least moving point were analyzed using computer program for image anaysis of specialized points. The results obtained were as follows: 1. The least moving points of control group during opening and dosing were dose to the mandibular foramen, but in the test group there were differences between two positions of the least moving points during opening and closing. 2. The variations of the least moving point were in the range of $0.02\sim0.05cm$ of X-coordinate and $0.07\sim0.10cm$ of Y-coordinate for control group, whereas in the range of $0.05\sim0.30cm$ of X-coordinate and $0.08\sim1.65cm$ of Y-coordinate for test group. 3. The index of variation during opening and dosing movements was shown in $0.8\sim1.0$ for the control group and in $0.56\sim2.6$ for the test group. 4. After the treatment of the test group No. 4 by occlusal splint the least moving point was dose to the mandibular foramen and the index of variation was changed from 25 to 05. 5. The tracing shape of the least moving point in the test group represented the irregularities compared to the control group. 6. The mandibular opening and dosing movements were simulated on the computer screen following the movement of the least moving point of instantaneous center of rotation.

• 한국지역지리학회지
• /
• 제9권3호
• /
• pp.314-328
• /
• 2003

본 연구는 아파트 주거공간에 기초한 지역공동체의 형성을 공동체 운동의 주체와 주민들을 대상으로 한 설문조사를 통하여 고찰하였다. 아파트 거주공간은 폐쇄적으로 구획화된 물리적 특성으로 인하여 공동체 형성에 많은 어려움이 있지만, 다른 한편으로는 공동체적 요소를 갖고 있기도 하다. 조사결과는 입주자 대표회의와 부녀회를 중심으로 여러 자발적 주민조직이 다양한 생활문화운동을 전개하는 것으로 나타나, 아직 규범적 공동체 운동까지 나아가지는 않았으나 보상적 공동체 운동에서 한 단계 더 발전한 모습을 보여주고 있다. 특히, 공동체 활동이 지역공동체의 근간이 될 수 있는 근린관계의 형성에 적극적 영향을 미치고 있으며, 공동체 활동에 대하여 주민 스스로 긍정적 평가를 내리고 있다. 본 연구의 함의는 현대 도시문제를 해결하는 한 대안으로 아파트 주민공동체 운동의 가치와 그 가능성을 보여주는 것이다.

• Safety and Health at Work
• /
• 제4권2호
• /
• pp.100-104
• /
• 2013

Background: The aim of this study was to assess public and private medical diagnostic laboratories in Nigeria for the presence of biosafety equipment, devices, and measures. Methods: A total of 80 diagnostic laboratories in biosafety level 3 were assessed for the presence of biosafety equipment, devices, and compliance rate with biosafety practices. A detailed questionnaire and checklist was used to obtain the relevant information from enlisted laboratories. Results: The results showed the presence of an isolated unit for microbiological work, leak-proof working benches, self-closing doors, emergency exits, fire extinguisher(s), autoclaves, and hand washing sinks in 21.3%, 71.3%, 15.0%, 1.3%, 11.3%, 82.5%, and 67.5%, respectively, of all laboratories surveyed. It was observed that public diagnostic laboratories were significantly more likely to have an isolated unit for microbiological work (p = 0.001), hand washing sink (p = 0.003), and an autoclave ($p{\leq}0.001$) than private ones. Routine use of hand gloves, biosafety cabinet, and a first aid box was observed in 35.0%, 20.0%, and 2.5%, respectively, of all laboratories examined. Written standard operating procedures, biosafety manuals, and biohazard signs on door entrances were observed in 6.3%, 1.3%, and 3.8%, respectively, of all audited laboratories. No biosafety officer(s) or records of previous spills, or injuries and accidents, were observed in all diagnostic laboratories studied. Conclusion: In all laboratories (public and private) surveyed, marked deficiencies were observed in the area of administrative control responsible for implementing biosafety. Increased emphasis on provision of biosafety devices and compliance with standard codes of practices issued by relevant authorities is strongly advocated.