• Title/Summary/Keyword: Clinical trial,

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The Change of Blood Pressure according to the Number of Measurements and the Number of Visits (측정 횟수 및 방문 횟수에 따른 혈압 변화)

  • Park, Ji-Eun;Lee, Min-Hee;Ryu, Yeon-Hee;Liu, Yan;Jung, Hee-Jung;Hong, Sang-Hoon;Lee, Seung-Deok;Kim, Nam-Kwen;Choi, Sun-Mi
    • Korean Journal of Oriental Medicine
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    • v.18 no.3
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    • pp.111-118
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    • 2012
  • Objective : The aim of this study was to investigate the number of measurements and visits for blood pressure measurement. We also analyzed the change of blood pressure based on the measurement method and measurement interval. Methods : Data of three clinical trials evaluating the effect of acupuncture, moxibustion, and qigong for pre and mild essential hypertension were used. Blood pressure was measured 3 times each visit with 1 or 5 minutes interval, and it was checked until $3^{rd}$ visit. Two trials used sphygmomanometer and another one trial used automatic device for blood pressure measurement. Results : The mean difference between $1^{st}$ and $2^{nd}$, and $2^{nd}$ and $3^{rd}$ measurement were significant in systolic (p<0.001) and diastolic blood pressure (p<0.001). However, in automated measurement or measuring with 1 minute interval, the difference between $2^{nd}$ and $3^{rd}$ was not significant. The mean of $1^{st}$ and $2^{nd}$ measurements was also significantly different from the mean of all three measurements in both systolic (p<0.001) and diastolic blood pressure (p<0.001). While the difference between each visit was not significant in diastolic blood pressure, the systolic blood pressure difference was significant between $1^{st}$ and $2^{nd}$ visit in automated and manual measurement. Conclusion : The mean of two measurements and three measurements were significantly different. The change of blood pressure was different according to the method and interval of blood pressure measurement.

Whole pelvic intensity-modulated radiotherapy for high-risk prostate cancer: a preliminary report

  • Joo, Ji Hyeon;Kim, Yeon Joo;Kim, Young Seok;Choi, Eun Kyung;Kim, Jong Hoon;Lee, Sang-Wook;Song, Si Yeol;Yoon, Sang Min;Kim, Su Ssan;Park, Jin-Hong;Jeong, Yuri;Ahn, Hanjong;Kim, Choung-Soo;Lee, Jae-Lyun;Ahn, Seung Do
    • Radiation Oncology Journal
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    • v.31 no.4
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    • pp.199-205
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    • 2013
  • Purpose: To assess the clinical efficacy and toxicity of whole pelvic intensity-modulated radiotherapy (WP-IMRT) for high-risk prostate cancer. Materials and Methods: Patients with high-risk prostate cancer treated between 2008 and 2013 were reviewed. The study included patients who had undergone WP-IMRT with image guidance using electronic portal imaging devices and/or cone-beam computed tomography. The endorectal balloon was used in 93% of patients. Patients received either 46 Gy to the whole pelvis plus a boost of up to 76 Gy to the prostate in 2 Gy daily fractions, or 44 Gy to the whole pelvis plus a boost of up to 72.6 Gy to the prostate in 2.2 Gy fractions. Results: The study cohort included 70 patients, of whom 55 (78%) had a Gleason score of 8 to 10 and 50 (71%) had a prostate-specific antigen level > 20 ng/mL. The androgen deprivation therapy was combined in 62 patients. The biochemical failure-free survival rate was 86.7% at 2 years. Acute any grade gastrointestinal (GI) and genitourinary (GU) toxicity rates were 47% and 73%, respectively. The actuarial rate of late grade 2 or worse toxicity at 2 years was 12.9% for GI, and 5.7% for GU with no late grade 4 toxicity. Conclusion: WP-IMRT was well tolerated with no severe acute or late toxicities, resulting in at least similar biochemical control to that of the historic control group with a small field. The long-term efficacy and toxicity will be assessed in the future, and a prospective randomized trial is needed to verify these findings.

Association with Self-Perception for Obesity and Mental Health among Korean Adolescent (한국청소년에서 자가비만인식도와 정신건강과의 관련성)

  • Hwang, In-Cheol;Lee, Kyoung-Shik;Park, Dong-Kyun;Jung, Eun-Young;Choi, Chung-Hyun;Cho, Seong-Jin;Bae, Seung-Min
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • v.22 no.2
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    • pp.112-119
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    • 2011
  • Objectives : Obesity has been linked to various psychological problems as well as medical complications, especially among adolescents. Previous studies have suggested an association between body weight and depression or self-esteem ; however, there has been little evidence on self-perception of weight and mental health. The aim of this study was to examine the association of perceptional weight status with mental health in Korean adolescents. Methods : This study was based on data obtained from the third Korean National Health and Nutritional Examination Survey (2005). The study sample consisted of 583 adolescents (268 boys, 315 girls) aged 12-18 years, who had completed the health survey, the health examination, and the nutritional survey. Participants were divided into two groups based on the actual or perceptional weight status: non-obese and obese. Questionnaires for stress, depressive mood, and suicidal thoughts were utilized as mental health indicators. Results : The agreement between actual and perceptional weight status was moderate (k value, 0.585 ; p<0.01). The influencing factors for the discrepancy between actual and perceptional weight status were body mass index of subjects and their parents' education. The obese group was likely to have higher stress levels and more experience of depressive mood or suicidal ideation in regard to both actual and perceptional weight status. A multiple logistic regression analysis revealed that girls who had perceived themselves as obese were more likely to have an experience of depressive mood than other girls (unadjusted OR, 4.98 ; adjusted OR, 5.15). Conclusion : An experience of depressive mood was significantly associated with the perception of weight status and not actual weight status in Korean female adolescents.

Report of the 3rd Japan-Korea Workshop on Acupuncture and EBM;Protocol development for the acupuncture trial on the osteoarthritis of the knee

  • Jang, Jun-Hyouk;Kenji, Kawakita;Hahn, Seo-Kyung;Park, Hi-Joon;Lee, Seung-Deok;Kim, Yong-Suk;Norihito, Takahashi;Toshiyuki, Shichidou;Kazunori, Itoh;Eiji, Sumiya;Eiji, Furuya;Hitoshi, Yamashita;Hiroshi, Tsukayama
    • Journal of Acupuncture Research
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    • v.23 no.6
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    • pp.239-254
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    • 2006
  • The 3rd Japan-Korea Workshop on Acupuncture and EBM was held at Kanazawa on June $16^{th}$. From Korea team, 4 papers were presented. Dr. Hahn introduced a new approach of data analysis on series of n-of-1 trials using the Bayesian statistics. It offered important information for the future n-of-1 trials. Dr. Park clearly demonstrated the significance of various sham devices proposed and stressed the importance of research questions when we choose the control intervention in RCT. Dr. Lee reported the results of survey in Korean Medical Doctors (KMD) for their point selection and techniques to the distal and local points. Dr. Kim presented the results of face to face survey on the KMD with 28 items for acupuncture treatment on the knee OA. Finally, a draft of protocol was introduced by Dr. Kim. The title was "multi-center, a randomized, single blinded, two arms, parallel-group study to compare the effectiveness and safety of 'individualized acupuncture' and 'standardized minimal acupuncture' in Korean and Japanese patients with knee osteoarthritis (Phase IV)". From Japan team, 7 speakers presented their comments and proposals on the protocol. Dr. Takahashi introduced several issues regarding n-of-1 trials and pointed out the importance of obtaining generalizability from n-of-1 trials. Dr. Shichidou pointed the importance of research design, selection of outcome measures and reduction of biases. Dr. Itoh presented the results of point selection for the knee OA based on the literature survey. Dr. Sumiya introduced several differences between KMD and Japanese acupuncturists based on the questionnaire used in KMD survey. Dr. Furuya demonstrated a result of press tack needle and its sham device on shoulder stiffness. Dr. Yamashita introduced the results of literature survey regarding adverse events occurred by acupuncture on knee OA. Dr.Tsukayama stressed the importance of responsibility of Institutional Review Board (IRB) for the conduction of clinical trials. After several issues were discussed, the need of continued meeting for final protocol development was agreed, then the workshop was closed.

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Effects of Integrative Korean Medical Treatment for a Failed Epidural Steroid Injections to L-spine Disk Herniation: A Retrospective Case Series (경막외 스테로이드 주사치료에 실패 후 한방복합치료에 의해 호전된 요추 추간판 탈출증 환자 10례 : 후향적 증례 연구)

  • Kim, Ji Su;Kim, Yoo Jong;Hong, Je Rak;Kim, Min Chul;Park, Han Sol;Kim, Seh Young;Seo, Young Woo;Lee, Sang Min;Seo, Young Hoon;Kim, Ki Ok;Kim, Tae Hun
    • Journal of Acupuncture Research
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    • v.32 no.4
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    • pp.203-211
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    • 2015
  • Objectives : The purpose of this study was to assess the effectiveness of integrative Korean Medical treatments for patients with L-spine disk herniation that showed no response to Epidural Steroid Injections (ESI). Methods : In this study, we reviewed the medical records of ten patients who showed no improvement or relapsed after ESI. The patients each received more than three weeks of integrative treatments at Mokhuri Neck&Back Hospital. The Visual Analog Scale (VAS) and Oswestry Disability Index (ODI) was measured before and after treatment. A statistical analysis to compare before and after treatments was assessed using paired t-test the SPSS 12.0 Windows program. Results : After three weeks of treatment, patients showed a significant decrease in VAS and ODI scores compared to before receiving treatment. VAS scores decreased from $5.3{\pm}1.25$ to $1.9{\pm}0.99$ (p<0.001), and ODI scores decreased from $59.8{\pm}22.2$ to $32.7{\pm}14.11$ (p<0.001). Conclusions : Complex Korean Medical treatment showed effectiveness in the treatment of L-spine HIVD patients that showed no response to ESI, and more objective research is needed.

A study on the Menstrual Pain and Dysmenorrhea, Factors Influenced to Them, and Self-Management Method for Them of College Students (일부 여대생의 생리통 및 월경곤란증과 그 관련요인에 관한 조사연구)

  • Han Sun-Hee;Hur Myung-Haeng
    • The Journal of Korean Academic Society of Nursing Education
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    • v.5 no.2
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    • pp.359-375
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    • 1999
  • This is a survey in order to provide basic information about menstrual pain management and dysmenorrhea management. Menstrual pain means low abdominal cramps during menstruation and dysmenorrhea means low abdominal pains, and other symtoms as lumbago, fatigue, G-I symptoms, etc. The purposes of this study were (1) to measure the menstrual pain and dysmenorrhea, (2) to determine factors influenced to them, and (3) to know self-management method for them of college students. The subject of this study consisted of 312 college students Data were collected by questionnaire which was to measure the menstrual pain(Visual Analogue Scale(VAS), dysmenorrhea (dysmenorrhea scale) and general informations from May to June, 1999. The results of this study were as follows ; (1) Mean age for subjects was 19.4 yrs, their height was 161.4Cm, weight, 50.9Kg, menarcheal age, 13.5yrs, menstural period, 30.1 days, and menstrual duration was 5.6 days. Most respondents replied that their menstrual bleeding was moderate (72.1%) and occured regularly(55.4%). (2) Mean menstrual pain was 5.20. Menstrual pain didn't be occured 17.4 % of respondents, periodically 46.0%, and intermittently 36.6%, most commonly beginning the first day of menstruation (3) Chief management method was endurance (40.4%), use of analgesics (29.5%) and bed rest(16.5%). (4) Factors influenced to menstrual pain were analgesics use, heavy bleeding, time of menstrual pain, life change during menstruation. (5) Most symptoms of dysmenorrhea were low abdominal pain(22.2%), lumbago (15.9%), fatigue(9.0%). (6) Factors influenced to dysmenorrhea were anlgesics use and menstrual pain. (7) By Pearson's correlation analysis, there was a significant correlation between menstrual pain and menarcheal age, menstrual period. menstrual duration. But there was no correlation between menstrual pain and height, weight (8) By Pearson's correlation analysis, there was a significant correlation between dysmenorrhea and menstrual period But there was no correlation between menstrual pain and menarcheal age, menstrual duration, height, weight The results demonstrate the importance of development and clinical trial of nursing intervention on menstrual pain and dysmenorrhea.

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FACIAL ASYMMETRY WITH MANDIBULAR PROGNATHISM - A NEW TRIAL OF CLASSIFICATION AND INTERPRETATION - (하악골 전돌증을 동반한 안모비대칭의 유형 분석)

  • Yoon, Kyu-Sik;Jung, Young-Soo;Kang, Goon-Chul;Park, Hyung-Sik
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.30 no.2
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    • pp.108-120
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    • 2004
  • Object : Patients with facial asymmetry accompanying mandibular prognathism have various causes and clinical features. So, it is difficult to find a satisfactory treatment method functionally and esthetically. Every traditional classification and interpretation to find etiopathogenesis and/or to establish ideal surgical modality has many limitations because it can't be applied simply to various conditions of patients with facial asymmetry accompanying mandibular prognathism. Therefore, we employ a new classification to interpret more details of the morphologic change of mandible and the spatial change of mandible and maxilla. Materials and Methods : Using panoramic X-ray films, PA cephalograms and submentovertex films of 126 patients diagnosed with facial asymmetry accompanying mandibular prognathism as resources, the following results were gathered after analyzing each characteristics through distributing the patterns according to the morphological mandibular asymmetry and mandibular and maxillary spatial asymmetry. Results : Almost frequency of morphological mandibular asymmetry was shown. In case of condyle-ramus elongation and body elongation group, it's frequency was the highest. Higher frequency of compensating vertical growth was shown on the side of over growing maxilla in case of vertical length difference between left and right condyle-ramus. On the other hand, higher frequency of no compensating vertical growth difference between left and right side was shown in case of no vertical length difference in condyle-ramus. Spatial mandibular asymmetry generally occurred when there was no morphological mandibular asymmetry. Correlation between condyle length difference and condyle-ramus length difference between left and right side was very high, but correlation between condyle length difference and body length difference, and correlation between condyle length difference and body vertical length difference was low. Conclusion : In case of patients with facial asymmetry accompanying mandibular prognathism, it is suggested that various pattern of facial asymmetry is occurred by the independent growth of each unit rather than dependent growth of other unit by major growth unit abnormality. Due to the untypical pattern and the various asymmetry occurring according to the changes of each mandibular growth unit, it is considered that an appropriate surgical method should be searched based on the accurate recognition of the each pattern for patients with facial asymmetry accompanying mandibular prognathism.

Application of low-crystalline carbonate apatite granules in 2-stage sinus floor augmentation: a prospective clinical trial and histomorphometric evaluation

  • Nakagawa, Takayuki;Kudoh, Keiko;Fukuda, Naoyuki;Kasugai, Shohei;Tachikawa, Noriko;Koyano, Kiyoshi;Matsushita, Yasuyuki;Sasaki, Masanori;Ishikawa, Kunio;Miyamoto, Youji
    • Journal of Periodontal and Implant Science
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    • v.49 no.6
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    • pp.382-396
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    • 2019
  • Purpose: The purpose of this study was to elucidate the efficacy and safety of carbonate apatite (CO3Ap) granules in 2-stage sinus floor augmentation through the radiographic and histomorphometric assessment of bone biopsy specimens. Methods: Two-stage sinus floor augmentation was performed on 13 patients with a total of 17 implants. Radiographic assessment using panoramic radiographs was performed immediately after augmentation and was also performed 2 additional times, at 7±2 months and 18±2 months post-augmentation, respectively. Bone biopsy specimens taken from planned implant placement sites underwent micro-computed tomography, after which histological sections were prepared. Results: Postoperative healing of the sinus floor augmentation was uneventful in all cases. The mean preoperative residual bone height was 3.5±1.3 mm, and this was increased to 13.3±1.7 mm by augmentation with the CO3Ap granules. The mean height of the augmented site had decreased to 10.7±1.9 mm by 7±2 months after augmentation; however, implants with lengths in the range of 6.5 to 11.5 mm could still be placed. The mean height of the augmented site had decreased to 9.6±1.4 mm by 18±2 months post-augmentation. No implant failure or complications were observed. Few inflammatory cells or foreign body giant cells were observed in the bone biopsy specimens. Although there were individual differences in the amount of new bone detected, new bone was observed to be in direct contact with the CO3Ap granules in all cases, without an intermediate layer of fibrous tissue. The amounts of bone and residual CO3Ap were 33.8%±15.1% and 15.3%±11.9%, respectively. Conclusions: In this first demonstration, low-crystalline CO3Ap granules showed excellent biocompatibility, and bone biopsy showed them to be replaced with bone in humans. CO3Ap granules are a useful and safe bone substitute for two-stage sinus floor augmentation.

Thematic Analysis of the Therapeutic Song Writing Experience of Music Therapy Interns: A Focus Group (음악치료 인턴들의 치료적 노래만들기 경험에 대한 주제분석: 포커스 그룹을 중심으로)

  • Park, Chanyang;Kim, Jinah
    • Journal of Music and Human Behavior
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    • v.17 no.1
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    • pp.1-24
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    • 2020
  • The internship is essential for the music therapy curriculum and affords interns the opportunity to apply their classroom-based knowledge and skills to real-world clinical settings. However, challenges associated with the internship can result in interns undergoing trial-and-error learning, interpersonal conflicts, and intrapersonal difficulties. An experiential music therapy group may be useful in helping interns process these incidents and develop their personal and professional skills. We explored the experiences of music therapy interns participating in therapeutic song writing. In this study, five music interns completed two 4-hour sessions of therapeutic song writing. Following the second session, a group interview was conducted with participants to gather data on their experiences. The interview was recorded, transcribed, and analyzed. Six themes and 18 sub-themes were derived from the data. The six themes were preconceptions of therapeutic song writing, meaningful lyric creation, challenges in song composition, structured experiences during song writing process, development of self-awareness through music, and relational experiences resulting from the group process. Participants were able to incorporate their individual internship experiences into a single song by communicating with group members during the step-by-step process. Participation in therapeutic song writing was found to help music therapy interns identify and process challenges encountered during their internship and further their personal and professional development.

A Comparison Study of Postural Control Measures Between Before and After Applying Temporomandibular Joint Balance Appliance-Golf (TBA-G) Using Balance Master System (Balance Master를 이용한 TBA-G 착용 전후 균형능력 평가 비교 연구)

  • Doo, Kyeong-Hee;Lee, Ji-Hyun;Lee, Dong-Hyuk;Kim, Soo-Kyung;Cho, Seung-Yeon;Park, Jung-Mi;Ko, Chang-Nam;Bae, Hyung-Sup;Park, Seong-Uk
    • The Journal of Korean Medicine
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    • v.35 no.1
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    • pp.50-57
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    • 2014
  • Objectives: The purpose of this study was to examine whether Temporomandibular Joint Balance Appliance-Golf (TBA-G) can improve postural control ability of healthy adults. Methods: Twenty participants (10 male, 10 female) aged 20 to 39 years were involved. Postural control ability of all participants was assessed before and after applying TBA-G with Balance $Master^{(R)}$ system. Modified clinical test sensory interaction on balance (mCTSIB), unilateral stance, weight bearing and rhythmic weight shift were used to evaluate postural control ability. Results: After applying TBA-G, mCTSIB on a firm plate with eyes open increased from 0.2 to 0.23 (p<0.05) but directional control was improved in slow and moderate velocity of front/back rhythmic weight shift test (P<0.05). In two cases with postural imbalance, most of the postural control measures improved after applying TBA-G. Conclusions: The results suggest that TBA-G could improve balance control ability. A larger controlled trial is needed to determine more accurately the effect of TBA-G on balance control ability.